This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.
Coronavirus, HIV, ARV, intermittence...(9)
Coronavirus: VICTORY ? or not ?...
Graphic update by worldometers and Southern France Morning Post.
| HCQ/AZIT vs. the rest | ||||||||
| HCQ/AZIT | the rest | |||||||
| Date | Infected (and treated) | deceased | % | Infected (untreated) | deceased | % | p | |
| 12/04/2020 | 2494 | 10 | 0,40 % | 4181 | 63 | 1,50 % | --- | |
| 11/04/2020 | 2401 | 10 | 0,41 % | 4100 | 63 | 1,53 % | --- | |
| 10/04/2020 | 2397 | 10 | 0,44 % | 3998 | 57 | 1,42 % | --- | |
| 09/04/2020 | 2285 | 10 | 0,45 % | 3931 | 57 | 1,45 % | --- | |
| 08/04/2020 | 2187 | 10 | 0,46 % | 3835 | 47 | 1,23 % | --- | |
| 06/04/2020 | 2179 | 9 | 0,41 % | 5527 (?) | 42 | --- | ||
| 05/04/2020 | 1962 | 7 | 0,35 % | 5411 (?) | 34 | --- | ||
| 03/04/2020 | 1818 | 5 | 0,27 % | 3505 | 33 | 1,1 % | --- | |
| 02/04/2020 | 1677 | 2 | 0,12 % | 2837 | 22 | 0,77 % | --- | |
| 01/04/2020 | 1524 | 1 | 0,06 % | 2663 | 17 | 0,63 % | --- | |
| 31/03/2020 | 1283 | 1 | 0,X% | 2430 | 16 | 0,x % | --- | |
| 30/03/2020 | 1291 | 1 | 0,08 % | 2222 | 16 | 0,70 % | --- | |
| 29/03/2020 | 1003 | 1 | 0,10 % | 1988 | 13 | 0,65 % | --- | |
| 27/03/2020 | 701 | 1 | 0,14 % | 1577 | 11 | 0,70 % | --- | |
| source: https://www.mediterranee-infection.com/covid-19/ | ||||||||
12/04/20: Marseille vs Mulhouse and the health passport
What about after the Peak? There is a real difference in health severity between the two cities. We can think that the immunization rate is also different. In China, production is already picking up a little. At some point, the same will happen in France, which is already suffering from sporadic outbreaks of self-inflicted unemployment. Bill Gates and Fauci are already talking about a health passport or immunity certificate. Elisa tests are being validated by the FDA (but where is Pasteur or Mérieux?)
The good business of the businessmen
And Hop, we throw away our spoon...
According to Le Point, via ActifSanté, dixit the epidemiologist of the Pitié Salpêtrière, Alexandre Bleibtreu:
HIV, COVID, Chloroquine and their mutual interactions I just came across a gem: Sida : la course aux molécules by Sébastien Dalgalarrondo, whose chapter on the Stalingrad trial is freely available.
On 11/04/20: Marseille ! Marseille outraged ! Marseille broken ! Marseille martyred ! but Marseille liberated ! Liberated by itself, liberated by its people with the help of...
We are at war, if, if, he told you so... Yes, yes... Oh No?, No? Really? Well no... End of the game they said in Marseille. The fallen Prince came to kiss the ring of the Sovereign Bridge...
The Marseilles strategy, open port to epidemic hazards, is threefold: test-isolate-treat. Even if we would have treated with a perlimpimpim powder, we will see, it remains to test-isolate, it is the Korean strategy. The expensive alternative is to confine... A desperate and hopeless strategy. The proof is in the pudding: you have to test-isolate-treat-with-what-you-can. Of course, there is still no double-blind, placebo-controlled trial. And the mediaphere, subsidized by the government, is offended by this. Did any of these hollering people realize that making a placebo takes 3 months? It is necessary to make gels with plaster, but also gels with the active ingredient, and finally, to check the bio-equivalence. However, between the therapeutic proposal and the end of the wave, only one month passed! And Gilead had all the time in the world to send Remdesivir to the IHU... They didn't, and they don't have any more. Gilead and its Gileaolatres (Pialoux, Molina, and so on), have been caught off guard. They now have all the time in the world to show that Remdesivir is not inferior to HCQ/AT, or even to make a triple combination, sold at a low price.
A control arm, drawn at random, but you get one: Marseille vs. the rest of the world. The FASEB-1 publication dates back to 2010, a long time already... And you want to wait for the publication of Quatuor? Good luck!!! And too little for me, thanks!....
A very interesting article by Michel de Lorgeril: COVID-19 and chloroquine, why so much anger? On one point he is right, Marseille does not formally establish that HCQ/AT works, but as far as the management of an epidemic in the city is concerned, for the moment Marseille is doing rather better, as the political decisions were taken too late, including too late to prepare a double-blind clinical trial.
On 10/04/20: IHU: 1 vs CHU: 3 so victory Raoult
Macron, after having been at the Kremlin (Bicetre), with Delfraissy, is at the IHU (with Delfraissy?). To be treated there?
The mortality rate in France is 10% (12,000 deaths for 120,000 cases), compared to 0.5% at the IHU. The extrapolation of the IHU results would have given 600 deaths. Therefore, 11400 deaths are due to the lack of foresight of Barré-Sinoussi, Delfraissy, Salomon and othersMolina is not going to bring back any of his money, that's for sure. Soon the judgment of Solomon... And where is Pialoux? Ah yes... At HIV-OnAir, sponsored by ViiV... Well... Quickly a PUT Gilead...
Hydroxychloroquine is not an anti-malaria drug, it is a molecule. Look carefully at its representation: it is not written a.n.t.i.-.m.a.l.a.r.i.a, it is C18H26ClN3O. It modulates the intra-cellular pH, thus the vacuole, useful, even necessary, for the replication of pathogens (including psalmodium, rickets and viruses,...), that's all.
The anti-viral Syllogism: Read, on the web: Coronavirus is a virus; Truvada is an antiviral; I have Truvada (PrEP), so I have a possibly effective drug against SARS-CoV-2. No! Tenofovir is not an anti-viral, it is an inhibitor (i.e., it inhibits more or less well, but usually quite well) of HIV reverse transcriptase, and also of HBV polymerase. How does this make it an inhibitor of any of the SARS-CoV-2 enzymes? The enzymes of SARS-CoV-2 are, subject to inventory, a helicase, two cysteine proteinases, an RNA polymerase, etc. In vitro, this does not even work!
The Syllogism of a Nobel Prize winner: COVID-19 is a viral disease, Azythromicin is an anti-bacterial, therefore AT cannot be useful against SARS-CoV-2. No, it is not an anti-bacterial, it is a molecule! With various mechanisms. Read again Barré-Sinoussi here: 'Sometimes you hear anything, for example, talking about bacteria when it is a viral infection.'.
Covidization: Now that there is a treatment, and identified risk factors(maybe not all), Is it worth being inoculated? Before vaccination there was variolization(wikipedia): The cure rate (at the IHU being 98%, the mortality barely 0.5%, and only in elderly subjects, rather often cardiac, the question arises for a young person to be inoculated, under medical monitoring, with a stock of HCQ/AT on hand, a PCR on the ass (to intervene before any viral outbreak). Why? Because the immunity certificate will soon be available (like a variolization certificate), and those who have such a certificate will find a job, and the others will not... You are a candidate submariner, but your hiring is on hold because you are preferred to others, smarter, more docile, whiter, but you are your dream: to enter the navy. And you, you have the famous certificate and the others? No... Your old mother is in EPHAD? With the famous certificate you can visit her. It's going to be a race for the certificate!. It's not a second AIDS! COVID is an immunizer!
Breakdown of Hydroxychloroquine? India bans the export, then re-authorizes it, piecemeal. No fun having Lupus right now...
Philippe Douste-Blazy and Christian Perronne (COLLECTIVE 3 AVRIL) need your help to the petition 'Covid-19 treatment: let's not lose any more time! #LoseNoMoreTime.
Discovery fails to recruit: a randomized double-blind trial launched in at least seven European countries to study the efficacy of several treatments, including Kaletra, is struggling to recruit participants in France, explains Jean-François Bergmann, former head of infectious diseases at Saint Louis Hospital in Paris.(source): 'In some hospitals, four out of five patients refuse to participate and refuse any treatment except hydroxychloroquine'. Well... Yes... How would you like to be randomized to Kaletra? (which a Chinese trial has already refuted).
On 09/04/20: Hidalgo: let's test, test, test. Finally!!!
Anne Hidalgo proposes a plan to get Paris out of its confinement, because, it is true, we will have to get out of it... Test, test and in priority the people who are/work in EPHAD. It is not too early!If the development of the PCR test requires a little practice (there are software for that...), its development is very fast, its delay of return a little long, as for the CV-HIV: a few hours. To understand quickly, I put here three resources: a basic video: 5 Minutes to Understand PCR, a summary of the development and optimization, and finally, an idea of the cost: a few euros of reagents, which can be ordered by internet. Of course you can do even cheaper and faster with an Elisa test, but it takes longer to develop
Happy with the Super intermittence. Well, I'll make it short... I just had a problem where I am happy, happy with the Super intermittence. I have a small surgery to do... except that I'm stuck, so the doctor suggests me to wait with some meds, it's a classic in this matter, because, she tells me, it's not the best time to go through the hospital. Yes, she is right...
What's-his-name is classic, I can easily find it on Wikipedia, but not bibule, which is rarer... No need to go to Action-Treatment, useless in this case, my usual doctor, not available... Hop, I go on drugbank, the reference in the matter. And there... Bingo: pharmacokinetic interaction (slowed metabolism). It's been a good week since I took ARVs, so I go there, and I have time to devise a strategy and go back to my usual, and still equally absent, doc. The plan:
- day of taking ARVs: 1/4 of taking these new meds
- the next day: 1/2 dose of these new meds
- for 12 days (yes, 12 days...), taken as prescribed.
On a 14 days cycle, I only lose 1 day of intake, and, I minimize the risk of interaction. Of course, I'll ask my infectious diseases specialist, just to be polite, but hey... He is busy elsewhere, obviously... And here, I think it's pretty good that I'm not on an injectable, because DTG (actually CTG) is incompatible! It would have been necessary to wait for the complete elimination, that is to say 1 to 2 months! There, frankly, 1/15 is better!
On 08/04/20: Are you SeroPo? That's right... Move along!...
IHU did not release its numbers yesterday, 07/04... The number of new patients admitted to IHU is declining... They did release this:
Not screening people in contact with the very old is criminal... There are going to be lawsuits, because with PCR, once you know what you are looking for, you concoct a combination of primers, which you choose from the catalog, you take that from the lab's stock and after a certain number of cycles (typically 40) you have the answer.
The genetic code having been published, any microbiologist of race, develops the manipulation. A PCR is done very well on any RNA/DNA, even prehistoric residue. Well... It eats up consumables (primers = primer) so if you want to make a lot of them, you need stock.
It's a bit like a color, if you have magenta, cyan and yellow on hand you can do what you want.
Let's take the example of a young girl, like Tatiana Ventose, who probably caught the virus, she thinks she is SeroPo-at SARS-CoV-2, she will soon have an undetectable CV. She can safely contribute to society... Question: Will she be confined? Wouldn't that be silly? In some places, 10-15% of the population is immune. Proportion that will increase. Containment will become untenable, even in the version advocated by the Academy of 'Medicine'.
The Dallas Buyer Club spirit and non-orthodoxy: We see a rebirth of a militant passion, because in the face of institutional inertia, sometimes, we must be able to act for ourselves, our loved ones or our allies of the moment. I am doing a critical and unorthodox blog, with one hand, and an orthodox proposal (OMNIBVS), with the other... It makes me angry to have to criticize Barré-Sinoussi, Pialoux, Delfraissy, Molina, Raffi, Gosn, and so on... We do the trial, we put Morlat and the HAS in motion and basta! We have better things to do than to fight against old moons, damn it!
On 07/04/20: HCQ/AZIT vs the standard: the gap is closing! We have to keep up...
Raoult does something very XXIst century: he publishes in real time. I like it! This is the future: we can no longer afford to wait 6 years in obscure conciliations for a very small ANRS-4D, which will have taken 18 months to publish... This is untenable. On the other hand, we must beware of one thing, which Lorgeril explained so well: we must wait until the end. The arguments of Barré Sinoussi, Pialoux are laughable. Molina, a little less so: he reports a certain disenchantment in having used HCQ, in the critical phase of the disease, which is contrary to Raoult's recommendation, who says that in the end it is useless. Here Molina is a little less guilty because his hands are tied by the Ministry of Health, which only lets him do it with his lips and when there is nothing else left. It doesn't make sense, but in this case, Molina is not the master of the operating mode. We'll come back to that. A persiflage of Axel Kahn is more difficult to counter-argue: How can you claim that early treatment saves lives when 85% of those infected are cured anyway?. The question is legitimate...
You treat early, in greater numbers, people who would not have died anyway... Don't be surprised to see less deaths... That's kind of the argument. Raoult is getting into trouble: the proportion of patients who come to the IHU a little too late is increasing... One can think that HCQ/AZIT has only a limited 'potency', expressed in Log of CV killed (like AZT or 3TC, in our country, which have 1 to 1.5 Log each). A patient comes in with a few Logs, that's fine, but with SARS-COV-2 we hear of 10 to 100 million copies, in some cases... And there, it may be too late for HCQ/AZIT, but maybe not for a HCQ/AZIT/? triple therapy, to come... We'll see.
On the face of it, the lack of hindsight attributable to real time, to Raoult time, can make an initial rather favorable impression change, even wrongly. Only an analysis after the fact, with the CV as a marker and sorting tool, will lift the mortgage.
If you follow my chart, also in real time, you may see something unpleasant: hysteresis. And that would be very interesting to see how SMART, START and JUPITER were stupid tests. Now we will see it in real time, and in fast time, it's great! That's exactly why I'm making the table, and soon... the curve... If we start the counter from the first day, Raoult is still ahead,
It's a bit technical, I agree, and I'll explain it a bit tomorrow. By the way, it's true that the blog is rather technical and difficult, but our interlocutors/loving Contradictors are Katlama, Schwartz, Leibowitch, and so on. One cannot hope to convince, with conferences at Pasteur, Salpétrière, CHU etc, without having some balls. Or money...
