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This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARV, intermittence...(12)

Coronavirus: Victory continued and soon to end

Graphic update by worldometers and Southern France Morning Post.

HCQ/AZIT vs (HCQ/AZIT + the rest)
	HCQ/AZIT				(HCQ/AZIT + the rest
Date	Infected (and treated)	deceased	%		Infected (all ttts)	deceased	%	p
04/05/2020	3227	16	0,50 %		4804	138	2,79 %	---
03/05/2020	3220	16	0,48 %		4797	133	2,78 %	---
02/05/2020	3207	15	0,47 %		4790	128	2,67 %	---
01/05/2020	3190	15	0,48 %		4776	128	2,69 %	---
30/04/2020	3181	15	0,47 %		4763	128	2,69 %	---
29/04/2020	3164	15	0,48 %		4718	125	2,65 %	---
28/04/2020	3143	15	0,48 %		4748	125	2,60 %	---
27/04/2020	3130	14	0,45 %		4718	121	2,56 %	---
26/04/2020	3081	13	0,42 %		4678	118	2,52 %	---
25/04/2020	3081	13	0,42 %		4678	113	2,42 %	---
24/04/2020	3060	12	0,39 %		4651	109	2,34 %	---
23/04/2020	3040	12	0,39 %		4599	107	2,33 %	---
22/04/2020	3039	12	0,39 %		4599	105	2,28 %	---
21/04/2020	2999	12	0,40 %		4579	100	2,18 %	---
20/04/2020	2970	12	0,40 %		4541	97	2,14 %	---
19/04/2020	2939	12	0,41 %		4520	97	2,14 %	---
18/04/2020	2853	12	0,42 %		4479	93	2,08 %	---
17/04/2020	2759	11	0,40 %		4420	85	1,92 %	---
16/04/2020	2716	11	0,41 %		4386	83	1,89 %	---
15/04/2020	2671	11	0,41 %		4337	78	1,80 %	---
14/04/2020	2628	10	0,38 %		4292	74	1,72 %	---
12/04/2020	2494	10	0,40 %		4181	63	1,50 %	---
11/04/2020	2401	10	0,41 %		4100	63	1,53 %	---
10/04/2020	2397	10	0,44 %		3998	57	1,42 %	---
09/04/2020	2285	10	0,45 %		3931	57	1,45 %	---
08/04/2020	2187	10	0,46 %		3835	47	1,23 %	---
06/04/2020	2179	9	0,41 %		5527 (?)	42	0,75%	---
05/04/2020	1962	7	0,35 %		5411 (?)	34	0,63%	---
03/04/2020	1818	5	0,27 %		3505	33	1,1 %	---
02/04/2020	1677	2	0,12 %		2837	22	0,77 %	---
01/04/2020	1524	1	0,06 %		2663	17	0,63 %	---
31/03/2020	1283	1	0,X%		2430	16	0,x %	---
30/03/2020	1291	1	0,08 %		2222	16	0,70 %	---
29/03/2020	1003	1	0,10 %		1988	13	0,65 %	---
27/03/2020	701	1	0,14 %		1577	11	0,70 %	---
source: https://www.mediterranee-infection.com/covid-19/

On 02/05/20: the Pangolins, the doctors,

@ThisIsNotThePangolins: As expected, some are going to search for SARS-CoV-2 related coronavirus in pangolins .... TRUMP does not care, as long as the Pangolin is... Chinese... Pangolins are mammals, so, according to the followers of the hypothetical @CestpouscestlesPangolins, they should make good animal models, for the future. One wonders if they have not, in fact, already been used as animal models, especially if they can be bought/sold at the market which is 800 m away from the Wuhan Virology Center.

Trachea hygiene: By dint of hearing simplistic advice in the media, one would forget a few others well known by Asian grandmothers. Wear a mask... at night, while sleeping. 8-9h without drinking a little, it dries the throat. By wearing a mask at night, you maintain a humidity in the breathing zone, thus in the trachea, which facilitates the evacuation of dirtiness. The gargle, that nobody mentions, is a simple method of personal hygiene: if you don't have a liquid bought in a pharmacy, you can use diluted Hextril, or Listerine (mouthwash) and make your daily gargle, when you go home. If you don't have anything, at least do it with salt water. Useful against THE virus? Who knows, but it is useful against the little banal things that become unnecessarily anxiety-provoking as soon as you have your first coughing fit.

Doctors praise HCQ/AZ and nobody sees any toxicity:

In Vitro: Nelfinavir better than Atazanavir??? One can doubt it: The advantage of a peer-reviewed publication is that glaring errors are corrected. In the In-Vitro study here, we find very different results from this one. The Brazilian study is better argued and takes a molecule with proven efficacy (Chloroquine) as a control: their lab found the same values as the others, on this molecule. The Japanese study (perhaps bad) has no validation point. One wonders... We read... We look at the graphs, and we are surprised.

The disconnected of Le Monde, the vaccines and 2 millions of Bill Gates: The wolf has been raised by Lorgeril: Gates makes a check of 2 Millions to Le Monde! A total of 4-5 millions!

Now the self-proclaimed censors will have to explain themselves... Their (few) subscribers will find it bad. What we must not forget, is that to get a 'help' from the B & M Foundation, we have to ask for it, and prove its efficiency, which, we see, has increased tenfold in 5 years! We are not surprised anymore by the pro-Vaxx, pro-Buzyn-Levy, pro-everything-that-stinks-about-itself bias. We didn't have much respect for them, it is true...

Le 02/05/20: BFM, ramdomisation, Stalingrad

Didier Raoult speaks on BFMTV: the complete interview. Pauline de Malesherbes... Not too bothered by the confinement, to come to Marseille... No matter... History will remember that Raoult wears a silver ring on his little finger... Bravo!

Randomization: There are ethical arguments against randomization. A fundamental mathematical argument clarifies a debate that has become hysterical. When we take a sample, for example a micro-trottoir, we may inadvertently or with disguised intention favor some over others... The result is tainted by noise and error. If we increase the number of observations, the gap will decrease, and the curve will get closer to the true reality. The law of large numbers allows us to interpret the probability as a frequency of occurrence(wikipedia). When we sample, we get closer to the 'true' probability, the more we increase the size of the sample, the more we take samples at random (ramdomization) and/or the more we ensure the comparability of the groups (intervention vs. controls) (e.g. the quota method for surveys or stratification for clinical trials). Whatever the case...

All this is a methodological improvement, made necessary by the small number. Do all the polls you want, the vote is the most important, because it is total. Here, we have 3 million infected people, and a number of people treated with HCQ (or HCQ/AZ) that is out of all proportion to the 'survey' that is the 'Discovery' trial, and we doubt that the results will be available before the end of the first episode... The HCQ/AZ series counts 3000 patients, and the control, well, it is all the others who will have been treated with nothing, tens of thousands of people. Except in Marseille, where the control group is rather small. Anyway... In India, the doctors immediately understood, and the Indian government (Make India Great Again) reserved HCQ/AZ for its population, and the expected hecatomb is not observed.

Randomization only makes sense if you can only afford to observe a small number. IHU, with these 75,000 tests performed, is not in this case...

Self-medication vs. randomization This is one of the reasons why I have long said that I will never participate in Quatuor (or in OMNIBVS for that matter). Only people who are in doubt should participate in a randomized trial. I, who practice the 1/15, participate in a piss-poor trial, it is to bias it... The Stalingrad trial: a double revolution: It is the French trial (Leibowitch) that establishes triple therapy. The other revolution is that it establishes the measurement of the CV as an end-point of the clinical trials, whereas until then, we were content to observe the clinical deterioration of the patients (which takes time and is not very nice for the patients). The whole ANRS clique (Delfraissy, Barré, Katlama, Costaglia...) all got on the end-point trial train, to finally change horses. For this, the CV was needed, the prototype of which is to be credited to Dr Mattez.

HCQ in the Fox News trap In the USA, conservatives, with TRUMP as their flag bearer, hope for a quick economic recovery. Their media of reference is Fox News. They saw in HCQ/AZ the messiah they were hoping for. Their Michel Cymes, a certain Dr. Oz, commentator of Fox News(video here). HCQ would soon attract the attention of Donald Trump. And Raoult would suddenly go from being a recognized microbiologist to a worldwide darling at Charles-Edouard Fox News, Internet. Afterwards, they would have to MAGA (Make America Great Again) by artificially replacing HCQ/AZ with Remdesivir and boosting Wall Street. If Remdesivir crystallizes greedy hopes, the disappointment will be great... But by then, we will have moved on. Such as the $500 million awarded to Moderna, a small biotech company, better known for its promises in the air (vaccine) than for its achievements...

Chronic treatment as prophylaxis? Raoult clearly asks the question: have the numerous patients under daily HCQ (for Lupus or other reasons) been protected against SARS-CoV-2? The answer is perhaps easier and faster to obtain than to do a 'clinical trial', alla 'Partners'.

The Discovery Journal: Clear: they can't seem to recruit... (Unlike 4D and Quatuor, whose ballot boxes were full even before the launch...). Is it Europe's fault? No! to common sense... You have 4 'chances' out of 5 to receive an ineffective or dangerous treatment! Bravo Pialoux! Bravo Yazdan!

HIV, ARVs and SARS-CoV-2: At the time of SARS-1 (2003) there were some in vitro tests, but the panel of molecules has grown since. An in-vitro study of PIs has provided some guidelines for their possible use, in particular Atazanavir. The publication: Nelfinavir inhibits replication of severe acute respiratory syndrome coronavirus 2 in vitro is worth a look. We will come back to it... The synergistic effect of HCQ/AZ allows to reduce the carriage from 21 days to 6 days. and to reduce the severity of the disease... Why not consider, one or 2 more molecules, for a synergistic bomb (a horse treatment...) which is safe and allows to reduce even more the carriage, for example to 2-3 days. See also

On 01/05/20: Pearls of Containment

Small pearl of containment A.Vivaldi 'Eia Mater' - Jakub J. Orlinski & A. Debicz... His Stay Home is very successful, too...

O Mother, source of tenderness,
Make me feel great sadness
So that I cry with you.

Replace O Mother by Homer, Homer, The name of your mother(I am sure you have one... ), O Virus, O eme-esse, it is still just as touching...

Interview with Raoult, decidedly very commented and followed... the consensus is Pétain, the original (paying), in Match:

Le 30/04/20: Perronne or how to be consensual with concepts of rupture

I advise you to listen to the interview of Christian Perronne, on April 27: Listen to him : Perronne is the one who supervised the FASEB-1 and -2 publications, which are the flagship of all of us...

Le 29/04/20: Natural end or rebounds

Raoult goes a bit fast... A truism: seasonal diseases stop (on their own)... Ok, but that's why they are called seasonal. The first SARS could have been contained during its resurgence, its last, as a truism would say. If it had not been contained, a little by chance, a little by careful monitoring, it would not have been contained, so... At that time, China's economy was smaller than Hong Kong's. Today, HK is less than 1%. Each area will want its own cordon sanitaire. Do you really think that tourists will be welcome in Corsica this summer? On arrival, a quarantine order... Raoult tells us: Look, the curve has a bell shape. Yes, but the city is also under a bell. Can we claim that the transmissibility is extinguished 'naturally'when we put such a lid on it. Ah!... But in Marseille... Well... Yes... Marseille is also under containment. But his strategy: test, isolate, treat (with what we have at hand, of course) is worth in an isolated area, Marseille in time of confinement yesterday, Corsica or Ré Island, tomorrow... With containment/quarantine of Seroneg-(at SRS-2),

On 04/28/20: In Vitro: more molecules...

Today, here it is: ivermectin inhibits SARS-CoV-2 replication in vitro. In first intention, we will see proposals bloom, which have been delayed by the refusal of the Chinese authorities to provide strains... It is understandable that this is annoying and that the WHO is in the hot seat.

Relationship with HIV: the relationship between SARS-CoV-5 and HIV had disappeared for a while. It is slowly being rebuilt: ivermectin is a rather good inhibitor of HIV-IN (integrase), not excellent excellent, but in a slightly different way than DTG... To be continued... Moreover, the question of the loss of INSERM accreditation in Marseille was made against the background of competition between the LEVY vaccine (the LEVY of the Minister BUZYN...) and that of Biosantech. We will have to dig a little, but if there is something, it will come out...

Raoult: common sense in a crazy world: his latest video: 'Update on the epidemic: are we really at risk of a second wave?' (this is not Radio-Raoult, which is on twitter, actually...). The model he refers to can be found here:Data-Driven Prediction of COVID-19 Pandemic End Dates. A single peak epidemic model, like the vast majority of seasonal infectious diseases. France is out of the woods by mid-May, and by June it's over! The debate about randomization, Redemsivir, etc. will dry up. What will be the use of tests, vaccines and other passports, apps, etc? We can start to ask ourselves the question...

Molecules, in-vitro vs in-vivo
Therapy	Efficacy In-vitro	Trial In-vitro	Efficacy In-Vivo	Test In-vivo
Remdesavir		Manli Wang		Y4
Favipiravir		Discovering drugs...		Favipiravir Treatment
Atazanavir		Atazanavir inhibits SARS-CoV-2...		Y4
Lopinavir	Z2	Z3		X
Hydroxychloroq.		X		Y4
HCQ/AT		Z3		X
ivermectin		Ivermectin inhibits SARS-CoV-2...		Y4

On 04/27/20: Atazanavir and Doxycycline

IHU's track record is clear and worthy of the trust placed in them by their funders. They were the first to collect viruses (from repatriated people), to grow cultures (we will see that this is the sinews of war), to increase the number of tests, to carry out in-vitro trials, to publish a mini-study, to inform the authorities and the public, to propose a strategy that makes sense. The people of Marseilles have reason to be proud.

The race for cultures: Lopinavir was introduced very early on, by anecdotal observation in Thailand. So we drop the Eclipse for a news that overshadows any reflection on the remission. Especially since if it is confirmed, there will be panic in the house, including for my readers.

National and international collaboration has been lacking, as can be seen in this video: Research at the NSB3 laboratory of the IHU, revealing the atmosphere. It is true that the Americans reproached the Chinese for not having provided strains, which would have allowed them to do a screening. Brazil has its very first cases at the end of March, and a first in-vitro test 2 weeks later. The lack of cooperation in this area has caused the identification of potentially effective molecules to be lost for several months. Once a strain is maintained, everyone treats it with what they have at hand... This Chinese study puts on the same level of in-vitro efficacy, remdesivir (which is not yet galenized), choloroquine (which has been mass-produced for more than 50 years...), it was published at the beginning of February. One can appreciate the French psychodrama about the inclusion of choloroquinine in the Discovery trial, which, as we can see, will come after the battle.

Molecules, in-vitro vs in-vivo
Therapy	Efficacy In-vitro	Test In-vitro	Efficacy In-Vivo	Test In-vivo
Remediesavir		Manli Wang		Y4
Favipiravir		Z3		Favipiravir Treatment
Atazanavir		Atazanavir inhibits SARS-CoV-2...		Y4
Lopinavir	Z2	Z3		X
Hydroxychloroq.		X		Y4

The wall of xxxx 'barons
Microbiology versus...
Who	His contribution	My comment	Source
D. Raoult	Y2	Y3	Y4
Z1	Z2	Z3	Z4
The (pharisaical) virology...
Barré-Sinoussi	Y2	Y3	Y4
Delfraissy	Z2	Z3	Z4
Pialoux	Y2	Y3	Y4
Molina	Z2	Z3	Z4
Costaglia	Y2	Y3	Y4
Z1	Z2	Z3	Z4