139

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARV, intermittent...

By Charles-Edouard!

Updated in real time! (the order is reversed)

Update in real time! (the order is reversed). The table below is updated by worldometers (based on Chinese 'war' propaganda).

18/02:

Dr. Anthony Fauci, (a.k.a. Big-Boss), said that the original idea for keeping people safely quarantined on the ship was not unreasonable. Yet, he adds:
All scenarios are possible: at best the virus stays contained in Wuhan and other countries manage to track/isolate/treat the victims, we get away with 10,000 deaths. Or, it starts again from somewhere vulnerable and it can quickly rise to 1,000,000.

No news on the ARV use front: a trial is reported here in Guangzhou. WHO says it is waiting for results. The Japanese government has begun preparations so that clinical trials using HIV drugs on the new coronavirus can begin as soon as possible. Japan appears to be preparing for a more widespread regional epidemic.

Japan confirms another 88 cases aboard the 'Diamond Princess' (total 542). Apparently, they are moving to allow people with negative status to leave the ship. They let people marinate in the best of incubators and now let them off regardless of that other eclipse that is the time between infection and the appearance of the viral load?!?! Finally... The governments that repatriate their citizens (Australia, UK, ...) put them back in quarantine upon arrival. But what is Goshn complaining about?

The epicenter declared by the Chinese propaganda authorities is the Huanan Fish and Seafood Market. How far is it from the P4 virology lab?

For those in whom the disease occurs, they either get over it or die. For the moment this ratio is 1/10...

The 17/02: Human experimentation of Viro-reality: the Diamond Princess

12% of the passengers now infected. What percentage do you think will remain unharmed? The USA has repatriated about 300 people, who will be quarantined. The Japanese authorities (neither bad) do not have enough kit to test the 3.000 people on the ship. How did the Chinese do for the 100.000 tests (at least!) they would have had to provide for their 70.000 'official' infected (source communist/Chinese propaganda)? How do you say wet finger in Chinese?

The Diamond Princess (a.k.a. the Petri dish of the Wuhan Virus) demonstrates what can happen when a virus circulates in a 'ghetto', a 'backwater', be it the Marais or Malawi: it's not so much the entrance door that counts but the promiscuity. The virus is damn contagious! The virus is very contagious : at 1% lethality (since patients in distress will have the right to a hospital, a real one...) it will make 40 deaths...

The USA will send experts... And France ?

The 16/02: shopping list

List of useful things that will disappear very quickly from the stalls: (under construction)
Masks, gauze, elastic band (mask making), ethanol (or household alcohol), disinfectants, gargle, rice, sugar, pasta, canned food, aspirin, medicine, cash

On the small boats, the lanterns, the alcohol, the boys, the girls, the laughter, the bursts of voices, and... the Wuhan Virus is at the party! Tomorrow, we will know more, but it smells like vinegar...

Biological Chernobyl? A little paranoia for the road: this article argues the case for the hypothesis of a manufactured virus. There will probably be a lot of Fake-News... Speculations are going well(example here). Even Bill Gates is getting involved! The important thing is to be prepared, to be organized. Even if not all of us die, a pneumonia like this must shake!

The 15/02: All in the same boat

The largest human Virology-reality experiment on the Diamond Princess: 'poor' innocent, uninfected people confined to a ship. An average infected Beijing goes up and down to Hong Kong: the virus is in charge!
67 new cases (not all patients are tested): it is only a matter of time before everyone is infected. The USA are repatriating their 380 nationals

According to the Taiwan Times, 'It is very possible to be infected a second time. Some people recovered from the first time by their own immune system, but the drugs they use damage their heart tissue, and when they catch it a second time, the antibody makes it worse and they die suddenly of heart failure' (unconfirmed).

2/14:

Well before the explosion, an article in Nature (2017): Inside China's [Wuhan] laboratory, ready to study the world's most dangerous pathogens is hardly reassuring. CCP propaganda is caught between the Party line and the Evidence: the Chinese CDC declares The State of War: not funny... Meanwhile, the epidemic reaches Shanghai: 300 more contaminations.

The 13/02:

It didn't miss! A left turn and a right turn... The propaganda tool of the CCP and its right arm, the WHO, probably a simple Excel table, did not resist to a glaring truth. The occasion of a redefinition of the cases has facilitated a change of gear; the catching up is 15.000 cases! Not bad! We're going to have to change the discourse and the device. Explanation:

On February 7, China shifted the focus by changing the definition of 'infection' so that 'future patients who have tested positive for the virus but have no symptoms will no longer be considered confirmed.'
Well, it seems that a few days later, China changed its mind and went back to the original definition of 'infection' while including 'clinical diagnosis' to determine if a new infection had occurred.

Closing a factory is easy, especially during a vacation period! Reopening it is another matter! When a case appears in a factory, and it has already happened, the whole staff is quarantined and the reopening postponed indefinitely. Imagine that it is a power plant...

Diamond Princess (Yokohama): confinement in a very small space favors the virus! Patients were confined even though they were not infected when the ship docked: they are infected because they were confined there (a ship is not a quarantine area!). If the explosion continues, doctors will have to remove the passengers and/or provide prophylactic treatment. If we enter the prophylactic phase, including with anti-proteases, please explain how this will not strain the ARV market...

The hypothesis that the Wuhan Virus is a chimera created in the only P-4 laboratory in China remains open. In 2014 the US ended subsidies to laboratories strengthening pathogens: the Chinese scientists [Zhengli Shi], on the other hand, returned home to Wuhan to continue their work... The same Zhengli Shi wrote the article claiming the 'natural' origin of the mutant. The People's Army has just taken control of the site... Demonstrating the 'natural' origin would be a good way to invalidate this hypothesis: we are not there!

12/02:

Two months after its appearance, what do we really know about the coronavirus? L'obs attempts an analysis, based on an article being proofread, written by quite credible people, at the very heart of the problem. The capacity to provide test kits is not infinite, and China is probably struggling. The slight downturn in the epidemic may just be a reflection of this inability. Still no case in Indonesia (which welcomes so many Chinese tourists...)! We would like to believe it... If the epidemic touches one of these countries where the health system is precarious (Burma, North Korea, etc), it will start again.

While the number of new cases seems to be decreasing, the number of people in serious condition continues to increase: it was 6 344 on Monday, but on Tuesday it was 7 241. The Diamond Princess cruise ship has become the largest (epi?)-center of infection outside China... Nice for the passengers who were not yet infected when they arrived in Yokohama waters. About five million people in Wuhan, a city of 11 million, have left the area for the Lunar New Year vacation since the outbreak was discovered...

, those whose immune systems are eventually destroyed, experience multiple organ failure and die. .
Sounds familiar, doesn't it?

11/02:

On 07/02, the Chinese authorities excluded from the count of infections, patients with positive serology but no symptoms; to identify 3000 pts/d. with positive serology, at least 10,000 test kits per day are needed. It seems doubtful that the capacity to perform tests is at this level: there are necessarily more and more undiagnosed infections.

The reports published by the propaganda organs of the Chinese CP (aka the Chinese government) line up too well not to be suspect! It seems that the Chinese authorities are getting too used to publishing data in accordance with the 7th plan! And it is not you or the WHO that they are trying to manipulate, but the Chinese opinion.

10/02:

Very interesting testimony, in the heart of the intensive care unit in Wuhan (in English, the version translated by Google here



To be continued ...

Coronavirus: will affect us more than it seems!

Either the virus has been mutated/assembled/selected on the Wuhan market, or it has been mutated/assembled/selected in the unique Chinese-designed P4 laboratory located in ... Wuhan(source). For the moment, there is no evidence that the infection is immunizing. It seems that the antibodies developed are short-lived, making re-contamination possible(source). Cured people cannot be hired as health/prevention workers, as it was the case for Ebola.

For the moment, the mortality rate seems low, but this is without counting all those (30,000...) who are still between life and death... The rate of recovery, to date, is not very high! This site aggregates the data in an interesting way; one can be surprised that the figures announced by the Chinese dictatorship form a perfect model! It is not good to be a doctor in contact with these patients, at the moment!(read here).

The prospect of a vaccine is far from obvious! This is a rule that many (including specialists/infectiogues of my acquaintance) forget a bit quickly! For a non-immunizing infection (e.g. Tuberculosis, HIV), the constitution of a (unique?) vaccine is probably illusory(cf the incredible fiasco of BCG, which does not protect at all... ) (note: the Biosantec approach remains relevant, on paper). If, as we start to suspect, the virus and its proteins have similarities with HIV, then this will affect us in more than one way: the production capacities will not be enough and the panic/requisition will dry up the supply chain in France, a country notoriously underdeveloped in this field.

I have a stock! But do you? Is this stock up to your needs (which must be calculated on a 7/7 basis) and those of your relatives? If the ARVs market is under pressure, the 'authorities' will have no choice but to rush patients to intermittent treatment, a protocol that is already authorized but most likely far below the possible savings. For sure, we will have to think about it! If this inspires you, talk about it in the comments!

Note: this topic is updated daily: come back to read it regularly!

10 key points of this video by Pr Fergusson:
- 50,000 new cases a day in China
- Infections double every 5 days
- The mortality rate is still unknown
- China is expected to peak in March
- The epidemic peak is still a month away
- It will be very difficult to control this epidemic as we did with SARS 15 to 20 years ago
- Cases are still underestimated
- Delays in death can be as long as three weeks
- Deaths reported outside China are not reassuring due to delays
- We still don't know all the effects

Here is how the Party makes up 'its' numbers (number of deaths divided by the number of 'cases'): with Excel, you can do it as accurately, without leaving your home!
1/30: 170/7821 = 2,1%,
1/31: 213/9800 = 2,1%,
2/01: 259/11880 = 2,1%,
2/02: 304/14401 = 2,1%,
2/03: 361/17238 = 2,1%,
2/04: 429/20471 = 2,1%,
2/05: 493/24441 = 2,1%
2/06: 564/28605 = 2,1%
Now: 724/34677 AGAIN = 2,1%... Funny, isn't it?

Feel free to comment, like, share and use

good weekend, good stuffing and not too many meds ... Huh?

97% of patients overmedicated, 22 million without treatment ... Let's stop this scandal!

overmedication is an opportunity if you know how to use it!

138

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Saint Darwin 12 February 2020

By Charles-Edouard!

[NdCh-E: Eviplera ®].
Well there you go, you start to understand...

Charles Darwin born on February 12, year 0

We celebrate Saint Darwin's day a little bit out of derision. We marvel at finding traces of ancient knowledge, lost and exhumed. Eratosthenes had measured the radius of the earth, spherical, with a fairly good accuracy, 2300 years ago. Hipparchus, in measuring the duration of a lunar eclipse, estimated that the moon was 65 terrestrial radii from the center of the Earth (close to the real 60.25) and that the radius of the moon was equal to one third of the terrestrial radius (in fact 0.25). Aristotle, on the other hand, is of a luminous clarity:
However, in practice, nothing prior to say 1700-1800 is useful. Before speaking of Sciences, one spoke of Natural Philosophy, already in opposition with Theology, predominant at the time. Before Darwin, the sciences were not in frank opposition with the idea of a created world. Buffon, who even recused himself, fearing the Church and the censorship ('better flat lying than hanging'), left us:
The evidence requires a work of the mind, product of the reflection and creative imagination of many scholars. Nothing clears a miracle better than the possibility of explaining its effect by natural causes. Darwin sets up a mechanism that founds modern biology. It will be completed, never denied.

Darwin says: 'it is like confessing a crime'.

All living things, past or present are all related to each other by a common ancestor. It is a strange and exciting feeling to think that yes, we are cousins of the Banana. You can reread 'The Inner Fish' by Neil Shubin or watch his TV version on youtube.

Until Darwin, it was delicate, but possible, to make a (hazardous) compromise between Nature and Creation. With Evolution (and therefore long time), this is no longer possible. Intelligence disappears from the picture, in favor of chance, large numbers, selections/cooperations/derivatives. The incremental prevails over the catastrophic.

OMNIBVS, Darwinian project: we can do even more intelligent!

We can consider OMNIBVS as a Darwinian progression, where each increment excludes a few percent, to arrive, by selection, at a privileged population of Super-intermittent (quasi-healed). The others enjoy a modest intermittency (4/7), which is already something... But there is another way to do it, if we understand the Eclipse well.

Our box is enriched with resolutely powerfultools: Islatravir, the Dodeca, the New Equation, The New Exploratory Method... With all these tools, we will have a new proposal that legitimizes the Super Intermittence (1/15 and beyond). We can defuse a legitimate anxiety and reconcile those who explore very early, because their risk is low, and those who delay, in view of an objectively higher risk. It remains to be objectivized... We can make by ourselves the keys of our liberation. By ourselves, necessarily... There is no need to rely on others, especially if it is an other person who takes his tax.

The exploration of the Eclipse does not necessarily have to be Darwinian. For now, it is... The Eclipse can be described as a crescent: it is a spherical projection. Like a crescent moon a tip is made of subjects with weak Eclipse, a (big?) body with medium Eclipse and a tip with very long Eclipse.

Infectiologists and the flat earth

If you teach the sphericity of the earth early on, children understand. The way teaching is done in science and medicine, one is afraid to observe that the earth is flat in primary school, rounded in secondary school and, finally, round for the privileged in higher education. This is silly, and it's fine with the Eclipse. When you start teaching with the Eclipse, a world otherwise reserved for an elite opens up to you. To confine yourself to 4/7 is a bit like admitting, shamefully, that the earth is a bit round. As long as your doctors have not taken the dimension of the Eclipse then, they are useless to you, even dangerous. (It is the dosage that is toxic, not the molecule!). In any case, don't count on me to support illusions...

Blog readership

No miracle... Blogger gives us a right to speak, not a right to an audience. A campaign of censorship/denigration/reporting had, for a time, a negative effect on our readership and visibility. That's behind us and the numbers are coming back up, which proves a good resistance to the opposing forces. It is an interesting and interested readership: the most viewed pages are precisely those that have the most added value: The Practical Guide 4/7, the list of alleviating doctors, the mono-DTG. It is also an important part of the blog format, as it allows: discussions, articles, news and resources such as FASEB-2.

Coronavirus: will affect us more than it seems! Article moved...

This case is getting bigger. The article is moved here

In the news

- 'I explained to a doctor that there was no ceiling dose': how opiates have drugged the United States. source Le Monde

- Gilead will test its Remdesivir. Gilead ? already the originator of Oseltamivir (tamiflu)... Ummm... How do you dose a drug that has no efficacy? Like for homeopathy???

- Look at'RETIREMENTS: THE KILLER FIGURE' on YouTube: here is a very interesting argument, well documented and which nobody has really ever taken into account...

- The site Parcours Positif calls for testimonies. I wonder if this is a real activist site or a BigPharma front. If you try to testify, we'll soon know where we stand! What do you think about it?

The French genius

Arthur Rimbaud's Sensation, March 1870, Poetry

By the blue evenings of summer, I will go in the paths,
Prickled by the wheat, treading the thin grass:
Dreamer, I will feel its freshness at my feet.
I will let the wind bathe my naked head.

I will not speak, I will not think anything:
But infinite love will rise in my soul,
And I will go far, far away, like a gypsy,
By Nature, - happy as with a woman.


Feel free to comment, like, share and use

Have a good weekend, good stuffing and not too many meds ... Huh?

137

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



tank and intermittence

By Charles-Edouard!

Intermittency, especially dynamic remission, is the repeated exploitation of a documented observation: the HIV Eclipse. The origin of the intrinsic difficulty that HIV has in resurfacing lies in several factors. One theory related to the extended exploitation of the Eclipse is the Choke-and-Mute(which I formally initiated). The Eclipse is observable, but few people are aware of the extraordinary opportunity it presents. A vast majority of physicians are unaware of its existence. Any discussion of intermittency must begin with a reminder of the Eclipse, and I will return to it in a future post.

Cellular DNA and Reservoir: an incongruous measure

A recent article (High' antiretroviral deintensification strategy and cellular HIV DNA levels) brings a recurring issue back into the spotlight. Modest (here EFV or NVP at 200 mg + 3TC, in 7/7) and effective disintentisation (RNA maintained at < 20 cp) would have no effect on HIV DNA (reservoir...). The Rouziouist hysteria would like to pass off the (pseudo) measurement of HIV DNA as quantitatively predictive of something.

It doesn't matter that it is a very bad predictor! A first scam was to make people believe thatHIV DNA is a predictor of the progression to the disease state (in this article). The measurement method, under active replication, shows at most that DNA (without treatment) and RNA (without treatment) are correlated. Big deal!

Especially since, in this case, what matters to us is the DNA under the undetectable cloak. We don't care about what happens outside the treatment.

A tendentious argument would be that lightening in general, or intermittence would increase the reservoir... So what? What is the interest of a low tank, if not a possible disposition to the long eclipse. Contemplating, as some do, its low DNA, saying that taking bigotry his treatment in 7/7 preserves this low reservoir, without being able to explain the advantage of a low reservoir (under treatment) is pure intellectual masturbation.

To help you out on the subject, I remind you that CHUN, in Toronto, took 2 patients with ultra-low reservoirs (in the Rouziouist sense) and made an interruption: one lasted 3-4 months, but the other... 1 week... Post-treatment controllers exist... But we can't predict who will be and for how long... DNA measurement is not a predictor of post-interruption control

Reservoir and persistence

There is no problem in HIV that cannot be solved. No problem... The treatment is effective, devilishly effective.
You deplore the fact that some people are diagnosed too late? Make the screening generalized and mandatory: technically it is possible.
Are you afraid of transmitting the disease to your partner or offspring? Take an effective treatment!
Multi-resistant virus? Today's treatment options include solutions for everyone.
Side effects? With intermittence, you have to be kidding!
The only real technical problem is the existence of a reservoir that serves as a trigger for a resurgence of the virus.

That's the only problem I have. If you have other problems, they are yours, not mine. Being the victim of an isolated incident does not make me a necessary prevention or alleviation/intermittence enthusiast.

The Rouzouist theory of an immediate rebound is false. The Silicon theory of an unquenchable reservoir for all is probably wrong too. With Super-Intermittence, the problem does not change in nature (I have experienced the failure without prejudicethe tank is not extinguished), it changes degree.

Tank, averages and trends

Siliciano(source here), ANRS-4D, etc. all make the same mistake. There is no conceptualization of what is happening in terms of readiness to rebound, by dint of attacking the other side of the Eclipse, where it closes. I went to Pasteur to plead for it: in vain... I presented the choke-and-mute there, which is a sketch. But, beyond this meritorious effort, no progress was made. And we didn't move forward because I didn't publish more, since I'm the only one who explained the importance of this question.

The mistake made by Siliciano, ANRS-4D, and so many others is to compare the mean (and standard deviation) between a before and after, over one year. This is the same mistake as for Levothyrox. Knowing thaton average DNA goes down too slowly (Siliciano) or does not go up (ANRS-4D...) has only one merit: that of not grossly invalidating the chosen dosage: From the point of view of the reservoir (DNA), the lifelong horse treatment (Siliciano), the modest lightening (ANRS, etc.) are not invalidated... Big deal: who cares, really... What matters is whether there are discrepancies. If some people start high and end up low, while others do the opposite, on average it is stable. What would be interesting to know is if there are people who diverge: either their 'true' tank goes up, or the 'true' tank goes down.

The convincing method is both the measurement tool and the intervention; the intervention is the exploration of the eclipse from below (successively going from x/7 to x/14, x/21, etc.); the measurement is to stop and look at 7,14,21, etc. Whether one pushes the exploration to the extreme or makes the measurement of the Eclipse it is the same thing. I went into extreme exploration mode, not to get rid of a toxicity, but to measure the Eclipse.

What interests us are the trajectories, over 2, 3, 4, 5 years. I make my trajectory, with the Rouzioux method... Well... I can see that this is not very interesting. Even 6 months after a dazzling RNA rise, I was already back to 1/7, and the reservoir (DNA) remained in its handkerchief: it is there, but measuring it regularly did not bring me anything. I continue nevertheless.

Reservoir and Strategies

At Pasteur, I presented a comparison between the Siliciano approach, the Wainberg approach and the Leibowitch approach. It is S. vs W. vs L. . Ergotate all you want, the only one that is accessible to you is the L. You don't have the tools for the S. nor for the W., but that's you... I'm the one who made the comparison, I'm in a good position to judge. And I can't prejudge what works on its own: I tried S. and L. and W., successively, in that order. For me, S then L then W did not lead to a disappearance of the tank(objective: the Infinite Eclipse). This time I try S + W + L. It's cheese AND dessert.

In the meantime, I have lost all attraction for the Infinite Eclipse... At 1/15 (or even 1/21, 1/30), I no longer see the point of going for the post-processing control. Bringing my release day from January 26 to 12 and then to 6 is a lot of effort for a very small gain. I'll gladly wait for Islatravir to bring the issue back up.

The fact remains that the 'true' tank can go in 3 directions: up, steady or down. If the hypothesis that the time to rebound is proportional to the 'true' tank is correct, then the rise of the tank should shorten the Eclipse to the point of dropping those who have been in super-intermittence for a long time. However, this is not observed.Rothenberger's study does seem to show a negative (and significant) relationship between Eclipse and time spent off treatment. If this were true, it would keep veterans and those treated too late from a near remission (1/15, 1/21...), but not the others. However, the (too?)-early treated are, in proportion, more and more numerous. The (too?)early treatment is to the detriment of the patients, except for those who have understood that the introduction of super intermittence in their strategy reverses this detriment favorably.

In a very next post we will go hunting for the predictive factors of the Eclipse!

Integration, tank, eclipse, drowning: same fight!

Integration, reservoir, eclipse, drowning are facets of the same specificity. In our context, the article Pro-Bono of Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications. (Avettand-Fènoël , Rouzioux & al.) and stop believing in everything and anything.

Is it even possible that the DNA goes up while the RNA does not? Show me a single case where you have a DNA rise in a context of no RNA rise. Only one case... So try to invalidate the assertion I am making here: Under RNA kept undetectable, DNA never goes up. Never!

Answer this obvious observation: there is an obvious and repeatedly demonstrated Eclipse of HIV, while there is no Eclipse of HBV. However, these are the same drugs (TDF/F-3TC), and therefore the same pharmacokinetics... S+/HBV+ are excluded from Quatuor (ask yourself why?) while S+/HBV- pass with flying colors and are candidates for OMNIBVS?

So go take a look at what integration is all about.

That the constitution of the reservoir is very early in the infection is generally accepted... This is what archives the founding virus and makes possible its ultra-majority resurgence, without treatment, that is, for all practical purposes, the therapeutically relevant disappearance of the acquired mutants, i.e. Drowning. Of course, it is necessary to give it time (therefore to have it) as it is attested in the publication FASEB-2.

Weekly intake and 1/15

Sunday the 26th will be my Liberation day!
Note: I just published my catch chart.

In the news

- ViiV has been rejected by the FDA for its injectable. Officially for a technicality see here. Well... it's only a postponement, and maybe a good plan for ViiV which could ask for an extension of its patent. Nevertheless, the usual parrots have kept you uninformed, that is to say trained, formatted, as agreed in the specifications.

- The pearl of the moment:(in Le Figaro): Denis Moreau: 'It is not because I am a believer that I am a fool!'. Well yes, precisely... To think is to give oneself the freedom to change one's mind, to believe is the opposite.

- Where do we find data on the Eclipse? In the trials on vaccines! For example. NCT02767193. Well... I'll read this and we'll see what we can learn from it...

Have a good weekend, good stuffing and not too many meds... Right?

136

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Dodecadism

By Charles-Edouard!

We are now far from all this:

Sometimes you have to wait to see them disappear too... Well... All this is far from me. Phew!...

Dodeca means... 12

Of course there are not 12 molecules! The idea comes from the analogy 'bomb (atomic) - silence'. I stood in front of the door of the 1/30 temple. At 1 in 30, you are the king of oil. So, when the virus goes up (a little) to 1/27, you're left with a dumb one. So close, it's infuriating!

For a while I hoped that DTG would be the decisive tool to get over this barrier. I explored, and, well, if it is, it's not obvious. But with Islatravir, it's bound to be different.

In the OMNIBVS approach, we will first prove the 2/7 on a large base, even if it means inflating the combo a bit, then, once the 2/7 (or even 1/7) is proven again (if the FASEB-2 proof is not enough for you) we can consider reducing the combo.

But is it really necessary? Someone was wondering about replacing his RPV in Eviplera® in 2/7, because of a minor mutation to RPV in his genotype. Why replace? Just add. It is true that RPV decreases a little the concentration of DTG, but not as much as NVP does. It is not clear whether adding a molecule is necessary, but it is sufficient and with ridiculously marginal toxicity.

Let's take examples of possible combos at 2/7: Juluca (DTG/RPV) + Truvada (TDF/F-3TC), or DTG/ATV + Truvada or NVP/DDI/TDF/F-3TC, or Biktarvy + RPV: these are perfectly bearable quadritherapies, at these homeopathic doses!

Why bother trying to optimize towards less, knowing that when we will be at OMNIBVS 2/7 (or even 1/7), the panel of available molecules will have changed? At this rate, we'll never get there.

You have to live with the times:

Some molecules appear, others disappear. Videx has disappeared from the shelves: it was BMS that killed it. We can live on the stock for a while, but the orthodox ICCARRIANS are already in a dead end: it is only a matter of time. Now, in the magic combo (patented) NVP and DDI form a couple: if you can't use Videx anymore, you have to replace it. Yes, but with what, knowing that NVP is not compatible with DTG (nor ATV, to a lesser extent). ABC? Yes, maybe, but it's not great in this context.

A hundred patients are going to the wall. Obsolescence is part of the pharmaceutical hold-up. Especially since to find a fresh doctor who prescribes NVP, you'll have to look!

As far as DDI is concerned, we won't cry too long, but you'll have to explain to me how dynamic healing is done without NVP! Which is probably the most efficient for our purposes (go figure...). The Great Turtle combo(if you don't know it, google it!) is OUT. Gold, OMNIBVS has to live...

When there are so many drugs, why bother?

The MOAB bypasses all constraints

Well... The use of the atomic bomb is a dirty business. Under the supervision of Donald Rumsfeld (you know... the mythical boss of... Gilead), the Americans have developed the Massive Ordnance Air Blast Bomb (MOAB): it's far from Hiroshima, but it's 'conventional' (sic). MOAB, it means rather Mother Of All Bombs (the mother of all bombs). Well, we put everything we have at hand and BOUM!

The dodeca is the same: we put everything we have at hand. And it's quite easy: let's say we start with Truvada® + Efavirenz (or NVP) and we make it 3/7 or better, as usual. The result is a large stock... We whine a little (or a lot) and we easily get a switch to Juluca, and the extra CVs that go with it... Well, here it is: you have the ingredients for your own recipe. This is your recipeYou have the ingredients for your personal recipe, not mine, and no one is there to tell you'this is it and not something else'.

Your Truvada® supply will be running low... Slowly! Because at 2/7 (or even 1/7) it will take forever! You will find a solution. That's what the internet is for, right? The PrePers are doing it well, so you can do it too. And then, after that, comes Islatravir, Doravirine, and so on and so forth. When you walk around at night with a flashlight, what's in front of you lights up and what's behind you goes out. It's as simple as that.

Dodeca, it still means that you have to pull yourself up by your bootstraps a bit: have several doctors (if needed), make your CVs. You can be in the patent orthodoxy and still be free. Being free does not mean doing everything and anything... And I call it Dodeca®. It's a great tool for exploring and then exploiting the Eclipse. And we try not to be too stupid: we avoid incompatibilities and hypersensitivities (in 1/7, we lose the mythridatization, e.g. ABC), Isentress ® which does not work.

My doctor knows how to do the 1/15, in Dodeca! If... If...

It's not the genius of the mountain pastures for all that! But since I came out, I might as well go all out. I start my coming-out with an introduction. I tell him about the eclipse and ask him how long it will last. Surprised, he tells me: a fortnight. Not so stupid, eh? There, you feel the surrender... And then the 1/7 that would make any 7/7 bigot jump up and down passes like a letter in the post. The next time you come with your suitcase, and you show him all the stock you have. You say nothing... The guy understands right away that you're the one in charge. If he doesn't do what you want, you go somewhere else, that's clear!

He gave me two prescriptions that knocked me on my ass:
- a CV prescription every month (valid for 1 year)
- a prescription with ALL the molecules that an honest girl should have (renewable eleven times, in 7/7, moreover)

He handed them to me, as if to say ' I'm a smart guy, I'm a smart guy'. Here's your paper, you're on your own.

Well, that's it! It is not more complicated than that!

I only take three molecules from the pharmacy, under the very real pretext of sufficient stock, where I only go once a quarter. And I go to the lab according to MY schedule.

Phew... So it was so simple.

This is how I do NFC3 (Charles-Edouard's New Formula), and don't ask me for more because I'm not the one who solves your problem: it's up to you to get off your ass.

My 1/15

Well... the first beacon went well. Nothing to say... Taken today, and appointment in 2 weeks...

OMNIBVS

The presentation that is now circulating among race clinicians is available here. It will be on youtube soon.

In the news

- Here is a video that will instruct the most novices: for us, here, it is far behind us, but let's admit that it will increase our potential audience, which is rather good... That's the whole point of Quatuor, to allow the regulatory registration of a procedure already authorized elsewhere. The problem is that this is its only interest: It's still a little piss-poor.

- Artificial intelligence invites itself to the personalization of treatment. We would have preferred intelligence at all. This is the stupidest, dumbest article of 2019! I don't understand how anyone can be so stupid... This is what happens when you put a 'black box' software in the hands of doctors. Of course, the usual parrots blindly echo it... It is so stupid... Especially since their stupidity is displayed in their diagrams: Science without knowledge is but the ruin of the soul... And you, will you be able to find by yourself what's wrong?

overmedication is a chance if you know how to take advantage of it!

135

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



New Horizons: over-14, over-30

By Charles-Edouard!

Pharmacokinetics, which has nothing to do with the Eclipse, has a thick skin!

What about us??? At 1/14, we don't ask ourselves the question! That's when we see! The Eclipse is the elephant in the room! We finally see it and it's Eureka!

First 1/14, first 1/30

I anticipated, in the previous post that 'on 14' was quite necessarily the new Frontier.

My first 1/14 from 2015 is in this post. 4 years already!... I was stuck before 1/30, and was hoping in DTG, which, as it turns out, doesn't necessarily offer what is missing to close the gap. As far as I know, I was the only one to have explored the Eclipse from top to bottom, from 1/7 to 1/27 (closing). Honestly, I was very satisfied!

There is a point where it comes up! And the further you go, the closer that moment gets. This leads to the following paradox: at the beginning you explore 1/8, 1/9, 1/10 by steps of 1, and you get bored!

Then you advance by steps of 2, to simplify your life, and, probably a mistake, you advance by steps of 3, where you are in fact close to the cliff. In all good logic, you should do the opposite. Move forward in big steps at the beginning, then more cautiously: 4/7, 2/7, 2/9, 2/11, 2/13, 2/14. But we will see that there is still more to do, in my opinion.

To each station its problem, its optimization, its combo

At each stop, which we call station, a new landscape is in front of you. No one would ever think of doing the Quadri-Leibo in 7/7! Everyone is wrong here... And a clinician says: 'don't count on me to prescribe Videx'.

I hear that... But that's not the question... The question is to prescribe Videx in 1/7, which is obviously a different context. Tomorrow someone would prove to me that AZT would allow me to make the link that I lack to go from 1/24 to 1/30, I would go without hesitation!!!

The 'on 14' has always existed

It is as old as ARVs! It's even very old! Well... You still don't see ... It's even the very first try... Still not? This is the 1 week ON 1 week OFF, which in our now accepted notation of x consecutive days is written 7/14... Here it is!...

The interesting thing about the 7/14 is that we dissociate the Eclipse from the choice of the combo: If you fail at 1/10, you don't know if it's because of the 1 or the 10. If you succeed at 7/14, you already have a good idea about the Eclipse, which you see, it's there in front of you. And if it doesn't do it, it won't do it either at 1/7.

Hence this proposal: 7/14; 6/14; 5/14; 4/14; 3/14; 2/14. That wouldn't be a bad New Exploratory Schedule. And with the long-acting molecules (NVP, DTG-and-copies, Islatravir), it's encouraging. Finally, there is no particular benefit in redoing ICCARRE, identically. Firstly, because it has already been done, so we know. But ICCARRE is done with molecules that are in disarray (Videx), in the hot seat (NVP), or flat (TDF/F-3TC).

With the new molecules, we can consider throwing the piggy bank further. Because at 2/14, or even 1/14, the injectable is no longer of any interest. And Merck (Islatravir) has to fight on 2 antagonistic fronts: Injectables (ViiV), and zigoto-4/7 in generics, which, for the time being, will appear to be of unparalleled boringness. And Merck is going to hide the main characteristic of Islatravir, because it must piss them off!

Afterwards, when we know how to do the 1/14 with Islatravir, we will be able to look back and see that there wasn't really that much difference between NVP and Islatravir, in terms of intracellular persistence. How stupid we are, we could have realized it before!!! Well... Yes...

Liberation Day

Here is the table of release days, according to the intermittence profile followed.

Rhythm	Liberation on...	Comments
4/7	July 28th	It's boring
3/7	June 6th
2/7	April 15th	it gets interesting
1/7	February 21st
1/14	January 26th	I'm here: cool
1/21	January 17th
1/30	Jan 12	With Islatravir? injectables = no thanks

My 1/14 and new flexibility

I missed the blood test, having preferred to coocoon some time after a difficult trip. I have a new flexibility: In x/7, I take the blood test on my birthday and I take the meds directly after the blood test.

In 1/14 (or even better), I plan to do it on day 13 or 14, so I have the possibility of a catch-up day. As the French labs do Shabbat (an outdated tradition...), it limits a bit, but well, it's only a few times a year.

In the news

Trulight: it's nothing, just noise... Who wants to take Truvada® 7/7 today? Barely 20% of patients have a reservoir < 800 cp DNA/million PBMC, and, taking into account the inclusion bias (de facto average CD4 = 800, endless inclusion), the potential target population is barely 10%, for a 10% failure rate... So, yes, it works for some, and good for them! And to the 90% who didn't fail, we ask the question: what do you do now? This test does not concern us. Now you know, and that's a good thing!

Mediator: (Here, an article from Le Monde) the whole trick of Servier is to have diverted the attention by pretending that their molecule is not of the class of FenFen (fenfluramines): We will see Merck doing the same with Islatravir: they will have to make up: we will soon see why...

The French genius of cold (brrrrr)

Mythical version by the unforgettable Klaus Nomi, gone too soon... The versions with bass are more accessible and just as chilling. See also here. Recently, Abdelazor's rondeau (Purcell again) has been brilliantly performed by X Varnus and B. J. Samodai. A more classical version here.

Feel free to comment, like, share and use

overmedication is an opportunity if you know how to use it!

134

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



The 1/14 is already healing a little...

By Charles-Edouard!

You'll have to get used to it:

Having followed the story for a long time and having fought with our friend for a long time, this is an honest testimony. There are now 2 of us, since I have just switched to 1/14, with an inflated combo. Our friend had a very small CV before treatment (3000). I'm a fan of the 'big bomb, long silence'. If others manage to do it with just a small grenade (DTG/3TC), well, all the better!

As for me, after my failure of DTG 150 mg 1/7, it is understandable that I don't do DTG/3TC in 1/14! Everyone does according to where they are and how they get there.

1/14, release day and social security contribution

I am for solidarity, but against abuse. Until recently, the basic young homo paid, on his workUntil recently, the basic young homo paid a family allowance contribution, which you'd have to be really twisted to think that he'd ever benefit from it. Everyone is exposed to unemployment or health risks: the contribution gives rights. No! I am not exposed to the risk of having many children! I find it disgusting to contribute through work. Through taxation, that's another thing. Very recently, the thing has been put back in order, which proves that my aversion to an iniquitous system was justified.

For health, likewise: there are young people who enter active life by being, from the start, net debtors of the system. A young gay man is 200 times more exposed to HIV than another! Fortunately, there is PreP (free) to set the record straight! A young Chinese gay man is overexposed to the risk, but his treatment, in the second largest economy in the world, is $60 a year! Some people like being a net contributor. Oh, I know the crybabies (profiteers) feel differently! Good for them: young gays vote with their feet and go live in Canada, Switzerland, etc... Where they are not subject to financial discrimination. France attracts poorly qualified people and turns away its graduates. And if you think that young German engineers are rushing to our borders for the privilege of financing the CAF, you are wrong!

To be a net contributor is a credit to those who find it abusive to unduly exploit a natural inclination. We will see, with Islatravir, that its invention did not cost Merck a penny, which is going to make billions on your back: that is the medical-pharmaceutical underworld. The CPAM will benefit from a windfall of hundreds of millions, thanks to the 4/7. Do you think for a moment that they will say thank you? Or that they will have contributed at all to its advent? No! Stipended 'assocs' are slowing down ! Have you seen them positively echoing Quatuor? Not even! All this little world is living off youNot even! a little less each year and good luck!

The 1/14 is not a beauty contest

For the 1/14, release day is January 26! 1 year of your treatments serve us 14 years. So let the 7/7, in maintenance, go to the end of their frightening logic and pay for the part of the drugs that do not make them more than a placebo or a food supplement!

I understand that trying 3/7, 2/7, etc., there are some who fail and must resume the same treatment at a more sustained pace. Getting to a dynamic remission may not be for everyone right away, and it will be quite technical, a technicality that your doctor(of my two) does not master. So what?! So what?! The one who arrives at the 1/14 marker, she doesn't care!!!. We have the right to explore and exploit an Eclipse whose existence is not in doubt!

It is not the race to the shallot. Anyway, the person who is at X/7 will necessarily ask himself one day the question of (X-1)/7. It's only a matter of time! And, with the arrival of Islatravir, the first molecule duly stamped: 10d. or more, things will move!!!

I'm pushing for a 3/7 trial, the only quick way to prove the robustness of 4/7; I'm pushing, but not more than that... The advent of 3/7 is inevitable (with Odyfsey, for example)

And our friend here has succeeded in 1/14 with DTG/3TC, without bloating a bit, but again, it is only a matter of time before he tries 6/21, 5/21, 4/21, etc. When Islatravir becomes available, will he substitute DTG for Islatravir (moderate genetic barrier)? No! he will add it, and there it is in TRI (or even Quadri, because they will be smart and forcefully combine it with Doravirine)

And, of course, the collaborator of service to persifler:

And to the question: which doctor? She never answers: and for good reason! Even Leibo is useless to us on 1/14, so useless at 1/14 or useless at all, it's the same

Obligation of treatment / Judiciarization

The USA is a theocracy, in case you didn't realize it... Here, in France, we are in the middle of a vaccination frenzy: But [the HAS] also raises the fact that 'HPV vaccination limited to girls and MSM raises questions of ethics, equal access to vaccination and stigmatization linked to sexual orientation and non-respect of privacy'. source: LeMonde

Well no!!! Vaccinating young gay men against HBV, to which they are more exposed, is a rather good idea, despite the proven risk of multiple sclerosis. The increased risk tilts the balance in favor of this vaccination, which I did myself, as such. Never Oh never, have I felt discriminated against for doing it and others not!!! This is ridiculous: we cry discrimination for everything and anythingThe side effects of this vaccination will not be detectable by the health care system, and we are heading towards a new health scandal.

We remind them, and the ActUpians too, thatthere is a jurisprudence, called Nuremberg jurisprudence (which is not nothing), which says that one cannot inflict a medical act for the benefit of others: It is not that eugenics does not work, it is that it is contrary to human dignityIt is not that eugenics doesn't work, it is that it is not: no, the massive HPV vaccination will have only a marginal effect. In Australia, which is an island, there is a very small effect (and none on cancers), and they don't count the side effects, because they can't make the correlation. That's right, you can't make the correlation... So what? This does not invalidate the suspicion of cause and effect. We are in the middle of a ridiculous situation and it was urgent to fire the ex-ActUp!

Have a good weekend, get drunk and don't take too many pills... Right?