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This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

DTG: a failure without induced resistance

By Charles-Edouard!

DTG: did my failure create resistance?

For those of you following along, I failed a lot of copies, a lot! Plus, it was maybe the only time I was behind on my resume schedule. I did it at 3 months, instead of 1 in the exploratory phase. That's how it is, sometimes I get stuck abroad, without access to the CV, or to the meds for that matter, hence the interest of the 1/X: you leave with a few weeks of treatment, but you stay for months (and months...), it's all good! Well, I did what I shouldn't do. Leibowitch said it again and again: you have to make your CVs(in the exploratory phase, of course).

Even if I was late, I did it... I was on DTG monotherapy, 150 mg in 1/7 (collated in a capsule, which is perhaps the problem). Well... The failure was only a half surprise. The height of the failure was a real surprise! I blew up my counter, and I think I even made the highest failure of all I read in Mono-DTG, that's saying something!

Damn, didn't I create some resistance?

Catching up with the DTG

Even Leibo didn't have much of an idea on the subject... However, I knew one thing, on the Integrase, my virus is clean! It's not complicated, it has never seen RAL (let alone EVG, I'm not that stupid). So, for me DTG would act like an Absolutegravir, a concept I developed, not tested, except that here it is the truth.

Understanding that viruses that have been exposed to old INIs (RAL, EVG) are likely to acquire new resistances under monoDTG is the Achilles heel of this strategy. On the contrary, when we look at the rare French publications on DTG resistance, we identify multi-resistant patients (INIs) included in the rescue trials. I have not seen any published resistance on originally clean viruses. In other words, de novo resistance on non-pre-exposed virus does not exist! And if you find any, please correct me.

This is very important because it is the cause of the extraordinary overdose of susceptible patients because the choice of the dose was guided by the dose needed for mutated viruses. In a word, thousands of patients are being overdosed with DTG (and soon injecting themselves) at a dose chosen to control the virus of the few who had messed up with the virus: you don't treat your virus, you treat someone else's.

For me, DTG was an Absolutegravir... So, if my vision of what is an Absolutegravir is right, this is the opportunity to try it! Leibo proposed a drowning. I decided to try resuppression with DTG, there would be time to do a drowning, if needed, later on. I have already explained the chosen scheme: I resuppressed with DTG, without making a resistance profile, assisted by usual and less usual companions: it worked like a charm. In 1 month it was fixed, as usual for DTG, so no damage... So DTG is still part of my world.

Has DTG remained an Absolutegravir?

If you failed Mono-DTG, you might be afraid that this wonderful property (Absolutegravir) is now a thing of the past... In Eclipsotherapy on Dodeca, we don't really care. But then again... If DTG is amputated, we might as well take it off Dodeca... The resistance profile, was not done, I resuppressed without worries, so basta!

Except that... The Lab got mixed up with the brushes! Yes, yes... It happens! They did a genotype in addition to the DNA quantification. Well... I don't have a lot of confidence in these explorations at the limits, but well... They did it, they did it

Well yes! No resistance mutations in the INI

That's it... that's what I thought! My virus stayed clean (at least what the lab says). I was a little suspicious, but it's reassuring to know that! You're doing great in Mono, and, you're still perfectly susceptible! DTG is great for those who know how to use it! And to use it alone! I was very careful not to associate it with 3TC, because the 184, you get it every time. But we're clean there too!

And elsewhere? I did 4/7, 2/7, 1/7, 1/15, 1/21, failed 1/27, Mono-DTG 25 mg 7/7, 12 mg 7/7, 150 mg 1/7 (failed) and nothing. Nothing from nothing... Not a single acquired mutation... Nowhere

In the exploratory phase, you have to make your CV!

Well... I didn't stay on Mono-DTG for long, so that must help a little. Since then I do my CVs religiously, in the descent phase. In stabilized phase, no... No injections, no more blood tests, the less I see the 'specialist', the better I feel... She is nice, very nice... She's nice, but you won't get better with her

Icing on the cake: the disappearance of the tank

This allowed me to discover(fortuitously, but not that much...) the disappearance of the tank: my big topic of the moment.

The next step after the disappearance of the tank is... It is... for another time ;-)

In the news

- A vaccine injection that must be repeated every 6 months!?!? Hello Houston: There is a problem...

- Mr. Zureik answers the challenge (it would deserve the Canard Enchainé): As an answer we have seen better!

- Actually, it's quite simple, you read about what makes the soap merchants tick. It's often interesting! It makes them angry because it attacks their business! The Chinese with HCQ, the Indonesians with IVT, the downgraded with NVP, the Malagasy with their syrup, they must be laughing! A good real laugh is communicative, it is joy!
Pr Perronne probably had the wrong idea about the herbal tea... Molecules coming from Nature are always there and immune to prevarication.

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