157

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARVs, intermittence...(20)

Coronavirus: Settlement of accounts and legal consequences

Graphic update by worldometers and Southern France Morning Post.

06/15/20: Give us back the Chloroquine

To illustrate the stupidity of the organizers of the Recovery (UK) trial, they used the HCQ dose in the indication of amidiasis control. Except that Hydroxycholoroquine is used for amoebiasis. Pr. Perronne declares in France-Soir (decidedly the best media, at the moment) 'I think he confused hydroxychloroquine with hydroxyquinoline.' We're not done laughing. The idea of overdosing, especially in acute treatment, comes from a discussion of pharmacokinetics found here. Now... It is true that in some patients, at Raoult, the dose reached is a little lower than expected and that this is correlated with rare failures. Well... We will see...

The real problem is that here is a molecule that was on the market until the end of January, that has been put on List 2, only to be BANNED in March! It is a total madness. Wait until the airlines get involved... Why them? Because travel prophylaxis are recommendations that are favorable to the development of air traffic. A proof? Remember the Air France International Vaccination Center - 148 rue de l'université 75007 Paris - Travel prophylaxis is of prime interest to airlines.

06/16/20: The black market of hydroxychloroquine

As a user of Plaquenil, on sale over the counter until January 2020(on sale OTC!!!), I didn't even know that it had been put on List 2. This seems very stupid to me, because the traveler's prophylaxis requires to start the prophylactic treatment a few days before departure. If not, you can find some on the spot, but it's not as good, but it's possible. In some areas, the parasite (malaria) has become resistant, so Plaquenil (or Nivaquine) are useless, but not everywhere... In addition, it is not expensive, and the danger to the heart is rare, or even non-existent, or even false, invented from scratch. Palpitations, the patient realizes it, so, frankly...

Get your supplies abroad. You will make a list of countries (many) where chloroquine is sold FREE. And every time you buy it, over the counter, you will shout, with a Marseilles accent: Paris on t'encule! (substitute Paris with whoever you like). And to take up an old slogan: 'molecules so that we fuck each other! Normally, when you come back from your trip, you have to continue the prophylaxis for another 2 months, so you buy this drug, illicit, 'sold in France under the brand name: 'du bon , du bon, Dubonnet'. If you are bothered at the customs, cough strongly, it will calm down the spirits (well... not sure...)

HCQ manufacturers are rubbing their hands. In India, the active ingredient is manufactured by ICPA and Cadila. ICPA's share price has risen from 1150 to 1600 since the beginning of the year, i.e. +40%, which is even better than Gilead. Raoult declares that he has no shares in Gilead or Sanofi, but hey... If I were the boss of ICPA, I would send some pills to IHU. Literally or figuratively? you decide, reader. The Indians, for the moment, it is their only weapon, so they will deploy it, it is normal. Hence Gilead's eagerness to ally with... Mylan...

HCQ to expand the Eclipse. This is not me saying it... But Ananworanitch, who even did a clinical trial, the intervention passed the ethics committees hurdle: so it's legitimate (it's not for ethics to decide if it's legitimate, it's just legitimate to talk about it). I didn't say that it works... I presented, in a conference, at Pasteur, the 3 strategies on the table: Wainberg (DTG pulse), Siliciano (latency inverter), Leibowitch (the Eclipse), and in fact, the fourth one (the Choke and Mute), which I conceptualized, which consists of attacking the Eclipsal cliff. I tried everything independently. The Pulse DTG gave me a phenomenal CV rise, which the latency inverter had failed to prevent. So I'm left with the Choke-and-Mute (1/15, 1/21, under PCR monitoring). But that doesn't mean I'm not interested in the rest. As a principal, no, but as an adjuvant, yes! By the way, I'm going on. What is there to lose?

Toward a ban on dexamethasone? HCQ jurisprudence prevails. If we ban (and even maintain the ban) of HCQ, which works or not, to be debated, then we go straight to the ban of dexamethasone by Macron/Philippe/Véran/Salomon, since the English report an efficiency (in the critical phase of the disease). If it works, it must be banned, that's obvious!

17/06/20: Perronne's book

Perronne's book was published today. Albin Michel has done a lot of work: it's a team effort! (In a word, considering the references, provided, a real work of journalistic verification, which seems to exceed the work of a single author. But well... I am not disappointed. To be disappointed, my expectations would have to be high. This was not the case. It is interesting, lively, in the thick of it.

He tells us about a virologist who would have received up to 500.000 Eu. from the Labs, indicating that fortunately (for him...) he will not mention any name. And my 11,5 Euros, the price of the book, is cat's piss ??? I don't buy a book to be told that such and such a person has touched it without being told who. Because the fact that Gilead is spraying all thePhariseevirology with a fire hose, thank you, we know!

Incidentally, he talks about Garches, about Aids, it's true that the subject of the book is COVID, not HIV, but well... Not a word about the study they published (and then withdrew, we still wonder why, since if they don't publish it, I will). Not a word about the other successes of Garches (ICCARRE, Lyme disease (does it really exist???), Leibowitch death. It seems that the authors have hardly set foot in Garches.

We learn some interesting things, but not much more than reading France-Soir (which is waking up, obviously). I'm at the point of believing that my Live, started very early in the case, is more interesting than the book of Perronne & Co. On the other hand, this book puts in black and white, for eternity, the state of unpreparedness of the 'best health care system in the world'.

The Dallas Buying Club: getting molecules is becoming difficult... We haven't heard the last of this affair, especially since intercontinental travel is not about to resume and this ends up being annoying. The International Post Office is suspended!

18/06/20: False advertising and counter-advertising: what to do?

When you have seen 7 times that BIC is better than DTG (of which it is a copy), that Videx is toxic, that NVP is obsolete, you end up believing it. Lorgeril, who knows a lot about cardiovascular disease, has written a very enlightening post on this point: ' Les inénarrables aventures des graisses saturées en compagnie des maladies cardiovasculaires'. You have identified the deception and you are happy! You won't be caught dead! Yes, you will! Because there is a group effect. You laugh at the toxicity of Videx, like the orthodox Leibowitchians, you are against the current, all happy, but you are marginalized. And since no one takes Videx anymore (except in Spain), Videx disappears and the market imposes itself on you. Fortunately, people in Spain still take Videx... Really??? Yes, BMS sees that sales are stable in Spain. Why is that? Because the whole of Europe has no choice but to go to Spain for supplies: it is the last bastion. This is how a grey, parallel market is set up, neither legal nor illegal. HCQ is the same: you just have to go and buy from where there are still some, especially since there will always be some, since there are authorized indications. The Pharma Giants had rushed to 'donate' HCQ to the US strategic stockpile (the federal government didn't spend a penny...) and here they are with millions of doses of the only thing that works against COVID, but as the FDA didn't find any Lazarus effect to it, they withdrew the temporary authorization, in other words, they banned it!!!! Just like in our country! By imitating us ! Because if France, the home of AHQ/AT, bans it, there is no longer any good reason to keep it as a safety stock. The Americans were afraid that Europe would drain HCQ. Fortunately, Macron/Philippe/Veran understood that it was better to be at ease with the Americans than to worry about the health of the French.

a fabricated toxicity. Here is what the CDC (Atlanta) had to say about it, until recently:

The supposed heart toxicity was fabricated! By whom? By Sanofi, of course! An over-the-counter drug is not reimbursed, but a prescription drug is! And as the century-old market for chloroquine is slowly disappearing (resitance of the parasite). Over the counter you sell it for $1, on prescription you sell it for $3. Of course, you will sell a little less... Sanofi ? A strange silence, don't you think?

19/06/20: HCQ and cardiac risk: an organized hysteria

Hysteria is a widely shared misconception that no one would dare to question until it is written off. The flat earth, the existence of a Jesus, cholesterol, BCG, etc., etc. etc. The idea is spread from book to book, without any verification. One comments on the commentator, who commented on another, etc. It is the man who saw the man who saw the bear. One remembers the false 'testimonies' against the intermittence. So we look for the source of this famous cardiac toxicity of HCQ, from which nobody dies. Here is what the FDA says about it: Hundreds of thousands of patients are treated daily (malaria, lupus, arthritis...), so reported cases, by whom? How many? What is 1 per 10,000, 1 per 100,000, 1 per 1 million?

Oh sure, there is probably an increase in arrhythmia, well... But that's what a lot of drugs do. And this is perhaps where the problem lies: this study Risk ofQT prolongation associated with the use of hydroxychloroquine with or without azithromycin in COVID-19 patients shows that the vast majority of the patients studied were already taking 2 QT prolonging drugs. So for them, unless they stopped, the time to get rid of SARS-CoV-2, they had 2, then 3 then 4 (AT) drugs with Qt prolongation! From there to die... Especially since COVID, from a mortality point of view, is still serious

The risk mounted on a pin: read, without laughing, on the WHO website: 6 April 2020 WHO 'Advice on the use of masks in the context of COVID-19'.
How do you want to make people understand the interest of the mask to people who do not wear underwear!!! Yes, we have no formal proof that a slip or a parachute is useful, while the critical risks are there!?! We are in full delirium!

Why is this interesting? Because HCQ will soon be part of our Anti... Anti-viral...

21/06/20: HIV, Intermittence: Charles-Edouard is back!

When I started talking about SARS-CoV-2, in XXX, I didn't think we would have such an anti-HCQ hysteria. My motivation was to comment on the use of ARVs in this context. ARVs were not retained, and everyone's attention was on COVID. There was no need to talk about anything else. I spoke early on about HCQ/AT dual therapy (known as Raoult's prorocole) and I followed suit. The natural slope followed by Raoult (culture techniques, in vitro trial, small primer trial...) is based on a deep and well argued reflection. I didn't know then that the world would split into 2 groups, the PRO-Raoult and the ANTI-Raoult. Having already used hydroxychloroquine, which I thought in all good faith to be sold FREE, during a trip, I was shocked to see the outburst of nonsense about its supposed danger. This hysteria having reached the top of things, it became impossible to get some, while we all have more or less relatives who, even today, are exposed to a mortal risk. I explored the possible alternatives (Doxycycline with or without ATZ Atazanavir), with 2 subjects of satisfaction: I have some, and it is not forbidden by the disastrous Veran/Salomon decree, so we can get some. I had also supplied Zinc. The course of events could have led one to believe that I had become a Radio Raoult, as one could have believed that I was Radio Leibo. This is not true. Radio Leibo exists, it is the Friends of ICCARRE, Radio Raoult, too, it is France-Soir. Reading France Soir (fed by Raoult and Co) made it unnecessary for me to comment.

Soon a classic HIV post: I have delayed the publication of articles that deal with the history of L'Eclipse, Biktarvy, adjuvant techniques. Publishing an interesting topic in July/August is the best way to make it go unnoticed! So that leaves us the leisure of an HIV article, at the end of June, and we start again in Sept, with Biktarvy (which starts its life of 1/7) and other exciting topics. The COVID soap opera is not over! but HIV is back in its place!

Suggested interactions between HCQ and common ARVs (in progress... 05/05)
Molecule	suspected effect
Abacavir	No corresponding record
Emtricitabine	No corresponding records
Lamivudine	No matching records
Tenofovir	No matching records
Efavirenz	The risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with efavirenz.
Etravirine	No corresponding records
Nevirapine	Nevirapine metabolism may be decreased when combined with hydroxychloroquine
Rilpivirine	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Rilpivirine
Atazanavir	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Atazanavir
Darunavir	No corresponding records
Fosamprenavir	No corresponding records
Lopinavir	Serum hydroxychloroquine concentration may be increased when combined with lopinavir.
Tipranavir	Tipranavir metabolism may be decreased when combined with hydroxychloroquine
Bictegravir	No corresponding records
Dolutegravir	No corresponding records
Elvegravir	No matching records
Raltegravir	No matching records
Cobicistat	No matching records
Ritonavir	Ritonavir serum concentration may be increased when combined with hydroxychloroquine
Maraviroc	No corresponding records
cave canem de rigueur this blog is not medical advice (especially since medicine has proven to be poor) source: drugbank

156

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARVs, intermittence...(19)

Coronavirus: Settling of accounts

Graphic update by worldometers and Southern France Morning Post.

10/06/20: Settling of accounts in OK Coral

Why is this case important to us? Simple... In some countries, industrialists engage in pure and simple corruption, with an envelope to whoever makes the decision. In France, public decision-makers rely on 'expert' recommendations, which sometimes even have a real 'liberal' status. This is called conflict of interest: it is not intelligible. In the French context, where the active corruption of public decision-makers is not obvious, the real investment of the industrialist is on the experts. Yes, but here it is... As an average patient or as an advocate for ANRS-4D, OMNIBVS, etc. you don't know who is who. If I'm at an OMNIBVS discussion table, for example, and Molina is there, well... Well, I have my own idea, my own private idea, and I don't express it here or anywhere else. But there are many unknown faces. Who will participate in the vote (of the budget), while I don't participate... It is in the secret of the alcoves.

Leibowitch went to Saint Antoine, to fish, for OMNIBVS. He came back empty-handed. Between the Saint Anthony of the good old days and the Saint Anthony of now, new faces have appeared. Me, in 2018, you put me in a room to present OMNIBVS. There are people, Lescure or Lacombre, perhaps, others, whom I do not know from Eve or Adam, given their marginal contribution to HIV. One day I gave a presentation in a university hospital, I was told that it was very successful, and as proof, there were even people from... At the time I was shocked. If I had known I would not have come, not like this. But how to know?

Raoult published a newsletter where he took the members of the CMIT (Collège d'enseignant en maladies infectieuses), listed their 'declared conflicts of interest'(i.e. the small ones..., because the big contracts are excluded from the field of the obligation of declaration... ) and looks at their 'public contribution' to the lynching of hydroxychloroquine, which had been on the market for more than 50 years, was put on List 2 in January, and was banned in March. He publishes, with Elsevier, Influence of conflicts of interest on public positions in the COVID-19 era, the case of Gilead Sciences. Apparently, there are some who wanted to sack Raoult, but worse punishment than Marseille, they did not find, so he is still there and he goes to the sulphateuse. The article will not disappear, because I will analyze it, publicly. Anyway, the justice system is already on the case. Raoult, bound by the jurisprudence of the Ordre des Médecins(exceptional justice if ever there was one), does not mention any name, but we will make the case go forward!

On this point, don't count on the usual hollers, they are all as rotten (and here I have kept the evidence...)

12/06/20: Christian Perronne: I ACCUSE

Christain Perronne is angry and he lets it be known! He publishes a book with Albin-Michel: Is there a mistake they didn't make? It's amazing. I've read the excerpt and I've already placed an order. Yet I'm sick of this virus! Just think, it's June 12 and HCQ, which was on sale until mid-January, on FREE sale, is always forbidden by this damn government that nobody wants anymore (except Merckel and Niels). Perronne is nevertheless a nice guy, maybe a little too nice, but he will have, by dint of diplomacy, succeeded in imposing ANRS-4D and its sequel, which is not nothing, and not much at the same time and which is the very object of my anger. The problem with ANRS-4D is that it does not go far enough! We need to do 3D, 2D, 1 D, 1/14. Remarks, if Perronne had the c****s to go to the end of things, I don't have a blog to do anymore, I move on to something else and basta. I'll keep the blog going as long as Perronne and the others don't get off their asses more.

He's got other things to worry about, but we... No! None of my readers have complained about COVID... While 7/7, it ruins your kidneys, your bones, your libido, your professional life, it's every day! We will get up from the COVID but the 7/7, it will leave you the aftermath! Delfraissy is Pétain... Perronne is the Italian ally. When Raoult says: 'Delfraissy is Pétain', he is not referring to a disgraced regime, but to the fact of recalling the old 'glories' of a trench warfare to manage the defeat of a Blitzkrieg. There, in one word, if one understands it well, without distorting the meaning, Raoult has hit the nail on the head! Who is guilty? The president? The Prime Minister? The ministers of health? The experts? They did not see it coming...
More serious: some knew. Perronne's book: A fierce, undeniable and worrying testimony.

The medical profession has lost all credibility: the fault of Véran & Co... And to the doctors themselves, because, except for a few loudmouths, we have not seen them defend their profession! Perronne does it, but for one Perronne how many defeatists? Have we seen the pharmacists rise to the occasion for the little Nivaquine, which they dispensed in millions of boxes, before they were forced to believe that it is a deadly, immediate poison.

I pity the parrots who only know how to say 'trust your doctor', because the basic doctor is like everyone else faced with a new question, which has not been explored.

12/06/20: Sartans: to stop or not to stop?

ACE inhibitors (sartans ) Since the virus clings to ACEs, a molecule that comes to sit on the receptor might seem favorable. Sartans would act a bit like Maraviroc (which blocks the CCR5 receptor, which is the pharmaceutical counterpart of the Berlin Patient strategy). Except that... There are 2 possible co-receptors (CCR and X4) and that by using Maraviroc, for example alone, in the presence of X4, there is an enrichment of X4, to the detriment of CCR5. In the end, there is not enough CCR5 for Maraviroc to be effective. In CEAs, there are several types, of which 2 situations are possible: sartans have a favorable effect on the virus or an unfavorable one (or neutral, but well...). There is no evidence to decide this.

I am very angry with these parrots who only know how to repeat over and over again: 'trust your doctor'! Except that the basic doctor doesn't know any more than the average Pekingese, since the suspicion of a possible role for sartans has only been raised in intelligible terms since Raoult made a rich description of COVID. This did not prevent the cardio-therapeutic 'Zotorities' from recommending continued treatment with sartans, without the slightest hint of a problem. They pulled this out of their hat. And, as the industry's mouthpiece, it is hard to see how they could have said anything else. The American Heart Association and the European Heart Association (at the height of corruption) did it early for people who had no documented cases at hand!

Raoult discusses this with precision, in this latest video(Microbiology Staff of 09/06/20 at minute 32) where he says: WE KNOW NOTHING. Faced with an unresolved question, the doctor is no better a fortune teller. When there is no knowledge, there is no knowledge, we have to admit it. Let's imagine that the analysis, which is difficult at the moment, leads to the conclusion that it is the sartans (the 'cure') and not the underlying condition (hypertension) that is THE cause of significant excess mortality among sartan users, well, AHA or ACS will have no other option than to denigrate and quickly forget their risky (and irresponsible, because there is no responsible signatory) position. So, it's all a bunch of hot air.

12/06/20: Sartans and medical corruption

The following is an excerpt from the article Renin-Angiotensin-Aldosterone System Inhibitors and Covid-19

The author endorses the opinion of the AHA and ECA based on an article by Mehra. Mehra ? ... Mehra ?? ... Yes, the same Mehra who published a completely misleading article in the Lancet, and who published this one, again on the basis of figures invented, prestidigitalised, by the sulphurous Surgisphere. This article appeared in the NEJM, and was retracted for the same reasons (falsification of data). But the opinion of the AHA (and ECA) are unchanged!

Supposed interactions between HCQ and common ARVs (in progress... 05/05)
Molecule	suspected effect
Abacavir	No corresponding record
Emtricitabine	No corresponding records
Lamivudine	No matching records
Tenofovir	No matching records
Efavirenz	The risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with efavirenz.
Etravirine	No corresponding records
Nevirapine	Nevirapine metabolism may be decreased when combined with hydroxychloroquine
Rilpivirine	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Rilpivirine
Atazanavir	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Atazanavir
Darunavir	No corresponding records
Fosamprenavir	No corresponding records
Lopinavir	Serum hydroxychloroquine concentration may be increased when combined with lopinavir.
Tipranavir	Tipranavir metabolism may be decreased when combined with hydroxychloroquine
Bictegravir	No corresponding records
Dolutegravir	No corresponding records
Elvegravir	No matching records
Raltegravir	No matching records
Cobicistat	No matching records
Ritonavir	Ritonavir serum concentration may be increased when combined with hydroxychloroquine
Maraviroc	No corresponding records
cave canem de rigueur this blog is not medical advice (especially since medicine has proven to be poor) source: drugbank

155

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARVs, intermittence...(17)

Coronavirus: We do the math

Graphic update by worldometers and Southern France Morning Post.

01/06/20: Self-medication, risks and medical failure

Karine Lacombe: premium non nocere, secondo nulla fare: that's my kitchen Latin! First do no harm and second do nothing! Well... What do we need old-fashioned precepts in the 21st century? If she was really in the premium no-no, Karine Lacombre, self-proclaimed HIV expert, and furiously insignificant, she would have jumped in the Intermittence train. Que neni.

Cardiac ? The double punishment We understand that the people most at risk of succumbing are the very old and/or the cardiac. Raoult tells us that thanks to HCQ/AT, there is no mortality under 70 years old (except for 1). So, in the arms of the valiant Raoult, only very old patients, mostly cardiac, died. These are the ones who would have benefited the most from a miracle treatment... However, they are probably the ones who were excluded from the treatment (...in order not to harm, as Karine Lacombe would say...): by excluding them from the treatment, they were probably condemned to die from COVID, rather than from QT prolongation or even torsade de pointes, which certainly sometimes killed, but not that much... The prolongation of QT, or even torsade de pointe, is not, far from it, a death sentence. We do not yet have the analysis of the control group at the IHU. We will see...

Angiotensin blockers (sartans): a predictable pharmaceutical risk, a deleterious prescription... They act by lowering blood pressure, hence the indication in arterial hypertension. In patients with systolic heart failure, they reduce the symptoms and the risk of cardiac accidents and are therefore an alternative to conversion enzyme inhibitors. Given the affinity of SARS-CoV-2 for Angiotensin, the existence of alternatives to Sartans, and their moderate usefulness, one may ask the question: should patients on Sartans be taken off their treatment, even temporarily, for the duration of the epidemic? The precious Lorgeril had this thought about COVID: 'There are many questions about ACE inhibitors and sartans; it would be better to stop them as a precaution and limit ourselves (for hypertension) to diuretics and beta-blockers...'.

02/06/20: Factor X and childhood immunity

The health crisis in France has left its mark...in Asia...Often cited as an example of excellence in its health system, the emperor was naked! Hence the opposite question... Why so few cases in Vietnam, and in Asia, home first? Everyone has their own explanation for what is known as the X factor (favorable). The question of the mortality of the elderly, in particular those on Satan sartans, will be all the more interesting as the WHO has published a very surprising opinion: that the ingestion of these molecules should not be stopped. Would hypertension be a risk factor for SARS-CoV-2? Covid-19 penetrates through the angiotensin 2 converting enzyme receptor. Hence the hypothesis raised that high blood pressure would worsen the infection. If so, should ACE inhibitors and sartans be stopped?

The WHO's argument is specious... In fact, there are 2 indications for sartans, serious cardiac pathology and common hypertension. Normally, in the first indication, which is rare, stopping the drug is harmful. In the second, temporary discontinuation, with possible substitution by an alternative, is not at all of the same gravity: 2 indications, with 2 distinct benefit/risk assessments (keeping in mind that the COVID risk is very high in patients on sartans). 2 groups, 2 potential decisions. The WHO takes the argument from one to apply it to the other. This reminds us of the phantom over-risk of START where the risk observed in countries with a high prevalence of tuberculosis is applied to you, which is idiotic, it should be remembered, especially for Molina, who has been a champion of it. Here is the WHO opinion COVID-19 and the use of angiotensin-converting enzyme inhibitors and receptor blockers, which concludes: 'There is low-certainty evidence that patients on long-term treatment with ACE inhibitors or ARBs are not at increased risk of malignant COVID-19'. So much for talking about nothing. Evidence that is considered inconclusive is not evidence... FRHTA, a promotional site targeting hypertensives, goes further, finding arguments in favor of taking sartans: 'anti-hypertensive treatments including a sartan or an ACE inhibitor should be continued during the COVID-19 epidemic because they may provide additional protection in case of a severe form of coronavirus infection'. The European Society of Cardiology quickly hammered home the point and recommended that ACE inhibitors or sartans should not be taken unless there are 'severe symptoms or sepsis'. I am as suspicious of the SEC as I am of the EACS (you know... Molina, Raffi...)... They are all false noses!

The Raoult Bomb: children were immune The benign Coronaviruses circulate every year, undetected, because without symptoms, in our toddlers. Who thus preserved a certain immunity. Enough for us to ask ourselves the question: what good will it do to vaccinate immunized populations? From there to find that the famous factor X, in Asians, was a pre-exposure to the benign coronavirus... We will see. The Raoult bomb is here: #LancetGate. The Nickel Pieds make science.

03/06/20: Self-Medication and the Failure of Medicine

Harvey A. Risch's article: Early outpatient treatment of symptomatic high-risk Covid-19 patients should be expanded immediately as a key to the pandemic crisis, is a good analysis of the current decision-making landscape. In the side effects section, it is noted that cardiac rhythm disturbances are rare and even when they occur they do not expose to a significant or immediate fatal risk. As this is a short treatment, prior screening by ECG is unnecessary. Thousands of screenings are needed to avoid a single death (in this case, it is necessary to reason in NTT - Number to treat). The number of ECGs to be performed to avoid even one death is enormous: it is impracticable and useless in a context of widespread generalization, which is obviously desirable.

You have been sold fear upon fear. In the light of the figures put forward, the warnings of Miss Lacombe, appear for what they are: a total perversion of medical thought.

A chain of incapacitated people: doctors could not prescribe, pharmacists could not deliver, logisticians could not supply, importers could not transport: it's like masks... Useless until we had them, they then became mandatory

A vaccine for immunized people !!?? Really??? There is an amusing theory that the immunity due to the BCG vaccination, abandoned in our country, still practiced in Asia, would be this X factor, the one that makes the difference between the West and the East... You have been (in-)voluntarily infected by a benign pathogen and here you are, immune, defeated, against a new and malignant pathogen... In a way, it is true... An indirect immunity... Why not ? It's the principle of BCG. That's also the reason why I only get the flu shot once in a while. So the idea is not stupid in principle. Except that if we follow what Raoult says, this secondary immunity has been conferred by benign coronaviruses, which have circulated widely, under the radar, in the past years. Kids from 5 to 10 years old have (not) seen many of them. At the mature age, this immunity decreases to be null in the old ages. (This is why the idea of vaccinating the elderly against the flu, without vaccinating the active carriers, the little ones we like to kiss, is so strange...). So we have locked up by force some little ones full of energy to spare, and we are going to want to vaccinate them by force!???

04/06/20: The foxes and the rabbits cry Robert MAY

We're going through a bad patch... Those who are familiar with the Leibowitchian pen may have had some difficulty in understanding the repeated allusion to rabbits, foxes and the forest. In simple cases, the evolution of populations can be modeled: this is the case of rabbits and lynx in Hudson Bay. The animal skins follow cycles: the years with rabbits, the foxes reproduce, the following year, they exterminate the rabbits, so they have nothing to eat, so no offspring, and the following year the rabbits are abundant, etc. This prey-predator model can be found in many fields.

As for the 2-body physics, it is quite easily solved through a 2-component Lokta-Volterra. As with the 3-body problem, the mathematics of a 3-component Lokta Voltera is difficult to access. However, the CD4/CD8 system is a dual and constrained system (because CD4 + CD8 = 70%). For rabbits, foxes, this constraint is the forest... We would like to understand the dynamics of the CD4 and CD8 populations, because the non-reconstitution of CD4 is a concern for some patients. A simple(simplistic?) version is to say that CD4 does not come back well, sometimes, because the forest is destroyed. This is the Leibowitchian metamorphosis. It is Lokta-Volterra with 2 populations and one constraint (CD4, CD8 and lymphoid tissue). The points of divergence between Leibo and Charles-Edouard are not numerous, and there, you have one. Anyway... I have points of difference with everyone, including myself... I know how to live in good understanding with the divergent ones.

Sir Robert May, baron of Oxford, aquitted us at 84 years(see Nature). Robert MAY made the first resolution of the Lokta-Volterra at 3 populations... If we know how to do, we can do. Leibo, him, he did not know, therefore he did not make. His metaphor is pretty and unusable. The Charles-Edouard, she knows how to do (thanks to R. MAY), therefore she does, and her metaphor brings more. One day, I will explain... Beyond the theoretical resolution of the 3 populations system, R. May has contributed a lot to the understanding of systems whose appearance is complex, even random, and the underlying equation is disconcertingly simple.

But to find the system of simple laws, underlying an observation which does not seem to make any tail nor head, it is a trade. The dynamics of complex systems is unintelligible to those who have not acquired the basic mathematical concepts. So, this is not the object here... My metaphor is CD4, CD8 and ... and ... and ... Well, I'll keep that to myself. But once we understand, and as Sonigo says 'biologists do not understand anything'The world is illuminated in a different way.

Leibowitch has shown us how to take advantage of the entry into the Eclipse, but not how to exploit the exit from the Eclipse, which is possibly a key to eradication. The 1/7 is still pretty damn limiting, especially when, in light of the hundred or so patients who do it, there is almost no failure. So we don't go far enough. 4/7 is trivial, and we only limit ourselves to 1/7 because Leibowitch needed to keep his precursor patients on a leash.
Robert May allowed me to cross the Rubi-con, and here we are in a vast field of exploration, the 1/15 and beyond, whose limit is not known. Thanks Bob!

06/06/20: THE AFFAIRS: our enemies come out of the woodwork

If Polanski had some success with Dreyfus, a hackneyed story, there is no need to imagine the Holywoodian success of a BioPic Raoult. The line of demarcation between Pro and Anti HCQ/AT is exactly the same as the one between intermittence and continuous treatment. But how do we know who and who, and why does it matter? Many doctors talk about others in an eliptical way, so as not to fall under the 'justice' of the ordinal (corporatism too). In public, Leibo denounced the 'barons of the chairs', without naming them. So, when you are on the side of the patients, it is anxiety-provoking and unworkable. HCQ/AT served as a revelation and the 'Raoult' side drapes itself in Care, while the 'Lacombe' side claims to be Research. Nothing could be further from the truth: Lacombe/Lescure have no contribution to research, whereas Raoult, discoverer of the Mimivirus, for example , is another bigwig in research... Already the claim of the label is false, and the divide is real and on an unequivocal front lineOn the one hand, there are the non-affiliates, on the other hand, there are the Co-Labo. This is obviously important, because I maintain a list of experienced doctors in Intermittence, and, we can now name the enemy: the list of signatories of an anti-Raoult appeal, to make a long story short, is remarkable(it is here). So I completed my list of allied doctors with a list of anti-Raoult doctors. It's worth what it's worth, but it's good...

the nickel feet of French virology:

Raoult used the same expression as me... It's probably just a coincidence... Finally, I can see where the expression 'Limpimpim's father powder' comes from. You learn something new every day.

EHPAD: the anguish remains: While the Indian Journal of Medicine publishes the results of a study on anti-Covid prophylaxis with HCQ, our elders are at the exact same risk as 2 months ago: It is enough that it appears in an EHPAD and it is the hecatombe. However, we still haven't ruled on the prophylaxis of caregivers... The most rifdiculous in the case is the inclusion of Nivaquine in list 2... Nivaquine?! It's just the active ingredient of our great grandparents' quinine syrup. We are in full delirium!

Apparently, France Soir made a not too stupid cover. Read also this article

07/06/20: How to prepare for the next crisis

The only thing that is predictable is that it will come back... 17 years between the 2 SARS, with MERS in between: next time we'll be a little better prepared. List under construction: masks, alcohol and gel, PQ, Kleenex, thermometer, flour, Zinc, Azythromycin, Doxycycline, HCQ, Oximeter, taste kit, smell kit, cash, meds,

Prophylaxis or treatment? in the context of therapeutic reduction...

Supposed interactions between HCQ and common ARVs (in progress... 05/05)
Molecule	suspected effect
Abacavir	No corresponding record
Emtricitabine	No corresponding records
Lamivudine	No matching records
Tenofovir	No matching records
Efavirenz	The risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with efavirenz.
Etravirine	No corresponding records
Nevirapine	Nevirapine metabolism may be decreased when combined with hydroxychloroquine
Rilpivirine	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Rilpivirine
Atazanavir	Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Atazanavir
Darunavir	No corresponding records
Fosamprenavir	No corresponding records
Lopinavir	Serum hydroxychloroquine concentration may be increased when combined with lopinavir.
Tipranavir	Tipranavir metabolism may be decreased when combined with hydroxychloroquine
Bictegravir	No corresponding records
Dolutegravir	No corresponding records
Elvegravir	No matching records
Raltegravir	No matching records
Cobicistat	No matching records
Ritonavir	Ritonavir serum concentration may be increased when combined with hydroxychloroquine
Maraviroc	No corresponding records
cave canem de rigueur this blog is not medical advice (especially since medicine has proven to be poor) source: drugbank