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Friday, May 1, 2020

151



This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.




Coronavirus, HIV, ARV, intermittence...(13)


Coronavirus: Victory continued and soon to end


Graphic update by worldometers and Southern France Morning Post.

HCQ/AZIT vs (HCQ/AZIT + the rest)
HCQ/AZIT(HCQ/AZIT + the rest
DateInfected
(and treated)
deceased%Infected
(all ttts)
deceased%p
10/05/20203273170,52 %48361453,00 %---
09/05/20203261170,52 %48321453,00 %---
07/05/20203248170,52 %48271442,98 %---
06/05/20203241170,52 %48181422,95 %---
05/05/20203233160,49 %48091402,91 %---
04/05/20203227160,50 %48041382,79 %---
03/05/20203220160,48 %47971332,78 %---
02/05/20203207150,47 %47901282,67 %---
01/05/20203190150,48 %47761282,69 %---
The complete table is available here
source: https://www.mediterranee-infection.com/covid-19/




On 10/05/20: First results, not flaming, with Atazanavir



For the moment we only have the summary... Until then... Raoult's article is published. The 'big' newspapers did not rush to get it, but well, in this internet age, what does the bottle matter... In Madrid, the verdict of an observational study with a control group ( download here):

On 09/05/20: S+ and excluded...from the Raoult protocol

I can hear Raoult or Perronne ranting like self-medication... Certainly, if we could do without it... The problem is not that these 2 are ramdomizing, no... It's that they exclude, and that you have to beware of them like Pialloux the plague! If you go to Pailloux (Tenon), which you should have avoided at all costs, except to be sodo ramdomized at the factor 4:5 (1 placebo, 2 useless, 1 dangerous) you were not entitled to HCQ/AT... But not at Raoult's either! Because of the inclusion (and therefore exclusion) rules.

What we learn from the early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: a retrospective analysis of 1061 cases in Marseille, France. Reasons for exclusion of 350 patients from the study.

If X then, no HCQ/AT... You didn't see that one! If X and over 65, no HCQ/AT, what does that mean? It means 10% mortality and not under reasonable conditions. Under 65? Well... You're going to shit 21 days instead of 6 but after all, if you're already stupid enough to fill up on drugs, don't be surprised if they don't give you anything in case of emergency! Oh yes... You could say: I'm going to stop the ARVs, treat my COVID, and then I'll start again... Like anyone would believe you. As if you could do it... Because, tough luck, you are on injectable DTG/RPV! This is a failure to adjust the shot!

you are on Eclipsotherapy (ultra intermittent), you suspect COVID, you take your bi-monthly meds before to go to Raoult/Perronne to be tested, and you have a 15-day window to treat your COVID, which is quite enough... On injectables, you had it in the bone...

On 08/05/20: Immunizing... or not...

The debate is on... With its huge cohort, the IHU was able to evaluate the serostatus of COVID-19 patients using an indirect immunofluorescence test and questions the potential efficacy of Serotherapy. The question of the second wave is of extreme economic importance: If one can work/travel more or less well in the Fall, it will be fine... Otherwise...

05/05/20: Ramdomizers and ... death...


No one wants their name associated with the Discovery trial... No one... You are killing your reputation and that of your hospital... The people of Marseille are proud of the IHU, the people of Amiens (Macron, Xavier Bertrand...), much less so. The Amiens University Hospital is testing chloroquine but has to postpone the Discovery trial due to lack of available drugs. Good excuse??? Because the patients did not take it. European trial ??? My ass (as we say Moncay)! Luxembourg: 1, the rest: ZeRo ! We'll see, when it's published, who will want to associate his name with it!

Contact: Florence Ader, MD +33 (0)4 72 07 15 60 florence.ader@chu-lyon.fr(source)
Contact: Hélène Espérou, MD +33 1 44 23 60 70 helene.esperou@inserm.fr (source)
Lionel Piroth, CHU of Dijon (source)
Jean-Luc Schmit, Amiens University Hospital. (source)

HCQ/AT: it is in the viremic phase, after that, it is no longer the time for anti-virals. One can think that the mode of action (electrolitic reduction of the vacuole) is moderate in the face of very high viremia (very high viremia is a failure factor reported by Raoult). Therefore a 'compassionate' trial is not relevant. We can give Paquenil, it doesn't eat bread, but, well... considering all the other things that need to be done. It would be like giving Truvada (alone, used as a PreP) to a terminally ill AIDS patient with 10,000,000 copies and hoping for a 'Lazarus effect'. Does hope make you live? No! Here, it kills!

check the contraindications to medication: This is an important point, accessible to the basic badger, no need for a doctor! First of all your basic doctor, how can she know if HCQ/AT is compatible with DTG, for example? By consulting action-treatments??? Well... No... Drugbank? Ah, that's better already... But well... It's on the Internet, the basic badger can read...

Supposed interactions between HCQ and current ARVs (in progress... 05/05)
Moleculesuspected effect
AbacavirNo corresponding record
EmtricitabineNo corresponding records
LamivudineNo matching records
TenofovirNo matching records
EfavirenzThe risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with efavirenz.
EtravirineNo corresponding records
NevirapineNevirapine metabolism may be decreased when combined with hydroxychloroquine
RilpivirineRisk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Rilpivirine
AtazanavirRisk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Atazanavir
DarunavirNo corresponding records
FosamprenavirNo corresponding records
LopinavirSerum hydroxychloroquine concentration may be increased when combined with lopinavir.
TipranavirTipranavir metabolism may be decreased when combined with hydroxychloroquine
BictegravirNo corresponding records
DolutegravirNo corresponding records
ElvegravirNo matching records
RaltegravirNo matching records
CobicistatNo matching records
RitonavirRitonavir serum concentration may be increased when combined with hydroxychloroquine
MaravirocNo corresponding records
cave canem de rigueur this blog is not medical advice
(especially since medicine has proven to be poor) source: drugbank


The Surrealist Interview of Peronne: it is here, and... There is everything.

Le 04/05/20: Self-medication or ... death...

Doctors are screaming like pigs whose throats are being slit at the mere mention of self-medication! I hear you, and I would gladly subscribe if there is an alternative... I have nothing against good medicine, as a proof, I'm doing my bit to encourage the mammoth to do OMNIBVS-3D, the least ambitious trial there is. Don't blame me! Well, you can try, if you like it, you'll get a rake! Faced with a mortal danger, it is legitimate to react. Leibowitch and Peronne, multi-recidivist in the matter, had the knack to publish in the middle of the world, in English, in a magazine that nobody reads, the best available option to date. And at the same time that they were prescribing only to well-informed people, here they are on TV sets, facing people drooling with the desire to get out of it, declaring at auction 'and it should not be that the patients self-prescribe!

What is the use of a doctor who prescribes an analysis that nobody can do? Today, May 4th, as the pandemic has passed its peak, the FDA has just authorized 'in emergency' (sic), the Roche Elisa kit. We had to wait until 13/03(source Roche) for the only kit that can be used with COBAS, which almost everyone has (except Raoult, obviously, or the vets). Take note: Neither Pasteur, nor Inserm, nor any of the braggarts, has published a single in-vitro trial: Zero... 2-3 publications in China, 1 in Brazil, one in Japan, 2 in France, 1 in Australia, and... That's all... don't rush to buy Roche stock, it's only up 2% right now... Because... They're not going to sell that much. No more than Gilead is going to sell Remedivir... Roche, they were clever, they managed to sell a whole stock of Tamiflu (molecule bought from... Gilead...) to the French government, at a low price, which, satisfied with its ineptitude, gave up buying masks... No mask, but Tamiflu by the ton. Since it's useless but we have it, well, doctors will be able to prescribe and patients won't self-medicate... with Tamiflu. Fortunately, masks are not in List 1 !!!

The entire medical profession is at a loss. Arrogating to themselves an exclusive right (in the name of what?) to prescribe HCQ (list 2, please, nivaquine too!!! They are crazy!) not prescribing it, not knowing how to prescribe it, not being able to prescribe it (see Solomon's Decree), and even so... The pharmacy can't deliver... The grandfathers and grandmothers who have relatives in Lupus, at least they can mount a defense, a legitimate defense!

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