172

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

The Fear of Healing: Variations on a Case

By Charles-Edouard!

News from our friend @Saamred

It's interesting to hear such good news from people who have read a lot of us... There are 3 types of PTCs (post treatment controlers): those that we find by chance (rare), those that we find by looking where we think we find them (Viscontis, Antwerp ...) and those of intention, who have undertaken a process in which control is possible. This is what interests us most!

The commentary is timely, since here is one who controls, but is afraid and resumes treatment ... This is the topic of the day...

A controller identified by chance...

Here, we will dwell and, for lack of a better word, embroider a bit, on what may have happened in a study in our Eclipse bibliography. Sneller (2020), takes chronic patients under effective treatment and studies the dynamics of rebound. There, Surprise!

One participant (#03), who spontaneously controlled his plasma viremia, resumed ART even before meeting the criteria for restart.

This patient is indeed found in the table, restarting treatment at week 13.

A PTC that falsifies this study, and the others...

We had seen that in the Davey Study, a very long Eclipse patient was distorting all the statistics. It lengthened the mean and especially the standard deviation(one should be wary of automatic calculations...). We had the table, we could redo the calculation. Here, it is the other way around: the patient takes the initiative to resume the treatment, thus shortening the recorded duration, integrated in the calculation.

The control arm tests are distorted

As we saw in the Levothyrox case, comparing population A to population B only makes sense if the standard deviation AND the range are both narrowed. In the 'modern' patient, this is no longer the case: we have a little of everything: between 1 and > 4 weeks

The Thirst for Glory incites to deceive the patients

Control arm trials are flawed, and sometimes unethical. Not the trial itself, but its preparation: an example is given by a Spanish study: Extremely low viral reservoir in chronically HIV-1 infected treated individuals.
What is the point of having a weak reservoir if not to be able to try PTC or, even better, Eclipsotherapy? Having a long Eclipse and treating 7/7: how stupid!

It is not difficult to imagine that the constitution of registers of patients pre-selected for trials is not compatible with explaining them on 4/7 (or even better). In order to do medical science, doctors are probably tempted to keep silent about reasonable alternatives...

On the road to recovery, there are...

Either the PTC or the Eclipsotherapy... Both allow to simulating a cure. Including seroreversion. Imagine: No RNA in the blood, no DNA in the reservoir, no residual meds in the body, and a negative serology. A sweet unattainable dream? Not sure, we'll see that another time...

Some anti-COVID news

-Ivermectin is entering the medicine cabinet. It is now the standard of care in many states (see here Ivermectin, used for Covid treatment in UP, replacing hydroxychloroquine. Funny to observe the absolutely canonical curves in India: one wave, an epidemic in decline, 10 times less deaths than in France. And, them, they still know how to make medicine!

- I tried the Raoult glove techniqueThe situation was right: I only had household alcohol (it leaves an unpleasant feeling on the skin) in a crowded place, touching a lot of things. It is necessary to understand it well:
-1- Beginning of the procedure: clean your hands well with alcohol (one that does not damage, if possible)
-2- Put on new or previously sterilized gloves
-3- Clean your gloved hands with alcohol (even rotten) very often (alarm every 30 min.)
-4- At the end of the procedure, disinfect the gloves well, then remove them and re-clean the hands
-5- Disinfect the gloves with alcohol (outside and inside) in order to reuse them (or destroy them)
Results: very good procedure, no hand aggression, use of cheap alcohol. Very happy!

- A reasonable plea for early treatment: The need for early management of patients with COVID-19

Obligation of treatment / Judiciarization

We are obviously interested in all the media hype about mandatory vaccination for an easily treatable disease, when, on the other hand, systematic HIV screening would allow its eradication... The associations do not want it... Why then ???

In the news

- Alex Sigal, excellent biologist, already quoted here, highlights a lower efficiency of acquired immunity against the Lacombe-AstraZeneca 501Y.V2 variant: Escape of SARS-CoV-2 501Y.V2 variants to plasma neutralization in convalescents

Whatever the concentration of 'old' antibodies the Lacombe-AstraZeneca mutant doesn't care!

One can expect a violent awareness of the consequences of the Pharisaical School of Verology(Lacombe, Pialloux, Pazdan, etc.) on the health crisis of nerves. If one (or more) variants could escape from a place of care, what about a place of manipulation such as Wuhan?

The French genius (well... yes... almost...)

This beautiful wool is the first award-winning work of Karl Lagerfeld. It's amazing! You can find it on YouTube. YouTube... from which Leibowitch has almost disappeared... Bizzare isn't it ? Almost 1 year since he left us. Not sure I'm inclined to comment anytime soon. Maybe time will help...

Feel free to comment, like, share and use

overmedication is an opportunity if you know how to use it!

171

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

The Saint Darwin 2021

By Charles-Edouard!

Alexandra Henrion-Caude is said to have said the following:

Well... In the hysteria of the moment, what seems to bother AHC is that it takes people away from their ordinary, millennial hysteria... She is clearly in the opposite camp... That said, she is challenging us in her professional field (the NRA) and I think it's a shame that censorship is the only argument she gets.

Darwin: the beginning of the end for a thousand-year-old hysteria

He says it himself: it is like confessing a crime. Certainly, primitive Darwinism exposes the commonancestry. It is a materialist atheist's delight to feel like a family among living beings: all alive, all cousins. Enjoyable...

This is the first time that a person has been able to see the world from a different perspective...

Raoult reminds us that incremental mutation is not the only cause of variation. Okay, Okay... Darwin was not yet into microbiology and gene exchange. Nevertheless, the selection pressure is THE issue of the moment, as raised by Raoult. If Remdesivir + Serotherapy(K. Lacombe and all the clique... ) are at the origin of new variants, it's going to look bad. No more need to let �� escape a laboratory virus. The whole world has become an open-air laboratory!

I am afraid that the same people who yesterday carried the 'principle' of precaution to the skies, are today communing in the Holy Vaccinal Ostia. The same people (Lacombe and Co.) who were pinning a fanciful toxicit�� of Quinine syrup, sweep you, today, off your feet the genomic risks of Genetic Vectors.

They will have scoffed a lot at those who found it very strange that a virus so well adapted appeared in the same city where experiments, forbidden elsewhere (and for good reason...), of function gains were made. The pendulum is now swinging in favor of this theory...

One cannot think of biology without Evolution... Back to Sonigo!

As a comment to a discussion that can be followed starting here: Are we paying for a fundamental error [...], Pierre Sonigo comments as follows:
Certainly... Provided that it is indeed a coronavirus avatar alone and not a chimera X + Corona. But, precisely...

The Ghost Pangolin, fucked by a Bat!!!

Finally, a reasoned discussion A Bayesian analysis concludes beyond any reasonable doubt that SARS-CoV-2 is not a natural zoonosis but rather a laboratory-derived virus.

Unless the virus has recombined in a natural environment with another virus (which one?), there is little evidence of genetic manipulation or laboratory recombination. However, the (only?) laboratory known to make gain of function is the one in... Wuhan. With the passage of time and the notorious inability to find the missing link, the theory that it is God who creates Adam Zhengli Shi who creates a virus is gaining momentum. Viruses have one (or more) ancestor(s). Only one, when it is a question of incremental mutations(for example in Remdesivir), several in case of recombination. The Wuhan Virus is remarkably different from what is known. And there is no need to go back before Methuselah!

Here is what we can fear in terms of 'natural' gain of function:
- An immunocompromised patient or a test tube
- suboptimal use of Remdesivir, or any other mutagen
- a few natural antibodies

And presto! Here is a variant with gain of function... And since there is fat, and manipulations take place on a large scale, we have the right to expect the worst... But then...

In the news...

- DUETTO: official announcement of the ANRS:
the ANRS 177 DUETTO trial, which should start in early 2021, will evaluate the non-inferiority of dual antiretroviral therapy taken 4 days out of 7 compared to continuous dual therapy at week 48, in virologically successful patients on ART.
This should piss off more than a few people, and I'm surprised that pharisaical vetrology hasn't managed to get it cancelled yet... To be continued...

Quatuor essay:
- EudraCT(2017-000040-17) indicates that the trial has been completed.
- ANRS informs that the lead article is in preparation.(press release of 11/30/20)
As a reminder, the objective is to evaluate the non-inferiority at 48 weeks of the strategy of taking antiretroviral treatment on 4 consecutive days out of 7 versus the strategy of continuous treatment 7 days out of 7, in patients with virological success on antiretroviral treatment (CV<50 copies/mL).

The results of the comparative phase, the only one allowing to rule on non-inferiority, are published. The authors concluded that the trial was non-inferior. The trial was continued to include all patients. The 2 arms being in the intervention, this continuation does not contribute to the comparison.

- New entry in my Eclipse bibliography: a CASTAGNA study, from 2019, with 9 patients, and a mini Eclipse of 2 weeks, mean at 21 d. As usual!

The French genius: Riri, Fifi and Loulou...

I had a lot of fun! Riri, Fifi and Loulou.. You should have thought about it. At the time when I was following the IHU videos, there were 400 subscribers. Today, the smallest video has 1 million views! To have identified that a banal molecule, that I had the opportunity to eat many times, that I buy without even thinking about it, recommended by the best medical journal(the Guide du Routard) can shorten your suffering time, I thought that was good... To gain a few days on a bad flu, why not? At the beginning, it was just that. Very quickly the world split in two: the Raoultian Dreyfusards and the anti. With so much bad faith that we end up with a selection bias: we don't even bother to listen to "the other side".

Now, I had the opportunity to reconnect to Fiolet's twitter(Nathan's is a real problem for us patients, which we will have to suffer from for many years). But Fiolet, him... He has a Belgian accent to cut to the knife a good little background, which invites to follow. And very quickly I find there the bias of all these popularizers, these keyboard seropos, who think they are doing the right thing by being the megaphone of the laboratories(to whom you owe your life, they claim), to the point of forbidding themselves (and you) the intelligence. Fiolet seems to think that any series of figures can be analyzed mathematically, without a deep, sharp knowledge of the field.

The self-criticism of the CMI editors (@CMIGate) suggests that a retraction is coming.