152

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARVs, intermittence...(14)

Coronavirus: The end is near

Graphic update by worldometers and Southern France Morning Post.

HCQ/AZIT vs (HCQ/AZIT + the rest)
	HCQ/AZIT				(HCQ/AZIT + the rest
Date	Infected (and treated)	deceased	%		Infected (all ttts)	deceased	%	p
10/05/2020	3273	17	0,52 %		4836	145	3,00 %	---
09/05/2020	3261	17	0,52 %		4832	145	3,00 %	---
07/05/2020	3248	17	0,52 %		4827	144	2,98 %	---
06/05/2020	3241	17	0,52 %		4818	142	2,95 %	---
05/05/2020	3233	16	0,49 %		4809	140	2,91 %	---
04/05/2020	3227	16	0,50 %		4804	138	2,79 %	---
03/05/2020	3220	16	0,48 %		4797	133	2,78 %	---
02/05/2020	3207	15	0,47 %		4790	128	2,67 %	---
01/05/2020	3190	15	0,48 %		4776	128	2,69 %	---
The complete table is available here
source: https://www.mediterranee-infection.com/covid-19/

The 14/05/20: Pr. Christian Perronne: and the self-medication

We resume a linear rhythm: the 14/05 is now at the bottom of the 13/05: the continuation is thus lower...

Le 13/05/20: Pr. Christian Perronne: multi-recidivist schyzophrenia

Following him, one becomes crazy: he is obsessed with self-medication. At each public intervention he repeats his pontificating oukase. It could not be otherwise: Has anyone ever seen a Herr Professor, head of Pole no less, say anything other than No to self-medication, Nein, Nein, Nein!!!. They are all in the same juice. It's Magneto Serge: you press the button and it's out. Except that the man has an honest background... This changes us from the rantanplans co-Labo-rators, nickel feet of thepharisaicalvirology, whose sordid plans are easy to expose... He rarely lies... Oh... It happens to him...(e.g. the report, in English, on ANRS-4D omits the known and recognized explanation of the 3 unfortunate little failures). But Well... So there he gets theOLYMPIC GOLD. His otherwise remarkable publication is a hymn to the right independent medication. Perronne is honest but not entirely honest. Under his auspices, we have the Leibowitch/Mattez articles FASEB-1 and 2. If Perronne would let the reader go through with the demonstration, this blog, which pains me so much to write, would have no reason to exist. The pathetic schemers, that everyone has understood by now, but this is more perverse.

The article is great Hydroxychloroquine plus azithromycin: potential benefit in reducing hospital morbidity due to COVID-19 pneumonia (HI-ZY-COVID) and Perronne doesn't hide anything or so little... You must read it! You will learn amazing things. Well... HCQ/AT worked in his case, we understood that. But you have to read carefully: no PCR curve...

On 05/14/20: Pr. Christian Perronne: useful but not essential...

If the vast majority of COVID diagnoses were confirmed by PCR, there is no follow-up curve... Raoult says he did 100,000 PCRs, he published a mini table corner study with comparative PCR curves. We will see if he publishes anything to compare the carriage (duration of infectivity), the argument that convinced us in the first place. With Perronne, none of this. Alvarez, after a few PCRs, he becomes saturated... We are not at all in the same environment. This is quite a feat for the flagship hospital of Stalingrad, which had to change its paradigm and substitute the viral load (PCR) to the good old count of deaths or aggravations. It is fortunate that Perronne did not randomize!

In an epidemic context, with well described symptoms, can we do without PCR? No if you play the Raoult game, yes if you only intend to treat symptomatic cases (e.g. Barbosa Esper), and even less if you play the Prophylaxis game. If you do not have PCR at hand, you have only 2 options: prophylaxis, or treatment at the onset of symptoms.

Low dose CT: As a patient, the hospital has one advantage: its technical platform. But if this platform is saturated, therefore rationed... The probability of being able to benefit from a low dose scan is low... In other words, there is no point in going to this hospital...

A priori screening (inclusion, therefore exclusion...): One of the interests in hetero-medication is an objective opinion on eligibility. Am I eligible? We do a screening electrocardiogram. What is the probability of discovering, on this occasion, a prolongation of Qt, which is a warning sign, more or less relevant. The subjects at risk are of a certain age and with age comes regular screening. Therefore, no new cardiac situations have been significantly discovered. This leads to the following situation: people with an identified cardiac problem, the vast majority of whom are not newly identified, will be excluded from treatment, even though they are the ones most in need of treatment. We don't have a hundred thousand alternatives. A COVID patient, with a heart condition, who goes to Garches will therefore be excluded from the (only?) treatment that could save him from a very dark future: 1 'chance' out of 2 to stay there. Isn't hydroxychloroquine then a lesser evil? And do you let the hospital doctor choose for you? There is no informed consent to a treatment that is not proposed to you... You are bound hand and foot, on the edge of the precipice and the wind is blowing! Perronne has been smarter than the others... It is true... But for one Perronne, how many morons?

Hydroxychloroquine, futile or overdosed: leaving your life in the hands of bad doctors(on the whole, they have not been famous...), means letting them either deprive you of HCQ, or give you 600 mg/day. For cardiac patients, this will move... There were alternatives and Perronne describes them, let's take advantage of them. Either skip HCQ, but take AT, that's the Perronne way, or half-dose HCQ + AT, that's the way chosen by the Borba team, duly cited by Perronne, who opens an interesting subject, obscured by Raoult. Raoult has published in-vitro HCQ, HCQ+ Azithromycin, HCQ+Doxycycline trials, with a bluffing effect for the latter 2, where one can imagine a favorable synergy. Yes... But what about Azithromycin alone? Before talking about synergy, in-vitro, we must study A, alone, B, alone, and finally A and B together. And that, Raoult has done without.
Of course the number of patients is low, because Garches was alone, but the AT arm (alone) performs globally as well as the HCQ/AT arm, and, in Borba(Effect of High vs Low Doses of Chloroquine), HCQ 300mg + AT is better than HCQ 600 mg/AT. For cardiac patients or those who were not aware of it, there was a solution: not to take HCQ, or just a little. How many doctors would have had this insight? Was the doctor who would have taken care of you at Bichat, Tenon, in this position? One can therefore think thata doctor can be at best useless, and very often the man who did not save your life.

Perronne with the cock and the knife is not doing so bad... But what a sorry admission of lack of means: not enough PCR, not enough small dose CT, and... no medicine, by order of the ministry (Perronne had the courage to put it down on paper). Raoult is more precise: the rich, the influential, the connected have been able to access the treatment. The bazanés, the colored, the colorful, the unclassified, the uneducated will have been the most affected in New York as in London.

Perronne: malmedication is guaranteed death: in a hollow way he attacks his colleagues, who, it is true, did not shine. With one hand he says: the vast majority of infectious diseases specialists suck, and with the other he says no to self-medication.
Does he want us dead or what???

Raoult and the shit catapult: once bombarded withPharisaicalineptitude, Marseille returns the favor by publishing thePharisaical'performance', compared to his own. That's 10 times more deaths for a population 3 times larger. The hour of reckoning has come... We will see tomorrow...

Le 15/05/20: Raoult and the legal proceedings

In a system that drags its Judeo-Christian heritage like a ball and chain, one cannot claim to be a Mandarina while at the same time ranting and raving. This applies to the CCP (Chinese Communist Party) as well as to the Vatican clique. The good people are waiting for the mesianic intructions of the academic or political 'authorities', who, in the absence of intelligence, will show authoritarianism. We see how, in Europe, the neighboring Protestant states have a less ideological response than their Catholic neighbors. This is particularly obvious in the United States: in New York, the Hispanic communities, gathering in small community churches, will have been the amplifier that was in our country La-Porte-Ouverte (Mulhouse), the what's-his-name sect in Korea. No! your fellow citizens do not thank you for your futile prayers and invite you to stop your deleterious antics!

Perronne/Truchis have a control arm, not intentional, which owes its existence not to the disastrous ramdomization alla Pialloux-Lacombe, but thanks, one might say, to the imbecile Veran/Salomon decree:

The Surrealist Interview of Peronne, in full collective hysteria, is to be read, it is here, and... There is everything.

Raoult: a loan for a return... The IHU publishes the curve Paris vs Marseille

HIV: S+ allowed to participate in HCQ/AT trial, in the USA It is published here. Note, it's a bit normal, since it is organized by the AIDS Clinical Research Group (ACTG). In the USA, there are still cases... In Marseille, no... On the other hand, the French Academy of Medicine has just lost an opportunity to keep quiet and to deplore the fact that many patients refused to enter the placebo group, the only one, according to the Academy, that could spread the science; it could have specified that they refused to enter the placebo group, at the risk of their lives. When we specify a little, we understand better the patients and even less the 'Academy'. They are mad as hell! This ideology of using a placebo on a disease that can lead to the death of the patient in a few weeks is sickening. If the result is very effective, who cares about the placebo effect?

05/16/20: pH modulation and/or specific inhibition

Seen from the point of view of a very small microorganism, the cell is a vast continent. An evolved virus comes with its own camper van. HIV comes with its own inhibitor of our natural inhibitor (ABOPEC), VIF. Without it, its race would have ended in the dustbin of our genome, consisting for about 10% of retroviral vestiges, various, prehistoric and incapacitated. The idea of adding an artificial inhibitor, targeting this or that enzyme that the virus produces for its replication is tempting, 'modern' and we can work to make it devilishly effective: it is the Inhibition Pathway. With a bit of luck, we can recycle an existing inhibitor, whose efficiency is not optimized, but not too bad: this is the ATV pathway (or LPV, to a lesser extent...).

To do this well, we need to take a 'bank' of molecules, and screen them by successive selection. This requires enormous means, inaccessible to the basic Institute. This is how Merck identified Diketo acid against integrase. Only BigPharma had the means to make this investment, and the resulting molecule, Raltegravir, arrived in 2007, 10 years after Stalingrad. A target of choice is the RNA-polymerase, because it is an enzymatic family common to RNA viruses (so not to retroviruses...). The ability to screen is at the center of this strategy: there are hundreds of thousands of small synthetizable molecules, and it is necessary to test several doses, and in several times, with controls: a pharaonic work. Either we tie up a thousand small hands (Chinese?), or we put a horribly expensive robot made by a megacapitalist (American?), which leaves us in the middle of the road, as we see for HIV.

The IHU and the accelerated, simplified screening: And we must be sure to inhibit the right virus... Ask Gallo, on whom Leibowitch had bet, who went wrong with HTLV... Designed to respond to bio-terrorism, the IHU has developed open and rapid methods. An epidemic wave, terrorist or not, is fast, we are not in the time of HIV...

05/17/20: pH modulation and/or specific inhibition (continued)

As an alternative to enzyme inhibition, one can consider a modification of the environment of the virus, which in this case is the vacuole, a kind of cell within a cell. The cell is its home, but it goes to the bathroom to do its business. If we reduce the size of the bathroom, it makes less little... Less... Not Zero... So the effect on the reccursive population decrease is limited: it takes a few days, and works less well on very very high viral loads.

HCQ as an adjuvant to intermittence There is a link between HCQ, replication, reservoir and intermittency... It is rather confusing.
HCQ has been used in at least three HIV circumstances, in clinical trials, with a control group:
- HIV without treatment, in the hope of delaying initiation of treatment, with results that may be misinterpreted; We'll come back to that. Here it is.
- HIV on effective ARV treatment, with the aim of improving the immunological response, with results in sharp contrast with the above. It is here
- HIV on effective ARV treatment, in a notably unsuccessful, but remarkably useful, Shock-and-Kill trial Beyond that, HCQ seems to have a beneficial effect on diabetes, HIV, osteoarthritis, according to this rundown: Does HCQ have benefits beyond mild diseases.

Maintaining chronicity

Supposed interactions between HCQ and current ARVs (in progress... 05/05)
Molecule	suspected effect
Abacavir	No corresponding records
Emtricitabine	No corresponding records
Lamivudine	No matching records
Tenofovir	No matching records
Efavirenz	The risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with efavirenz.
Etravirine	No corresponding records
Nevirapine	Nevirapine metabolism may be decreased when combined with hydroxychloroquine
Rilpivirine	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Rilpivirine
Atazanavir	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Atazanavir
Darunavir	No corresponding records
Fosamprenavir	No corresponding records
Lopinavir	Serum hydroxychloroquine concentration may be increased when combined with lopinavir.
Tipranavir	Tipranavir metabolism may be decreased when combined with hydroxychloroquine
Bictegravir	No corresponding records
Dolutegravir	No corresponding records
Elvegravir	No matching records
Raltegravir	No matching records
Cobicistat	No matching records
Ritonavir	Ritonavir serum concentration may be increased when combined with hydroxychloroquine
Maraviroc	No corresponding records
cave canem de rigueur this blog is not medical advice (especially since medicine has proven to be poor) source: drugbank