181

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

DTG: a failure without induced resistance

By Charles-Edouard!

DTG: did my failure create resistance?

For those of you following along, I failed a lot of copies, a lot! Plus, it was maybe the only time I was behind on my resume schedule. I did it at 3 months, instead of 1 in the exploratory phase. That's how it is, sometimes I get stuck abroad, without access to the CV, or to the meds for that matter, hence the interest of the 1/X: you leave with a few weeks of treatment, but you stay for months (and months...), it's all good! Well, I did what I shouldn't do. Leibowitch said it again and again: you have to make your CVs(in the exploratory phase, of course).

Even if I was late, I did it... I was on DTG monotherapy, 150 mg in 1/7 (collated in a capsule, which is perhaps the problem). Well... The failure was only a half surprise. The height of the failure was a real surprise! I blew up my counter, and I think I even made the highest failure of all I read in Mono-DTG, that's saying something!

Damn, didn't I create some resistance?

Catching up with the DTG

Even Leibo didn't have much of an idea on the subject... However, I knew one thing, on the Integrase, my virus is clean! It's not complicated, it has never seen RAL (let alone EVG, I'm not that stupid). So, for me DTG would act like an Absolutegravir, a concept I developed, not tested, except that here it is the truth.

Understanding that viruses that have been exposed to old INIs (RAL, EVG) are likely to acquire new resistances under monoDTG is the Achilles heel of this strategy. On the contrary, when we look at the rare French publications on DTG resistance, we identify multi-resistant patients (INIs) included in the rescue trials. I have not seen any published resistance on originally clean viruses. In other words, de novo resistance on non-pre-exposed virus does not exist! And if you find any, please correct me.

This is very important because it is the cause of the extraordinary overdose of susceptible patients because the choice of the dose was guided by the dose needed for mutated viruses. In a word, thousands of patients are being overdosed with DTG (and soon injecting themselves) at a dose chosen to control the virus of the few who had messed up with the virus: you don't treat your virus, you treat someone else's.

For me, DTG was an Absolutegravir... So, if my vision of what is an Absolutegravir is right, this is the opportunity to try it! Leibo proposed a drowning. I decided to try resuppression with DTG, there would be time to do a drowning, if needed, later on. I have already explained the chosen scheme: I resuppressed with DTG, without making a resistance profile, assisted by usual and less usual companions: it worked like a charm. In 1 month it was fixed, as usual for DTG, so no damage... So DTG is still part of my world.

Has DTG remained an Absolutegravir?

If you failed Mono-DTG, you might be afraid that this wonderful property (Absolutegravir) is now a thing of the past... In Eclipsotherapy on Dodeca, we don't really care. But then again... If DTG is amputated, we might as well take it off Dodeca... The resistance profile, was not done, I resuppressed without worries, so basta!

Except that... The Lab got mixed up with the brushes! Yes, yes... It happens! They did a genotype in addition to the DNA quantification. Well... I don't have a lot of confidence in these explorations at the limits, but well... They did it, they did it

Well yes! No resistance mutations in the INI

That's it... that's what I thought! My virus stayed clean (at least what the lab says). I was a little suspicious, but it's reassuring to know that! You're doing great in Mono, and, you're still perfectly susceptible! DTG is great for those who know how to use it! And to use it alone! I was very careful not to associate it with 3TC, because the 184, you get it every time. But we're clean there too!

And elsewhere? I did 4/7, 2/7, 1/7, 1/15, 1/21, failed 1/27, Mono-DTG 25 mg 7/7, 12 mg 7/7, 150 mg 1/7 (failed) and nothing. Nothing from nothing... Not a single acquired mutation... Nowhere

In the exploratory phase, you have to make your CV!

Well... I didn't stay on Mono-DTG for long, so that must help a little. Since then I do my CVs religiously, in the descent phase. In stabilized phase, no... No injections, no more blood tests, the less I see the 'specialist', the better I feel... She is nice, very nice... She's nice, but you won't get better with her

Icing on the cake: the disappearance of the tank

This allowed me to discover(fortuitously, but not that much...) the disappearance of the tank: my big topic of the moment.

The next step after the disappearance of the tank is... It is... for another time ;-)

In the news

- A vaccine injection that must be repeated every 6 months!?!? Hello Houston: There is a problem...

- Mr. Zureik answers the challenge (it would deserve the Canard Enchainé): As an answer we have seen better!

- Actually, it's quite simple, you read about what makes the soap merchants tick. It's often interesting! It makes them angry because it attacks their business! The Chinese with HCQ, the Indonesians with IVT, the downgraded with NVP, the Malagasy with their syrup, they must be laughing! A good real laugh is communicative, it is joy!
Pr Perronne probably had the wrong idea about the herbal tea... Molecules coming from Nature are always there and immune to prevarication.

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Science under finance is only ruin of the Man...

180

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

Intermittence and flu vaccine

By Charles-Edouard!

The Thai health system offers the best quality/price ratio, it is well known. ARVs are not subsidized and are affordable for the average tourist. And the trip is fun! The problem is the cost of Biktarvy: 58 Eu./month (in France, it is at least 10 times that!), while NVP/TDF/F-3TC is 19 Eu. / month. There are many testimonies of use in 2/7... It leaves one dreaming! The (anti-)French social security system is a burden on the gross salary and favors relocations...

The flu shot? Not for me this year

Before, I had no objection... That was before I read, under the pen of the excellent Pr. Montagnier, that repeated vaccination does not bring anything, especially if one has already had a few natural influenzas. I am one of those people who listen to our best Nobel Prize winner. Do you have anything better to propose ? Well... So I listen... So, I made a bad quote: vaccine every 5-6 years, not more. On the other hand, I am very careful about the pneumococcus. Everyone around me is up to date.

2020: a useless vaccine!

I let myself be convinced by the usual TV shopping and I took the flu shot in 2020, so as not to be confused with the other lisp. As a result, I took the shot the only year the flu did not circulate

Vaccine and HIV: beware of CV rebound

Yes, yes... I know it's fashionable to participate in social networks by advising the vaccine to S+. All the more easy as for this blind medical advice, the selective censorship lets it happen... Of course...

You can look up the references on Pubmeb, there is a plethora of articles that note a (temporary) rise in CV just after the flu vaccination. The patient who is monitoring her CV during the ICCARRIAN descent phase can therefore consider doing her CV BEFORE getting vaccinated (eventually): there is no point in panicking. I even pushed the envelope a bit further by going to the hospital to have my blood sample taken (yuck...) and by handing my vaccine box to the doctor on duty, who made a face but did it, not for free, but for free!

It's not a big deal, but as soon as you mention the risk of blip, you get lynched!

Well... I did the vaccine and no CV, it's just as well, since we're going to go easy on the CVs, now that the 1/15 is well secured...

In France, flu vaccination is recommended for people over 6 months old belonging to a group at risk of complications (people over 65 years old, people with severe asthma or chronic lung diseases, people with severe immune deficiency). I have not seen a blind recommendation for S+ in general

The 2022 vaccine is kif-kif 2021??

According to Wikipedia, the effectiveness is usually assessed by calculations and simulations (whose results depend a lot on the chosen hypotheses ). Someone will have to explain to me the effectiveness of the 2021 vaccine, a period when Influenza has not circulated at all! In a context where people were cautious, it did not circulate: caution works! About the flu...

Weekly intake and 1/15

In fact, it's confirmed, my tank is gone (in the blood...) Before even asking the question of what made this possible, the question of what to do in 2022 arises.
I have never seen in the literature a trial showing the disappearance of the reservoir, i.e. with a before/after, including in the 'cure' trials (except perhaps, to be checked, the one in Brazil, recently). In other words, this is new... I'm exploring... Of course, this is great: here is what the biologist says

Obligation of treatment / Judiciarization

... The injectables are coming... That's it!

In the news

- Injectables are coming (finally!): the commercial match will soon be Vocabria(2 big shots every 2 months) vs Islatravir(in 1/7 'official' and more if affinity). The Tele- BichatAchat will have a great time!

- I am now on Telegram: see the link https://t.me/charles_edouard

- Another excellent article: Should we vaccinate against PCR detection or against Covid-19 disease? by Pierre Sonigo, Caroline Petit, Nathalie Jane Arhel

- No impact of HIV on the consequences of SARS-Cov2, according to this article, except, perhaps, when CD4 is low...

- Actions Traitements has a new information booklet: L'allègement thérapeutique dans le traitement du VIH. Go there if you want... My Practical Guideis online since... 2014!

The French genius

Samson François plays Debussy... This is not German music, nor even European! (I don't know what that means...) Suite Bergamasque : Clair de lune

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The real insider tip is to know which doctor to go to...