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Monday, February 1, 2021

171



This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.


The Saint Darwin 2021

By Charles-Edouard!

Alexandra Henrion-Caude is said to have said the following:

Well... In the hysteria of the moment, what seems to bother AHC is that it takes people away from their ordinary, millennial hysteria... She is clearly in the opposite camp... That said, she is challenging us in her professional field (the NRA) and I think it's a shame that censorship is the only argument she gets.

Darwin: the beginning of the end for a thousand-year-old hysteria


He says it himself: it is like confessing a crime. Certainly, primitive Darwinism exposes the commonancestry. It is a materialist atheist's delight to feel like a family among living beings: all alive, all cousins. Enjoyable...

This is the first time that a person has been able to see the world from a different perspective...


Raoult reminds us that incremental mutation is not the only cause of variation. Okay, Okay... Darwin was not yet into microbiology and gene exchange. Nevertheless, the selection pressure is THE issue of the moment, as raised by Raoult. If Remdesivir + Serotherapy(K. Lacombe and all the clique... ) are at the origin of new variants, it's going to look bad. No more need to let �� escape a laboratory virus. The whole world has become an open-air laboratory!

I am afraid that the same people who yesterday carried the 'principle' of precaution to the skies, are today communing in the Holy Vaccinal Ostia. The same people (Lacombe and Co.) who were pinning a fanciful toxicit�� of Quinine syrup, sweep you, today, off your feet the genomic risks of Genetic Vectors.

They will have scoffed a lot at those who found it very strange that a virus so well adapted appeared in the same city where experiments, forbidden elsewhere (and for good reason...), of function gains were made. The pendulum is now swinging in favor of this theory...

One cannot think of biology without Evolution... Back to Sonigo!


As a comment to a discussion that can be followed starting here: Are we paying for a fundamental error [...], Pierre Sonigo comments as follows:
Certainly... Provided that it is indeed a coronavirus avatar alone and not a chimera X + Corona. But, precisely...

The Ghost Pangolin, fucked by a Bat!!!


Finally, a reasoned discussion A Bayesian analysis concludes beyond any reasonable doubt that SARS-CoV-2 is not a natural zoonosis but rather a laboratory-derived virus.

Unless the virus has recombined in a natural environment with another virus (which one?), there is little evidence of genetic manipulation or laboratory recombination. However, the (only?) laboratory known to make gain of function is the one in... Wuhan. With the passage of time and the notorious inability to find the missing link, the theory that it is God who creates Adam Zhengli Shi who creates a virus is gaining momentum. Viruses have one (or more) ancestor(s). Only one, when it is a question of incremental mutations(for example in Remdesivir), several in case of recombination. The Wuhan Virus is remarkably different from what is known. And there is no need to go back before Methuselah!

Here is what we can fear in terms of 'natural' gain of function:
- An immunocompromised patient or a test tube
- suboptimal use of Remdesivir, or any other mutagen
- a few natural antibodies

And presto! Here is a variant with gain of function... And since there is fat, and manipulations take place on a large scale, we have the right to expect the worst... But then...

In the news...


- DUETTO: official announcement of the ANRS:
the ANRS 177 DUETTO trial, which should start in early 2021, will evaluate the non-inferiority of dual antiretroviral therapy taken 4 days out of 7 compared to continuous dual therapy at week 48, in virologically successful patients on ART.
This should piss off more than a few people, and I'm surprised that pharisaical vetrology hasn't managed to get it cancelled yet... To be continued...

Quatuor essay:
- EudraCT(2017-000040-17) indicates that the trial has been completed.
- ANRS informs that the lead article is in preparation.(press release of 11/30/20)
As a reminder, the objective is to evaluate the non-inferiority at 48 weeks of the strategy of taking antiretroviral treatment on 4 consecutive days out of 7 versus the strategy of continuous treatment 7 days out of 7, in patients with virological success on antiretroviral treatment (CV<50 copies/mL).

The results of the comparative phase, the only one allowing to rule on non-inferiority, are published. The authors concluded that the trial was non-inferior. The trial was continued to include all patients. The 2 arms being in the intervention, this continuation does not contribute to the comparison.

- New entry in my Eclipse bibliography: a CASTAGNA study, from 2019, with 9 patients, and a mini Eclipse of 2 weeks, mean at 21 d. As usual!

The French genius: Riri, Fifi and Loulou...


I had a lot of fun! Riri, Fifi and Loulou.. You should have thought about it. At the time when I was following the IHU videos, there were 400 subscribers. Today, the smallest video has 1 million views! To have identified that a banal molecule, that I had the opportunity to eat many times, that I buy without even thinking about it, recommended by the best medical journal(the Guide du Routard) can shorten your suffering time, I thought that was good... To gain a few days on a bad flu, why not? At the beginning, it was just that. Very quickly the world split in two: the Raoultian Dreyfusards and the anti. With so much bad faith that we end up with a selection bias: we don't even bother to listen to "the other side".

Now, I had the opportunity to reconnect to Fiolet's twitter(Nathan's is a real problem for us patients, which we will have to suffer from for many years). But Fiolet, him... He has a Belgian accent to cut to the knife a good little background, which invites to follow. And very quickly I find there the bias of all these popularizers, these keyboard seropos, who think they are doing the right thing by being the megaphone of the laboratories(to whom you owe your life, they claim), to the point of forbidding themselves (and you) the intelligence. Fiolet seems to think that any series of figures can be analyzed mathematically, without a deep, sharp knowledge of the field.

The self-criticism of the CMI editors (@CMIGate) suggests that a retraction is coming.

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