175

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Bithérapies en Cycle Court

By Charles-Edouard!

Dovato in x/7: first favorable results!

The DUETTO trial (ANRS) is announced... Well... Why not: Relief AND Intermittence combined. CoronaFolie obliges, it drags on... To the point of arriving after the battle, a bit like Recovery. Too late, it's too late... Well, we know since August 2008, in the NCT00708110 trial (Phase IIa Dose-ranging Study of GSK1349572 in HIV-1 Infected Adults), that the action of DTG lasts 3-4 days at least after the last dose. So trying DTG/3TC in 4/7 makes sense. By the way, it's JeSuisDuTreize (Mono-DTG in 4/7) who hooked me up.

So, here is our ANRS, although not very valiant, which extends the success of Quatuor(not her idea...) towards a consensual thing, which allows at least to clear the ground where the stipendiated Pharmacolâtres had with impunity amalgamated Lightening and Intermittence.

Dr. Lanzafame submits a letter to the Editor of the International Journal of Antimicrobial Agents, by M to Phillipe Colson (IHU, again!) , which is published in March 2021. The original is here. I propose a translation here: Short-cycle therapy (5 days on/2 days off) with a Lamivudine + Dolutegravir regimen in a cohort of virologically suppressed HIV-infected patients

Dovato in 5 of 7: no failure in a cohort of 27 patients

As usual, nobody talks about it, but it is interesting (and that is why the omerta is total...), and here, it is not only the result that counts. One will be sensitive to the way of presenting... Well... 27 patients, various profiles, go from Dovato 7/7 to Dovato 5/7. Nobody goes above 50, so it's all good!

A tribute to Leibowitch and the Eclipse

This is encouraging... Can do better...

Why not 6/7 ? or 6,5/7, while we are at it ??? That works too! A fortiori! Staying miles behind the front line does not allow to flush out the enemy. What will these pussilanimities be worth the day when Merck will excite, at the cost of propagandist contributions, the cage to the crazy parrots? A short shot is better than a crooked shot(Katlama, Raffi and so on), but it is still too short!

7/7 End of game, thanks to Islatravir and ... Merck

I anticipated a simple marketing problem: how can Merck regain market share with Islatravir without taking advantage of its extended pharmacodynamics (more than 10 days)? First approach: divide the dose by 10... That way you have to take it every day, and it's the JackPot. Except that now with Biktarvy practiced for a long time in 4/7, or even 2/7 or better, there is not much room for a 7/7... And ViiV which proposes an injectable...

Merck is also considering an injectable, with Doravirine. Bad luck: it doesn't work! Well... It probably does work, but the worshippers of the Pharmacokinetic Goddess lose their minds and give up the game.

Anyway, Merck (cf MK-8507) has understood what makes Islatravir strong: a 'trick' invented... almost 20 years ago! and, unwillingly, we say, launches a bi-therapy in weekly doses. You read that right! Phew!!! Saved!

At least they think so... The Phase II clinical trial is here. We'll see if it's a success: it's about time! Because Merck is accumulating failure after failure(Dutrebis and Issentress HD, which nobody is taking... ). Did you see how fast they developed a new ARV with extended duration of effect? Funny ... No ??

What will Gilead do? What are we going to do? We'll see that another time...

Weekly intake and 1/15

The mystery of the missing tank is slowly becoming clearer... Is it its disappearance that allows the 1/15 or is it the 1/15 that caused its disappearance. Well... On this one we are rather on the right side of the handle. Better to be cured without really knowing why than to think about doing nothing (Rouxioux, Hoqueloux, etc.)

Obligation of treatment / Judiciarization

It may have gone unnoticed, but YouTube has explicitly listed, and named (please!), H*Q and I*T as cause for banning. They didn't mind Foley's decapitation, but Kory's, Perronne's, etc. explanations were not. Ah well, no! Let's go to the trash! Long live cancel culture! Well... The history of the Disappeared Reservoir will also pass perhaps under the yoke of censors, who made literary studies, precisely because Sciences put them off... Conjuration of the fools...

In the news

- Garches will be a difficult label to wear... Davido, trained at a good school, therefore, safeguards his professional future. He comments, positively, on an essay that leaves however perplexing: In serious pneumonia, in hospitals, an antibacterial profilaxis is given. Isn't this futile? A double-blind trial with a non-inferiority threshold. Well... The (small) group without prophylaxis does statistically no worse than the (small) group with. So it's all good! Except that in the group without, he has a death by... bacterial sepsis. But well... It doesn't bother anyone...

- The "Journal of Experimental Pathology" publishes the study of Claude Escarguel, on the interest of azithromycin in the prevention of long Covid! But well... Nobody is interested, especially not the ANSM, whose transparency commission seems to be invisible(read Maudrux here)... Well... We are not done with I*T since it is an inhibitor of entry into the reservoir... Funny, isn't it ?

We still haven't found the pangolin... Raoult, in 2 times 3 movements, he found you an intermediary for the M.1 (green monkey of Senegal) for the M.4 (mink of Mayenne, whose genome was withdrawn from the public attention). The Chinese, they are desperately looking for the Missing Pangolin. They are looking for, they are looking for... Just like the enlightened man of Nazareth, he probably never existed except in a hysterical delirium...

The State of Goa (India) is doing a deworming campaign by providing I*T kits to the population for therapeutic and/or preventive use, all at the same time, hoping to curb the epidemic surge that India is undergoing. The WHO has rightly denounced the uselessness of the gesture. We will see! As a result, no more pharmaceutical I*T is available, including in India... One can still find veterinary I*T, but it is difficult to find a factual difference (other than the presentation, as it is generally a paste), such as a difference in purity, in molecule, etc. Nada

The French genius taken over by a Russian

Ravel's bolero accompanied the Russian Pluchenko in his sporting and artistic feat: the quadruple-triple-double jump in skating. He is the first (the first Quad is by Browning, it seems). You can find this video on YouTube, which has not aged. It is sublime. It took more than 15 years for a small Asian jig (Uno) to make the first Quadruple Flip. Since then, there is not a single champion who does not combine several Quad.

Between the first and the second, there is a lapse of time, then everything accelerates to the point of banality.

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Turn off the TV and don't be fooled by Pharisaical veracity

174

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

PCR at home? We're getting close...

By Charles-Edouard!

An often forgotten point of view...
Children, people in institutions, seniors in nursing homes, hospitalized people, etc. do not have control over their intake. They are administered to them. Since there is no hope of curing them in 7/7, we might as well give them the benefit of therapeutic progress as soon as possible! I don't see why we should continue to overwhelm them with useless drugs.

Let no one enter here, unless he is undetectable

You will find in Leibowitch's writings a slightly offbeat, slightly utopian reflection. He and the gays are not of the same side... Well... Nobody is perfect ;-)
So we made him discover the underground places of 'conviviality' in Paris. While doing so, where the guys have the easy No-Kapot. There, we understand that it's like with the minks: the virus has a good game. Well... He had hijacked the Platonic motto: Let no one enter here unless he is an undetectable surveyor. And to imagine PCR boxes at the entrance of the 'clubs' ...

Technically unfeasible, yes, but... It changes

The small HIV self-test is rather easy, convenient and... unaffordable... At 24 Eu. the sesame, it's as if there was none! So... PCR: don't count on it. The absence of a test method deprives the good students of the magic sesame. Note, with the vaccine passport, it will come out one day... Seroneg and undetectable, same fight QR-code...

I follow what is said at the IHU(the rest bores me... ) and come across the PCR POC, which they are spearheading, at least here. That is to say, the PCR at the ass of the truck... At the ass of the ... On the spot, you know! You don't go to the lab, you do it on the spot and you get the result in 30 min.(or even less, if needed)

It's not the 30 minutes that interest me... I found in a tweet of Pr Chabriere, between the mistakes of orthogafs, the investment cost of the PCR POC(point of care = on the spot)

A PCR POC machine for... 7000 Eu.: it is not 100.000...

He said: 7.000 Euros, 30 min... The medical or nursing practice, specialized, will be able to equip itself! Even the Corsicans, or other iliens, will be able to bring the analysis closer to their idilic living environment. No more need to send the samples (or the patients) on the continent. 7.000 Eu. with regard to the insane sums wasted (including in the medicaments, 1 billion per year, only for the Seropos of France), that can find its place! Of course, it will be necessary to fight against the monopoly of biologists, apparently the best paid profession in France...

The intermittent follow-up CV: can we do without it?

Just by asking the question, you immediately understand that it annoys... And for good reason! The ANRS-4D trial was published with a fraud that is often overlooked but obvious from the raw data: the only patients with a CV lift had placed themselves off-protocol. This is not to say that all off-protocol patients jumped. Far from it, as will be discussed about Quatuor. In eligible , rhythm-compliant patients, the number of cases in which the CV served a purpose is very exactly ZéRo.

Leibo, he was eating me up when I said that... But take a good look at the data: out of a hundred patients, 7/7, in-protocol, not a single feedback... That's it, the dônnées, that's it...

I am orthodox: I do my CV in close quarters, especially during the downhill period. But here, CoronaFolie obliges, I don't have access to the CV anymore. Anyway... Over a year I was able to check the efficiency of my 1/15. I'm not going to deprive myself of it because of the lack of legitimacy of a government of incompetents... So I don't do anything: no CV, no progression in my descent... I take my male in patience. Well...

And what about the others ? Well... It's variable. I even suspect some blind runs. It would piss me off if I expected people to follow a piece of advice I gave them. But, like I am not in the medical advice businessthere are no followers and nonfollowers. There are people who do, who don't do... without safeguards, without guidelines, without even believing in Bichat's or Saint Antoine's stipendiary Cassandras anymore.(there are still people to go there ??)

Obviously, without prejudice, from what I can see...

173

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

The fourth molecule

By Charles-Edouard!

You can find on the excellent blox of gerard maudrux

Synergies and reinforcement for 1/7 (or even better)

For initiation and continuous treatment, it is historically considered that 3 molecules are sufficient. Practitioners (e.g. Germans) were already doing induction/maintenance. Today too, there seems to be nothing to prevent the use of DTG x 2 /TDF/3TC followed fairly quickly by DTG/TDF/3TC then DTG (1/2) /TDF/3TC or DTG /3TC or even DTG /3TC (in 4/7) as we will soon see. Putting an extra pill, when the circumstance allows or requires it, is admissible...

Videx in addition, a futile intuition/orthodoxy?

The very first successful patient in 1/7 appears in FASEB1, and is described as being on Quad Therapy (NVP/DDI/FTC/TDF). I am not sure if the patient was on this quad before starting ICCARRE or if the boosting occurred along the way. It seems that it was like that, by chance, and that Leibo continued like that considering that the prejuduce (1 Videx more) was not very big with regard to an eventual securing.

He was keen on it, but readily admitted that there was no evidence of the futility (or not) of this reinforcement. To do the right thing (and to please the Stakanovists of the methodology), one would have had to do a good large group randomly allocated with and without reinforcement. Under these circumstances, the futility test is... futile. So not done.

For a long time, I promoted the Leibowitchian orthodoxy of the fourth molecule, aware that there was no formal proof. I have to admit that this did not convince many people. This blog is not a medical advice: you will be inspired by it, it is your choice, you will not be inspired by it, it is also your choice. And if it doesn't work, don't bother to come and bitch about it: this blog is not a medical advice, it's a double-sided cave canem: I don't encourage anyone and, conversely, no one bothers me. Right?

The fourth molecule can be useful: here is why...

For a long time, I thought that we had not done the manipulation that consists in removing the fourth molecule and see what happens. Strictly speaking, as far as I know, this manipulation has not been done. But another one... Which informs us in the same way... Except that we didn't see that it could be interpreted that way.

If the Fourth Molecule had not been removed, it could have been replaced by a placebo. That's what protocolists are like. Leibo was a doctor first and foremost, so the placebo was not his thing... The idea of replacing the Videx with plaster ... I let you judge... Well... However, Videx no longer exists, so it should have been replaced by something, a placebo? no... But...

Replacement of Videx by DTG

As Videx disappears, we start to have a good idea of the 'power' of DTG, hence the simple idea of replacing Videx by DTG. But there, there is a wolf! The literature states that NVP reduces the amount of DTG in plasma. You will be surprised to know that this is a work of Raffi(yes, the same one who... ). If we stick to Raffi's conclusion, it's not a big deal, we pretend nothing happened. Except that Raffi, he looks at 7/7. DTG fills the bathtub, NVP empties it, but since we fill it right after, the bathtub doesn't really get empty. In 1/7, we don't fill the tub a second time! And so... DTG disappears. DTG has an antidote: it is NVP!

We make NVP/DDI/TDF/3TC then we substitute, we think we make NVP/DTG/TDF/3TC, and, in fact we make NVP/DTG/TDF/3TC, i.e., a classical IRT NVP/TDF/3TC... And this? It jumps! Does it always work? No! There are exceptions, but well... We can see that with NVP/TDF/3TC, there is a benefit to supplement with DDI (or something else?)

DTG in 1/7: In TRI or in QUADRI? That is the question

All indications are that DTG counts for two: it is potent (over 4.5 Log) and it has a pharmacodynamic remanence of at least 3-4 d. Of course, we have evidence of success in 1/7...

One way to do suspenders and belt, is to take Morning and Evening. Note that in the free zone, you can find a DTG/TAF/F-3TC combo, at a very low price. In the mafia zone, not yet... Well, it's a bit of a pity... Now, the goal of the maneuver is to catch the payers (social security, etc...) on the Biktarvy ® combo. If the payer gets cheated, that's his business. From our perspective, we do not identify any difference between DTG and BTC(and for good reason!).

In practice, we read testimonials of 2/7 with Biktarvy. Why not? Now, I also don't see what we have to lose by reinforcing a bit... With what? RPV, ATV (without booster, since the usefulness of booster in 1/7 is far from being obvious: futile or even counterproductive, in this context), etc.

Islatravir: addition or substitution?

Especially sinceIslatravir is coming. Well... Overdosing seems to be avoided, on paper(too bad... ). Well... The dilemma of the 4th molecule is there in front of us: Islatravir® is not very powerful (1,5 Log) but very persistent (10 days at least!). It makes you want to use it. As an addition or as a substitution? For me, it will probably be used to replace one of the molecules that I probably have too much of. For those who stayed in IRT all the way down, the question will be interesting. Might as well start thinking about it!

In the news

- A controversy (pro and anti HCQ), a randomized trial and each side claims victory! This is normal: in order to be published, the authors conclude that it doesn't work... This allows them to reveal their data, which show... that it works!

We have a bit the same thing with the Eclipse: all conclude to a quick rebound, because such is the Zeitgeist, but, in reality, it is long enough to be exploited. Nobody would dare to write that!

Genius, but not French...

THE (not THE) French genius, and of its language, is to say THE Covid, as it is quite natural. That's THE genius of the language, it's precisely what can't be reasoned... Especially since in reality we are entering the era of the Covid.E.s...
There is no genius of the Europeans, who taken as a whole, are rather sterile... It is illusory: I could not even name a contemporary Polish or Bulgarian author. And there are other geniuses... Sometimes one remains amazed by other ways, other voices.

Miyasaki appeals to an ecologically sensitive public, so youtube advised me this strange and bewitching video: 450 Subscribers, 2000 readings, we are far from the Raoultian Million views, but still, it's something else... And precisely... It is... different... Enjoy!

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The real insider tip is to know which doctor to go to...

172

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

The Fear of Healing: Variations on a Case

By Charles-Edouard!

News from our friend @Saamred

It's interesting to hear such good news from people who have read a lot of us... There are 3 types of PTCs (post treatment controlers): those that we find by chance (rare), those that we find by looking where we think we find them (Viscontis, Antwerp ...) and those of intention, who have undertaken a process in which control is possible. This is what interests us most!

The commentary is timely, since here is one who controls, but is afraid and resumes treatment ... This is the topic of the day...

A controller identified by chance...

Here, we will dwell and, for lack of a better word, embroider a bit, on what may have happened in a study in our Eclipse bibliography. Sneller (2020), takes chronic patients under effective treatment and studies the dynamics of rebound. There, Surprise!

One participant (#03), who spontaneously controlled his plasma viremia, resumed ART even before meeting the criteria for restart.

This patient is indeed found in the table, restarting treatment at week 13.

A PTC that falsifies this study, and the others...

We had seen that in the Davey Study, a very long Eclipse patient was distorting all the statistics. It lengthened the mean and especially the standard deviation(one should be wary of automatic calculations...). We had the table, we could redo the calculation. Here, it is the other way around: the patient takes the initiative to resume the treatment, thus shortening the recorded duration, integrated in the calculation.

The control arm tests are distorted

As we saw in the Levothyrox case, comparing population A to population B only makes sense if the standard deviation AND the range are both narrowed. In the 'modern' patient, this is no longer the case: we have a little of everything: between 1 and > 4 weeks

The Thirst for Glory incites to deceive the patients

Control arm trials are flawed, and sometimes unethical. Not the trial itself, but its preparation: an example is given by a Spanish study: Extremely low viral reservoir in chronically HIV-1 infected treated individuals.
What is the point of having a weak reservoir if not to be able to try PTC or, even better, Eclipsotherapy? Having a long Eclipse and treating 7/7: how stupid!

It is not difficult to imagine that the constitution of registers of patients pre-selected for trials is not compatible with explaining them on 4/7 (or even better). In order to do medical science, doctors are probably tempted to keep silent about reasonable alternatives...

On the road to recovery, there are...

Either the PTC or the Eclipsotherapy... Both allow to simulating a cure. Including seroreversion. Imagine: No RNA in the blood, no DNA in the reservoir, no residual meds in the body, and a negative serology. A sweet unattainable dream? Not sure, we'll see that another time...

Some anti-COVID news

-Ivermectin is entering the medicine cabinet. It is now the standard of care in many states (see here Ivermectin, used for Covid treatment in UP, replacing hydroxychloroquine. Funny to observe the absolutely canonical curves in India: one wave, an epidemic in decline, 10 times less deaths than in France. And, them, they still know how to make medicine!

- I tried the Raoult glove techniqueThe situation was right: I only had household alcohol (it leaves an unpleasant feeling on the skin) in a crowded place, touching a lot of things. It is necessary to understand it well:
-1- Beginning of the procedure: clean your hands well with alcohol (one that does not damage, if possible)
-2- Put on new or previously sterilized gloves
-3- Clean your gloved hands with alcohol (even rotten) very often (alarm every 30 min.)
-4- At the end of the procedure, disinfect the gloves well, then remove them and re-clean the hands
-5- Disinfect the gloves with alcohol (outside and inside) in order to reuse them (or destroy them)
Results: very good procedure, no hand aggression, use of cheap alcohol. Very happy!

- A reasonable plea for early treatment: The need for early management of patients with COVID-19

Obligation of treatment / Judiciarization

We are obviously interested in all the media hype about mandatory vaccination for an easily treatable disease, when, on the other hand, systematic HIV screening would allow its eradication... The associations do not want it... Why then ???

In the news

- Alex Sigal, excellent biologist, already quoted here, highlights a lower efficiency of acquired immunity against the Lacombe-AstraZeneca 501Y.V2 variant: Escape of SARS-CoV-2 501Y.V2 variants to plasma neutralization in convalescents

Whatever the concentration of 'old' antibodies the Lacombe-AstraZeneca mutant doesn't care!

One can expect a violent awareness of the consequences of the Pharisaical School of Verology(Lacombe, Pialloux, Pazdan, etc.) on the health crisis of nerves. If one (or more) variants could escape from a place of care, what about a place of manipulation such as Wuhan?

The French genius (well... yes... almost...)

This beautiful wool is the first award-winning work of Karl Lagerfeld. It's amazing! You can find it on YouTube. YouTube... from which Leibowitch has almost disappeared... Bizzare isn't it ? Almost 1 year since he left us. Not sure I'm inclined to comment anytime soon. Maybe time will help...

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overmedication is an opportunity if you know how to use it!

171

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

The Saint Darwin 2021

By Charles-Edouard!

Alexandra Henrion-Caude is said to have said the following:

Well... In the hysteria of the moment, what seems to bother AHC is that it takes people away from their ordinary, millennial hysteria... She is clearly in the opposite camp... That said, she is challenging us in her professional field (the NRA) and I think it's a shame that censorship is the only argument she gets.

Darwin: the beginning of the end for a thousand-year-old hysteria

He says it himself: it is like confessing a crime. Certainly, primitive Darwinism exposes the commonancestry. It is a materialist atheist's delight to feel like a family among living beings: all alive, all cousins. Enjoyable...

This is the first time that a person has been able to see the world from a different perspective...

Raoult reminds us that incremental mutation is not the only cause of variation. Okay, Okay... Darwin was not yet into microbiology and gene exchange. Nevertheless, the selection pressure is THE issue of the moment, as raised by Raoult. If Remdesivir + Serotherapy(K. Lacombe and all the clique... ) are at the origin of new variants, it's going to look bad. No more need to let �� escape a laboratory virus. The whole world has become an open-air laboratory!

I am afraid that the same people who yesterday carried the 'principle' of precaution to the skies, are today communing in the Holy Vaccinal Ostia. The same people (Lacombe and Co.) who were pinning a fanciful toxicit�� of Quinine syrup, sweep you, today, off your feet the genomic risks of Genetic Vectors.

They will have scoffed a lot at those who found it very strange that a virus so well adapted appeared in the same city where experiments, forbidden elsewhere (and for good reason...), of function gains were made. The pendulum is now swinging in favor of this theory...

One cannot think of biology without Evolution... Back to Sonigo!

As a comment to a discussion that can be followed starting here: Are we paying for a fundamental error [...], Pierre Sonigo comments as follows:
Certainly... Provided that it is indeed a coronavirus avatar alone and not a chimera X + Corona. But, precisely...

The Ghost Pangolin, fucked by a Bat!!!

Finally, a reasoned discussion A Bayesian analysis concludes beyond any reasonable doubt that SARS-CoV-2 is not a natural zoonosis but rather a laboratory-derived virus.

Unless the virus has recombined in a natural environment with another virus (which one?), there is little evidence of genetic manipulation or laboratory recombination. However, the (only?) laboratory known to make gain of function is the one in... Wuhan. With the passage of time and the notorious inability to find the missing link, the theory that it is God who creates Adam Zhengli Shi who creates a virus is gaining momentum. Viruses have one (or more) ancestor(s). Only one, when it is a question of incremental mutations(for example in Remdesivir), several in case of recombination. The Wuhan Virus is remarkably different from what is known. And there is no need to go back before Methuselah!

Here is what we can fear in terms of 'natural' gain of function:
- An immunocompromised patient or a test tube
- suboptimal use of Remdesivir, or any other mutagen
- a few natural antibodies

And presto! Here is a variant with gain of function... And since there is fat, and manipulations take place on a large scale, we have the right to expect the worst... But then...

In the news...

- DUETTO: official announcement of the ANRS:
the ANRS 177 DUETTO trial, which should start in early 2021, will evaluate the non-inferiority of dual antiretroviral therapy taken 4 days out of 7 compared to continuous dual therapy at week 48, in virologically successful patients on ART.
This should piss off more than a few people, and I'm surprised that pharisaical vetrology hasn't managed to get it cancelled yet... To be continued...

Quatuor essay:
- EudraCT(2017-000040-17) indicates that the trial has been completed.
- ANRS informs that the lead article is in preparation.(press release of 11/30/20)
As a reminder, the objective is to evaluate the non-inferiority at 48 weeks of the strategy of taking antiretroviral treatment on 4 consecutive days out of 7 versus the strategy of continuous treatment 7 days out of 7, in patients with virological success on antiretroviral treatment (CV<50 copies/mL).

The results of the comparative phase, the only one allowing to rule on non-inferiority, are published. The authors concluded that the trial was non-inferior. The trial was continued to include all patients. The 2 arms being in the intervention, this continuation does not contribute to the comparison.

- New entry in my Eclipse bibliography: a CASTAGNA study, from 2019, with 9 patients, and a mini Eclipse of 2 weeks, mean at 21 d. As usual!

The French genius: Riri, Fifi and Loulou...

I had a lot of fun! Riri, Fifi and Loulou.. You should have thought about it. At the time when I was following the IHU videos, there were 400 subscribers. Today, the smallest video has 1 million views! To have identified that a banal molecule, that I had the opportunity to eat many times, that I buy without even thinking about it, recommended by the best medical journal(the Guide du Routard) can shorten your suffering time, I thought that was good... To gain a few days on a bad flu, why not? At the beginning, it was just that. Very quickly the world split in two: the Raoultian Dreyfusards and the anti. With so much bad faith that we end up with a selection bias: we don't even bother to listen to "the other side".

Now, I had the opportunity to reconnect to Fiolet's twitter(Nathan's is a real problem for us patients, which we will have to suffer from for many years). But Fiolet, him... He has a Belgian accent to cut to the knife a good little background, which invites to follow. And very quickly I find there the bias of all these popularizers, these keyboard seropos, who think they are doing the right thing by being the megaphone of the laboratories(to whom you owe your life, they claim), to the point of forbidding themselves (and you) the intelligence. Fiolet seems to think that any series of figures can be analyzed mathematically, without a deep, sharp knowledge of the field.

The self-criticism of the CMI editors (@CMIGate) suggests that a retraction is coming.

170

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

January 24th: Liberation Day!

By Charles-Edouard!

My new rhythm: the 1st and 15th of the month

My old rhythm was every other Monday, so 1/14. So 26 weeks.

It's an interesting concept: the day of liberation is a known concept, it's the day from which we stop working to pay taxes and we start, finally, to work for ourselves. There was a time when my day of economic liberation was very late in the year: I spent my life feeding the mamouth!

Reduce the number of alarms

In 1/14 mode, I had 3 alarms: the 1st of the month, to check that my administrative tasks are done (accounting, declaration, invoices, etc...) and 2 alarms programmed to follow my medication intake and be sure not to forget anything. Around Sept 2020, I merged everything: I set an intake on the 1st of each month (and its general alarm) and I have a specific alarm on the 15th of the month. The alarm on the 1st of the month is general, the boring things to do, so one more or less boring thing... There is no stress... So I only have one alarm on the 15th.

I play the little train

For some time now, I've been taking meds every day (we manage the after-effects...). They are incompatible with ARVs! Hence the medical interest of the 1/15. I don't take them the day of the ARVs and that's all, it's simple and efficient.

Healing, even at a mini level, is too serious a matter to leave to forgetful doctors. The pillbox is your friend... Mine is not ordinary... I use the pillbox with removable case from MUJI. I have several tens of them, that is to say about fifty hundred boxes. I prepare my boxes well in advance and I assemble the little trains once a quarter. No, no, I don't fill them every week... Every week I take out the pillbox, neatly arranged in s��quence and basta: I only handle the medocs once every 3-6 months.

No stress, no pathos, no forgetting. Especially since with Dodeca, you have to do things right (there is an order to follow).

The days of liberation according to the rhythm

Where we understand that it is more attractive to go from 4/7 to 2/7 than from 1/15 to 1/21!... Does the healing escape us? Yes, maybe... And then?!

Rhythm	Nb of days	Day of release
7/7	365	Never
6/7	313	10 November
5/7	261	19 September
4/7	209	July 29th
3/7	156	06 June
2/7	104	15 April
1/7	52	22 February
1/14	26	27 January
1/15	24	25 January
1/21	17	18 January
1/30	12	January 13

What has become of my tank, that so close I had held?

It's gone!!! So there... Well, I don't think much of residual DNA measurement, Rouzioux style... But hey... I do it every year, to see... If it went up a lot, it would be interesting. The value itself does not help us much, but maybe the trend... In a pinch... Well... We don't know... So we measure with the tools we have...

Well... The surprise of the surprise, it is that we can't do it anymore...

No reservoir (in the sense of Rouzioux) does it mean no virus? no resurgence in case of stop? Not really... The very few who succeeded in PTC (post treatment control) had a non-measurable reservoir, but patients with an ultra-low reservoir (non-measurable in standard) nevertheless saw the virus resurface. Simply, we have seen our detractors raise the spectre of an enrichment of the reservoir, but I do not see this. This allows me to put this argument of the "anti-cure"(all the Gileadolaters, all the Pharisee verology, etc.) in its right place: the trash can...

What is amazing is that the disappearance of the tank is 6 months after my unappealing failure at 1/7 in DTG 150 mg... We already know that: doing an ATI (analytical interruption), for example, has no measurable consequence, at 6 months, on the DNA reservoir. In this case, it was not an ITA, but I was not very worried either. With good reason: now it is verified.

No tank ... Not a huge ratio either

The CD4/CD8 ratio moves very slowly, at the rate of the eventual disappearance of supernumerary CD8. Knowing that their half life is 9 months, it's not worth monitoring every 5 minutes... But anyway... It is stable, very slightly above 1. A little too slightly for my taste to resume our long march towards 1/30 without worry. I'll wait a bit, especially since I don't have access to the CVs anymore, so it's quiet...

Do my anti-tank actions have anything to do with it?

What anti-tank actions? It's simple, I make a list of all the proposals that have been made here and there, I keep only those that are accessible to me and I go... Which one do I choose? None, I do them all... Hoping that one of them will work. It's the cocktail strategy, and even mega-cocktail.

There are in-vitro manips that eliminate the r��servoir. Then comes the question of in-me practice. There, for the record, I may have inadvertently r��ceeded in implementing the Weinberg proposal. We'll see about that some other time....



overmedication is an opportunity if you know how to use it!

169

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



The Eclipse has lengthened: from a few days to a few weeks...

By Charles-Edouard!

The ICCARRE website is back online...

At the very beginning, when I became aware of the existence of an alternative to overmedication, I kept reading and rereading the same pages: Faseb, Valas, Pictorus... The emergence was that the information was rare... With Internet, one could find... It was necessary to get a little wet... So the more entry points you have, the better. For the curious mind, ICCARRE can be a door to Eclipsotherapy, which is the inevitable extension of it.

The Eclipse : subject of research...

If, one day, a research group is launched, the first work will be to establish the state of the art of knowledge... In a word, to make a bibliography. It's long and tedious, nobody really wants to do it, especially when you think you've done everything. But it is not the case! It's time consuming and needs to be maintained. Well... Once it is done, we understand a little better.

Convincing visualization of the biblio

So I took my biblio, and classified in a table, by year of publication, indicating the number of patients and the characteristics of the observed Eclipse. Then, I interpret the mini to estimate if such or such strategy is reasonably possible or not. The capture link allows quick access to the biblio verification by exposing the part of the reference that documented the table. This is the most difficult part: the data we are interested in are often buried in another discussion, typically the control patients in a vaccine or shock-and-kill intervention. I have retained only the control patients to avoid any objections. Since the interventions studied had no effect whatsoever, they could have been legitimately included. But then again... Given the large number of cases listed, this was not necessary...

The cliff and the continental shelf

Wherever you start from, if you walk towards the west, you will reach the sea. If you arrive by the cliff the fall will be brutal; by the beach, it is safer. The Eclipse, at its beginning, was short, for almost everybody: the bell curve was very tight. Except for 2-3 days of clear weather, we were soon facing a wall. This wall was a collective one, since, more or less, everyone was entitled to it, in similar times. It was enough to play the penguins at the edge of the ice floe. Nobody dared to do it, but if the first one survived, we threw ourselves into the water. and again, until the hecatomb started. So there was a particular interest in looking at what others were doing... The ICCARRE study is that... The precursors move forward and where the danger becomes a reality, we stay away.

By multiple attempts, a strategy is revealed that is better than the others. You should observe the first flock of sheep. Then, one can protocolize on a choice of molecules and a predefined rhythm. It's 4/7, and OMNIBVS. This is true if we are all subjected to a similar risk, let's say identical to make it short. But today, this is not true!
If the wall is at D+4, for all or a large number, we all go until D+2 or D+3 and basta, we can hardly hope for better. Dr Cal COHEN (FOTO) validates the 5/7 and invalidates the 4/7, because of failures under PI (Kaletra®...) and gives up the game. The gain is modest and it is denigrated as negligible (which will have been prejudicial). Leibo goes further... He sees that Kaletra® and Isentress® do not work, but perseveres with NNRTIs, in particular NVP, which has the longest persistence. He attributes the feasibility of the 1/7 to the sole merit of his magic NVP/DDI/TDF/F-3TC combo.

ICCARRE is on the way to obsolescence

In 2020, the observed lengthening of the Eclipse makes ICCARRE in the process of obsolescence: the mean has shifted and the standard deviation strongly lengthened: eclipses of 4, 15, 21, 30 days are not rare anymore. In fact, one can speculate that it is not the eclipse that has changed but the population. By treating better, earlier and stronger, the population is enriched in favorable cases. Have the disadvantaged of history disappeared? Who knows... They are a minority and will perhaps 'jump' to 3/7, 2/7... Certainly... And then??? For the patients, more and more numerous, with long eclipse, the past experience of the patients with short eclipse does not teach them anything. Even worse, the protocolist approach deprives them of the formulas of quasi-healing.

On a beach, the risk of sinking, suddenly, at the next step is very low, as long as one progresses cautiously, well aware that one is not going to cross the ocean any more. The marginal risk of going from X/7 to (X-1)/7 is lower than the non-inferiority limit. So 3/7 is not inferior to 4/7, 2/7 not inferior to 2/7, 1/9 not inferior to 1/7, etc. Because the slope is gentle...

We can also reasonably think thatISLATRAVIR will change all that.

The very idea that a selection bias may exist is, in fact, an argument in favor of Eclipsotherapy. We'll see about that next time...

In the news

- The document that is circulating strongly: COVID support by Invermectin. I am now trying to get my hands on the tablet version. I already have the veterinary version...

- One can read Barrier to Resistance of Dolutegravir in Two-Drug Combinations

- Alexandra Calmi has co-published an opinion piece against sexism in the profession... I notice a bias: Ladies are, in general, AGAINST the Short Cycle, and among the PROs there are mainly gentlemen... Besides, what bothers me is not the person of A. CALMI but her impressive distortion of mind. For example, she tells you that the relief must be conditioned to the dosage in the blood. However, an excellent work has been done to show that the "threshold" doses used do not make any sense... And this work has been done by... Alexandra Calmi! To put it differently, what I find disappointing about A. Calmi is that she undertakes something a bit original, iconolastic, interesting, and, it ends up in the most banal orthodoxy: she does not learn from her own work

- Apparently people have trouble understanding synergy. When A is synergistic with B, you can afford to put less A and less B... The associated diagram is called ISOBOLOGRAM (see Quantitative analysis of dose-effect relationships.... So if it is problematic to reach quickly the sufficient concentration of HCQ alone, the necessary dose of HCQ when in COMBINATION with azithromycin is much lower. This may have escaped Pialloux who claimed to amazed crowds that HCQ would be tested alone, just like the others... It's a good vintage Pialloux... It's a pity, but that's how it is...

- Apparently RAFFI finally admitted to be the author of the verbal threats made to Raoult, using the cell phone of the infectious diseases department of the CHU of Nantes. Raffi did not identify himself so everyone suspects everyone in the department... I can't explain the atmosphere!

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Turn off the TV and don't be fooled by the Parisian vereology... And ... Best Wishes for 2021!!!