184

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Mono-Cabotegravir: it makes sense!

By Charles-Edouard!

Read right here, in the discussion ...

Knock on wood... That is to say, hoping that it will hold up against all odds? At the beginning, in 6/7, I was a bit nervous. Knowing where The Monster is, at D+27 in my case, knowing if he has a reservoir lair), disappeared in my case, it helps to live confidently, without even touching wood. We can consider 2 approaches: Eclipsotherapy (measuring the Eclipse, then adjusting the tempo, or cautious advance, under frequent CV, at the beginning, starting with 2/8... This is how I discovered my new mode...

The Right Dose: a promise never kept

Overdosing does not happen by chance: it is imposed, among other things, by the emergency. ARVs, when combined, can do more than add up. By synergy, 1+1 = 3 or 4 or...10. Synergy will apply to A+B (e.g. HCQ+AT), but not to A+X. The Zotorities, (in fact, only the FDA counts) were considering an adapted dosage, reflecting the synergy. That's good, that's legitimate, but in a hurry... The pressure was on for a "let's see what happens next".

It's understandable. The promise is legitimate... The labs are doing their jobs, each one on its side, proposing the maximum dose, without even trying to position themselves on an optimum of efficiency, cf RAL, EFV, and so on, the Zotorités have done theirs: authorize, and behind... Behind... The medical profession is absent! Patients you have been betrayed! Betrayed by whom? The medical profession which has failed to keep its promise and its self-proclaimed deontology of not doing (too much) harm!

They did not do the job! Period! Some of them have tried a little, the Fauci, Leibowtich, Katalama, A. Calmi, with more or less intelligence and more or less perseverance. The associations have seen their members change, the initial pugnacity is lost: nobody cares and the victim is you! Doubly... Firstly because the overdose is never a plus in terms of health, and also because the billion Euros thrown out of the window, it is as many relocations, unemployment and social suffering!

Overdosing: EFV, NVP, RAL and the ultimate... DTG

In a famous article, A. Calmi gives some historical examples. Alaxandra, why stop in such a good way? Why offer the dosage only to patients who do not tolerate it well, as if toxicity was limited to intolerability.

The most devastating drug is Efavirenz. First, because its tolerability is so poor. Secondly, because the shameless dose of 600 mg has finally been replaced by 400 mg (see WHO). Ah yes... Replaced in the USA and in countries that depend on American aid... Yes, today we have better combos in Kinshasa than in Paris. It's to die of overdose! Finally, because the phase 2 trial did indicate 200 mg as the dose to be retained. Even worse, this trial, which is supposed to protect against overdose, was done at 200, 400 and 600 mg. 200 mg was the lowest dose tested. So to know the dose to be retained, it would have been necessary to (re)test lower. A theoretically favorable value is ... 60 mg (in combination with TDF/F-3TC), but it has not been tested!

RAL is a real galenic disaster: the manufacturer is on its third galenization! In the UK, the reference treatment is RAL 1200 mg + ABC 600 mg + 3TC 300 mg, PER DAY! It's crazy! And people are taking it! Without question ???

NVP is a lot of nonsense! Even in Bichat (Peytavin ?) we realized it! That's how obvious it is! The bioavailability of the prolonged form (XR, in 1 tablet) is such that the dose in fine is 4 times less than the ANRS threshold dose, and it works. This dose is reached with a single standard 200 mg tablet. The ANRS threshold dose has not been corrected for this. So we have publications with NVP 200 mg + 3TC 300 mg, without concern. Note that patients who take 400 mg embedded in a plastic foam only receive 200 mg, so they do not realize it but their dose has been reduced de facto. The fact remains that this drug is too expensive and moreover it is not beautiful to see!

The worst of the worst is DTG: 15 times the IC90! Only that!

DTG is overdosed: CTG is the proof

The FDA distinguishes 3 types of patients: the newcomers(the naive, so aptly named), the experienced(yes, yes, they do participate in full-scale experiments) in success, the experienced in failure: If we propose a pharmaceutical formulation to these patients in despair, it is the MA assured, without discussion. This is normal. For the latter, it is 100 mg/d. Well... let's not quibble, that's the dose used for rescue, in a perilous situation. At the usual rate of ... 1200 Eu/month, it is classic, shocking but classic. The others? Well, it's less. But not less turnover, right? I'm a big Pharma who just saved your ass, so be nice. 600 Eu/month is the usual rate. And by simple rule of three, for 600 Eu/month, you will get 50 mg. Is it useless? But we don't care: we have to save ViiV from bankruptcy (all their drugs are in the public domain).

So we give 50 mg to people who don't need it. Who doesn't need it? People who have a susceptible virus? Who is susceptible to a susceptible virus? People who are genotyped seriously (or even phenotyped) and people who are successful. So, in these people, yes! we can lower the dose, even to the reasonably acceptable dose in the phase 2 trial, i.e. 10 mg of DTG. But we, the chemists stuffed with $$, have something better! We will give you the same corkscrewbut change the handle. We change the name, the thing, we redo the studies, we drown the fish poison and... We change the dose(of the same corkscrew)... And... The target population.

We fire the Trojan horse, the failed patients, the few who have allowed us to stuff the whole planet, and us (in $$) at the same time. Read the HAS, here: right on target:
In these patients, 50 mg DTG is 15 times (15 times!!!) the IC90. With CTG, at 30 mg, it will be 2 times less corkscrew (technically we say pharmacore), that is 7 times the IC90 . And it is indeed the ideal IC90, since we have selected the susceptible patients. So even 30 mg seems huge!

Mono-DTG works on susceptible viruses and serious patients

There is a wonderful Swiss trial with 100% success (try to do better!). Lanzafame published its results on patients, without too restrictive screening, it also works if you follow the protocol well. Once people have proven that the virus is not twisted and that they know how to follow the protocol, one wonders why on earth they should stay at 50 mg!

I did Mono-DTG 1/2 pill (6 months) then Mono-DTG 1/4 pill (6 months), in 7/7, with no worries, no failure, no resistance acquired, nothing, Nada. To me, I should not be offered VOCABRIA... With my experience of Mono-DTG 12,5 mg (7/7), I will always go for MONO-CTG 7/7, just for fun.

Mono-CTG injection: it looks good...

Good compliance is key to success with Mono. And what better way to measure and guarantee compliance than with injections? It is not easy to hide or minimize non-adherence with injections... So, then... Well, that's for another time! Subscribe now!

The orphan virus is making babies

- Will mass vaccination, with a mono-centric strategy, prove to be a big mistake? I doubt that history will ever judge it. The West has been living for 2000 years in a macabre, obsolete hysteria... And the inventory of this millennial error is still pending. Is vaccination reversible? In general, no... For a real vaccine, it is not... But here? Antibodies have a limited lifespan, it is a chance to seize! Also if your virus acquires resistance, you have the choice (if you are allowed to...) between overdosing and drowning. You have to make a choice and beware of resistance breeders. While we can, drowning is my strategy of last resort. Sonigo has been explaining for a long time that from evolution to evolution, the virus should become more contagious AND less virulent. P. Sonigo gave an excellent interview. Geert Vanden Bossche explains here, in French, that the succession of waves indeed favors contagiousness, but that there is no apodictic necessity for less virulence. I had said, at the beginning, that a selective strategy of Covidization of the youngest would be possible. Now on the table: omicronization of the injected...

The false witnesses and their obliged accomplices

Francis Palombi will have admitted having deceived the journalists of BFM, at the time of a shooting at the hospital of Neuilly Ambroise Pare. Caught red-handed, he declares: Bad comedian certainly. Sincere at least. I assume my convictions. Did BFM let itself be trapped? Or has seized the opportunity to stage the convictions of... BFM. The debate on intermittence will have been polluted by false testimonies AND those who allowed them. This is important: the responsibility of the false witnesses exists, but the responsibility of the media who carry an intention, even a conviction, is even greater.

In the news

- I had pointed out Fenton's post, here is the interview he gave (and which disappeared quickly...). Beyond this controversy, his blog addresses a very interesting issue: the assessment of risk by the Bayesian method

- two articles of great importance for us: A possible sterilizing treatment for HIV-1 infection without stem cell transplantation and Distinct mechanisms of long-term virological control in two HIV-infected individuals

- Links disappear with time... My new MegaArchive keeps this blog in-extenso as well as all the resources, including video: nothing will be lost anymore...

- Happy Holidays !!!

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Turn off the TV and don't be fooled by the Parisian venality

183

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

A giant step towards recovery and that's me!

By Charles-Edouard!

My tank has disappeared... or... did I make my tank disappear?

As long as you give a prize (INSERM) or a lot of $$, it would be nice to do it for a real real ization. And, to give to those who do. Not to the spectators! The spectators watch, amazed, admire and... Applaud!

Without further ado I reveal where I stand, and we discuss it afterwards. My tank is measured every year: 2015, 2016, ... 2018. Low but present, unequivocal. 2019 and 2020: three attempts where the lab said they were unable to do the measurement. 2021: the laboratory confirms the undetectability: it is without appeal: something happened!

And this something is huge: the disappearance of the tankit's gone under the radar! Now, if you find even one doctor capable of showing such a masterful Before-After, just let me know: I have never seen one: it is the GRAAL of the grail: no one has ever managed to do it, except by genetically modifying the individual and perhaps in the Biosantech trial (to be verified...). You know how to do this, you are part of the Kador, the STARS. And if you don't know how, well, you are not a STAR.

We are talking about DNA(measurement of the reservoir according to the ANRS method) and not RNA(whose undetectability is maintained by the ICCARRE+ method)

Under the radar! it is under the radar...

When the numbers are low, the validity of the results is questionable... Yes, yes, yes... And we'll do it again in 2022(if this stupidity of sanitary pass has ended, if not, we'll do it later, or elsewhere... ). I'm not worried or in a hurry... from 2015 to 2018, the lab was able to come out with results, but not in 2019 (twice...) we suspected something! Again in 2020... These are background noise problems: the signal is drowned in a small hubbub. So for 2021, I used a little trick (that I got from Ananworanwich) to try to get the signal back to the best I could dream of. Who knows... But at least the machine spit out something! It spit out ZéRo, and that's not nothing!

When does it go under the radar?

Good question... First, when it was above the radar, it was for real. How do we know? because several months before the last 'positive' reading, I had a (very) high RNA reading (at that level of CV, it's not a blip!). This virological failure, frankly, will have been recovered with brilliance, and above all, a few months after the incident, the reservoir was as usual, in conformity with the classical observation that a short period under active viremia does not affect the reservoir level.

So moving the tank, one way or the other, is no small feat! You make a controlled slip and it doesn't change your burden. The alla Pharisee argument that intermittency (or even failure) would make the tank go up (boo!...) is at odds with what we know. There is no need to worry unnecessarily...

I think that the passage under the radar dates from 2019, and that 2021 is only a confirmation. Besides, after 3 unsuccessful readings, we could have already ruled. And all these impossible or null measures, are in a series that starts in 2019 and interrupts an earlier series of remarkable consistency!

No more reservoir? What's the point? What to do next?

As long as you have a tank left, there are a lot of questions that don't arise! Nobody asks them... And when you don't have a tank anymore, everything comes up: you are in terra incognita! So, we'll see about that next time

Obligation of treatment / Judiciarization

When a virus comes from nowhere and appears 800 m from the only laboratory in the world working on these living viruses, we say that a pangolin has been killed by a bat. When a variant appears without any known recent emergence (despite 2 million genotypes!) we immediately find the source: an S+ patient with uncontrolled HIV... Oh well... The use of some mutagenic molecule? No ? Really? No? Well... If you say so. Of course, there were some who immediately decried the situation and wished it would end: hear, hear !

In the news

- Raoult said he reviewed a forthcoming article on a very large prophylaxis study at HCQ... Hi... Hi... He knows the result... Do you? Not yet... He seems quite confident about the future, don't you think?

- In the meantime, a large prophylaxis study with VMI confirms, not surprisingly, that it has a role to play!

- Merck announces that it has stopped its Islatravir study in 1/7, under a pretext as futile as it is unverifiable. Let's keep an eye on Merck's next announcements on Islatravir. I bet that they did not hang up their apron and that the others finally gave in in the negotiations... Merck's initial objective was always injectable. The oral form in 1/7 was only for as long as there was no injectable solution... And if the injectable that we feel is coming does not work, there will always be time to come back to 1/7, but in IRT, this time, as it would have been reasonable to do from the start... We'll see... The saga continues, and we will come back to it.

- bad luck: Pasteur (Lille) interrupts its clinical trial... For lack of patients! In the middle of the e-ieme wave! You have to do it!!! it's here. By dint of being soaped the board, it wears out!(Even Pasteur... Apart from laying down algorithmic elucubrations that leave one quite perplexed...)

- Pr S. Gayet is an infectiologist who seems to deal with nosocomial diseases in hospitals (of which Covid is a part...). Behind his phlegm and his Alsatian accent, he says exactly the same thing as Raoult. It is less brilliant, less striking, but it is kif and it is here.

- A stellar article by Norman Fenton, who notes a wave of deaths, NOT Covid, among NON-vaccinated people, coinciding with the (NON)vaccination campaign, whereas this campaign is, for them, a NON-event! The (non covid) deaths of the freshly vaccinated (side effect: death...) have been attributed... to the cohort of the ... NON-vaccinated. So, of course, when you correct the bias, it looks bad. It's a bit hard to read and it's here.

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I'm walking against the current, because I don't know how to walk against my heart...