Raltegravir 1200 mg

Summer 2016: we offered a serial: ANRS-4D and the cheaters Summer 2017: we will debunk DOMONO: It starts here

This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

Towards Raltegravir 1200 mg: One thousand two hundred !!!

By Charles Edouard!

People eventually understand, which gives this:

There we go! One more who understood! Overmedication creates damage (sometimes fatal), and de-escalation is on the way. It has its enemies: the medico-pharmaceutical mob! Well, what is happening on Raltegravir will allow us to expose ambitions, mechanisms, tricks, actors and the lack of patient protection. Let's start by drawing the landscape...

Reminder: in our hit-parade towards 1/7, Isentress® is one of those to avoid

Isentress®: a problematic pill

Isentress® contains Raltegravir, the first (non-exclusive) Integrase Inhibitor, marketed in 2007. A revolution. Merck has tens of thousands of molecules. They played the mule (method now obsolete), have prepared as many test tubes as molecules and tested for a possible effectiveness against HIV. They find a candidate (diketo acid), ask the chemists to improve a little. One ends up synthesizing a molecule. And there we go ...

There is a catch: the molecule passes the stomach wall but not the intestinal wall. It is annoying: if the drug has not been well disintegrated in the stomach, the small remaining stone goes to the intestine, where it no longer has any chance to enter the bloodstream. Unlike NVP or Videx, among others.

If you miss your absorption in the stomach, there is no catch-up (the intestine): you succeed and you have your plasmatic dose, you miss and you have only half (at best). To do 365 times / year! In the same patient, there will be days with and days without ... Big problem!

We will increase the success rate by doubling the number of attempts: and Hop! There we go to Twice a daily (700 dosing per year!), It is a Royal Pain in the ass, but in 2007, we accommodate ourselves.

Obviously the dose is also maxed: 800 mg / day: the highest dose among usual ARVs!

But as one puts a lot into a tablet (400 mg), the tablet is very compressed. It is hard as a pebble, which will make things worse ... The pebble diffuses in the stomach in a very variable way, which is the only opportunity. Shit!

But hey, the manufacturer does not care, patients just have to swallow the shit: we take our money and you get lost. And above all, out of question to admit any error.

In maintenance, the 3 modes of dosing

Merck method: Twice a day, 12 hours apart (400 mg then 400 mg). A small study shows a very slight benefit to this method, and as the dosage is not the responsibility of the pharmacist, but of the physician, Merck plays conservatively. The Merck-boys will be deployed to spread the voice of their master. Merck, knowing the cause of the problem, has already planned to reformulate the drug ...

German method: very popular in Germany. Practitioners allow their 'observant' patients (since Germans...) to take the 2 tablets at 1 time. Overall satisfaction ... The practitioner is happy, the patient also, having the impression of having / being personalized (thus loyalty).

'Italian' Method (abusively known as Charles-Edouard's, I have only published the relevant info here, also see here): It consists in chewing before swallowing, which allows to take all in one go!

I have buddies who tell me 2x400 mg, in 1 time, My doctor tells me in 2 times (in 7/7). This team of Italian clinicians say 2x400 mg, chewing, in 1 time, in 7/7, and Leibowitch, it says 1 x 400 mg in 4/7! What a diversity! (with no significant difference in effectiveness).

Mandatory or influenza vaccines, Levothyrox®, RAL 1200 mg: a hysteria

With the Levothyrox® scandal, one could observe the morgue by the manufacturer (Merck, again), the State authorities, who deny, in block, any side effect. Three million French patients take Levothyrox®, and are despicable imbeciles proportionately! Obviously, there is over-prescription! The medico-pharmaceutical mob has no limits!

Same for vaccines, we will vaccinate our small frogs against Hepatitis B (multiple sclerosis will become an infantile disease). A child (made) deficient, it's for life! Influenza is a benign disease, and your cellular immunity (CD4) has nothing to do (or so little) with your humoral immunity (which protects those who have had it, or its vaccine, 2 or 3 times): no influenza vaccine for Charles-Edouard! (replay this interview)

Then Merck works towards a RALTEGRAVIR at 1200 mg. What made Merck move? The arrival of EVG (Stribild®) or Tivicay®, which are in a single dose per day? Well no, they are announced since 2010 ... The loss of market share is real. And especially the loss margin is even harder, with the arrival of generics: we must keep positions by giving a boost to patents; And since they did not invent anything, well they will propose the once-daily by imposing 1200 mg!

Those who practiced the German or Italian way will find themselves at the wall.

Reminder: anyone interested in remission (relative, of course) should proscribe RAL.

So they will double the dose! Doubling ?? Wait, Charles Edward! From 800 mg / d to 1200mg is quite already violent, but not quite double ... Yes, yes, double ... You will understand ... It will be for a next time ... we will follow this as it will be droll and ridiculous!

Well, the case is advertised in the Lancet: Raltegravir 1200 mg once a day versus raltegravir 400 mg twice daily. Good reading!

Have a good Week, good fuck and do not abuse of meds/drugs

Feel free to comment, to to share and to use

Have a good Week, good fuck and do not abuse of meds/drugs

>

Comments

Steve 22 Oct. 2017


Charles-Edouard! 30 Oct 2017