177

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

The request made to Marie

la HASByCharles-Edouard!

Haute Autorité de Santé: it drags, it drags...

It has been almost a year since the HAS was asked to include in its work program the formalization in its 'recommendations' of what is already in the 'Morlat' recommendations.

Well... 1 year already and no way to know if it has been included in the 'work' program. At this speed, it is not sure that the HAS still exists when it will be released!

The formalism to which one must adhere to make such a request is in itself a first barrier. But that doesn't matter... On the form the HAS has received the document in due form. But it's been 1 year since we had any news...

The technical argument: General statement to explain the request

This is how the text starts:

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Quote of the month...

From the famous Dr. Zelenko :

And you thought it was age and some comorbities!

Well no... If you are Chinese, Korean or even Indian (yes, yes...) your 'chances' of passing are not comparable with, well, let's take the most sinister example: Londoners(or even the inhabitants of the 93, that's not sad either!). As for the doctor, we've understood that for a long time!

The real insider tip is to know which doctor to go to...

176

This was originally published here, in French (link).
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Genesis of Islatravir: 1- Race for Efficiency

By Charles-Edouard!

Islatravir and Soy Sauce

To understand Islatravir and what I'm going to talk about today, you have to be sure you've read this first post, because Islatravir is a novel that starts a thousand miles away from 1/15...

At the beginning was a group of Japanese university researchers who were looking for ways to add value to food products, by breaking molecules to make 'valuable' molecules at lower cost... In a word, cutting a big molecule, existing and cheap, rather than synthesizing, ex-nihilo. Vast program where the Ministry married them with a local Kronenbourg, a brewer of beer (agrobusiness, we say...).

The idea is to cut 'natural' molecules into elementary bricks. This allows to manufacture animated acids for which the market (pharmacy, biology,...) is emerging. The beer brewer doesn't care about this, but a manufacturer of Soy sauce, the one that decorates your Sushis (yes, yes...) has a division of specialized products. Yamasa (Soy Sauce) takes the place of Asahi (Beer) in this academic project. Surprising, isn't it? Neither Merck nor the usual parrots will tell you this. Because Merck will defend itself from the shameless price it will get for its research efforts, which were insignificant, as we shall see...

Islatravir and Efficacy Gain

The project is the manufacturing by (enzymatic?) cutting of molecules in bricks, with very high added value, at lower cost... At the turn of the century, the most expensive molecules, facing huge challenges of industrialization, are the ARVs, which the (third) world needs so much. So here are our brilliant university chemists(paid by the penny) who undertake to make a derivative ARV, which costs less! Thus saving the world from a certain AIDS death.

A major track is the increase of efficiency. Indeed, if we use less drugs for the same effect, it costs less per patient. Leibowitch develops a method(largely ignored by the medical-pharmaceutical mafia) which divides the cost by 10. The Japanese chemists will reduce the cost by ... One thousand!(and we will combine the two, hi, hi, hi... ). Efavirenz is 600 mg, Islatravir is 0,75 mg, which makes a ratio of 1 to 1000, by a ladleful!

So here are our chemists who start with an expensive molecule and try to improve it. Well... The scheme is hyperclassic, we start from a molecule with a known but moderate efficiency and we try to adapt the molecule to its target. A vast program!

Step 1: better resistance profile but high toxicity...

NRTIs are 2', 3'-dideoxynunucleoside (ddN) derivatives whose efficacy is due to the fact that nucleosides are RT chain terminators (CT). However, all these drugs have a low barrier to resistance. Since the structural difference between dN and ddN is whether or not they have 3'-OH, they surmised that the presence or absence of 3'-OH changes the resistance profile. A 4'-substituted 2-desoxynucleoside (4'SdN) substituent at the 4'-position was designed to achieve this goal (Fig. below).

In their hypothesis, the new compound can be recognized by Reverse Transcriptase (of HIV), and mess with it... That would be cool! The problem is that it is also recognized by the human DNA polymerase, which would be highly toxic.

Step 2: solve the toxicity problem...

Well yes... We might be able to treat better, of course, but increasing toxicity is not great, especially in the context of the 2000s. We will see next time how they solved this problem

Obligation of treatment / Judiciarization

The idea of making screening compulsory, regular, for all, from 15 to 75 years old, for transmissible diseases (HIV, HCV, Syphillis, etc) seems to me to be quite acceptable: screening is without danger, by itself it allows to reduce the epidemic, it does not imply a compulsory treatment. Voluntary screening with community pressure on risk groups has had its day: it is useful but we have reached a plateau. While we have spent crazy amounts of money(yours) for a virus that probably escaped from a research center(not from our country), we could finally put in place a total strategy of multiple screening. Of course, the associations, who gain from the 'targeting' and the martyrdom of the afficinados of natural contraceptive penetration, are against it. What the hell!

They are against you as patients and participate in the expansion of the epidemic, under the guise of fighting against it. They are the objective ally of BigPharma, which would not be at all happy with the extinction of the epidemic. Have we ever seen these associations of frightened seronegs come to your rescue for the intermittence? Never... Total radio silence.

Protocol medicine is becoming totalitarian medicine... It is inevitable!

In the news

- The front line in the global war on Benevolent Medicine is currently in the state of Goa, India. Maudrux, bothered by the Council to the Orders, is following up on it, here. This state has taken it upon itself to deal with the Indian resurgence of the epidemic by distributing Ivermectin widely. The crisis is being contained, which no one is talking about. After Chiapas, all of Mexico is getting in on the act. Opposite Goa, Tamir Nadul (180 million inhabitants) is a comparison for having followed the negative advice of the WHO and thus backed off. Two regions, in the same area, epidemic at the same time, 2 opposite strategies, this makes a credible judge of peace. Concerned' but not destitute doctors have taken the case against the State of Goa to the Supreme Court, citing the negative warning of the WHO. The Government of Goa, defends its initiative, with arguments in support. The Supreme Court lets it go ahead: see here...(one will remember the role of an Indian Supreme Court in the resolution of the Gordian knot where the ARV industry had taken the HIV world hostage)

- Remarkable interview with Prof. Montagnier: we will come back to it, one day, because his argument on the thermodynamic stability of DNA deserves our attention. The argument has its part in my strategy of reducing the reservoir.

- The IHU (Pr Raoult) publishes its series of 10,000 patients treated in day hospitals: no deaths in patients under 60 years of age, if HCQ/AT. If we exclude very old patients with low life expectancy (heavy comorbidities), they have only 3 deaths out of 10,000, if HCQ/AT. This is the largest single-center series in the world! Greetings to the Pharisees!

The French genius... seen from America...

Did you know that? The late Anthony Perkins (Hitchcock's Psycho), sadly deceased from AIDS, had tried his hand at French song. There is no more after in Saint-Germain... It's nice, and touching. You Tube offers it to you. Let's enjoy it !

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175

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Bithérapies en Cycle Court

By Charles-Edouard!

Dovato in x/7: first favorable results!

The DUETTO trial (ANRS) is announced... Well... Why not: Relief AND Intermittence combined. CoronaFolie obliges, it drags on... To the point of arriving after the battle, a bit like Recovery. Too late, it's too late... Well, we know since August 2008, in the NCT00708110 trial (Phase IIa Dose-ranging Study of GSK1349572 in HIV-1 Infected Adults), that the action of DTG lasts 3-4 days at least after the last dose. So trying DTG/3TC in 4/7 makes sense. By the way, it's JeSuisDuTreize (Mono-DTG in 4/7) who hooked me up.

So, here is our ANRS, although not very valiant, which extends the success of Quatuor(not her idea...) towards a consensual thing, which allows at least to clear the ground where the stipendiated Pharmacolâtres had with impunity amalgamated Lightening and Intermittence.

Dr. Lanzafame submits a letter to the Editor of the International Journal of Antimicrobial Agents, by M to Phillipe Colson (IHU, again!) , which is published in March 2021. The original is here. I propose a translation here: Short-cycle therapy (5 days on/2 days off) with a Lamivudine + Dolutegravir regimen in a cohort of virologically suppressed HIV-infected patients

Dovato in 5 of 7: no failure in a cohort of 27 patients

As usual, nobody talks about it, but it is interesting (and that is why the omerta is total...), and here, it is not only the result that counts. One will be sensitive to the way of presenting... Well... 27 patients, various profiles, go from Dovato 7/7 to Dovato 5/7. Nobody goes above 50, so it's all good!

A tribute to Leibowitch and the Eclipse

This is encouraging... Can do better...

Why not 6/7 ? or 6,5/7, while we are at it ??? That works too! A fortiori! Staying miles behind the front line does not allow to flush out the enemy. What will these pussilanimities be worth the day when Merck will excite, at the cost of propagandist contributions, the cage to the crazy parrots? A short shot is better than a crooked shot(Katlama, Raffi and so on), but it is still too short!

7/7 End of game, thanks to Islatravir and ... Merck

I anticipated a simple marketing problem: how can Merck regain market share with Islatravir without taking advantage of its extended pharmacodynamics (more than 10 days)? First approach: divide the dose by 10... That way you have to take it every day, and it's the JackPot. Except that now with Biktarvy practiced for a long time in 4/7, or even 2/7 or better, there is not much room for a 7/7... And ViiV which proposes an injectable...

Merck is also considering an injectable, with Doravirine. Bad luck: it doesn't work! Well... It probably does work, but the worshippers of the Pharmacokinetic Goddess lose their minds and give up the game.

Anyway, Merck (cf MK-8507) has understood what makes Islatravir strong: a 'trick' invented... almost 20 years ago! and, unwillingly, we say, launches a bi-therapy in weekly doses. You read that right! Phew!!! Saved!

At least they think so... The Phase II clinical trial is here. We'll see if it's a success: it's about time! Because Merck is accumulating failure after failure(Dutrebis and Issentress HD, which nobody is taking... ). Did you see how fast they developed a new ARV with extended duration of effect? Funny ... No ??

What will Gilead do? What are we going to do? We'll see that another time...

Weekly intake and 1/15

The mystery of the missing tank is slowly becoming clearer... Is it its disappearance that allows the 1/15 or is it the 1/15 that caused its disappearance. Well... On this one we are rather on the right side of the handle. Better to be cured without really knowing why than to think about doing nothing (Rouxioux, Hoqueloux, etc.)

Obligation of treatment / Judiciarization

It may have gone unnoticed, but YouTube has explicitly listed, and named (please!), H*Q and I*T as cause for banning. They didn't mind Foley's decapitation, but Kory's, Perronne's, etc. explanations were not. Ah well, no! Let's go to the trash! Long live cancel culture! Well... The history of the Disappeared Reservoir will also pass perhaps under the yoke of censors, who made literary studies, precisely because Sciences put them off... Conjuration of the fools...

In the news

- Garches will be a difficult label to wear... Davido, trained at a good school, therefore, safeguards his professional future. He comments, positively, on an essay that leaves however perplexing: In serious pneumonia, in hospitals, an antibacterial profilaxis is given. Isn't this futile? A double-blind trial with a non-inferiority threshold. Well... The (small) group without prophylaxis does statistically no worse than the (small) group with. So it's all good! Except that in the group without, he has a death by... bacterial sepsis. But well... It doesn't bother anyone...

- The "Journal of Experimental Pathology" publishes the study of Claude Escarguel, on the interest of azithromycin in the prevention of long Covid! But well... Nobody is interested, especially not the ANSM, whose transparency commission seems to be invisible(read Maudrux here)... Well... We are not done with I*T since it is an inhibitor of entry into the reservoir... Funny, isn't it ?

We still haven't found the pangolin... Raoult, in 2 times 3 movements, he found you an intermediary for the M.1 (green monkey of Senegal) for the M.4 (mink of Mayenne, whose genome was withdrawn from the public attention). The Chinese, they are desperately looking for the Missing Pangolin. They are looking for, they are looking for... Just like the enlightened man of Nazareth, he probably never existed except in a hysterical delirium...

The State of Goa (India) is doing a deworming campaign by providing I*T kits to the population for therapeutic and/or preventive use, all at the same time, hoping to curb the epidemic surge that India is undergoing. The WHO has rightly denounced the uselessness of the gesture. We will see! As a result, no more pharmaceutical I*T is available, including in India... One can still find veterinary I*T, but it is difficult to find a factual difference (other than the presentation, as it is generally a paste), such as a difference in purity, in molecule, etc. Nada

The French genius taken over by a Russian

Ravel's bolero accompanied the Russian Pluchenko in his sporting and artistic feat: the quadruple-triple-double jump in skating. He is the first (the first Quad is by Browning, it seems). You can find this video on YouTube, which has not aged. It is sublime. It took more than 15 years for a small Asian jig (Uno) to make the first Quadruple Flip. Since then, there is not a single champion who does not combine several Quad.

Between the first and the second, there is a lapse of time, then everything accelerates to the point of banality.

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Turn off the TV and don't be fooled by Pharisaical veracity

174

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

PCR at home? We're getting close...

By Charles-Edouard!

An often forgotten point of view...
Children, people in institutions, seniors in nursing homes, hospitalized people, etc. do not have control over their intake. They are administered to them. Since there is no hope of curing them in 7/7, we might as well give them the benefit of therapeutic progress as soon as possible! I don't see why we should continue to overwhelm them with useless drugs.

Let no one enter here, unless he is undetectable

You will find in Leibowitch's writings a slightly offbeat, slightly utopian reflection. He and the gays are not of the same side... Well... Nobody is perfect ;-)
So we made him discover the underground places of 'conviviality' in Paris. While doing so, where the guys have the easy No-Kapot. There, we understand that it's like with the minks: the virus has a good game. Well... He had hijacked the Platonic motto: Let no one enter here unless he is an undetectable surveyor. And to imagine PCR boxes at the entrance of the 'clubs' ...

Technically unfeasible, yes, but... It changes

The small HIV self-test is rather easy, convenient and... unaffordable... At 24 Eu. the sesame, it's as if there was none! So... PCR: don't count on it. The absence of a test method deprives the good students of the magic sesame. Note, with the vaccine passport, it will come out one day... Seroneg and undetectable, same fight QR-code...

I follow what is said at the IHU(the rest bores me... ) and come across the PCR POC, which they are spearheading, at least here. That is to say, the PCR at the ass of the truck... At the ass of the ... On the spot, you know! You don't go to the lab, you do it on the spot and you get the result in 30 min.(or even less, if needed)

It's not the 30 minutes that interest me... I found in a tweet of Pr Chabriere, between the mistakes of orthogafs, the investment cost of the PCR POC(point of care = on the spot)

A PCR POC machine for... 7000 Eu.: it is not 100.000...

He said: 7.000 Euros, 30 min... The medical or nursing practice, specialized, will be able to equip itself! Even the Corsicans, or other iliens, will be able to bring the analysis closer to their idilic living environment. No more need to send the samples (or the patients) on the continent. 7.000 Eu. with regard to the insane sums wasted (including in the medicaments, 1 billion per year, only for the Seropos of France), that can find its place! Of course, it will be necessary to fight against the monopoly of biologists, apparently the best paid profession in France...

The intermittent follow-up CV: can we do without it?

Just by asking the question, you immediately understand that it annoys... And for good reason! The ANRS-4D trial was published with a fraud that is often overlooked but obvious from the raw data: the only patients with a CV lift had placed themselves off-protocol. This is not to say that all off-protocol patients jumped. Far from it, as will be discussed about Quatuor. In eligible , rhythm-compliant patients, the number of cases in which the CV served a purpose is very exactly ZéRo.

Leibo, he was eating me up when I said that... But take a good look at the data: out of a hundred patients, 7/7, in-protocol, not a single feedback... That's it, the dônnées, that's it...

I am orthodox: I do my CV in close quarters, especially during the downhill period. But here, CoronaFolie obliges, I don't have access to the CV anymore. Anyway... Over a year I was able to check the efficiency of my 1/15. I'm not going to deprive myself of it because of the lack of legitimacy of a government of incompetents... So I don't do anything: no CV, no progression in my descent... I take my male in patience. Well...

And what about the others ? Well... It's variable. I even suspect some blind runs. It would piss me off if I expected people to follow a piece of advice I gave them. But, like I am not in the medical advice businessthere are no followers and nonfollowers. There are people who do, who don't do... without safeguards, without guidelines, without even believing in Bichat's or Saint Antoine's stipendiary Cassandras anymore.(there are still people to go there ??)

Obviously, without prejudice, from what I can see...

173

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

The fourth molecule

By Charles-Edouard!

You can find on the excellent blox of gerard maudrux

Synergies and reinforcement for 1/7 (or even better)

For initiation and continuous treatment, it is historically considered that 3 molecules are sufficient. Practitioners (e.g. Germans) were already doing induction/maintenance. Today too, there seems to be nothing to prevent the use of DTG x 2 /TDF/3TC followed fairly quickly by DTG/TDF/3TC then DTG (1/2) /TDF/3TC or DTG /3TC or even DTG /3TC (in 4/7) as we will soon see. Putting an extra pill, when the circumstance allows or requires it, is admissible...

Videx in addition, a futile intuition/orthodoxy?

The very first successful patient in 1/7 appears in FASEB1, and is described as being on Quad Therapy (NVP/DDI/FTC/TDF). I am not sure if the patient was on this quad before starting ICCARRE or if the boosting occurred along the way. It seems that it was like that, by chance, and that Leibo continued like that considering that the prejuduce (1 Videx more) was not very big with regard to an eventual securing.

He was keen on it, but readily admitted that there was no evidence of the futility (or not) of this reinforcement. To do the right thing (and to please the Stakanovists of the methodology), one would have had to do a good large group randomly allocated with and without reinforcement. Under these circumstances, the futility test is... futile. So not done.

For a long time, I promoted the Leibowitchian orthodoxy of the fourth molecule, aware that there was no formal proof. I have to admit that this did not convince many people. This blog is not a medical advice: you will be inspired by it, it is your choice, you will not be inspired by it, it is also your choice. And if it doesn't work, don't bother to come and bitch about it: this blog is not a medical advice, it's a double-sided cave canem: I don't encourage anyone and, conversely, no one bothers me. Right?

The fourth molecule can be useful: here is why...

For a long time, I thought that we had not done the manipulation that consists in removing the fourth molecule and see what happens. Strictly speaking, as far as I know, this manipulation has not been done. But another one... Which informs us in the same way... Except that we didn't see that it could be interpreted that way.

If the Fourth Molecule had not been removed, it could have been replaced by a placebo. That's what protocolists are like. Leibo was a doctor first and foremost, so the placebo was not his thing... The idea of replacing the Videx with plaster ... I let you judge... Well... However, Videx no longer exists, so it should have been replaced by something, a placebo? no... But...

Replacement of Videx by DTG

As Videx disappears, we start to have a good idea of the 'power' of DTG, hence the simple idea of replacing Videx by DTG. But there, there is a wolf! The literature states that NVP reduces the amount of DTG in plasma. You will be surprised to know that this is a work of Raffi(yes, the same one who... ). If we stick to Raffi's conclusion, it's not a big deal, we pretend nothing happened. Except that Raffi, he looks at 7/7. DTG fills the bathtub, NVP empties it, but since we fill it right after, the bathtub doesn't really get empty. In 1/7, we don't fill the tub a second time! And so... DTG disappears. DTG has an antidote: it is NVP!

We make NVP/DDI/TDF/3TC then we substitute, we think we make NVP/DTG/TDF/3TC, and, in fact we make NVP/DTG/TDF/3TC, i.e., a classical IRT NVP/TDF/3TC... And this? It jumps! Does it always work? No! There are exceptions, but well... We can see that with NVP/TDF/3TC, there is a benefit to supplement with DDI (or something else?)

DTG in 1/7: In TRI or in QUADRI? That is the question

All indications are that DTG counts for two: it is potent (over 4.5 Log) and it has a pharmacodynamic remanence of at least 3-4 d. Of course, we have evidence of success in 1/7...

One way to do suspenders and belt, is to take Morning and Evening. Note that in the free zone, you can find a DTG/TAF/F-3TC combo, at a very low price. In the mafia zone, not yet... Well, it's a bit of a pity... Now, the goal of the maneuver is to catch the payers (social security, etc...) on the Biktarvy ® combo. If the payer gets cheated, that's his business. From our perspective, we do not identify any difference between DTG and BTC(and for good reason!).

In practice, we read testimonials of 2/7 with Biktarvy. Why not? Now, I also don't see what we have to lose by reinforcing a bit... With what? RPV, ATV (without booster, since the usefulness of booster in 1/7 is far from being obvious: futile or even counterproductive, in this context), etc.

Islatravir: addition or substitution?

Especially sinceIslatravir is coming. Well... Overdosing seems to be avoided, on paper(too bad... ). Well... The dilemma of the 4th molecule is there in front of us: Islatravir® is not very powerful (1,5 Log) but very persistent (10 days at least!). It makes you want to use it. As an addition or as a substitution? For me, it will probably be used to replace one of the molecules that I probably have too much of. For those who stayed in IRT all the way down, the question will be interesting. Might as well start thinking about it!

In the news

- A controversy (pro and anti HCQ), a randomized trial and each side claims victory! This is normal: in order to be published, the authors conclude that it doesn't work... This allows them to reveal their data, which show... that it works!

We have a bit the same thing with the Eclipse: all conclude to a quick rebound, because such is the Zeitgeist, but, in reality, it is long enough to be exploited. Nobody would dare to write that!

Genius, but not French...

THE (not THE) French genius, and of its language, is to say THE Covid, as it is quite natural. That's THE genius of the language, it's precisely what can't be reasoned... Especially since in reality we are entering the era of the Covid.E.s...
There is no genius of the Europeans, who taken as a whole, are rather sterile... It is illusory: I could not even name a contemporary Polish or Bulgarian author. And there are other geniuses... Sometimes one remains amazed by other ways, other voices.

Miyasaki appeals to an ecologically sensitive public, so youtube advised me this strange and bewitching video: 450 Subscribers, 2000 readings, we are far from the Raoultian Million views, but still, it's something else... And precisely... It is... different... Enjoy!

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172

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

The Fear of Healing: Variations on a Case

By Charles-Edouard!

News from our friend @Saamred

It's interesting to hear such good news from people who have read a lot of us... There are 3 types of PTCs (post treatment controlers): those that we find by chance (rare), those that we find by looking where we think we find them (Viscontis, Antwerp ...) and those of intention, who have undertaken a process in which control is possible. This is what interests us most!

The commentary is timely, since here is one who controls, but is afraid and resumes treatment ... This is the topic of the day...

A controller identified by chance...

Here, we will dwell and, for lack of a better word, embroider a bit, on what may have happened in a study in our Eclipse bibliography. Sneller (2020), takes chronic patients under effective treatment and studies the dynamics of rebound. There, Surprise!

One participant (#03), who spontaneously controlled his plasma viremia, resumed ART even before meeting the criteria for restart.

This patient is indeed found in the table, restarting treatment at week 13.

A PTC that falsifies this study, and the others...

We had seen that in the Davey Study, a very long Eclipse patient was distorting all the statistics. It lengthened the mean and especially the standard deviation(one should be wary of automatic calculations...). We had the table, we could redo the calculation. Here, it is the other way around: the patient takes the initiative to resume the treatment, thus shortening the recorded duration, integrated in the calculation.

The control arm tests are distorted

As we saw in the Levothyrox case, comparing population A to population B only makes sense if the standard deviation AND the range are both narrowed. In the 'modern' patient, this is no longer the case: we have a little of everything: between 1 and > 4 weeks

The Thirst for Glory incites to deceive the patients

Control arm trials are flawed, and sometimes unethical. Not the trial itself, but its preparation: an example is given by a Spanish study: Extremely low viral reservoir in chronically HIV-1 infected treated individuals.
What is the point of having a weak reservoir if not to be able to try PTC or, even better, Eclipsotherapy? Having a long Eclipse and treating 7/7: how stupid!

It is not difficult to imagine that the constitution of registers of patients pre-selected for trials is not compatible with explaining them on 4/7 (or even better). In order to do medical science, doctors are probably tempted to keep silent about reasonable alternatives...

On the road to recovery, there are...

Either the PTC or the Eclipsotherapy... Both allow to simulating a cure. Including seroreversion. Imagine: No RNA in the blood, no DNA in the reservoir, no residual meds in the body, and a negative serology. A sweet unattainable dream? Not sure, we'll see that another time...

Some anti-COVID news

-Ivermectin is entering the medicine cabinet. It is now the standard of care in many states (see here Ivermectin, used for Covid treatment in UP, replacing hydroxychloroquine. Funny to observe the absolutely canonical curves in India: one wave, an epidemic in decline, 10 times less deaths than in France. And, them, they still know how to make medicine!

- I tried the Raoult glove techniqueThe situation was right: I only had household alcohol (it leaves an unpleasant feeling on the skin) in a crowded place, touching a lot of things. It is necessary to understand it well:
-1- Beginning of the procedure: clean your hands well with alcohol (one that does not damage, if possible)
-2- Put on new or previously sterilized gloves
-3- Clean your gloved hands with alcohol (even rotten) very often (alarm every 30 min.)
-4- At the end of the procedure, disinfect the gloves well, then remove them and re-clean the hands
-5- Disinfect the gloves with alcohol (outside and inside) in order to reuse them (or destroy them)
Results: very good procedure, no hand aggression, use of cheap alcohol. Very happy!

- A reasonable plea for early treatment: The need for early management of patients with COVID-19

Obligation of treatment / Judiciarization

We are obviously interested in all the media hype about mandatory vaccination for an easily treatable disease, when, on the other hand, systematic HIV screening would allow its eradication... The associations do not want it... Why then ???

In the news

- Alex Sigal, excellent biologist, already quoted here, highlights a lower efficiency of acquired immunity against the Lacombe-AstraZeneca 501Y.V2 variant: Escape of SARS-CoV-2 501Y.V2 variants to plasma neutralization in convalescents

Whatever the concentration of 'old' antibodies the Lacombe-AstraZeneca mutant doesn't care!

One can expect a violent awareness of the consequences of the Pharisaical School of Verology(Lacombe, Pialloux, Pazdan, etc.) on the health crisis of nerves. If one (or more) variants could escape from a place of care, what about a place of manipulation such as Wuhan?

The French genius (well... yes... almost...)

This beautiful wool is the first award-winning work of Karl Lagerfeld. It's amazing! You can find it on YouTube. YouTube... from which Leibowitch has almost disappeared... Bizzare isn't it ? Almost 1 year since he left us. Not sure I'm inclined to comment anytime soon. Maybe time will help...

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overmedication is an opportunity if you know how to use it!

171

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.

The Saint Darwin 2021

By Charles-Edouard!

Alexandra Henrion-Caude is said to have said the following:

Well... In the hysteria of the moment, what seems to bother AHC is that it takes people away from their ordinary, millennial hysteria... She is clearly in the opposite camp... That said, she is challenging us in her professional field (the NRA) and I think it's a shame that censorship is the only argument she gets.

Darwin: the beginning of the end for a thousand-year-old hysteria

He says it himself: it is like confessing a crime. Certainly, primitive Darwinism exposes the commonancestry. It is a materialist atheist's delight to feel like a family among living beings: all alive, all cousins. Enjoyable...

This is the first time that a person has been able to see the world from a different perspective...

Raoult reminds us that incremental mutation is not the only cause of variation. Okay, Okay... Darwin was not yet into microbiology and gene exchange. Nevertheless, the selection pressure is THE issue of the moment, as raised by Raoult. If Remdesivir + Serotherapy(K. Lacombe and all the clique... ) are at the origin of new variants, it's going to look bad. No more need to let �� escape a laboratory virus. The whole world has become an open-air laboratory!

I am afraid that the same people who yesterday carried the 'principle' of precaution to the skies, are today communing in the Holy Vaccinal Ostia. The same people (Lacombe and Co.) who were pinning a fanciful toxicit�� of Quinine syrup, sweep you, today, off your feet the genomic risks of Genetic Vectors.

They will have scoffed a lot at those who found it very strange that a virus so well adapted appeared in the same city where experiments, forbidden elsewhere (and for good reason...), of function gains were made. The pendulum is now swinging in favor of this theory...

One cannot think of biology without Evolution... Back to Sonigo!

As a comment to a discussion that can be followed starting here: Are we paying for a fundamental error [...], Pierre Sonigo comments as follows:
Certainly... Provided that it is indeed a coronavirus avatar alone and not a chimera X + Corona. But, precisely...

The Ghost Pangolin, fucked by a Bat!!!

Finally, a reasoned discussion A Bayesian analysis concludes beyond any reasonable doubt that SARS-CoV-2 is not a natural zoonosis but rather a laboratory-derived virus.

Unless the virus has recombined in a natural environment with another virus (which one?), there is little evidence of genetic manipulation or laboratory recombination. However, the (only?) laboratory known to make gain of function is the one in... Wuhan. With the passage of time and the notorious inability to find the missing link, the theory that it is God who creates Adam Zhengli Shi who creates a virus is gaining momentum. Viruses have one (or more) ancestor(s). Only one, when it is a question of incremental mutations(for example in Remdesivir), several in case of recombination. The Wuhan Virus is remarkably different from what is known. And there is no need to go back before Methuselah!

Here is what we can fear in terms of 'natural' gain of function:
- An immunocompromised patient or a test tube
- suboptimal use of Remdesivir, or any other mutagen
- a few natural antibodies

And presto! Here is a variant with gain of function... And since there is fat, and manipulations take place on a large scale, we have the right to expect the worst... But then...

In the news...

- DUETTO: official announcement of the ANRS:
the ANRS 177 DUETTO trial, which should start in early 2021, will evaluate the non-inferiority of dual antiretroviral therapy taken 4 days out of 7 compared to continuous dual therapy at week 48, in virologically successful patients on ART.
This should piss off more than a few people, and I'm surprised that pharisaical vetrology hasn't managed to get it cancelled yet... To be continued...

Quatuor essay:
- EudraCT(2017-000040-17) indicates that the trial has been completed.
- ANRS informs that the lead article is in preparation.(press release of 11/30/20)
As a reminder, the objective is to evaluate the non-inferiority at 48 weeks of the strategy of taking antiretroviral treatment on 4 consecutive days out of 7 versus the strategy of continuous treatment 7 days out of 7, in patients with virological success on antiretroviral treatment (CV<50 copies/mL).

The results of the comparative phase, the only one allowing to rule on non-inferiority, are published. The authors concluded that the trial was non-inferior. The trial was continued to include all patients. The 2 arms being in the intervention, this continuation does not contribute to the comparison.

- New entry in my Eclipse bibliography: a CASTAGNA study, from 2019, with 9 patients, and a mini Eclipse of 2 weeks, mean at 21 d. As usual!

The French genius: Riri, Fifi and Loulou...

I had a lot of fun! Riri, Fifi and Loulou.. You should have thought about it. At the time when I was following the IHU videos, there were 400 subscribers. Today, the smallest video has 1 million views! To have identified that a banal molecule, that I had the opportunity to eat many times, that I buy without even thinking about it, recommended by the best medical journal(the Guide du Routard) can shorten your suffering time, I thought that was good... To gain a few days on a bad flu, why not? At the beginning, it was just that. Very quickly the world split in two: the Raoultian Dreyfusards and the anti. With so much bad faith that we end up with a selection bias: we don't even bother to listen to "the other side".

Now, I had the opportunity to reconnect to Fiolet's twitter(Nathan's is a real problem for us patients, which we will have to suffer from for many years). But Fiolet, him... He has a Belgian accent to cut to the knife a good little background, which invites to follow. And very quickly I find there the bias of all these popularizers, these keyboard seropos, who think they are doing the right thing by being the megaphone of the laboratories(to whom you owe your life, they claim), to the point of forbidding themselves (and you) the intelligence. Fiolet seems to think that any series of figures can be analyzed mathematically, without a deep, sharp knowledge of the field.

The self-criticism of the CMI editors (@CMIGate) suggests that a retraction is coming.