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This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARV, intermittence...(15)

Coronavirus: The end is near

Graphic update by worldometers and Southern France Morning Post.

HCQ/AZIT vs (HCQ/AZIT + the rest)
	HCQ/AZIT				(HCQ/AZIT + the rest
Date	Infected (and treated)	deceased	%		Infected (all ttts)	deceased	%	p
10/05/2020	3273	17	0,52 %		4836	145	3,00 %	---
09/05/2020	3261	17	0,52 %		4832	145	3,00 %	---
07/05/2020	3248	17	0,52 %		4827	144	2,98 %	---
06/05/2020	3241	17	0,52 %		4818	142	2,95 %	---
05/05/2020	3233	16	0,49 %		4809	140	2,91 %	---
04/05/2020	3227	16	0,50 %		4804	138	2,79 %	---
03/05/2020	3220	16	0,48 %		4797	133	2,78 %	---
02/05/2020	3207	15	0,47 %		4790	128	2,67 %	---
01/05/2020	3190	15	0,48 %		4776	128	2,69 %	---
The complete table is available here
source: https://www.mediterranee-infection.com/covid-19/

18/05/20: Settling of accounts in French virology (or what's left of it...)

The video where Raoult explains how Pasteur, Bichat, were saturated, how XXX (Xaxier Lescure? ) and Karine Lacombe got respectively $500.000 and $200.000 is here

Maintaining the chronicity

05/19/20: How to humanize an animal virus, without getting too tired

The Raoult & Co quickly succeeded in isolating and cultivating the virus (harvested from humans). Professional work. After all, Saddam was falsely accused of doing it... This is the way to prove in vitro that a molecule can be effective. We do this with the human virus. But before the human virus, how did we do it? With bat virus... To be cultivated in... a bat animal house, or else, in a compatible culture medium. Raoult & Co took less than a month, taking advantage of already published recipes (SARS-1.0)... That's it! You have a virus in culture. And as the other guy would say, you just have to change the medium gradually.

It is only a matter of time that a Laboratory tries to do it... American, Chinese, North Korean, Iranian, even... Australian, because that is where the hypothesis comes from (read Nikolai Petrovsky In silico comparison of spike-ACE2 protein binding affinities between species; significance for the possible origin of SARS-CoV-2 virus. First, they are going to make a computer simulation, if it is not completely crazy. Then, they will take Mouse Virus (Made in China), blood or a bat substitute (Made in China), it will cost them quite a lot, but VERO or expired (human) blood bags, and, we substitute little by little. We create an adverse pressure with an anti-ACE2
China? It's the new Wild West of genetic biology. That's where it's happening... And if it is not there, it is in the USA, with... Biologists 'Made In China'.

Ah!!! Thepharisaicalvirology, bribed, unable to make any culture (Pasteur = Flat Encephalogram). The only one who knows how to simulate something is Rouzioux, but apart from simulating the Panic of the Great Rebound, she doesn't have much experience.

Karine Lacombe: You will find that I am slow to start... It is that I do not watch any more the French TV... And I missed the Karine Lacombe sequence... A viral video did not miss it, but here it is, I'm not too interested, but it's hilarious! Well, it would be funny if it were not pathetic. Karine Lacombe defended herself against the sums received from the Labs by her 'expertise' (HIV/HCV?). I, who have my finger on the wire, have never heard of Karine Lacombe in HIV... I went to search the reference database, and there, there is nothing, or so little! search link. Ah... She participates in all the small criterium of province, and never leaves the pack... Expertise, expertise, you have to say it fast...

Trump on Hydroxychloroquine... He is of a certain age, he has traveled the world, so he knows Nivaquine... Raoult is starred in the USA, by a rather long article in the New York Times.

Raoult, he doesn't do tongue-in-cheek: Watch 'Can the innovation process respect the rule?' on YouTube.

05/20/20: Prescription and medicine cabinet

The disastrous sequence of the Veran/Salomon decree (of legal death) shows one thing: the regulatory system most often works in your favor, sometimes against you. A decision, arbitrary, dictatorial, is imposed on you directly or indirectly (via the MA, the Pharmacy, your employer,...). You are only autonomous if you have anticipated. If you have not anticipated, you are caught in a trap that can deprive you of years of life, of means of existence, etc.

The death of young people, by refusal of care Grandma is 85 years old, her life is slowed down (to be continued)

How Raoult refutes Axel Kahn's argument We have seen everything and anything. Axel Kahn's argument is perhaps the most subtle: what does it prove to cure people who would have been cured anyway? Well... There is an advantage to heal faster, to be contagious for less time... But anyway... Raoult has an elegant demonstration: look at the deaths among my under 60 (or even 70) year olds, i.e. those who, effectively, had the best chance of getting out of it unscathed: At the IHU, zero deaths under 60, one unfortunate death between 60 and 70... Elsewhere, a statistical distribution where people under 60 years old contribute for about 15% (I did not do the calculation again). Among (still quite) young people, a mortality all the more shocking as it is avoidable, among people who had years ahead of them...

21/05/20: Optimal prescription and medicine cabinet

The ideal is to maintain a stock that can respond to the emergency: You need to have something to zap the virus immediately, in case of an outbreak: DTG (or BIC), TDF/3TC, ATV (or DRV?), RPV (or EFV or NVP, if you are not allergic to them), and therefore either an extended prescription, or a rotation of prescriptions. For example, ATV/TDF/F-3TC in 7/7, for 1 year, then RPV/DTG in 7/7, for 1 year, etc. Does this bother you? Get over it, becausewith the advent of Islatravir, that's what you'll do. With Biktarvy, you are within the bounds of Leibowitchian orthodoxy, because BIC (or DTG) counts as 2 (on paper). Islatravir will probably be coformulated, and not with BIC. Maybe we should consider having 2 doctors, if needed...
To this, we need to add a sufficient number of CVs (in the exploratory phase), let's say a CV 1 prescription per month, renewable 11 times (handwritten, 'valid for 1 year') and basta.

Then Hydroxychloroquine and Azythromycin... For hydroxychloroquine (or even chloroquine) it should be quite simple, but with the ambient hysteria and the normative madness of the puritans, we are not safe from anything, and it is precisely their harmful existence that justifies the small safety stock. Think also that the whole planet will want it...
Azythromycin: Unlike HCQ, a common prophylaxis, you may find it difficult to get Azythromycin, especially because everyone will want it, so you will be screwed... An alternative, validated in vitro, is Doxycycline, and here, it's good timing, because it's the anti-chlamydia prophylactic (or even Siphyllis, more or less...) advocated by ... Molina(read here). Since you are already treated for a venereal disease (HIV), getting prescribed some Doxycycline, before tackling the titillating subject of Azythromycin may be interesting.

22/05/20: Who to treat or not

Interesting reflection by Dr Marc Girard: One of the most distressing 'experiments' has been that of COVID in France... Its most effective mirror was the one in Taiwan... That is to say, the rare Chinese who are not under the totalitarian control of the CCP. The (in)effectiveness of the response in Mainland, Communist China is partly 'excusable' by the fact that it is there that the release of the virus took place, and that they were the first temporal victim. Such an epidemic is always very deadly at the beginning, because at the beginning only the dead are detected. In a 'modern' follow-up we can consider a PCR surveillance in the Institute of Virology of Wuhan, and in the surrounding population. Not for what it will have been (hypothesis under evaluation) but for what it could be The Source (and one could ask the question for the P3 and P4 labs, in France and elsewhere).

Taiwan: 0.3 deaths per million inhabitants is anecdotal. Well... Taiwan is an island, with many reasons to be wary of its giant neighbor. But France and Italy are victims of their tourist ideologies. Dario Nardella, Mayor of Florence, had called for a Campaign of Accolades to the Chinese, whose satirical name is: 'One road, one belt, one virus', and that the Chinese official media hastened to publish on Youtube (if, if, we still find it...)

23/05/20: The pangolin's name is Gérard...

We still haven't found the intermediate Pangolin... Desproges had already named him: his name is Gérard(you tube /INA). @cestpasnouscestlesPangolins : the tracking continues... And the Chinese not in a hurry... Obviously...

The number of people who make a causal relationship between the presence of the laboratory, world flagship of the Coronavirus, in the city of Wuhan and its Epicenter... In Wuhan... is growing. The question is not to know if they are right or not... But to know if they are right or wrong, there will be economic repercussions for China, where many western investors are positioned. A Chinese stock market crack would do well for TRUMP

Hydroxycholoroquine or the art of breaking the mood: the mere mention of Marseille is enough to ruin the mood between the best lovers. In a very documented way, INSERM (Levy-who has always failed to succeed with his HIV vaccine) wanted to take over the IHU, without going through the compensation process... Gilead, ViiV, Merck took possession of molecules and were trusted. This same trust has not been given to dwarfs such as Phamasset, Shionogi, Yamaya, JT, etc. We tell you Gilead this, Gilead that, the Gileadolatres fall in pamoison, but Shinadzi, they do not even know... Raoult didn't let himself go, and that makes the show, obviously. Besides, he made technological and strategic choices, which he explained well before this crisis, and which deserve the detour! No second containment for Marseilles: one thing is sure, the people of Marseilles will not accept a second containment, especially if the great scientist tells them that it is useless or of little use.

a very documented table has been published here, not ashp (an association of pharmacies, it seems). It allows to see which molecules have been used in Vitro. The ones in my table are quoted, there are others. Doxycycline is the only one missing. So it is not uninteresting...

The use of Hydroxycycline, for something other than COVID: this includes: improvement of CD4/CD8 ratio, improvement of insulin sensitivity. That's something I'm interested in. In the development of things, you identify something interesting and then you move on, simply because there is no business model. The HIV treatment cycle is one of them: since the first publications (e.g. FOTO, Breather...) we have been distracted by other things...

Remdesivir: no therapeutic use, but they will manage to sell some, the cut-off fell on Friday evening, after the closing of the financial markets (as if by chance...). Except for the group in oxygen phase, and still... As Didier would say, when you are no longer in the viral phase, what good is an anti-viral... The reading of the week end, for Gileadolaters, is here: Remdesivir for the Treatment of Covid-19 - Preliminary Report

Prophylaxis or treatment? in the context of therapeutic reduction...

Suggested interactions between HCQ and common ARVs (in progress... 05/05)
Molecule	suspected effect
Abacavir	No corresponding record
Emtricitabine	No corresponding records
Lamivudine	No matching records
Tenofovir	No matching records
Efavirenz	The risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with efavirenz.
Etravirine	No corresponding records
Nevirapine	Nevirapine metabolism may be decreased when combined with hydroxychloroquine
Rilpivirine	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Rilpivirine
Atazanavir	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Atazanavir
Darunavir	No corresponding records
Fosamprenavir	No corresponding records
Lopinavir	Serum hydroxychloroquine concentration may be increased when combined with lopinavir.
Tipranavir	Tipranavir metabolism may be decreased when combined with hydroxychloroquine
Bictegravir	No corresponding records
Dolutegravir	No corresponding records
Elvegravir	No matching records
Raltegravir	No matching records
Cobicistat	No matching records
Ritonavir	Ritonavir serum concentration may be increased when combined with hydroxychloroquine
Maraviroc	No corresponding records
cave canem de rigueur this blog is not medical advice (especially since medicine has proven to be poor) source: drugbank