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Friday, April 3, 2020

149



This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.




Coronavirus, HIV, ARVs, intermittence...(11)


Coronavirus: VICTORY and endgame (?)...


Graphic update by worldometers and Southern France Morning Post.

HCQ/AZIT vs (HCQ/AZIT + the rest)
HCQ/AZIT(HCQ/AZIT + the rest
DateInfected
(and treated)
deceased%Infected
(all ttts)
deceased%p
26/04/20203081130,42 %46781182,52 %---
25/04/20203081130,42 %46781132,42 %---
24/04/20203060120,39 %46511092,34 %---
23/04/20203040120,39 %45991072,33 %---
22/04/20203039120,39 %45991052,28 %---
21/04/20202999120,40 %45791002,18 %---
20/04/20202970120,40 %4541972,14 %---
19/04/20202939120,41 %4520972,14 %---
18/04/20202853120,42 %4479932,08 %---
17/04/20202759110,40 %4420851,92 %---
16/04/20202716110,41 %4386831,89 %---
15/04/20202671110,41 %4337781,80 %---
14/04/20202628100,38 %4292741,72 %---
12/04/20202494100,40 %4181631,50 %---
11/04/20202401100,41 %4100631,53 %---
10/04/20202397100,44 %3998571,42 %---
09/04/20202285100,45 %3931571,45 %---
08/04/20202187100,46 %3835471,23 %---
06/04/2020217990,41 %5527 (?)420,75%---
05/04/2020196270,35 %5411 (?)340,63%---
03/04/2020181850,27 %3505331,1 %---
02/04/2020167720,12 %2837220,77 %---
01/04/2020152410,06 %2663170,63 %---
31/03/2020128310,X%2430160,x %---
30/03/2020129110,08 %2222160,70 %---
29/03/2020100310,10 %1988130,65 %---
27/03/202070110,14 %1577110,70 %---
source: https://www.mediterranee-infection.com/covid-19/


On 04/26/20: Atazanavir and Doxycycline



On 04/25/20: To govern is to foresee...

The armies bought chloroquine 'as a precaution', in China (there is a factory in France, but well...)... If ever this treatment was finally validated by the health authorities... Which ones? Salomon or the military authorities? Interesting question: The frigate Provence is affected. HCQ/AT reduces severity if treated early enough. Case Study (of war): Do you treat or not? Warning: in case of wrong answer you will be transferred to Garches Tenon, as punishment.

'France has adopted a prudent position (sic!): hydroxychloroquine is authorized in hospitals only, and only for serious cases. That is to say for cases where it does not work anymore... We understood it well. Everyone has understood... Explain to me how this is a prudent position... It is a state position, unsustainable.

04/24/20: Picrocholine quarrels on toxity

Chloroquine (and its better-tolerated version hydroxychloroquine) was available over the counter! Here is what the Guide du Routardsays about it For prophylaxis, the dose was lower, but it was necessary to continue to take it 2 months after the return. Now, we have better, and, the pathogen is resistant in many countries so we restrict the sale. The debate on toxicity is irrelevant, as it is. Even the IHU reports deaths under HCQ (10 to be precise): yes... There are deaths under HCQ, but they did not die of HCQ, they did not have a bad virus by chance? The question can become absurd. Mr Marius is 75 years old, he has a heart condition, and positive for SARS-CoV-2 (@PandaVirus), it's not too serious yet; the cardiologist is not hot. But we don't have anything else on hand. We try HCQ/AT, his condition requires anti IL-6, then heparin, then this, then that, no luck... Marius dies. Try to prove that the doctor made a bad choice...

According to our clever Minister Veran,'There is no such thing as Dr. Raoult's protocol, there is a drug that you take when you are sick and that is either effective or not'. Nice truism. Can his majesty enlighten us on which treatments are effective and which are not? This could be useful for the 10-20.000 French people who will die by May 11... 500/day will die in the next 15 days. So let our Minister-Neurologist, show us the road to follow, because the sleeve effects never cured anyone!

The 10,000 deaths of Solomon Marseille serves a basin of 1 million, and has the best center of expertise in France, financed by the community. By partially applying the recommendation of the IHU, Marseilles counts 107 deaths to date. Sixty times more is 6,000. We are already at 20,000 and it is not finished! People sometimes take a month to die from COVID-19. All these deaths are due to Solomon/Veran/Macron. They were avoidable deaths, unnecessary deaths, undue suffering. You don't need to be an enarque or a senator to see the terrible mistake that has been made, 'straight in the boots', without listening, deaf, as usual of Macron. Those who have lost or are going to losean old relative are not likely to forget!

Poor Azithromycin, it is also doomed to the gémonies... 3 millions of prescriptions per year in the USA, only that... And Doxycycline is the fourth most prescribed antibiotic across the Channel.

The Gilead PUT: As announced here, and without any surprise, Gilead's stock has taken a beating!

After the marriage for all, now it's the marriage for nobody... A few years ago, you were tackled to the ground to get a mask in your underwear, now you are fined if you don't wear it

On 04/23/20: Taiwan, Korean submission, Atazanavir and Doxycycline

China, Korea and Mulhouse are examples of what not to do... In viral ecology, there are sources, sinks and amplifiers. A Chinese philogenic study (see one of the past posts) had shown that the emergence of the @PandaVirus predates the explosion in the Wuhan Market, the city at 'P4'. The market is an amplifier: it is being destroyed. In Korea and France, the Shincheonji Church of Jesus and La Porte Ouverte sects are amplifiers demonstrated and protected by the power: they are social harm under protection (evangelical-American authorities by proxi). These cockroaches must be held accountable! It is nevertheless the Open Door, which, by itself, is the amplifier of the Alsatian catastrophe. Secularism is not a doctrine but a compromise, which ceases when one of the parties physically attacks the Nation. Taiwan, which the WHO considers, diplomatically wrongly, as an integral part of China, and therefore under its jurisdiction, is the country (because it is a country...) that is doing the best. Detailed measures here: Response to COVID-19 in Taiwan: Big Data, new technologies and proactive testing. The example to follow, including in terms of democracy and natural sexuality rights, is Taiwan, not Korea, which is a horror in every way, and the evangelical entryism in France (remember the Veilleurs...) is no less detestable.

Taiwan brings a political answer (in the noble sense), pragmatic, where France is engulfed in its totalitarian demons. The individual is powerless... Hence the urgency to know what to do to free oneself. The liberticidal morgue of the 'authorities' of France has become detestable, and the only way out is in the exploration/exploitation of personal solutions. As Raoult says, one must deal with what one has... But who has Hydroxychloroquine at hand? And with the infamous Solomon's decree, there is no risk of finding any, even while waiting for the onset of symptoms. The impossibility to get the drug in time, by an authoritarian decision, justifies that we try to supply it in advance. If you get there ahead of time, you have a chance to get out. If you stay within the Solomon's perimeter, and the virus catches you, you're in trouble. Drastic containment and Solomon's decrees are two sides of the same coin. If you forbid modern techniques (masks, tests, Plaquenil...) of which doctors and pharmacies are deprived by decree, you only have to decree the economic and social armageddon, great Macronist specialty. You pull on the handbrake while braking with your foot after having pressed on the accelerator (cf La-Porte-Ouverte-à-tous-virus). It sucks!

In my medicine cabinet what will I find interesting? For the moment I'm looking for the good old Quinine syrup of my grandparents, including its diluted form: Dubonnet. Not sure if it's very useful, but hey... It can't hurt...
I also have Atazanavir and Doxycycline. On prescription, that I got them... And I paid for them. Atazanavir, it's Leibowitch who put me on it, even though I had a negative preconception about protease inhibitors, since they inhibit a lot of things, as we'll see... But in Ultra-intermittence, it works very well and I am pleasantly surprised to tolerate it well. It has pharmacokinetic synergy with DTG, Katlama says it's a good idea, Leibo does it without Ritonavir (using a hepatic metabolism inhibitor doesn't appeal to me), so I' ve got it... A Brazilian team has just published an in-Vitro study, using a similar methodology to the IHU one, with some interesting additions. And validates ATZ/RTV as well as ATV without RTV, in-vitro.
Doxycycline is probably Molina's only useful contribution to medicine. He published it as a Prophylaxis against hot piss and possibly against syphillis. I myself have nothing against drug prophylaxis and take it, when indicated, including against malaria. And with the Super Intermittence, I am not afraid of any overmedication or interaction. IHU has published an in-vitro study of Doxycycline on SARS-CoV-2 (aka @PandaVirus), which enters the very closed club of candidates.

There are alternatives to Raoult, what could be more normal, but there is no in-vitro trial by Pasteur, Inserm, Bichat, Cochin, Lyon, nothing... One would think that there is no one capable of doing a PCR or a culture! If it wasn't for the IHU, we would be totally blind. I am neither Radio-Leibo nor Radio-Raoult, but we have to admit that there is nothing else: NOTHING.
The slaughter continues in the non-HCQ/AT arm of Marseille...

The MBS Bomb: Mohamed Ben Salman or Mother Bomb from Saudis: 24 super tankers, representing 50 million barrels are on their way to the Cushing terminal. Unless TRUMP puts a stop to it, the WTI barrel will remain under $10, until the Wahhabi Tsunami is over. TRUMP will have little choice but to force them to divert to Europe or Asia

Three men from Westchester, New York, are suing the WHO, alleging that it mishandled the pandemic. The lawsuit demands that WHO pay 'incalculable' damages for losses suffered... Several US states have launched lawsuits against China... When will we see a lawsuit against ANRS and HAS, for overmedication/poisoning?

Le 22/04/20: Medicine by evidence vs medicine by risk analysis!

An analysis of the South Korean experience can be found here, with a very detailed version here. The craze for the Korean method deserves some reservations. If crisis management gives us lessons, let's not forget those, more discreet but more efficient, of those who knew how to avoid the crisis, such as Taiwan, systematically quoted as an example, superbly ignored by the WHO (CCP-infested). (I have pruned a little to make it readable quickly)

Let's comment a bit: remdesivir and its proven good clinical tolerability: Oh well? Please read Compassionate Use of Remdesivir for Patients with Severe Covid-19, funded by Gilead, which signals the end of Redemsivir in widespread use. In it, the evidence of supposed 'good clinical tolerability' is set aside, for an unproven relative 'benefit'. In short: Remdesivir is toxic and futile. We don't really care because the drug doesn't even exist (only the molecule, in injectable form, available in very small quantities). I would like to take a Gilead PUT, but I can't find any... Obviously, the issuing banks don't dare to do it...

South Korea as an example of democracy??? 0% of practicing Christians before the American invasion and 30% today, it's a good example of possible and deep transformation of a society. An example put forward by all evangelist fundraisers. Not sure that religiosity, exacerbated homophobia, police and judicial arbitrariness makes it my cup of tea... Not my kind of beauty... It would be quite appropriate to evaluate the role of religious gatherings in the explosion of infectious respiratory diseases: this applies to Daeju (Korea), Mulhouse, Morocco and even Mecca. This type of vectors benefits from resonance boxes, opportunistic amplifiers: Good Word and Naughty Virus share the same breath.

Let's comment further: 'the antibiotic seems however to cause toxicity without significant additional benefit'.

1- the argument of flagrant toxicity holds little in the face of the enthusiasm of doctors to use it (2 billion dollars in sales in 2013, source Forbes), Pfizer donates 500 million doses in Africa (2015, source Pfizer)
2- AT shows a synergistic effect, in-vitro, and in a small preliminary trial, in-vivo. Synergy? this is exactly what we observe with some anti-retrovirals, AZT+3TC being the historical example. So before claiming 'no significant additional benefit', you'll have to argue a bit!

So yes to the Korean method, without Kaletra, since it is the IHU proposal: Test, Isolate, Treat

The proof or the minimization of the risk: Lorgeril staunchly supports the ramdomized, if possible double-blind, trial. A young man on YouTube tries to explain: Should we rush testing of COVID-19 treatments? But we are still waiting for the results of Discovery, and we will have them when the wave is over and the epidemic is over. Arriving with 'the proof' at the end of the battle, what is the point? Especially since now a phase 3 trial, called futility trial, will no longer be done against placebo but against HCQ/AT, which has imposed itself as a standard (gloden standard). Nothing is of interest unless it is a comparison between X and HCQ/AT, which has become the 'new normal', whether you like it or not... Apart from the remaining Gileadologists (Pialoux, Molina, etc...) nobody will prescribe Remdesivir, which is not even available. Besides, we will be able to make a list of the 'bad' ones, those who claim to be doctors and have randomized the patients. Because now they're going to have the families after them... The families of people who died in the arms of Remdesivir or Kaletra or Placebo, are entitled to have it in the back of their minds.

Lorgeril is right to claim that the IHU is against randomized placebo-controlled trials: it is documented in this video: Against randomized trials. It is necessary to reintegrate the context: serious, fast and... short epidemic. See Raoult's latest video on the subject. For the moment, apart from the IHU, a very nice tool financed by your taxes, there is not much that makes sense...

On 04/21/20: After the publication of the IHU, towards a republican lawsuit!

Bunch of idiots: Pharmacies banned from buying and selling masks!!!That's enough!

Publication of the IHU: I had already shared the summary, in French, here. The article, in pre-publication, is put on their website: Early treatment of 1061 COVID-19 patients with hydroxychloroquine and azithromycin, Marseille, Francewhile the trial of Pr Reynes has, in fact, not yet started (according to the database here

I publish a translation in French: Etude Hospitaliere SARS-CoV2quine(in process of formatting... )



Soon, for 1 barrel of WTI purchased, 2 barrels of WTI offered + 1 free refill and 1 full wash with polish!

The price of a box of Kaletra is exploding: In Russia, if nothing else, it is traded at $100 a box where the posted price is ... $12

The Raoult is a guy who takes his hair out of the air: see his 2 interviews in the Marcelle online journal (yes, yes...): it's here: Interview with the one who is at the heart of the polemics: Didier Raoult. and But who is professor Raoult. He has not given an interview to any of the 'big' subsidized newspapers. It is understandable that they are a bit angry with him...

Le 20/04/20: China will pay! and what about the ramdomized tests



Molecules, in-vitro vs in-vivo
TherapyEfficacy
In-vitro
Trial
In-vitro
Efficacy
In-Vivo
Test
In-vivo
RemediesavirManli WangY4
FavipiravirZ3Favipiravir Treatment
AtazanavirAtazanavir inhibits SARS-CoV-2... Y4
LopinavirZ2Z3X
Hydroxychloroq.XY4


The wall of xxxx 'barons
Microbiology versus...
WhoHis contributionMy commentSource
D. RaoultY2Y3Y4
Z1Z2Z3Z4
The (pharisaical) virology...
Barré-SinoussiY2Y3Y4
DelfraissyZ2Z3Z4
PialouxY2Y3Y4
MolinaZ2Z3Z4
CostagliaY2Y3Y4
Z1Z2Z3Z4

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