This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.
Coronavirus, HIV, ARVs, intermittence...(20)
Coronavirus: Settlement of accounts and legal consequences
Graphic update by worldometers and Southern France Morning Post.
06/15/20: Give us back the Chloroquine
To illustrate the stupidity of the organizers of the Recovery (UK) trial, they used the HCQ dose in the indication of amidiasis control. Except that Hydroxycholoroquine is used for amoebiasis. Pr. Perronne declares in France-Soir (decidedly the best media, at the moment) 'I think he confused hydroxychloroquine with hydroxyquinoline.' We're not done laughing. The idea of overdosing, especially in acute treatment, comes from a discussion of pharmacokinetics found here. Now... It is true that in some patients, at Raoult, the dose reached is a little lower than expected and that this is correlated with rare failures. Well... We will see...
The real problem is that here is a molecule that was on the market until the end of January, that has been put on List 2, only to be BANNED in March! It is a total madness. Wait until the airlines get involved... Why them? Because travel prophylaxis are recommendations that are favorable to the development of air traffic. A proof? Remember the Air France International Vaccination Center - 148 rue de l'université 75007 Paris - Travel prophylaxis is of prime interest to airlines.
06/16/20: The black market of hydroxychloroquine
Get your supplies abroad. You will make a list of countries (many) where chloroquine is sold FREE. And every time you buy it, over the counter, you will shout, with a Marseilles accent: Paris on t'encule! (substitute Paris with whoever you like). And to take up an old slogan: 'molecules so that we fuck each other! Normally, when you come back from your trip, you have to continue the prophylaxis for another 2 months, so you buy this drug, illicit, 'sold in France under the brand name: 'du bon , du bon, Dubonnet'. If you are bothered at the customs, cough strongly, it will calm down the spirits (well... not sure...)
HCQ manufacturers are rubbing their hands. In India, the active ingredient is manufactured by ICPA and Cadila. ICPA's share price has risen from 1150 to 1600 since the beginning of the year, i.e. +40%, which is even better than Gilead. Raoult declares that he has no shares in Gilead or Sanofi, but hey... If I were the boss of ICPA, I would send some pills to IHU. Literally or figuratively? you decide, reader. The Indians, for the moment, it is their only weapon, so they will deploy it, it is normal. Hence Gilead's eagerness to ally with... Mylan...
HCQ to expand the Eclipse. This is not me saying it... But Ananworanitch, who even did a clinical trial, the intervention passed the ethics committees hurdle: so it's legitimate (it's not for ethics to decide if it's legitimate, it's just legitimate to talk about it). I didn't say that it works... I presented, in a conference, at Pasteur, the 3 strategies on the table: Wainberg (DTG pulse), Siliciano (latency inverter), Leibowitch (the Eclipse), and in fact, the fourth one (the Choke and Mute), which I conceptualized, which consists of attacking the Eclipsal cliff. I tried everything independently. The Pulse DTG gave me a phenomenal CV rise, which the latency inverter had failed to prevent. So I'm left with the Choke-and-Mute (1/15, 1/21, under PCR monitoring). But that doesn't mean I'm not interested in the rest. As a principal, no, but as an adjuvant, yes! By the way, I'm going on. What is there to lose?
Toward a ban on dexamethasone? HCQ jurisprudence prevails. If we ban (and even maintain the ban) of HCQ, which works or not, to be debated, then we go straight to the ban of dexamethasone by Macron/Philippe/Véran/Salomon, since the English report an efficiency (in the critical phase of the disease). If it works, it must be banned, that's obvious!
17/06/20: Perronne's book
Perronne's book was published today. Albin Michel has done a lot of work: it's a team effort! (In a word, considering the references, provided, a real work of journalistic verification, which seems to exceed the work of a single author. But well... I am not disappointed. To be disappointed, my expectations would have to be high. This was not the case. It is interesting, lively, in the thick of it.
He tells us about a virologist who would have received up to 500.000 Eu. from the Labs, indicating that fortunately (for him...) he will not mention any name. And my 11,5 Euros, the price of the book, is cat's piss ??? I don't buy a book to be told that such and such a person has touched it without being told who. Because the fact that Gilead is spraying all the
Incidentally, he talks about Garches, about Aids, it's true that the subject of the book is COVID, not HIV, but well... Not a word about the study they published (and then withdrew, we still wonder why, since if they don't publish it, I will). Not a word about the other successes of Garches (ICCARRE, Lyme disease (does it really exist???), Leibowitch death. It seems that the authors have hardly set foot in Garches.
We learn some interesting things, but not much more than reading France-Soir (which is waking up, obviously). I'm at the point of believing that my Live, started very early in the case, is more interesting than the book of Perronne & Co. On the other hand, this book puts in black and white, for eternity, the state of unpreparedness of the 'best health care system in the world'.
The Dallas Buying Club: getting molecules is becoming difficult... We haven't heard the last of this affair, especially since intercontinental travel is not about to resume and this ends up being annoying. The International Post Office is suspended!
18/06/20: False advertising and counter-advertising: what to do?
When you have seen 7 times that BIC is better than DTG (of which it is a copy), that Videx is toxic, that NVP is obsolete, you end up believing it. Lorgeril, who knows a lot about cardiovascular disease, has written a very enlightening post on this point: ' Les inénarrables aventures des graisses saturées en compagnie des maladies cardiovasculaires'. You have identified the deception and you are happy! You won't be caught dead! Yes, you will! Because there is a group effect. You laugh at the toxicity of Videx, like the orthodox Leibowitchians, you are against the current, all happy, but you are marginalized. And since no one takes Videx anymore (except in Spain), Videx disappears and the market imposes itself on you. Fortunately, people in Spain still take Videx... Really??? Yes, BMS sees that sales are stable in Spain. Why is that? Because the whole of Europe has no choice but to go to Spain for supplies: it is the last bastion. This is how a grey, parallel market is set up, neither legal nor illegal. HCQ is the same: you just have to go and buy from where there are still some, especially since there will always be some, since there are authorized indications. The Pharma Giants had rushed to 'donate' HCQ to the US strategic stockpile (the federal government didn't spend a penny...) and here they are with millions of doses of the only thing that works against COVID, but as the FDA didn't find any Lazarus effect to it, they withdrew the temporary authorization, in other words, they banned it!!!! Just like in our country! By imitating us ! Because if France, the home of AHQ/AT, bans it, there is no longer any good reason to keep it as a safety stock. The Americans were afraid that Europe would drain HCQ. Fortunately, Macron/Philippe/Veran understood that it was better to be at ease with the Americans than to worry about the health of the French.
The supposed heart toxicity was fabricated! By whom? By Sanofi, of course! An over-the-counter drug is not reimbursed, but a prescription drug is! And as the century-old market for chloroquine is slowly disappearing (resitance of the parasite). Over the counter you sell it for $1, on prescription you sell it for $3. Of course, you will sell a little less... Sanofi ? A strange silence, don't you think?
19/06/20: HCQ and cardiac risk: an organized hysteria
Hysteria is a widely shared misconception that no one would dare to question until it is written off. The flat earth, the existence of a Jesus, cholesterol, BCG, etc., etc. etc. The idea is spread from book to book, without any verification. One comments on the commentator, who commented on another, etc. It is the man who saw the man who saw the bear. One remembers the false 'testimonies' against the intermittence. So we look for the source of this famous cardiac toxicity of HCQ, from which nobody dies. Here is what the FDA says about it: Hundreds of thousands of patients are treated daily (malaria, lupus, arthritis...), so reported cases, by whom? How many? What is 1 per 10,000, 1 per 100,000, 1 per 1 million?Oh sure, there is probably an increase in arrhythmia, well... But that's what a lot of drugs do. And this is perhaps where the problem lies: this study Risk ofQT prolongation associated with the use of hydroxychloroquine with or without azithromycin in COVID-19 patients shows that the vast majority of the patients studied were already taking 2 QT prolonging drugs. So for them, unless they stopped, the time to get rid of SARS-CoV-2, they had 2, then 3 then 4 (AT) drugs with Qt prolongation! From there to die... Especially since COVID, from a mortality point of view, is still serious
The risk mounted on a pin: read, without laughing, on the WHO website: 6 April 2020 WHO 'Advice on the use of masks in the context of COVID-19'.
How do you want to make people understand the interest of the mask to people who do not wear underwear!!! Yes, we have no formal proof that a slip or a parachute is useful, while the critical risks are there!?! We are in full delirium!
Why is this interesting? Because HCQ will soon be part of our Anti... Anti-viral...
21/06/20: HIV, Intermittence: Charles-Edouard is back!
When I started talking about SARS-CoV-2, in XXX, I didn't think we would have such an anti-HCQ hysteria. My motivation was to comment on the use of ARVs in this context. ARVs were not retained, and everyone's attention was on COVID. There was no need to talk about anything else. I spoke early on about HCQ/AT dual therapy (known as Raoult's prorocole) and I followed suit. The natural slope followed by Raoult (culture techniques, in vitro trial, small primer trial...) is based on a deep and well argued reflection. I didn't know then that the world would split into 2 groups, the PRO-Raoult and the ANTI-Raoult. Having already used hydroxychloroquine, which I thought in all good faith to be sold FREE, during a trip, I was shocked to see the outburst of nonsense about its supposed danger. This hysteria having reached the top of things, it became impossible to get some, while we all have more or less relatives who, even today, are exposed to a mortal risk. I explored the possible alternatives (Doxycycline with or without ATZ Atazanavir), with 2 subjects of satisfaction: I have some, and it is not forbidden by the disastrous Veran/Salomon decree, so we can get some. I had also supplied Zinc. The course of events could have led one to believe that I had become a Radio Raoult, as one could have believed that I was Radio Leibo. This is not true. Radio Leibo exists, it is the Friends of ICCARRE, Radio Raoult, too, it is France-Soir. Reading France Soir (fed by Raoult and Co) made it unnecessary for me to comment.Soon a classic HIV post: I have delayed the publication of articles that deal with the history of L'Eclipse, Biktarvy, adjuvant techniques. Publishing an interesting topic in July/August is the best way to make it go unnoticed! So that leaves us the leisure of an HIV article, at the end of June, and we start again in Sept, with Biktarvy (which starts its life of 1/7) and other exciting topics. The COVID soap opera is not over! but HIV is back in its place!
| Suggested interactions between HCQ and common ARVs (in progress... 05/05) | ||
| Molecule | suspected effect | |
| Abacavir | No corresponding record | |
| Emtricitabine | No corresponding records | |
| Lamivudine | No matching records | |
| Tenofovir | No matching records | |
| Efavirenz | The risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with efavirenz. | |
| Etravirine | No corresponding records | |
| Nevirapine | Nevirapine metabolism may be decreased when combined with hydroxychloroquine | |
| Rilpivirine | Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Rilpivirine | |
| Atazanavir | Risk or severity of QTc prolongation may be increased when hydroxychloroquine is combined with Atazanavir | |
| Darunavir | No corresponding records | |
| Fosamprenavir | No corresponding records | |
| Lopinavir | Serum hydroxychloroquine concentration may be increased when combined with lopinavir. | |
| Tipranavir | Tipranavir metabolism may be decreased when combined with hydroxychloroquine | |
| Bictegravir | No corresponding records | |
| Dolutegravir | No corresponding records | |
| Elvegravir | No matching records | |
| Raltegravir | No matching records | |
| Cobicistat | No matching records | |
| Ritonavir | Ritonavir serum concentration may be increased when combined with hydroxychloroquine | |
| Maraviroc | No corresponding records | |
| cave canem de rigueur this blog is not medical advice (especially since medicine has proven to be poor) source: drugbank | ||
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