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Saturday, September 24, 2016

Pr. Delfraissy's surrender

Pr. Delfraissy's surrender
This paper was originally published here, in French. We provide this translation for your convenience. Some practical aspects may differ where you live.


The ANRS announces Quartuor:


The introductory course is done in 7/7 ... Should we now recommend 4/7 days in current practice? NO said Delfraissy / ANRS: Pffffff !!! It's hard to have put our trust in these guys ...

ANRS-4D: there was cheating and even sabotage: the results prove it!

Two camps clash: Septists against Tempists


- The septists, infected by a Septisticum parasite: they only swear by 7/7strategies
- The tempists, proponents of the Viral Eclipse: the virus takes 7-21 j. before showing its nose: They follow the Tempo

It is by no means a 'enlightning' camp versus a 'conservative' camp. No, on one side we have the septists on the other, the tempists.

- The septists have an apocalyptic vision: 7 days otherwise, the Apocalypse
- The tempists have a temporal vision: the action adjusts to the viral tempo

I have used ICCARRE 1/7 and HYPO-DOLU (another 1/7): it works. So be it. When you witness the 1/7 at work , then you understand.

There is no question here of a showdown "massive therapy" versus "lighter therapy", but Septists against Tempists.

The ANRS and the blow snow job.

This is not a tiff amoung pharmacokinetists, between Peytavin one side, and Alvarez on the other. Between the proponents of a minimal plasmatic concentration, and the proponents of a residual concentration in the cell.

No, this is something deeper: the virus is integrated into the genome: it is comfortable, don't bother it, is is napping: it is the Sabbath, a long Sabbath ... It is a lentivirus, after all.

The confrontation was deferred by the desire of Prof. Delfraissy. It has happened: they are defeated.

The surrender is booked: there is no place for rear guard skirmishes.

SURRENDER does mean SURRENDER.


RESIGNATION is not our purpose (it's inevitable, so without interest), because actually it is the SEPTISM, which infects the entire profession, that surrenders.

Among the first to have published on the viral Eclipse, we find Antony FAUCY (the Big Boss at NIH) and Mark Dybul: it dates back to ... 2003!

It is the confrontation of the Alliance Faucy-Dybul-Leibowitch and Axis Ananworanich-Delfraissy-Katlama.

The SURRENDER, dear Professor Delfraissy, is not a "peace of the Braves": the SURRENDER is to let its territory to the winner: the real-virologists who-have-understood-the-virus: we can no longer accept SABOTEURS, who may compromise the upcoming new age. How can we accept cheating and sabotage in an ANRS?

Losers must recede: we will put them to trial them in due time.

The judiciary suit, the evaluation of the ANRS, all this will take place, in due time. The Pr. Delfraissy, perpetually tanned, is not just a one-time fuse: the entire Septism collapses.

A crooked medico-capitalistic construction will disappear, it is inevitable; since the Viral Eclipse is a factual reality.

It is known and recognized by FAUCY-the-Great who finally wins. Will Delfraissy and his tiny ANRS go against FAUCY-Dybul-Leibowitch?

Applause: Delfraissy, the artist, the man who we will have cost us 3 billion, has capitulated: Quartuor trial has been announced, even before being conceived: 640 patients!

Why 640? Is the size, 640, up to the challenge?

Yes, from the perspective of those who panick-decided, to save face, diffuse the bomb.

No, from the point of view of the victors, the scientific virology Alliance, attached to the facts

Facts are stubborn, the Eclipse Viral exists, it is measurable, I explained how to do (if you want to have fun).

In the Anticopernicus world, the Eclipse is denied. Copernicus, Newton win because they predict the Eclipse, and the commoner can see with his own eyes. Anyone can measure the eclipse, if wanted ... I started a post series here, and here. The measurement is not so important, as long as you know how to benefit from it.

Applause: Delfraissy the artist, the man instrumental in postponing , yet launching, ANRS-4D ... Exit through the back door or face-saving matters little to us: patients are not fooled by the guilty procrastination: patients who can not register to Quatuor, due to lack of spots, will need a solution.

And Congratulations to Leibowitch to Truchis, and other advocates of the Faucy-Dybul insight. Thank you for the hundreds of years of pharmaceutical remission ...



This paper was originally published here, in French. We provide this translation for your convenience. Some practical aspects may differ where you live.


Saturday, September 17, 2016

First Line Dolutegravir monotherapy

First Line Dolutegravir monotherapy
This paper was originally published here, in French. We provide this translation for your convenience. Some practical aspects may differ where you live.

This post is a follow-up to attack monotherapy and monotherapy of attack: the scoop.

jesuisdutreize, true pioneer, opens the frontier (in maintenance):

We fear Nope: an firstline therapy is taken, the virus is blasted, you let it cool, then, allow it a siesta and you maintain with 4/7. It was nontheless necessary to realize that Tivicay® Monotherapy is an effective firstline therapy (finally ...). If it had been possible with AZT or PIs, we would not be here, with these new questions. If the manufacturer had not cleverly obfuscated results, we would have realized faster!

Lanzafame opens the show: FirstLine Tivicay ® Monotherapy


Like us, Dr. Massimiliano Lanzafame opens his account of experience with the extraordinary results of ING 111521 (the page in French is more complete).

He recalls: Ddolutegravir 50 mg demonstrated a high power with a reduction of 2.5 log after 10 days of monotherapy.

We said: Log 2.5 is a low-estimate: maybe this is more!

The results speak for themselves:



Crystal clear: First line Tivicay® monotherapy : 9 naives patients = 9 success !
How many successes with First line Tivicay® ?:
- ING 111521 : 8
- Dr Lafeuillade : 1
- Dr Lanzafame : 9
Total : 18 (very good!)
Here, we are expecting confirmation results by Pr Katlama (Paris) ... We are not the least worried!

Normal values vs desirable values


The normal value is estimated as follows: take patients without problem, measure, calculate the mean and standard deviation and anything above (say, 2.5% below and 2.5% above) is deemed not normal.


The 'normal' salary and the desirable minimum wage, are not the same thing!

Desirable: looking at patients without problems, and those with problems, and put a threshold: those above are less problem-prone, those below are more likely problem-prone.

And it's not the same! And not the same at all times ...

Example: CD4 value 'normal' is 800, and, say, greater than 500; the desirable value is > 350 (for short ...)


To determine the desirable value, one must look at Joe-on-the-street patients (excluding those who already have the Achilles heel, it is another matter, and not a matter of concentration) who fail with dolutegravir (excluding other causes such as toxicity). To do this we will have to find patients who are failing with dolutegravir: good luck! Do you know patients failing with dolutegravir? Good Luck!

There, it's that simple: pharmacokineticists are unable to document a desirable dose ... And no one raises the question: why? How come? No ... They do not care. We force-feed, we force-feed ...

Well, then the force-feds are fed-up and fire the quacks: and this is normal!

Sorry... This is desirable !!!

Good Weekend and good fuck


Saturday, September 3, 2016

ANRS-162-4D: cheaters are exposed

ANRS-162-4D: cheaters are exposed
This paper was originally published here, in French. We provide this translation for your convenience. Some practical aspects may differ where you live.

This what ANRS-4D uncovered


In short:
- J. Leibowitch was right: you can follow the 4/7 schedule, within the rules
- Eviplera ® (Complera ®) is eligible 4/7
- You can go direct to 4/7: bypassing 6/7, 5/7
- There was cheating in this trial
- There was sabotage in this unsponsored trial (see below)
- No intrinsic failure in this trial
- For patients 100% eligible and 100% adherent, regular VL inform us of nothing: they are useless

2 cheaters: revealed by their concentrations!


No doping! Not cheating! No cheaters: dosage reveals who pees blue, and also those who do not take their meds at all!

Le Figaro exposes the cheating:

"Of the 4 patients failing, one quickly abandoned by fear, and two are unlikely to have followed their treatment," says Pierre de Truchis (Hospital Raymond Poincaré), who led the study.

Yes, of Truchis has indeed granted an interview! He leaches out here:
Dr. De Truchis: ... two of the three had low plasma levels of drugs which suggests they did not take quite the expected dose of drugs.

Who are the 2 patients in question? identifying 2 patients 3 on low dosage criterion is easy ... Since 1 of 3 patients always a largely measurable concentration.

Patient number 2 obviously take Atripla ®; he has Efavirenz concentrations, while ON, well above the average (3669 for an average of 2218 among 100 patients) and, while in OFF period, has 1543 (an average of 692 when OFF), which is even a concentration worthy of ON. If de Truchis accounts that patient #2 as one who does not take these meds, he will have clarify. Because, in the published poster, patient # 2 taking his medication properly.

Who are those, then, who do not take the dose as ordered by the trial? Apart from # 1 and # 3? Whose doses are so low that they are not detected. Including in the period in which they were supposed to take meds. So that's quite clear.

You have undetectable concentrations when you are supposed to take medication and that you claim 100% adherence: you are lying!

Dear: Your doctor has prescribed Kivexa + 1 protease inhibitor, to be taken daily, and you miss doses? We understand you ... You are in a vicious circle: you are under PIs, you miss doses, your doctor realizes it, fears resistance, so leaves you under PIs. We understand your interest for the short cycle. We understand ... But you lied to the investigator ... Your lie costs us: redo the trial, delay deployment of the strategy for yet another 3, 4 or 5 years. The millions of patients who are waiting for a reliable strategy or simply treatment (because of shortages), do not say thank you! Here your lies have been damaging and are reprehensible.

Note for future trials: people want to go participate in a trial just to have an excuse to stop their treatment should not be included. This should be the first criteria for non-inclusion in the trial. Exclude anyone who would want to participate just to stop treatment.

We always thank the volunteers ... but not the liars!

Cheating (provisional): it does not count!

Read our complete analysis here!


This paper was originally published here, in French. We provide this translation for your convenience. Some practical aspects may differ where you live.