150

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARV, intermittence...(12)

Coronavirus: Victory continued and soon to end

Graphic update by worldometers and Southern France Morning Post.

HCQ/AZIT vs (HCQ/AZIT + the rest)
	HCQ/AZIT				(HCQ/AZIT + the rest
Date	Infected (and treated)	deceased	%		Infected (all ttts)	deceased	%	p
04/05/2020	3227	16	0,50 %		4804	138	2,79 %	---
03/05/2020	3220	16	0,48 %		4797	133	2,78 %	---
02/05/2020	3207	15	0,47 %		4790	128	2,67 %	---
01/05/2020	3190	15	0,48 %		4776	128	2,69 %	---
30/04/2020	3181	15	0,47 %		4763	128	2,69 %	---
29/04/2020	3164	15	0,48 %		4718	125	2,65 %	---
28/04/2020	3143	15	0,48 %		4748	125	2,60 %	---
27/04/2020	3130	14	0,45 %		4718	121	2,56 %	---
26/04/2020	3081	13	0,42 %		4678	118	2,52 %	---
25/04/2020	3081	13	0,42 %		4678	113	2,42 %	---
24/04/2020	3060	12	0,39 %		4651	109	2,34 %	---
23/04/2020	3040	12	0,39 %		4599	107	2,33 %	---
22/04/2020	3039	12	0,39 %		4599	105	2,28 %	---
21/04/2020	2999	12	0,40 %		4579	100	2,18 %	---
20/04/2020	2970	12	0,40 %		4541	97	2,14 %	---
19/04/2020	2939	12	0,41 %		4520	97	2,14 %	---
18/04/2020	2853	12	0,42 %		4479	93	2,08 %	---
17/04/2020	2759	11	0,40 %		4420	85	1,92 %	---
16/04/2020	2716	11	0,41 %		4386	83	1,89 %	---
15/04/2020	2671	11	0,41 %		4337	78	1,80 %	---
14/04/2020	2628	10	0,38 %		4292	74	1,72 %	---
12/04/2020	2494	10	0,40 %		4181	63	1,50 %	---
11/04/2020	2401	10	0,41 %		4100	63	1,53 %	---
10/04/2020	2397	10	0,44 %		3998	57	1,42 %	---
09/04/2020	2285	10	0,45 %		3931	57	1,45 %	---
08/04/2020	2187	10	0,46 %		3835	47	1,23 %	---
06/04/2020	2179	9	0,41 %		5527 (?)	42	0,75%	---
05/04/2020	1962	7	0,35 %		5411 (?)	34	0,63%	---
03/04/2020	1818	5	0,27 %		3505	33	1,1 %	---
02/04/2020	1677	2	0,12 %		2837	22	0,77 %	---
01/04/2020	1524	1	0,06 %		2663	17	0,63 %	---
31/03/2020	1283	1	0,X%		2430	16	0,x %	---
30/03/2020	1291	1	0,08 %		2222	16	0,70 %	---
29/03/2020	1003	1	0,10 %		1988	13	0,65 %	---
27/03/2020	701	1	0,14 %		1577	11	0,70 %	---
source: https://www.mediterranee-infection.com/covid-19/

On 02/05/20: the Pangolins, the doctors,

@ThisIsNotThePangolins: As expected, some are going to search for SARS-CoV-2 related coronavirus in pangolins .... TRUMP does not care, as long as the Pangolin is... Chinese... Pangolins are mammals, so, according to the followers of the hypothetical @CestpouscestlesPangolins, they should make good animal models, for the future. One wonders if they have not, in fact, already been used as animal models, especially if they can be bought/sold at the market which is 800 m away from the Wuhan Virology Center.

Trachea hygiene: By dint of hearing simplistic advice in the media, one would forget a few others well known by Asian grandmothers. Wear a mask... at night, while sleeping. 8-9h without drinking a little, it dries the throat. By wearing a mask at night, you maintain a humidity in the breathing zone, thus in the trachea, which facilitates the evacuation of dirtiness. The gargle, that nobody mentions, is a simple method of personal hygiene: if you don't have a liquid bought in a pharmacy, you can use diluted Hextril, or Listerine (mouthwash) and make your daily gargle, when you go home. If you don't have anything, at least do it with salt water. Useful against THE virus? Who knows, but it is useful against the little banal things that become unnecessarily anxiety-provoking as soon as you have your first coughing fit.

Doctors praise HCQ/AZ and nobody sees any toxicity:

In Vitro: Nelfinavir better than Atazanavir??? One can doubt it: The advantage of a peer-reviewed publication is that glaring errors are corrected. In the In-Vitro study here, we find very different results from this one. The Brazilian study is better argued and takes a molecule with proven efficacy (Chloroquine) as a control: their lab found the same values as the others, on this molecule. The Japanese study (perhaps bad) has no validation point. One wonders... We read... We look at the graphs, and we are surprised.

The disconnected of Le Monde, the vaccines and 2 millions of Bill Gates: The wolf has been raised by Lorgeril: Gates makes a check of 2 Millions to Le Monde! A total of 4-5 millions!

Now the self-proclaimed censors will have to explain themselves... Their (few) subscribers will find it bad. What we must not forget, is that to get a 'help' from the B & M Foundation, we have to ask for it, and prove its efficiency, which, we see, has increased tenfold in 5 years! We are not surprised anymore by the pro-Vaxx, pro-Buzyn-Levy, pro-everything-that-stinks-about-itself bias. We didn't have much respect for them, it is true...

Le 02/05/20: BFM, ramdomisation, Stalingrad

Didier Raoult speaks on BFMTV: the complete interview. Pauline de Malesherbes... Not too bothered by the confinement, to come to Marseille... No matter... History will remember that Raoult wears a silver ring on his little finger... Bravo!

Randomization: There are ethical arguments against randomization. A fundamental mathematical argument clarifies a debate that has become hysterical. When we take a sample, for example a micro-trottoir, we may inadvertently or with disguised intention favor some over others... The result is tainted by noise and error. If we increase the number of observations, the gap will decrease, and the curve will get closer to the true reality. The law of large numbers allows us to interpret the probability as a frequency of occurrence(wikipedia). When we sample, we get closer to the 'true' probability, the more we increase the size of the sample, the more we take samples at random (ramdomization) and/or the more we ensure the comparability of the groups (intervention vs. controls) (e.g. the quota method for surveys or stratification for clinical trials). Whatever the case...

All this is a methodological improvement, made necessary by the small number. Do all the polls you want, the vote is the most important, because it is total. Here, we have 3 million infected people, and a number of people treated with HCQ (or HCQ/AZ) that is out of all proportion to the 'survey' that is the 'Discovery' trial, and we doubt that the results will be available before the end of the first episode... The HCQ/AZ series counts 3000 patients, and the control, well, it is all the others who will have been treated with nothing, tens of thousands of people. Except in Marseille, where the control group is rather small. Anyway... In India, the doctors immediately understood, and the Indian government (Make India Great Again) reserved HCQ/AZ for its population, and the expected hecatomb is not observed.

Randomization only makes sense if you can only afford to observe a small number. IHU, with these 75,000 tests performed, is not in this case...

Self-medication vs. randomization This is one of the reasons why I have long said that I will never participate in Quatuor (or in OMNIBVS for that matter). Only people who are in doubt should participate in a randomized trial. I, who practice the 1/15, participate in a piss-poor trial, it is to bias it... The Stalingrad trial: a double revolution: It is the French trial (Leibowitch) that establishes triple therapy. The other revolution is that it establishes the measurement of the CV as an end-point of the clinical trials, whereas until then, we were content to observe the clinical deterioration of the patients (which takes time and is not very nice for the patients). The whole ANRS clique (Delfraissy, Barré, Katlama, Costaglia...) all got on the end-point trial train, to finally change horses. For this, the CV was needed, the prototype of which is to be credited to Dr Mattez.

HCQ in the Fox News trap In the USA, conservatives, with TRUMP as their flag bearer, hope for a quick economic recovery. Their media of reference is Fox News. They saw in HCQ/AZ the messiah they were hoping for. Their Michel Cymes, a certain Dr. Oz, commentator of Fox News(video here). HCQ would soon attract the attention of Donald Trump. And Raoult would suddenly go from being a recognized microbiologist to a worldwide darling at Charles-Edouard Fox News, Internet. Afterwards, they would have to MAGA (Make America Great Again) by artificially replacing HCQ/AZ with Remdesivir and boosting Wall Street. If Remdesivir crystallizes greedy hopes, the disappointment will be great... But by then, we will have moved on. Such as the $500 million awarded to Moderna, a small biotech company, better known for its promises in the air (vaccine) than for its achievements...

Chronic treatment as prophylaxis? Raoult clearly asks the question: have the numerous patients under daily HCQ (for Lupus or other reasons) been protected against SARS-CoV-2? The answer is perhaps easier and faster to obtain than to do a 'clinical trial', alla 'Partners'.

The Discovery Journal: Clear: they can't seem to recruit... (Unlike 4D and Quatuor, whose ballot boxes were full even before the launch...). Is it Europe's fault? No! to common sense... You have 4 'chances' out of 5 to receive an ineffective or dangerous treatment! Bravo Pialoux! Bravo Yazdan!

HIV, ARVs and SARS-CoV-2: At the time of SARS-1 (2003) there were some in vitro tests, but the panel of molecules has grown since. An in-vitro study of PIs has provided some guidelines for their possible use, in particular Atazanavir. The publication: Nelfinavir inhibits replication of severe acute respiratory syndrome coronavirus 2 in vitro is worth a look. We will come back to it... The synergistic effect of HCQ/AZ allows to reduce the carriage from 21 days to 6 days. and to reduce the severity of the disease... Why not consider, one or 2 more molecules, for a synergistic bomb (a horse treatment...) which is safe and allows to reduce even more the carriage, for example to 2-3 days. See also

On 01/05/20: Pearls of Containment

Small pearl of containment A.Vivaldi 'Eia Mater' - Jakub J. Orlinski & A. Debicz... His Stay Home is very successful, too...

O Mother, source of tenderness,
Make me feel great sadness
So that I cry with you.

Replace O Mother by Homer, Homer, The name of your mother(I am sure you have one... ), O Virus, O eme-esse, it is still just as touching...

Interview with Raoult, decidedly very commented and followed... the consensus is Pétain, the original (paying), in Match:

Le 30/04/20: Perronne or how to be consensual with concepts of rupture

I advise you to listen to the interview of Christian Perronne, on April 27: Listen to him : Perronne is the one who supervised the FASEB-1 and -2 publications, which are the flagship of all of us...

Le 29/04/20: Natural end or rebounds

Raoult goes a bit fast... A truism: seasonal diseases stop (on their own)... Ok, but that's why they are called seasonal. The first SARS could have been contained during its resurgence, its last, as a truism would say. If it had not been contained, a little by chance, a little by careful monitoring, it would not have been contained, so... At that time, China's economy was smaller than Hong Kong's. Today, HK is less than 1%. Each area will want its own cordon sanitaire. Do you really think that tourists will be welcome in Corsica this summer? On arrival, a quarantine order... Raoult tells us: Look, the curve has a bell shape. Yes, but the city is also under a bell. Can we claim that the transmissibility is extinguished 'naturally'when we put such a lid on it. Ah!... But in Marseille... Well... Yes... Marseille is also under containment. But his strategy: test, isolate, treat (with what we have at hand, of course) is worth in an isolated area, Marseille in time of confinement yesterday, Corsica or Ré Island, tomorrow... With containment/quarantine of Seroneg-(at SRS-2),

On 04/28/20: In Vitro: more molecules...

Today, here it is: ivermectin inhibits SARS-CoV-2 replication in vitro. In first intention, we will see proposals bloom, which have been delayed by the refusal of the Chinese authorities to provide strains... It is understandable that this is annoying and that the WHO is in the hot seat.

Relationship with HIV: the relationship between SARS-CoV-5 and HIV had disappeared for a while. It is slowly being rebuilt: ivermectin is a rather good inhibitor of HIV-IN (integrase), not excellent excellent, but in a slightly different way than DTG... To be continued... Moreover, the question of the loss of INSERM accreditation in Marseille was made against the background of competition between the LEVY vaccine (the LEVY of the Minister BUZYN...) and that of Biosantech. We will have to dig a little, but if there is something, it will come out...

Raoult: common sense in a crazy world: his latest video: 'Update on the epidemic: are we really at risk of a second wave?' (this is not Radio-Raoult, which is on twitter, actually...). The model he refers to can be found here:Data-Driven Prediction of COVID-19 Pandemic End Dates. A single peak epidemic model, like the vast majority of seasonal infectious diseases. France is out of the woods by mid-May, and by June it's over! The debate about randomization, Redemsivir, etc. will dry up. What will be the use of tests, vaccines and other passports, apps, etc? We can start to ask ourselves the question...

Molecules, in-vitro vs in-vivo
Therapy	Efficacy In-vitro	Trial In-vitro	Efficacy In-Vivo	Test In-vivo
Remdesavir		Manli Wang		Y4
Favipiravir		Discovering drugs...		Favipiravir Treatment
Atazanavir		Atazanavir inhibits SARS-CoV-2...		Y4
Lopinavir	Z2	Z3		X
Hydroxychloroq.		X		Y4
HCQ/AT		Z3		X
ivermectin		Ivermectin inhibits SARS-CoV-2...		Y4

On 04/27/20: Atazanavir and Doxycycline

IHU's track record is clear and worthy of the trust placed in them by their funders. They were the first to collect viruses (from repatriated people), to grow cultures (we will see that this is the sinews of war), to increase the number of tests, to carry out in-vitro trials, to publish a mini-study, to inform the authorities and the public, to propose a strategy that makes sense. The people of Marseilles have reason to be proud.

The race for cultures: Lopinavir was introduced very early on, by anecdotal observation in Thailand. So we drop the Eclipse for a news that overshadows any reflection on the remission. Especially since if it is confirmed, there will be panic in the house, including for my readers.

National and international collaboration has been lacking, as can be seen in this video: Research at the NSB3 laboratory of the IHU, revealing the atmosphere. It is true that the Americans reproached the Chinese for not having provided strains, which would have allowed them to do a screening. Brazil has its very first cases at the end of March, and a first in-vitro test 2 weeks later. The lack of cooperation in this area has caused the identification of potentially effective molecules to be lost for several months. Once a strain is maintained, everyone treats it with what they have at hand... This Chinese study puts on the same level of in-vitro efficacy, remdesivir (which is not yet galenized), choloroquine (which has been mass-produced for more than 50 years...), it was published at the beginning of February. One can appreciate the French psychodrama about the inclusion of choloroquinine in the Discovery trial, which, as we can see, will come after the battle.

Molecules, in-vitro vs in-vivo
Therapy	Efficacy In-vitro	Test In-vitro	Efficacy In-Vivo	Test In-vivo
Remediesavir		Manli Wang		Y4
Favipiravir		Z3		Favipiravir Treatment
Atazanavir		Atazanavir inhibits SARS-CoV-2...		Y4
Lopinavir	Z2	Z3		X
Hydroxychloroq.		X		Y4

The wall of xxxx 'barons
Microbiology versus...
Who	His contribution	My comment	Source
D. Raoult	Y2	Y3	Y4
Z1	Z2	Z3	Z4
The (pharisaical) virology...
Barré-Sinoussi	Y2	Y3	Y4
Delfraissy	Z2	Z3	Z4
Pialoux	Y2	Y3	Y4
Molina	Z2	Z3	Z4
Costaglia	Y2	Y3	Y4
Z1	Z2	Z3	Z4

149

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARVs, intermittence...(11)

Coronavirus: VICTORY and endgame (?)...

Graphic update by worldometers and Southern France Morning Post.

HCQ/AZIT vs (HCQ/AZIT + the rest)
	HCQ/AZIT				(HCQ/AZIT + the rest
Date	Infected (and treated)	deceased	%		Infected (all ttts)	deceased	%	p
26/04/2020	3081	13	0,42 %		4678	118	2,52 %	---
25/04/2020	3081	13	0,42 %		4678	113	2,42 %	---
24/04/2020	3060	12	0,39 %		4651	109	2,34 %	---
23/04/2020	3040	12	0,39 %		4599	107	2,33 %	---
22/04/2020	3039	12	0,39 %		4599	105	2,28 %	---
21/04/2020	2999	12	0,40 %		4579	100	2,18 %	---
20/04/2020	2970	12	0,40 %		4541	97	2,14 %	---
19/04/2020	2939	12	0,41 %		4520	97	2,14 %	---
18/04/2020	2853	12	0,42 %		4479	93	2,08 %	---
17/04/2020	2759	11	0,40 %		4420	85	1,92 %	---
16/04/2020	2716	11	0,41 %		4386	83	1,89 %	---
15/04/2020	2671	11	0,41 %		4337	78	1,80 %	---
14/04/2020	2628	10	0,38 %		4292	74	1,72 %	---
12/04/2020	2494	10	0,40 %		4181	63	1,50 %	---
11/04/2020	2401	10	0,41 %		4100	63	1,53 %	---
10/04/2020	2397	10	0,44 %		3998	57	1,42 %	---
09/04/2020	2285	10	0,45 %		3931	57	1,45 %	---
08/04/2020	2187	10	0,46 %		3835	47	1,23 %	---
06/04/2020	2179	9	0,41 %		5527 (?)	42	0,75%	---
05/04/2020	1962	7	0,35 %		5411 (?)	34	0,63%	---
03/04/2020	1818	5	0,27 %		3505	33	1,1 %	---
02/04/2020	1677	2	0,12 %		2837	22	0,77 %	---
01/04/2020	1524	1	0,06 %		2663	17	0,63 %	---
31/03/2020	1283	1	0,X%		2430	16	0,x %	---
30/03/2020	1291	1	0,08 %		2222	16	0,70 %	---
29/03/2020	1003	1	0,10 %		1988	13	0,65 %	---
27/03/2020	701	1	0,14 %		1577	11	0,70 %	---
source: https://www.mediterranee-infection.com/covid-19/

On 04/26/20: Atazanavir and Doxycycline

On 04/25/20: To govern is to foresee...

The armies bought chloroquine 'as a precaution', in China (there is a factory in France, but well...)... If ever this treatment was finally validated by the health authorities... Which ones? Salomon or the military authorities? Interesting question: The frigate Provence is affected. HCQ/AT reduces severity if treated early enough. Case Study (of war): Do you treat or not? Warning: in case of wrong answer you will be transferred to Garches Tenon, as punishment.

'France has adopted a prudent position (sic!): hydroxychloroquine is authorized in hospitals only, and only for serious cases. That is to say for cases where it does not work anymore... We understood it well. Everyone has understood... Explain to me how this is a prudent position... It is a state position, unsustainable.

04/24/20: Picrocholine quarrels on toxity

Chloroquine (and its better-tolerated version hydroxychloroquine) was available over the counter! Here is what the Guide du Routardsays about it For prophylaxis, the dose was lower, but it was necessary to continue to take it 2 months after the return. Now, we have better, and, the pathogen is resistant in many countries so we restrict the sale. The debate on toxicity is irrelevant, as it is. Even the IHU reports deaths under HCQ (10 to be precise): yes... There are deaths under HCQ, but they did not die of HCQ, they did not have a bad virus by chance? The question can become absurd. Mr Marius is 75 years old, he has a heart condition, and positive for SARS-CoV-2 (@PandaVirus), it's not too serious yet; the cardiologist is not hot. But we don't have anything else on hand. We try HCQ/AT, his condition requires anti IL-6, then heparin, then this, then that, no luck... Marius dies. Try to prove that the doctor made a bad choice...

According to our clever Minister Veran,'There is no such thing as Dr. Raoult's protocol, there is a drug that you take when you are sick and that is either effective or not'. Nice truism. Can his majesty enlighten us on which treatments are effective and which are not? This could be useful for the 10-20.000 French people who will die by May 11... 500/day will die in the next 15 days. So let our Minister-Neurologist, show us the road to follow, because the sleeve effects never cured anyone!

The 10,000 deaths of Solomon Marseille serves a basin of 1 million, and has the best center of expertise in France, financed by the community. By partially applying the recommendation of the IHU, Marseilles counts 107 deaths to date. Sixty times more is 6,000. We are already at 20,000 and it is not finished! People sometimes take a month to die from COVID-19. All these deaths are due to Solomon/Veran/Macron. They were avoidable deaths, unnecessary deaths, undue suffering. You don't need to be an enarque or a senator to see the terrible mistake that has been made, 'straight in the boots', without listening, deaf, as usual of Macron. Those who have lost or are going to losean old relative are not likely to forget!

Poor Azithromycin, it is also doomed to the gémonies... 3 millions of prescriptions per year in the USA, only that... And Doxycycline is the fourth most prescribed antibiotic across the Channel.

The Gilead PUT: As announced here, and without any surprise, Gilead's stock has taken a beating!

After the marriage for all, now it's the marriage for nobody... A few years ago, you were tackled to the ground to get a mask in your underwear, now you are fined if you don't wear it

On 04/23/20: Taiwan, Korean submission, Atazanavir and Doxycycline

China, Korea and Mulhouse are examples of what not to do... In viral ecology, there are sources, sinks and amplifiers. A Chinese philogenic study (see one of the past posts) had shown that the emergence of the @PandaVirus predates the explosion in the Wuhan Market, the city at 'P4'. The market is an amplifier: it is being destroyed. In Korea and France, the Shincheonji Church of Jesus and La Porte Ouverte sects are amplifiers demonstrated and protected by the power: they are social harm under protection (evangelical-American authorities by proxi). These cockroaches must be held accountable! It is nevertheless the Open Door, which, by itself, is the amplifier of the Alsatian catastrophe. Secularism is not a doctrine but a compromise, which ceases when one of the parties physically attacks the Nation. Taiwan, which the WHO considers, diplomatically wrongly, as an integral part of China, and therefore under its jurisdiction, is the country (because it is a country...) that is doing the best. Detailed measures here: Response to COVID-19 in Taiwan: Big Data, new technologies and proactive testing. The example to follow, including in terms of democracy and natural sexuality rights, is Taiwan, not Korea, which is a horror in every way, and the evangelical entryism in France (remember the Veilleurs...) is no less detestable.

Taiwan brings a political answer (in the noble sense), pragmatic, where France is engulfed in its totalitarian demons. The individual is powerless... Hence the urgency to know what to do to free oneself. The liberticidal morgue of the 'authorities' of France has become detestable, and the only way out is in the exploration/exploitation of personal solutions. As Raoult says, one must deal with what one has... But who has Hydroxychloroquine at hand? And with the infamous Solomon's decree, there is no risk of finding any, even while waiting for the onset of symptoms. The impossibility to get the drug in time, by an authoritarian decision, justifies that we try to supply it in advance. If you get there ahead of time, you have a chance to get out. If you stay within the Solomon's perimeter, and the virus catches you, you're in trouble. Drastic containment and Solomon's decrees are two sides of the same coin. If you forbid modern techniques (masks, tests, Plaquenil...) of which doctors and pharmacies are deprived by decree, you only have to decree the economic and social armageddon, great Macronist specialty. You pull on the handbrake while braking with your foot after having pressed on the accelerator (cf La-Porte-Ouverte-à-tous-virus). It sucks!

In my medicine cabinet what will I find interesting? For the moment I'm looking for the good old Quinine syrup of my grandparents, including its diluted form: Dubonnet. Not sure if it's very useful, but hey... It can't hurt...
I also have Atazanavir and Doxycycline. On prescription, that I got them... And I paid for them. Atazanavir, it's Leibowitch who put me on it, even though I had a negative preconception about protease inhibitors, since they inhibit a lot of things, as we'll see... But in Ultra-intermittence, it works very well and I am pleasantly surprised to tolerate it well. It has pharmacokinetic synergy with DTG, Katlama says it's a good idea, Leibo does it without Ritonavir (using a hepatic metabolism inhibitor doesn't appeal to me), so I' ve got it... A Brazilian team has just published an in-Vitro study, using a similar methodology to the IHU one, with some interesting additions. And validates ATZ/RTV as well as ATV without RTV, in-vitro.
Doxycycline is probably Molina's only useful contribution to medicine. He published it as a Prophylaxis against hot piss and possibly against syphillis. I myself have nothing against drug prophylaxis and take it, when indicated, including against malaria. And with the Super Intermittence, I am not afraid of any overmedication or interaction. IHU has published an in-vitro study of Doxycycline on SARS-CoV-2 (aka @PandaVirus), which enters the very closed club of candidates.

There are alternatives to Raoult, what could be more normal, but there is no in-vitro trial by Pasteur, Inserm, Bichat, Cochin, Lyon, nothing... One would think that there is no one capable of doing a PCR or a culture! If it wasn't for the IHU, we would be totally blind. I am neither Radio-Leibo nor Radio-Raoult, but we have to admit that there is nothing else: NOTHING.
The slaughter continues in the non-HCQ/AT arm of Marseille...

The MBS Bomb: Mohamed Ben Salman or Mother Bomb from Saudis: 24 super tankers, representing 50 million barrels are on their way to the Cushing terminal. Unless TRUMP puts a stop to it, the WTI barrel will remain under $10, until the Wahhabi Tsunami is over. TRUMP will have little choice but to force them to divert to Europe or Asia

Three men from Westchester, New York, are suing the WHO, alleging that it mishandled the pandemic. The lawsuit demands that WHO pay 'incalculable' damages for losses suffered... Several US states have launched lawsuits against China... When will we see a lawsuit against ANRS and HAS, for overmedication/poisoning?

Le 22/04/20: Medicine by evidence vs medicine by risk analysis!

An analysis of the South Korean experience can be found here, with a very detailed version here. The craze for the Korean method deserves some reservations. If crisis management gives us lessons, let's not forget those, more discreet but more efficient, of those who knew how to avoid the crisis, such as Taiwan, systematically quoted as an example, superbly ignored by the WHO (CCP-infested). (I have pruned a little to make it readable quickly)

Let's comment a bit: remdesivir and its proven good clinical tolerability: Oh well? Please read Compassionate Use of Remdesivir for Patients with Severe Covid-19, funded by Gilead, which signals the end of Redemsivir in widespread use. In it, the evidence of supposed 'good clinical tolerability' is set aside, for an unproven relative 'benefit'. In short: Remdesivir is toxic and futile. We don't really care because the drug doesn't even exist (only the molecule, in injectable form, available in very small quantities). I would like to take a Gilead PUT, but I can't find any... Obviously, the issuing banks don't dare to do it...

South Korea as an example of democracy??? 0% of practicing Christians before the American invasion and 30% today, it's a good example of possible and deep transformation of a society. An example put forward by all evangelist fundraisers. Not sure that religiosity, exacerbated homophobia, police and judicial arbitrariness makes it my cup of tea... Not my kind of beauty... It would be quite appropriate to evaluate the role of religious gatherings in the explosion of infectious respiratory diseases: this applies to Daeju (Korea), Mulhouse, Morocco and even Mecca. This type of vectors benefits from resonance boxes, opportunistic amplifiers: Good Word and Naughty Virus share the same breath.

Let's comment further: 'the antibiotic seems however to cause toxicity without significant additional benefit'.

1- the argument of flagrant toxicity holds little in the face of the enthusiasm of doctors to use it (2 billion dollars in sales in 2013, source Forbes), Pfizer donates 500 million doses in Africa (2015, source Pfizer)
2- AT shows a synergistic effect, in-vitro, and in a small preliminary trial, in-vivo. Synergy? this is exactly what we observe with some anti-retrovirals, AZT+3TC being the historical example. So before claiming 'no significant additional benefit', you'll have to argue a bit!

So yes to the Korean method, without Kaletra, since it is the IHU proposal: Test, Isolate, Treat

The proof or the minimization of the risk: Lorgeril staunchly supports the ramdomized, if possible double-blind, trial. A young man on YouTube tries to explain: Should we rush testing of COVID-19 treatments? But we are still waiting for the results of Discovery, and we will have them when the wave is over and the epidemic is over. Arriving with 'the proof' at the end of the battle, what is the point? Especially since now a phase 3 trial, called futility trial, will no longer be done against placebo but against HCQ/AT, which has imposed itself as a standard (gloden standard). Nothing is of interest unless it is a comparison between X and HCQ/AT, which has become the 'new normal', whether you like it or not... Apart from the remaining Gileadologists (Pialoux, Molina, etc...) nobody will prescribe Remdesivir, which is not even available. Besides, we will be able to make a list of the 'bad' ones, those who claim to be doctors and have randomized the patients. Because now they're going to have the families after them... The families of people who died in the arms of Remdesivir or Kaletra or Placebo, are entitled to have it in the back of their minds.

Lorgeril is right to claim that the IHU is against randomized placebo-controlled trials: it is documented in this video: Against randomized trials. It is necessary to reintegrate the context: serious, fast and... short epidemic. See Raoult's latest video on the subject. For the moment, apart from the IHU, a very nice tool financed by your taxes, there is not much that makes sense...

On 04/21/20: After the publication of the IHU, towards a republican lawsuit!

Bunch of idiots: Pharmacies banned from buying and selling masks!!!That's enough!

Publication of the IHU: I had already shared the summary, in French, here. The article, in pre-publication, is put on their website: Early treatment of 1061 COVID-19 patients with hydroxychloroquine and azithromycin, Marseille, Francewhile the trial of Pr Reynes has, in fact, not yet started (according to the database here

I publish a translation in French: Etude Hospitaliere SARS-CoV2quine(in process of formatting... )

Soon, for 1 barrel of WTI purchased, 2 barrels of WTI offered + 1 free refill and 1 full wash with polish!

The price of a box of Kaletra is exploding: In Russia, if nothing else, it is traded at $100 a box where the posted price is ... $12

The Raoult is a guy who takes his hair out of the air: see his 2 interviews in the Marcelle online journal (yes, yes...): it's here: Interview with the one who is at the heart of the polemics: Didier Raoult. and But who is professor Raoult. He has not given an interview to any of the 'big' subsidized newspapers. It is understandable that they are a bit angry with him...

Le 20/04/20: China will pay! and what about the ramdomized tests

Molecules, in-vitro vs in-vivo
Therapy	Efficacy In-vitro	Trial In-vitro	Efficacy In-Vivo	Test In-vivo
Remediesavir		Manli Wang		Y4
Favipiravir		Z3		Favipiravir Treatment
Atazanavir		Atazanavir inhibits SARS-CoV-2...		Y4
Lopinavir	Z2	Z3		X
Hydroxychloroq.		X		Y4

The wall of xxxx 'barons
Microbiology versus...
Who	His contribution	My comment	Source
D. Raoult	Y2	Y3	Y4
Z1	Z2	Z3	Z4
The (pharisaical) virology...
Barré-Sinoussi	Y2	Y3	Y4
Delfraissy	Z2	Z3	Z4
Pialoux	Y2	Y3	Y4
Molina	Z2	Z3	Z4
Costaglia	Y2	Y3	Y4
Z1	Z2	Z3	Z4

148

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARV, intermittent...(10)

Coronavirus: VICTORY ? or not ?...

Graphic update by worldometers and Southern France Morning Post.

HCQ/AZIT vs. the rest
	HCQ/AZIT				the rest
Date	Infected (and treated)	deceased	%		Infected (untreated)	deceased	%	p
19/04/2020	2939	12	0,41 %		4520	97	2,14 %	---
18/04/2020	2853	12	0,42 %		4479	93	2,08 %	---
17/04/2020	2759	11	0,40 %		4420	85	1,92 %	---
16/04/2020	2716	11	0,41 %		4386	83	1,89 %	---
15/04/2020	2671	11	0,41 %		4337	78	1,80 %	---
14/04/2020	2628	10	0,38 %		4292	74	1,72 %	---
12/04/2020	2494	10	0,40 %		4181	63	1,50 %	---
11/04/2020	2401	10	0,41 %		4100	63	1,53 %	---
10/04/2020	2397	10	0,44 %		3998	57	1,42 %	---
09/04/2020	2285	10	0,45 %		3931	57	1,45 %	---
08/04/2020	2187	10	0,46 %		3835	47	1,23 %	---
06/04/2020	2179	9	0,41 %		5527 (?)	42	0,75%	---
05/04/2020	1962	7	0,35 %		5411 (?)	34	0,63%	---
03/04/2020	1818	5	0,27 %		3505	33	1,1 %	---
02/04/2020	1677	2	0,12 %		2837	22	0,77 %	---
01/04/2020	1524	1	0,06 %		2663	17	0,63 %	---
31/03/2020	1283	1	0,X%		2430	16	0,x %	---
30/03/2020	1291	1	0,08 %		2222	16	0,70 %	---
29/03/2020	1003	1	0,10 %		1988	13	0,65 %	---
27/03/2020	701	1	0,14 %		1577	11	0,70 %	---
source: https://www.mediterranee-infection.com/covid-19/

Le 19/04/20: Rupture 'Made in CHINA': beware of the counter-shock!

Your pharmacy assures you:'there is no risk of rupture on your medicines'. When BMS unilaterally stopped supplying Videx, nobody saw it coming. I was already interested in the alternatives, so I don't really care, but in Leiboo-land there was panic. Today the crisis is not on the finished product, but on the intermediary products, those necessary for one or other of the chemical stages in the manufacture of active ingredients. Breakdown of malonic acid! Production capacities have migrated to China, where they are currently being reduced. As a result, no more malonic acid, and no more malonic acid means no more Valproate: depakine... The people whose survival depends on depakine, and who will have understood this, will stock up and when Mrs Michou goes to her pharmacy, in 2 months, there will be a shortage: the wave will spread. The indirect overmortality will spread by waves, far into the future, in all aspects of 'critical' manufacturing. And then you will discover that the 'European sovereignty' dear to your 'President', simply does not exist.

Molecules, in-vitro vs in-vivo
Therapy	Efficacy In-vitro	Trial In-vitro	Efficacy In-Vivo	Test In-vivo
Y1	Y2	Y3	Y4
Z1	Z2	Z3	Z4

DisCoVeRy trial: Here is the description of the DisCoVeRy trial: But who the hell would accept to be randomized 1:1:1:1:1!?!? Obviously, the patients are in such a state that the informed decision is rather difficult. But hey... Where on earth is the in-vitro trial that could make one think of any efficacy of Lopinavir/RTV (aka Kaletra ®)!? If it doesn't work in the lab why expect it to work in the clinic? And why this one? Why not MaTuVuNaVir, PialouConVir, TaGeuleOnTeVir, which have no effect but want to have their 15 minutes of audience! Pfff

Le 18/04/20: Made in CHINA: lies, stock market manipulation and incompetence

Coronavirus: did the SARS-CoV-2 come out of the Wuhan laboratory?. the question agitates the media, such as Le Monde. Le Monde publishes 'The coronavirus, made from the AIDS virus? The very contested thesis of Professor Montagnier. In question a podcast on Pourquoi Docteur. The article of the decoders is of a distressing superficiality. Neither journalist, nor milliner, nor carpenter, nor sheep farmer are sufficient qualifications to establish/establish scientific theories. Neither the Bible, nor the Koran, nor Le Monde are scientific publications, they are just talk... Montagnier is interested in the thesis of Jean-Claude Perez, an info-mathematician of his friends, who explores public data (genomes), in search ofpatterns, also a friend of Benveniste. These idiots of creationists are fond of it, wrongly, but it stinks a bit of ass anyway.

In genomes, there would be an ordering at a greater or lesser distance, like wavelets, characteristic. If a fragment has wavelets with the same harmonics as the target genome, it integrates in a more stable way(I'll make it short...). He argues, with recursive analysis, that SARS evolves by enriching its harmonics (Fibonacci waves), which makes it more stable and more compatible with the human genome, in particular chromosome 4. It is an unusual school of thought, unintelligible to a 20th century mind, but accessible to the independent researcher of the 21st century, a century where algorithmic tools (e.g. R) and genomes are freely available. Moreover, it identifies sequences, rather short, it is true, which are also on HIV-1, HIV-2, SIV. Since the sequences are short, don't be surprised to find identical sequences in other viruses: a sweet potato virus, a nectarine virus or a wasp virus. One should not stop at anecdotal evidence, and ask oneself what a sequence of a nectarine virus is doing there... Because his argument is not there... He 'observes' several sequences and that these sequences form an 'optimal' pattern unlike a random presence.

We can see here that Perez's presentation is of a different quality of reflection than what Le Monde suggests, which has long claimed that Montagnier is senile...

First, the 6 insertions are very contiguous: 169 bp in the 275 bp regions; second, the inserted HIV/SIV strains are very homogeneous: origins Russia, Ivory Coast, Netherlands, Malawi. Third, the 6 inserts are positioned in this order in Covid-19: RT (POL) ENV ENV ENV ENV POL. Is the symmetry anecdotal or a remarkable signature of a typically human will of organization.... So would it be a Pangolin, eating nectarines, and traveling to Russia, the Ivory Coast? or a virothèque bookworm? Perez's perspective may be worrisome: SARS-CoV-2 would have some characteristics of a quasi-retrovirus with the ability to integrate (and create a reservoir?). If this is the case, we are in deep trouble...

I am willing to argue against the Perez/Montagnier hypothesis... Let the debate enlighten us! Even if it means invalidating. Let it happen at that level and let an argumented refutation be made. Perez does not claim that the virus is an artificial construction... He gives the sequences and their positions. His work is here (not my kind of beauty...). What Le Monde has done (argument from authority, anecdote, derogatory insinuation...) is misleading and abject. An argumented rebuttal, point by point, of Perez would be admissible, a trial in senility, no!

Bingo on Doxycycline! I was right to be happy to have them in stock: the number of tested and effective in vitro solutions has just increased from 2 to 3. There was Remdesivir (Gilead), HCQ/AT, and now Doxicycline has been added. In vitro antiviral activity of doxycycline against SARS-CoV-2. That's it! The nickel-plated feet ofPharisaicalvirology will be able to make an addition to DISCOVERY! Because trying in-vivo molecules that did not work in-vitro (e.g. Lopinavir), it's silly. Do not try those which, non-toxic, work in-vitro is even more stupid. Obviously, you need to have patients, which in Marseille is no longer the case.

SARS has become a strategic weapon: in order to test molecules in-vitro, it was necessary to have the virus and to know how to cultivate it. The Chinese published the genetic code but did not provide a strain... Not nice. The 'western' research thus lost 3 months... Could the IHU, for example, have cultivated a strain that it did not have? Could it have tested a Remdesivir, which obviously Gilead does not provide?

Variolization / Covidization: This is an amazing discussion, and one that will become obvious over time... What kind of government is this that ignores the populo, gasses the retirees, and locks up 100% of the population in undignified conditions. Remarks... The French are calves! 85% would approve a restriction of the liberties (tracer app, etc)! We don't see that anywhere else! In fact, the French are afraid of each other. Marseille having known, as well as not, to absorb the first wave, will necessarily experience the deconfinement earlier than the others.

Obviously, Leibo would have been of great help. As a legacy, he entrusted his documentary fund to the ENS: Caroline Petit, an HIV biologist, recovered and maintained the paper archives of Jacques Leibowitch. She is the author of the biography of J. Leibowitch and of the description of the fonds at the ENS. Actually, I try not to think about it too much...

04/17/20: Gilead's stock price...

The whole world and the financial planet are turned upside down. A Tweet from TRUMP and the party is over. The virus is pandemic, devastating, and, there is no cure or vaccine. US indices soared 3% overnight following a fake news brief from Barron's magazine stating that 125 patients had experienced a 'reduction in symptoms'' (which means nothing) with Remdesivir (Gilead, you know, the lab whose consultants come to insinuate that the very cheap competitor, HCQ/AT, doesn't work).

The sample size (125) is very small, so we don't know if the patients cured themselves or thanks to the expensive Remdesivir (Axel Kahn's argument), which the test has no comparator.

It would obviously be a great relief to have confirmation that Remdesivir protects or cures Covid-19... which made Gilead jump by 17%! This all looks like a gigantic hoax, orchestrated by a wonderful coincidence, shortly before the close of the stock market month. This unfortunately ticks all the boxes of a massive stock market manipulation.

On 04/16/20: Made in CHINA: @cestpasnouscesthepangolins

Gen. Mark Milley, chairman of the Joint Chiefs of Staff (U.S.), confirmed that the U.S. is seriously interested in the theory that COVID-19 came from the Wuhan lab, but that 'we don't know more at this point.' Here is a certainty: apart from Ebola, China and its sanitary system is at the origin: xxx.

The 'scientific' council claims, fortnight after fortnight, the extension of the confinement. The argument is: if we lift the containment, the peak we were trying to avoid will occur. This is true. And it will happen again on May 11, in six weeks, in July, etc. Singapore is experiencing it bitterly. Once a model thanks to a clever mix of social distancing, massive testing and isolation, the city-state is facing a rebound in infections. Between the beginning of March and the beginning of April, the number of patients has increased tenfold. Unavoidable... Unless you covidise!

The 'real' Marseilles business, a.k.a. Les Grands Magasins des Quartier Nord, is at a standstill, and the local caids will want to resume their 'little' business. If the police are not covidised, while the others will feel free of everything, I do not explain you the atmosphere... Inevitable... Unless you covidise!. Raoult will be carried as a Roman triumph, and Jupiter, ah... Jupiter... There are people who hope to know what Jupiter thinks of the Ponte Souverain... The real question is: What does the Sovereign Pontiff think of Jupiter? The ponte has a wide open platform and the 06 of TRUMP!

The PUT Molina: There was a time when Molina, Pialoux, Barré, were bankable... It's over... Like Lehman Brothers. The 'pieds nickelés' of the Parisian virology is absent.

Single screening: COVID/HIV/HCV/HBV/Syphillis: Until self-tests are available, Elisa type tests will be done by blood sampling in the laboratory, I suppose... This may be a unique opportunity to advocate for a single test: COVID/HIV/HCV/HBV/Syphillis. For the whole population ... At least above a certain age, and still... Test, identify/isolate, treat: we have treatments for everything and this is a great opportunity...

The Wall of xxxx 'barons
Microbiology versus...
D. Raoult	Y2	Y3	Y4
Z1	Z2	Z3	Z4
The (pharisaical) virology...
Barré-Sinoussi	Y2	Y3	Y4
Delfraissy	Z2	Z3	Z4
Pialoux	Y2	Y3	Y4
Molina	Z2	Z3	Z4
Costaglia	Y2	Y3	Y4
Z1	Z2	Z3	Z4

Which president had the necessary stature?
President	Your rating	Ranking
de Gaulle
Pompidou
Giscard
Mitterand
Chirac
Sarkozy
Hollande
Macron

On 04/15/20: COVID-19: Same City Comparison HCQ/AT vs.

'I am essential ... I am talking to God!': Virginia pastor who defied containment order dies of COVID-19. GodThe Virus will recognize his own...

Unable to get Hydroxychloroquine and AT: according to this doctor's testimony. Out of stock? No. Decision of the ministry. To be remembered for the future, I think that one day my medicine cabinet will contain some, not to protect me from the virus, but from the decisions that could be adverse to us. To be continued, but not immediately...

Relationship between chloroquine and HIV: it exists and is quite confusing. I am preparing a file on the subject. We will see...

On 04/14/20: Covidization by age group

Fresh out of the IHU: Coronavirus: Decline of the epidemic in Marseille, in video
The selective covidization can be done by age group, taking care to isolate the elderly. The little Nicolas goes to school, he will catch the nice virus, just as he would have caught the measles in other times. He will not see it pass, and if need be, he will find refuge under the priest's cassock the coat of the Good Professor Raoult (alias HCQ/TZ). In France, only one under 10 years old among the 13.000 deaths... But if Nicolas goes home for a big poutou to grandma, it's not great. Unlike the flu (where the youngest are the vectors), with SARS-CoV-2 (aka @PandaVirus), the youngest are not super-conaminators. On the other hand, the older ones make good prey. So the selective covidization, what we are preparing you for, must be 'surgical', as we say: no collateral victims, please.

On 04/13/20: Group immunity and other strategies

To distract oneself, one can reread TheAppeal of June 18. One can, without too much disgust, watch this video from Le Monde, where is explained what is also shown on the graph. To flatten the curve will be done by keeping the surface under the curve, because, it is necessary to reach (quickly? as in Mulhouse?) an immunity to 70%. Unless the country is completely isolated, the method of decontamination by piece, at 2% mortality (thus without overloading the reactors) is 60,000,000 x 0.7 x 0.02, i.e. 840,000 deaths, the 'passive' Raoult method is 189,000 deaths, selective covidisation (young patients in good health) under medical supervision is probably almost nothing...

700.000 people live in Ephad. So many families who will find it bad...

The good business of the businessmen: On this plan, there is a lot to say... The American bank Capital One was 'saved' from the deluge by a trick that deserves to be understood. For your business, you took out a bank loan with your apartment (1/2 million) and the beautiful country property you had just inherited (1/2 million): this serves as collateral for your loan of 1 million, now invested in your business project. The country property, badly insured, burns. It is only worth the land. Worried, the bank asks you to increase your guarantee proportionally, so you sell what can be sold, at a low price, it is the margin call. If everyone does the same thing at the same time, bankruptcy is guaranteed. Unless, unless, the FED, the lender of last resort, gives you a generous loan, without demanding any guarantee. and CapitalOne is out of the woods... For the moment...
the Fed has in fact promised that no listed company, no municipality, no insolvent borrower would go bankrupt in the foreseeable future...