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This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Choke and Mute #2

By Charles-Edouard!

Here is the nice month of May. Tribute to Cora Vaucaire...

I will always love cherry time, and the memory I keep in my heart

Towards a new Eclipse Equation

We saw in the previous post how the Eclipse equation, basic, responds well to known phenomena. History shows us that a new theory emerges by refutation of the old ones: the universal theory of gravity (Newton) is a refutation of Descartes, the theory of Evolution (Darwin) a refutation of William Paley, the theory of relativity (Einstein) a refutation of Newton. Einstein who made 2 theories on the same subject...

The 'Shock-and-Kill' strategy is very well understood when reading our basic Equation. However, we have already tried the Shock-and-Kill for a good fifteen years and we can't do it! When something doesn't work, we can start with the idea that it doesn't work because we didn't try hard enough, that we need more! Europe doesn't work, it's because there is not enough of it! AZT doesn't work: we increase the dose! We know the story. 'Insanity is repeating the same mistakes and expecting different results'(amusing article on this subject)

ICCARRE 1/7 (or even 1/15) works, without theory: competence without understanding. Our goal will be to improve the Eclipse Equation, in order to account for ICCARRE.

New equation with epigenetic distribution

The basic equation does not account for ICCARRE nor for the attrition of the reservoir by incorporation of R263K mutants, due to DTG (Mesplède lab manip).

An additional variable is introduced to account for the epigenetic availability to contribute more or less quickly to the rebound. Below a certain level of activity, infected, latent CD4 cells are considered as potential contributors independent of each other. Once replication resumes, the whole thing goes haywire, in an explosive chain reaction. The system enters phase 3 (explosive) and we leave the domain of validity of the Equation. The term introduced is called EpigeneDist. Epigenetic because it is epigenetic by nature, Dist because it is a distribution.

When measured repeatedly, in the same patient, by successive analytical interruptions, the eclipse is substantially always the same.

EpigeneDist: a promptness distribution

EpigeneDist. reports a distribution of readiness to initiate the viral rebound. If it is in the form of, for example, a distribution function, we will obtain a distribution of the duration of the Eclipse, whereas it is rather a constant. EpigeneDist is therefore more likely to be an arithmetic, geometric or higher moment average. EpigeneDist is not a distribution function per se, but the synthetic representation of this diversity. The underlying distribution is a stochastic randomness (a stochastic process is a random function, its argument is time, with an irreversible and ineluctable course).

The proposal that the eclipse can be lengthened, by introducing mutants with reduced fitness, for example R236K by DTG, exists elsewhere, on paper and in test tubes.

At the same time, it has been proven (ICCARRE) that a progressive reduction of the number of doses can be proposed, thus opening the duration of non-taking from 3 to 4 days, then to 5 or 6. EpigeneDist is a duration. The longer it is, the longer the Eclipse is: it is therefore in the numerator

The new equation allows to account for the opening of the Eclipse by progressive methods aiming at eliminating the proviruses which are the most prompt to start a replication.

Charles-Edouard: The Book!

The systematic hostage-taking of immunocompetent seropositives by militant and stipendiated seronegs deserves a strong response. It will take us 1 to 2 years... The project 'Charles-Edouard: The Book!' is launched... The book will be free and available on the Internet. It's a work in progress... As usual...

For now, there is already a page!

Towards the obligation of treatment

Here is what will incite to enter in the treatment: the right to forget is going to be opened to the seropositives. It is important to understand 2 things: It is in the objective interest of the associations of Seronegs to make the treatment 'compulsory' and that the 'patients' associations are no longer directed by Seropositives. There you go, the world becomes intelligible again. What will the 'Elite Controllers' patients do? Or the immunocompetent-untreated? One man's right leads to another's obligation... Stay tuned, you are not safe from surprises!

In the news

- Videx, prescribed as the 4th molecule, is it over? Well, that's just great! Hard for those who can't take Abacavir or Tenofovir. The anti-ICCARRE morons have won this round. You'll have to get it far away (e.g. Red Cross in Thailand) or substitute ABC(most likely) or TDF. I have never used Videx, I warned my readers! We can also replace it with DTG, if experience, once again, contradicts pharmacokinetics, now demonetized... Ah, the time when Act-Up was claiming is long gone! (see the video!)

- ActupParis: the management was kicked out by ... the activists... It is true that Act-Up-Paris had admitted that it could not face the financial disengagement of ... Gilead, which was 45.000 Euros!

- The ANRS has published on the effects of a caspase inhibitor. Thescientific article is here.

The French genius

When you're in the cherry season
If you're afraid of heartbreak
Avoid the beautiful

Miyazaki fans will love this version in Porco Rosso (youtube)

See the excellent video by Dr. Rahbi: Manipulating numbers and doctors

Feel free to comment, like, share and use

Have a good weekend, good stuffing and not too many meds ... Huh?