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This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARVs, intermittence...(6)

Coronavirus, HIV: the Live Continue below...

Graphic update by worldometers.

March 22, 20: The live show resumes in week 7

The rest is here...

Le 22/03/20: Surface vs Enzymes vs Vacuole: anti-vacuole advantage

Here is the article: Hydroxychloroquine and azithromycin as treatment for COVID-19: results of a non-randomized open-label clinical trial

To enter or once entered, the 'victim' cell expresses surface proteins: this is the target of antibodies, thus of vaccines. Inside the cell, the virus machinery exploits the cellular environment to produce its proteins/enzymes: this is the target of inhibitors. A 'working/isolation space' is created around the replicating virus: the vacuole (for example, it is the vacuole that houses chlorophyll in plant cells). By modulating the pH around the vacuole, chloroquine reduces this vacuole, thus the living space of the virus, whose replication is generated. This is the accepted mechanism for the anti-malarial effect, but also for the anti-racketsia (Pr. Raoult's speciality), and possibly for the anti-SARS effect...

Taiwan has a good management of the crisis

Le 20/03/20: Reading Charles-Edouard is useful!

It's radio silence at Rantanplans. Make your choice and stick to it! It's Leibowitch or Lifetime Horse Treatment, Didier Raoult or Michel Cymes, Lorgeril or Danchin. Our readers are on the spot since Saint Darwin's day, February 12th 2020.

Sometimes the information that matters to you is hidden in the background... For example: your hospital has no Nivaquine or Azythromycin on hand. If not a blackbird... Pr. David Paterson (Queensland, Australia) maintains that kaletra can work... But well... For the moment it does not (source A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19)
On the other hand, Pr Raoult mentions doxycycline... A possible alternative? I'm interested in that, because I have doxycycline! Pr Didier Raoult:

3/19/20: D. Raoult approved by Trump, but not yet by FDA. To be continued

Translation of the original article:

03/17/20: Italy: 350 dead! Fauci is the boss

Fauci ? Fauci?? It is the father of the 'on 14'... And it dates... But anyway... Preventing Big-Pharma from doing its business(on your back...) is not a good thing: better lying than hanging. Right now, he is on all the screens of CNN, because Trump's antics are fine for 5 minutes...

France in Lock-down mode... Who would have predicted it ??? Ah... Well... I did... I did!

The boss of the moment is Bruno Canard, who leaves, here and there, a few yells about the poor funding of virology research: he(CNRS) gives us his view on the SARS-CoV-2 epidemic (aka CoVID-19, aka @PandaVirus), the fundamental research, the fight against these viruses. He also explains in this video (New drugs against new threats) the mechanism of drug development. This is the royal road, which was taken by DTG (but not Islatravir, curiously). Rupintrivir (close to L-Valine) is a candidate inhibitor of an SARS protease. Also try reading this valuable resource : nextstrain.org and nextstrain.org: Misconceptions.

And a very XVth century way to get rid of social protest... While Korea shows us the example (test, test, test...), the Macrosphere is in panic mode. Prof. Didier Raoult makes the point (100.000 views, already...), and it's clear: we have to test, test, test: it will cost less to the economy than a total lockdown! Fauci described the challenge: to do 1 million tests in a few days... And treat, at least with what we already have on hand, chloroquinine (?), to reduce community CV and carriage.

We read in businesses open despite the coronavirus: 'Places of worship, [...] will remain open, but can not accommodate more than twenty people, except in the case of funerals for which no limit is given. Great country!

Le 16/03/20: Genome, enzymes and molecule repositioning

In fact, to understand everything about this Coronavirus, it is enough to follow, very attentively, it is true, the conference made by Bruno Canard, our national expert in Coronavirus, at Pr Raoult. Everything, or almost, is there...

We learn that @PandaVirus is indeed a SARS, and even a SARS 2.0, hence its usual acronym (replacing the politically correct COVID-19): SARS-CoV-2.

That a virus escape had already occurred: at minute 5:15, where he talks about SARS1.1, in 2013, 'coming out of containment'... He says it... Cash.

This new SARS is quite complicated, because it has a repair enzyme. Like any RNA virus, its replication is subject to errors, but it corrects them, with a well explained mechanism: we cannot therefore hope to induce errors in its replication by sending it simple noisemakers, such as Ribavirin.

We learn that the very creative Rega Institute (distributed by Jansens, of Johnson & Johnson) (Tenovofir, Rilpivirine, among others - they are not wankers -) have one or more inhibitor candidates. It will probably require inhibiting several enzymes, including the repair enzyme. So, we should be able to do it.

For the moment, it's hard to see the role that ARVs could play, except perhaps protease inhibitors, or analogues, with a 'reparase' inhibitor...

The FED has succeeded in plunging the markets... Bravo! The Deutsche Bank share was worth 100 euros in 2007, it is worth less than 5 today. Soon a Lehmann moment?

We learn here(Le Figaro) that Mulhouse has been hit hard by a contamination outbreak of 2000 people, following a gathering of an evangelical church. It's the same problem as in Korea (not the same sect, I hope). Spreading the good news is also spreading the good virus. Iran, Italy, Korean sect, Alsatian sect... In the USA, it will be a hit!!!