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This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



The Eclipse has lengthened: from a few days to a few weeks...

By Charles-Edouard!

The ICCARRE website is back online...

At the very beginning, when I became aware of the existence of an alternative to overmedication, I kept reading and rereading the same pages: Faseb, Valas, Pictorus... The emergence was that the information was rare... With Internet, one could find... It was necessary to get a little wet... So the more entry points you have, the better. For the curious mind, ICCARRE can be a door to Eclipsotherapy, which is the inevitable extension of it.

The Eclipse : subject of research...

If, one day, a research group is launched, the first work will be to establish the state of the art of knowledge... In a word, to make a bibliography. It's long and tedious, nobody really wants to do it, especially when you think you've done everything. But it is not the case! It's time consuming and needs to be maintained. Well... Once it is done, we understand a little better.

Convincing visualization of the biblio

So I took my biblio, and classified in a table, by year of publication, indicating the number of patients and the characteristics of the observed Eclipse. Then, I interpret the mini to estimate if such or such strategy is reasonably possible or not. The capture link allows quick access to the biblio verification by exposing the part of the reference that documented the table. This is the most difficult part: the data we are interested in are often buried in another discussion, typically the control patients in a vaccine or shock-and-kill intervention. I have retained only the control patients to avoid any objections. Since the interventions studied had no effect whatsoever, they could have been legitimately included. But then again... Given the large number of cases listed, this was not necessary...

The cliff and the continental shelf

Wherever you start from, if you walk towards the west, you will reach the sea. If you arrive by the cliff the fall will be brutal; by the beach, it is safer. The Eclipse, at its beginning, was short, for almost everybody: the bell curve was very tight. Except for 2-3 days of clear weather, we were soon facing a wall. This wall was a collective one, since, more or less, everyone was entitled to it, in similar times. It was enough to play the penguins at the edge of the ice floe. Nobody dared to do it, but if the first one survived, we threw ourselves into the water. and again, until the hecatomb started. So there was a particular interest in looking at what others were doing... The ICCARRE study is that... The precursors move forward and where the danger becomes a reality, we stay away.

By multiple attempts, a strategy is revealed that is better than the others. You should observe the first flock of sheep. Then, one can protocolize on a choice of molecules and a predefined rhythm. It's 4/7, and OMNIBVS. This is true if we are all subjected to a similar risk, let's say identical to make it short. But today, this is not true!
If the wall is at D+4, for all or a large number, we all go until D+2 or D+3 and basta, we can hardly hope for better. Dr Cal COHEN (FOTO) validates the 5/7 and invalidates the 4/7, because of failures under PI (Kaletra®...) and gives up the game. The gain is modest and it is denigrated as negligible (which will have been prejudicial). Leibo goes further... He sees that Kaletra® and Isentress® do not work, but perseveres with NNRTIs, in particular NVP, which has the longest persistence. He attributes the feasibility of the 1/7 to the sole merit of his magic NVP/DDI/TDF/F-3TC combo.

ICCARRE is on the way to obsolescence

In 2020, the observed lengthening of the Eclipse makes ICCARRE in the process of obsolescence: the mean has shifted and the standard deviation strongly lengthened: eclipses of 4, 15, 21, 30 days are not rare anymore. In fact, one can speculate that it is not the eclipse that has changed but the population. By treating better, earlier and stronger, the population is enriched in favorable cases. Have the disadvantaged of history disappeared? Who knows... They are a minority and will perhaps 'jump' to 3/7, 2/7... Certainly... And then??? For the patients, more and more numerous, with long eclipse, the past experience of the patients with short eclipse does not teach them anything. Even worse, the protocolist approach deprives them of the formulas of quasi-healing.

On a beach, the risk of sinking, suddenly, at the next step is very low, as long as one progresses cautiously, well aware that one is not going to cross the ocean any more. The marginal risk of going from X/7 to (X-1)/7 is lower than the non-inferiority limit. So 3/7 is not inferior to 4/7, 2/7 not inferior to 2/7, 1/9 not inferior to 1/7, etc. Because the slope is gentle...

We can also reasonably think thatISLATRAVIR will change all that.

The very idea that a selection bias may exist is, in fact, an argument in favor of Eclipsotherapy. We'll see about that next time...

In the news

- The document that is circulating strongly: COVID support by Invermectin. I am now trying to get my hands on the tablet version. I already have the veterinary version...

- One can read Barrier to Resistance of Dolutegravir in Two-Drug Combinations

- Alexandra Calmi has co-published an opinion piece against sexism in the profession... I notice a bias: Ladies are, in general, AGAINST the Short Cycle, and among the PROs there are mainly gentlemen... Besides, what bothers me is not the person of A. CALMI but her impressive distortion of mind. For example, she tells you that the relief must be conditioned to the dosage in the blood. However, an excellent work has been done to show that the "threshold" doses used do not make any sense... And this work has been done by... Alexandra Calmi! To put it differently, what I find disappointing about A. Calmi is that she undertakes something a bit original, iconolastic, interesting, and, it ends up in the most banal orthodoxy: she does not learn from her own work

- Apparently people have trouble understanding synergy. When A is synergistic with B, you can afford to put less A and less B... The associated diagram is called ISOBOLOGRAM (see Quantitative analysis of dose-effect relationships.... So if it is problematic to reach quickly the sufficient concentration of HCQ alone, the necessary dose of HCQ when in COMBINATION with azithromycin is much lower. This may have escaped Pialloux who claimed to amazed crowds that HCQ would be tested alone, just like the others... It's a good vintage Pialloux... It's a pity, but that's how it is...

- Apparently RAFFI finally admitted to be the author of the verbal threats made to Raoult, using the cell phone of the infectious diseases department of the CHU of Nantes. Raffi did not identify himself so everyone suspects everyone in the department... I can't explain the atmosphere!

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Turn off the TV and don't be fooled by the Parisian vereology... And ... Best Wishes for 2021!!!