Essai pour Tests: NE PAS EFFACER

Essai-20220417-151413

105

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Choke and Mute #2

By Charles-Edouard!

Here is the nice month of May. Tribute to Cora Vaucaire...

I will always love cherry time, and the memory I keep in my heart

Towards a new Eclipse Equation

We saw in the previous post how the Eclipse equation, basic, responds well to known phenomena. History shows us that a new theory emerges by refutation of the old ones: the universal theory of gravity (Newton) is a refutation of Descartes, the theory of Evolution (Darwin) a refutation of William Paley, the theory of relativity (Einstein) a refutation of Newton. Einstein who made 2 theories on the same subject...

The 'Shock-and-Kill' strategy is very well understood when reading our basic Equation. However, we have already tried the Shock-and-Kill for a good fifteen years and we can't do it! When something doesn't work, we can start with the idea that it doesn't work because we didn't try hard enough, that we need more! Europe doesn't work, it's because there is not enough of it! AZT doesn't work: we increase the dose! We know the story. 'Insanity is repeating the same mistakes and expecting different results'(amusing article on this subject)

ICCARRE 1/7 (or even 1/15) works, without theory: competence without understanding. Our goal will be to improve the Eclipse Equation, in order to account for ICCARRE.

New equation with epigenetic distribution

The basic equation does not account for ICCARRE nor for the attrition of the reservoir by incorporation of R263K mutants, due to DTG (Mesplède lab manip).

An additional variable is introduced to account for the epigenetic availability to contribute more or less quickly to the rebound. Below a certain level of activity, infected, latent CD4 cells are considered as potential contributors independent of each other. Once replication resumes, the whole thing goes haywire, in an explosive chain reaction. The system enters phase 3 (explosive) and we leave the domain of validity of the Equation. The term introduced is called EpigeneDist. Epigenetic because it is epigenetic by nature, Dist because it is a distribution.

When measured repeatedly, in the same patient, by successive analytical interruptions, the eclipse is substantially always the same.

EpigeneDist: a promptness distribution

EpigeneDist. reports a distribution of readiness to initiate the viral rebound. If it is in the form of, for example, a distribution function, we will obtain a distribution of the duration of the Eclipse, whereas it is rather a constant. EpigeneDist is therefore more likely to be an arithmetic, geometric or higher moment average. EpigeneDist is not a distribution function per se, but the synthetic representation of this diversity. The underlying distribution is a stochastic randomness (a stochastic process is a random function, its argument is time, with an irreversible and ineluctable course).

The proposal that the eclipse can be lengthened, by introducing mutants with reduced fitness, for example R236K by DTG, exists elsewhere, on paper and in test tubes.

At the same time, it has been proven (ICCARRE) that a progressive reduction of the number of doses can be proposed, thus opening the duration of non-taking from 3 to 4 days, then to 5 or 6. EpigeneDist is a duration. The longer it is, the longer the Eclipse is: it is therefore in the numerator

The new equation allows to account for the opening of the Eclipse by progressive methods aiming at eliminating the proviruses which are the most prompt to start a replication.

Charles-Edouard: The Book!

The systematic hostage-taking of immunocompetent seropositives by militant and stipendiated seronegs deserves a strong response. It will take us 1 to 2 years... The project 'Charles-Edouard: The Book!' is launched... The book will be free and available on the Internet. It's a work in progress... As usual...

For now, there is already a page!

Towards the obligation of treatment

Here is what will incite to enter in the treatment: the right to forget is going to be opened to the seropositives. It is important to understand 2 things: It is in the objective interest of the associations of Seronegs to make the treatment 'compulsory' and that the 'patients' associations are no longer directed by Seropositives. There you go, the world becomes intelligible again. What will the 'Elite Controllers' patients do? Or the immunocompetent-untreated? One man's right leads to another's obligation... Stay tuned, you are not safe from surprises!

In the news

- Videx, prescribed as the 4th molecule, is it over? Well, that's just great! Hard for those who can't take Abacavir or Tenofovir. The anti-ICCARRE morons have won this round. You'll have to get it far away (e.g. Red Cross in Thailand) or substitute ABC(most likely) or TDF. I have never used Videx, I warned my readers! We can also replace it with DTG, if experience, once again, contradicts pharmacokinetics, now demonetized... Ah, the time when Act-Up was claiming is long gone! (see the video!)

- ActupParis: the management was kicked out by ... the activists... It is true that Act-Up-Paris had admitted that it could not face the financial disengagement of ... Gilead, which was 45.000 Euros!

- The ANRS has published on the effects of a caspase inhibitor. Thescientific article is here.

The French genius

When you're in the cherry season
If you're afraid of heartbreak
Avoid the beautiful

Miyazaki fans will love this version in Porco Rosso (youtube)

See the excellent video by Dr. Rahbi: Manipulating numbers and doctors

Feel free to comment, like, share and use

Have a good weekend, good stuffing and not too many meds ... Huh?

104

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Choke and Mute: ICCARRian Remission

By Charles-Edouard!

Condensed from the blog of Dr. Christian Lehmann:

Well said! As early as 2002, Dr. M. Girard had predicted the extended vaccination obligation... Today, everything is in place for the obligation of overmedication...

CHOKE-and-MUTE: a new approach to remission

CHOKE-and-MUTE is a new approach to remission, already clinically proven. We are working on its experimental modeling...

Summary:
- Eclipse equation
- New equation with epigenetic distribution
- Stochastic modeling and the Choke-and-Mute mechanism
- Comparison between remission strategies (cure)
- Why a theory is needed
- Why basic research is needed

The Eclipse: so many times observed

In the suppressed and stable patient, the resumption of viral activity is delayed. The rebound is initially nil, then starts, and finally explodes until it reaches levels similar to the Zenith without treatment. The image of a total eclipse of the Sun by the Moon is relevant, except that the non linear phase of the viral explosion is exponential (limited)

In the Choke-and-Mute strategy (ICCARRE), we maintain the infra-detectability: only the first 2 phases are of interest (red line above)

Eclipse equation

To account for the 2 phases (pharmaceutical persistence and takeoff), we formalize a 2 components equation. We have described it here and exposed its simplified form:

Eclipse equation and pharmacokinetics

This equation is a good representation of known phenomena. First of all, pharmacokinetics... The arrival of long-lasting N/NRTIs is announced: Elsufavirine, already approved in Russia and another one by Merck: MK-8591 (EFdA ) (to compare with the other new products). The manufacturers will, in any case, look at weekly dosing and counter the arrival of injectables. We already know how to make the weekly dose. Tomorrow, there will be a multitude of commercial options

Eclipse equation and Elite controllers

The equation also accounts for Elite controllers and controllers, where the eclipse is infinite or very long...

Eclipse equation and non-competent proviruses

The Eclipse equation accounts well for the integration of non- or low-competent proviruses (in particular unspliced vs. multiplied RNA, which may account for the particular success attributed to Nevirapine)

This is somewhat analogous(but not quite) to the Wainberg proposal to replace the virus with a much less available R263K mutant.

Eclipse equation and Berlin patient

When susceptibility is zero, the eclipse becomes infinite: this is the case in the cure of the Berlin patient; this is the strategy of CCR5 inhibitors. This is probably one of the serious leads for static remission (without episodic maintenance)

Eclipse equation and prolonged control

Prolonged control exists, it is documented in 2-3% of patients treated for a long time. If we go looking for them, we find them... If, if... we will come back one day... It is also possible in(some, not all) patients with very low reservoirs. For example the Toronto patient, also known as the CHUN patient and the rare Viscontis. The same CHUN that, on the contrary, showed that a very low reservoir was not sufficient to allow a sufficient truce. This term is probably conditional on something else... But what?

New Equation with epigenetic distribution

The basic equation is very useful. To account for ICCARRE or the attrition of the reservoir by incorporation of R263K mutants, due to DTG (Mesplède lab manip), it must be made to live.

So we have to complete our basic equation, which we will do next time...

Judicialization to counteract the obligation to treat

Our way of thinking will collide with a new objective of the medical-pharmaceutical mob: the obligation of treatment.

- To the chapter Morlatan-you-are-deceiving, you can add a documented error, by a factor of 4(at least!) on the threshold concentration of Nevirapine. We will come back to this...

In the news

- drug-induced depression is a brain injury, not just a passing mood. HAND also: Aberrant occipital dynamics differentiate HIV-infected patients with and without cognitive impairment

- Dr. Asperger was a eugenicist... Well... Who wasn't then? You will see how the treat-all hysteria will break and carry away the Nuremberg code...

- A. Faucy's surprising comment on the usefulness of a low efficiency vaccine. This guy is a Kador, we are told: he effectively launched, then buried, the short cycle... Low efficiency vaccine = creation/fixation of new mutants! Bravo!!!

The French genius

It is the year of Debussy... So I propose a César-Franck break, with Lugansky(Prelude, Fugue & variation), the purists will be touched by E. Power Biggs on the organ. There are so many adaptations. This one, on sax, is touching...

Enjoy also S. Rodriguez (Rachmaninoff) before it disappears... Thanks to

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97% of patients overmedicated, 22 million without treatment... Let's stop this scandal!

103

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



ICCARRE in Moscow

By Charles-Edouard!

ICCARRE-Le-Grand at the Tsars

After the success of the presence, noticed (since ignored by the medical-pharmaceutical underworld), of 4/7 at IAS-2017, ICCARRE is announced at VI International Eastern Europe and Central Asia AIDS Conference 2018, in Moscow.
Sounds a bit like Tintin in the Land of the Soviets... You won't be there, neither will I... Here is an exclusive preview(the company does not shy away from any sacrifice...) of the patient cases that will be presented. There are about ten of them... So I put 3 of them here, and I will put the others as we go along.

Patient #1: in 1/7 since 2009

8 years of treatment for only 1 toxicity! Here is the work... This is a patient case, sourced by J. Leibowitch, and therefore duly registered in Pr Péronne's department, in Garches. Don't tell us (or insinuate) that it doesn't exist!
As you can see on the graph, the patient had 2 treatment interruptions (therapeutic vacations) before maintaining, in a continuous and uninterrupted way, her undetectable CV. This illustrates the clear advantage to ICCARRE, which provides both therapeutic benefit and reduced toxicity.

Patient #2: in 2/7 since 2011

7 years of treatment for only 1 toxicity! An ICCARRE-le-Grand not too advanced, cushy, in 2/7. 15 years of benevolent treatment. Oh, how envious I am!
No mystery, today like yesterday, you have to run all over Paris to find a doctor who can handle it... When I compare it to my own doctor, it's light years away. And my doctor is not a light, he's nice, but on this one, he's a bit of a pushover. Besides, I only listen to him with a distracted ear...

Under ICCARRE (#3): 2 natural births

Well... There are people in life who think that everything stops for them... The veterans knew how to wait a little before entering the treatment. Yéni or Morlat recommendations? I don't give a damn! Oh my, how hateful is all this over-medication...

And this haughty contempt!

What a nice denial inflicted to the stipendiated morons... Brrr... Just to think that these people would like to forbid us, us honnites, to reproduce.
Hi, Hi, Hi, we're getting there with the kiki!

10 patient cases for ICCARRE 1/7

That's a lot! It makes for a nice, convincing presentation... We will explore them one by one, otherwise we will have indigestion. The Russians, familiar with American-style 'fake news', will appreciate it!

In the news

The question of the super mutation (known as 3'PPT) in vivo is on everyone's mind. It has been detected in only 1 patient, in DOMONO, for a rise to ...798... Well... Super mutation?... The authors also indicate: [pre-existing] Proviruses containing a single INSTI-RAM is the mechanism of failure. This is very much in line with the Achilles Heel warning.

- Morlat was completely off the mark regarding the 'threshold' dose for NVP; this was highlighted by the VERxVE trial found here: 4 to 8 times overdose! Trust them, they tell us... We will come back to this!

- A new article without much interest: Dolutegravir resistance mutations

The French genius

Francis Blanche does the product placement trick on TV. Is this a bygone era? Well, no... With monetization (You Tube), the activists in robes take advantage of it to throw us medicaments at all costs!

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good weekend, good stuffing and not too many meds ... Huh?

102

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



2 blogs and 1 interesting site

By Charles-Edouard!

A tenuous thread of thought

The vital information of relief reaches you: you go looking for information. You will find pseudo-information (total denial) or quasi-information, restrictive, distorted and no less misleading, and rare reliable sources.

The Morlat report, under the aegis of the ANRS, recommends ICCARRE, without explaining how to do it... It delays on Mono-DTG, which works very well if one knows how to do it and takes care not to quote the ICCARRE scientific literature: that tells you the level! The (only?) interest of the Morlat recommendation is that it assures you that weight reduction, in particular ICCARRE, is not a trick of gogos...

It is conducive to the autonomous mode: great! Why don't you go do that with injectables? There you are free and you regulate your practice as diabetics do: intervention and control. They do the control first, on a drop of blood, then adjust the intake. In the short cycle, it's the opposite, you go step by step and you ensure with close CV.

This is a good example ofself-posology, freely managed by the patient, and completely legitimate.

The scientific literature

Unfortunately sparse: 1 publication every 3 years, in different journals, in English, and sometimes paying! As for me, when my doctor mentioned Leibowitch's name, only to say that he is retired, I found myself stuck. So I pulled the ball out, by myself, thread by thread, and constituted a bank of information, which I gladly share.

Here you can find the scientific articles, translated, illustrated and enriched with practical guides. I also wish to pay tribute to the precursors.

The allegeurs have testified and offer a site

The hundred or so patients at 2/7 (or 1/7) are grouped in an association... They have a little party on December 1st, and that's it... They made testimonies, a book, TV appearances, a Facebook page. What more can they do ???

Richard Cross is doing a hell of a job: can we ask for more? They now have a website: Go there!

Patrick Valas' blog

When I was in trouble, he saved me! It was, at the time, the only resource readily available, the only one! It fits on one page, and it has (almost) everything. You can read hundreds of pages and internet resources, all of them megaphones of the medical-pharmaceutical mob, and, in the immensity of stupidity, the Web, there was only one luminous source, capable of enlightening your universe from a saving angle: Patrick Valas' blog.

At that time, it was the only window open on Leibowitch's immense work (clinical trials, publications, patents, videos, radio, etc.). So it was not 'fake news': (almost) everything is referenced in it. I read it, reread it, reread it again, reread it again: my screen is overlaid with the page I consulted so much.

The presentation is a bit like that of the precursors: you have to search. It is an Ali-baba cave and what a wealth! Today, ANRS-4D has demonstrated the intrinsic ZéRo failure. The small stream, the clinics and the autonomous, grows, and drowns in a river, mainstream. We left (five) hundred; but by a quick (??) reinforcement, we saw ourselves (three) thousand by arriving at the port

Jon D Barnett's blog (closed)

Very different perspective, reflection and personal testimony of a community activist, on the ground, in a big city, a bit provincial: Kansas City. This environment and this testimony are completely different, he meets real people, in the long term (it's not New York!), a little left to themselves (think of the Dallas buyer's club). The academic reflection in less, the good country sense in more... His blog has been closed...

First he observes that ARVs, especially the ubiquitous NRTIs, are deadly toxic. All of them... He stops the treatment and, oh surprise, the dreaded disease does not arrive. His CD4 count goes down, but no matter: no health problems. Well yes... How can you get tuberculosis in Kansas City? or salmonellosis in those people who are obsessed with disinfectant and overcooking. Kansas City is not Tambacounda(Senegal): so nothing happens to it. Of course not! The basic badger readily believes in the excess risk, which is very real in Africa with tuberculosis, not in Landerneau. Jon then questions everything, in particular the CD4 hysteria. He denounces the 'forums' held by Big Pharma's stipendiaries. For a while, he frequented the denialists (see: Contestation of the responsibility of HIV in AIDS: Wikipedia), before moving away from them.

The interesting page, unavailable, is the one where he discusses his treatment, resumed after years of vacations: no NRTI, a PI monotherapy (which works more or less), his mono-DTG, which works (the 5/7 on Mono-DTG, started too early, is abandoned) and a virulent criticism of these abusive 'recommendations'(guidelines), written with a pen held by the Labs. His youtube channel, resists, probably not for long.

In the news

- This article made the buzz; the interesting part (David Gerrold) is the one about robots...

- How smallpox vaccination could still save lives

- No news? Good news! We don't hear from Quartet! Already 4 months they are in the 4/7 relief, and, It goes on! Without a hitch! Nobody talks about it? We are!

The French genius (oxymoron version...)

Kaletra monotherapy goes out the window: Lopinavir/r monotherapy cannot be considered non-inferior to EFV/FTC/TDF... Nice double-negative! But what on earth was the ANRS doing in this mess? Amusing the gallery? You be the judge... And don't forget to judge! Because this fiasco will have cost you your money and your prospects, real, proven, of ICCARRIAN remission.

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good weekend, good stuffing and not too many meds ... Huh?

101

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Shock-and-kill

By Charles-Edouard!

On unnecessary and deleterious medication... Deleterious or not, unnecessary overmedication is ... useless! Genvoya® contains a powerful metabolism inhibitor: Cobicistat. Virologically inactive, it is not harmless.

The great subject of the moment is a questioning of the dogma of provirus integration, following the discovery of replicating but not integrated viruses (E. Thierry, ..., Delelis)
This is really THE topic of the moment, so let's continue our entry: it's exciting!

What is Shock-and-Kill?

The video on the right describes Shock-and-Kill: it is a bit simplistic and the visualization is sometimes distorted. Let's start with this approach anyway: the proviral DNA is integrated into the genome of 'memory' CD4 cells: it enters latency. John Le Carré would have spoken of a dormant cell.

The problem is that the dormancy isnever explained, nor the mechanism envisaged to bring it out of dormancy: a test tube manipulation, with a hyper-dangerous molecule! In practice, in clinical trials, the failures follow one another and are too similar.

The patient, credulous, is fooled: we entertain the gallery. And we take advantage of this to suggest that an early treatment would be favorable to a low reservoir, which would be favorable to a possible Shock-and-Kill... This fable going in the direction of the early treatment, therefore of the treatment-plus, therefore of the consumption-plus, finds good souls, stipendiated, to repeat with envy this tomorrow-we'll-rase-gratis, therefore, quickly, enter the treatment, illico-presto, without forgetting to pay the bill.

A well-concealed DNA

Popular imagery imagines a piece of DNA in a double helix, ready for use, transcription and expression: a devil in a box, but without the box... Just look at the picture above, the DNA is well unfolded...

In our previous post, we had seen, that in fact, the provirus is 'protected' by a methylation gangue, and, moreover, wrapped around the histone. This shaping is modulated by a histone deacetylase. The idea is therefore to inhibit this enzyme to give the green light to transcription.

I mix up methylation and histone: It doesn't matter... A detailed explanation by Margolis can be found here... In practice we try cocktails and it doesn't work...

Valproic acid (Depakine): authorized and dangerous molecule

Drug against epilepsy, strongly advised against women of childbearing age, because of its serious teratogenic effects on the embryo and the fetus and neurodevelopmental disorders induced in the future child and adult. Discovered by chance in a laboratory in Grenoble, it was the first to be effective against epilepsy, a serious disease with no cure: it was therefore authorized.

Opening the gangue where DNA is normally encapsulated is not harmless. The most visible consequence: abnormal babies, with a distinctive face (known as pear-shaped), which will have been deliberately hidden. Babies born under Depakine : the extent of the scandal becomes clearerThe risk of congenital malformations in 40% of pregnancies.

An untargeted strategy, marginal effectiveness

The can opener does not target its action on boxes identified by what is inside: the gangues are opened at random, including those that would be better left as they are... We open, we open and we make the genes (not only the provirus) express themselves, at random. So yes, we do observe a small induced, transient rise of the CV. But then... And then?

Then we do some tests, like SEARCH 019, already discussed here Always no effect on the Eclipsealways unchanged.

What future for the Shock-and-Kill?

The latest trial is the BCN02-Romi. The pharmacological gain is only a few weeks (and still... It is not sure), where the average of the natural Eclipse (patients treated very early) is already 3 weeks.

The only benefit will have been a few boxes (1-2?) put in reserve in the medicine cabinet. That is to say peanuts compared to ICCARRE 4/7 or 1/7.

Trials on mice are taking place... The new concepts try to get rid of Valproate.

There are many other proposals with generous funding...

Abivax is tempted. Except that obtaining a reduction of 131 copies of proviral RNA (per million PBMC) does not induce any gain on the Eclipse (see here). Zero, nichts, nada...

Illusory Shock-and-Kill or well-tried ICCARRE?

What we are interested in is whether to wait for the results of an illusory Shock-and-Kill, invalidated by 13 years of unsuccessful efforts, or to benefit from a proven strategy today, which will have benefited every patient, without exception.

This is the subject of the moment and it is time to move forward because we have been distracted by Siliciano, Margolis and others...

In the news

- ICCARRE in the program of VI International Eastern Europe and Central Asia AIDS Conference 2018In Moscow, meeting the need and listening...

- For ViiV, Bictegravir (Gilead) is copying DTG, and is going to court; an out-of-court settlement, as was the case in 3TC vs F-3TC, would be detrimental to patients: the truth would remain unknown and Gilead could maintain a molecule (or a combined drug) under patent, while the original would already be free (this is how Truvada will have continued to be very expensive, while TDF/3TC is negotiated at 30 Eu./per patient and per year!)

The French genius

Clair de lune (Debussy): Alexandre Tharaud, Yoann Bourgeois - piano & dance on YouTube. It is an allegory of the 3 steps, then six, with falls and rebounds. In the serenity of a light, certainly less flamboyant than the miraculous Sun, but light all the same...

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97% of patients overmedicated, 22 million without treatment... Let's stop this scandal!

100

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Provirus and histones

By Charles-Edouard!

Dr. Lafeuillade wrote: a doctor should never say that... and even has a website to present his book. One of us has read it...


Lafeuillade named Hypodolu the Mono-DTG in 1/7: it is a lightening. He proposed it (press release); he talks about it a bit here; then, he didn't talk about it anymore... Did he screw up? In this case, we would have liked to know... For me, it was a big mess (Mono-DTG 150 mg, 1/7), whereas Mono-DTG, in 7/7 at 50 mg, then 25 mg then 12.5 mg and also 50 mg in 4/7 had worked well... Some patients fail with Mono-DTG, without integrase mutation (cf DOMONO): can we have a major failure with Absolutegravir? This press release and its presentation at CROI-2018: DTG resistant mutation without genomic integrationcould enlighten us! Well... I'm not too worried... The patients have all successfully deleted... Well, thanks for this information, we'll come back to it! Until then, let's review our classics...

DNA, chromosomes and pads (histones)

Prof. Even knows how to popularize this whole thing: it will appear in his next book, so I'll make it short... DNA is this long double helix thread: it measures 2 meters, which for a cell is a lot: at our scale it would be 20 km. We can imagine it perfectly rolled up in the chromosomes, like a sausage. It is more complicated than that! A very good presentation can be found here. This video explains and also this one how a segment of DNA, integrated, can perfectly not express itself naturally. The buzzword isepigenetics...

P-H Gouyon explains it with simplicity: the DNA contains the recipe of the apple pie... But it is not the recipe that makes the pie: you need the ingredients, the baker, the opportunity to make it, etc.
Pr. PZ Myers puts the role of epigenetics and genetics into perspective...

The received idea that DNA is a protein factory has been challenged by Pr. C. Lewontin(the triple helix): the message is finally getting through... It is enough to remember that our heart cells have the same DNA as our fat cells. But they are different. However, there is always a tendency to think that expression will inevitably occur, and even quickly. This is not correct.

Proviral DNA is the king of napping

Once it has written itself into the genome of a CD4, the provirus is encapsulated in a histone (the pad), it is even protected by a chemistry called methylation. This methylation is a barrier, not the only one, to the expression of proviral DNA. When the CD4 is activated, excited, it will happen quickly. After several months of treatment, everything calms down and we go to the latent state.

Latency

We are told that the reservoir is in a latent state, but we are not told that of the fact and during the latency, it is, obviously, useless to treat. It's like putting weed killer on top of the snow: it's a total nonsense! To laugh, we can have fun with the hysteria of Pr. Rouzioux-des-critères...

Shock-and-Kill strategy

In a next post we will see how this methylation and winding in histones are the target of Shock-and-Kill, proposed by Siliciano, and implemented with histone deacetylase inhibitors, permitted but very dangerous.

Choke-and-Mute Strategy

The strategy behind ICCARRE is to drop a bomb and then leave its place to silence. It is natural, economical, ecological, epigenetic and proven. It leads to a dynamic remission for all. We will see, later, the mechanisms.

In the news

The headline is tantalizing: Australia on the verge of eradicating cervical cancer. To date, the incidence of cervical cancer has not changed one bit! If this hysteria leads to the disappearance of HPV, a cause of discomfort in Homo Sapiens Homo, why not? It is indeed a real benefit to others, for a personal benefit not demonstrated.

The French genius

- No man is a prophet in his own country: ICCARRE will be presented at the VI International Eastern Europe and Central Asia AIDS Conference 2018In Moscow, where the need is great: Possibilities of interrupting therapy in patients with sustained HIV suppression.

- In 1913, Apollinaire read... Apollinaire: Under the Mirabeau Bridge... (France Culture).

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good weekend, good stuffing and not too many meds ... Huh?

Long Vacation

A long vacation

For a long time, this blog has not been translated into English. We are resuming translation and you may go here to read the next translation, or jump here for the latest translated post

099

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Healing: 3 proposals, one of which walks

By Charles-Edouard!

Joëlle's testimony

You are making progress, my dear, you are making progress! Think about the frequent resumes, and give your news.

Healing: 3 proposals

Around 2003, Robert Siliciano theorized that a cure would be impossible. Until recently, there was only one proposal for remission, that of Siliciano, based on his theory of the reservoir: unchanging in its content, stable in its quantity.

In fact, there are 3 theories of reduction of the operational reservoir, therefore, of the functional cure.

A- Siliciano theory

The reservoir is constituted as soon as the primary infection occurs, and does not change (or only slightly) in its content: it always contains the active virus (most often wild). The only way out is to decrease quantitatively the reservoir to hope to play Visconti, for a few lucky chronic patients. One thing leading to another, he developed a proposal for a quantitative reduction of the reservoir and obtained funding for laboratory trials. The strategy is sold to the funders and made popular under the name shock-and-kill.

B- the Wainberg theory

With Dolutegravir one can modify the content of the reservoir(read here) to introduce R263K, which reduces the reservoir until it disappears: Wainberg has done lab tests (read here) and proposed a cycle of progressive attenuation of the reservoir(read here): his proposed cycle is not consistent with his theory, however, it is possible to think of an alternative cycle. This is how yours truly had succeeded in some things but not in the proposed cycle: the proposed implementation is not very practical, but the substance is good: we must advance this way, which is the first laboratory proposal to challenge Siliciano on his ground, and offer us a perspective...

C- the Leibowitch / Sonigo / Charles-Edouard theory

Sonigo is a golden-boy of French biology... He explains the Eclipse to Leibowitch as expected and necessary: he tells us that this is what happens(see the graph), without the theory being explicit(if you read Kupieck and Sonigo, you understand the spirit). For lack of having been able to read under his pen a theory of the Eclipse, I was reduced to writing the Equation. I will therefore, in abstantia, write a stochastic theory of the Eclipse. It concerns the random events of resurgence: the afficionados of the series Death Note will be seduced(I will call it that). To put it simply, proviral candidates have a delay in emergence which is an intrinsic property of theirs: a kind of (over)life expectancy, well hidden as they are. With the progressiveness of the ICCARIAN descent, those who have a short hidden survival will be de-zoned at 4/7, then at 3/7, ... The reservoir sees the quickest proviruses disappear, only the slowest, the deepest, the most irremediable ones remain: the window always opens more and more, to close again, fatally, but then, after 15, 20, 30 days...

Burial of the DNA in the pads (histones)

Each of the theories is based on the burial of the DNA in the pads (histones): Siliciano wants to use histone strippers (e.g. Depakine!!!), Wainberg wants to move to deep histones, Leibowitch allows expression-prone histones to be dezoned: only proviruses buried in deep histones remain. Putting the 3 proposals in parallel allows us to identify a common theoretical core: burial in histones.
Prof. Philippe Even explains it remarkably well and we are impatiently waiting for his next book: it's inside! Failing that, I will do it for you: it is fascinating!

Parallels and implementation

It allows us to highlight the Leibowitchian proposal as being, to this day, the only proposal immediately availablecertainly imperfect...

A- Siliciano: attractive, but using dangerous openers (opening histones is opening the can of worms: cf dekapine): for the moment it is a failure! The patients treated in primo will be the best candidates. As it uses molecules, on an experimental basis, with the promise of profits, it receives subsidies from Washington.

B- Wainberg: attractive, modern (DTG...), demonstrated on tissues (in the lab), but difficult to implement: no known implementation (and I failed, need I remind you?). Mono-DTG patients will be the best candidates... As she makes DTG a healing molecule, she was receiving subsidies from ViiV, but well... Who to finance the end of her pension?

C- Leibowitch: counter-intuitive, unless one theorizes well, imperfect (because limited to 1/ Xmax). Advantage: its implementation is proven, costs nothing and the immediate benefit to the patient (even if it is capped). Patients who have passed the 4/7 are good candidates. If the ANRS was not so poor, it could have enriched the expertise of the Eclipse and made a major breakthrough... Well... no... We will have to do without them.

ICCARRE and dynamic remission

If the Grand-ICCARRE (1/7, 1/15...) is presented in this way as one of the 3 proposals in the running for remission, it still has more gumption than the anecdotal little drumbeat. Leibowitch doesn't care about the underlying cause of post-treatment delay and theories: it works and it suits him! I still don't understand how the proselytizers of the progressive, Darwinian method don't conceptualize that the Grand-ICCARRE is more than just an alleviation: it is a dynamic remissionthey have their finger on the most brilliant invention of the century, and, seem to look the other way

Well... We'll see next time what is the burial in the pads (histones)

In the news

- The Frenchjustice system nails the hepatitis B vaccine

The French genius

P-H Guyon explains, in a few words, at minute 1:11:40, the myth of Daedalus, the father of ICCARRE, who always has a technical solution to everything. He invented the extended prescriptions, the always more. ICCARE has a father: over-medication! Daedalus is a bit like Siliciano...

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97% of patients overmedicated, 22 million without treatment... Let's stop this scandal!