166

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Timothy had the gold medal, I had the silver

By Charles-Edouard!

I am publishing, in extenso, in French, the original testimony, unpublished in French, of Timothy Ray Brown, known as the Berlin Patient, recently deceased. It is from his own pen, short, clear and very instructive...

Timothy Ray Brown interests me... He was my only competitor

6 years of anonymity vs. 6 years of rehabilitation

We understood that it was not an easy task. Reading the Figaro Madame, one could think that this poor man had come out of anonymity, after much hesitation, whatever it cost him, to save humanity. What a beautiful fable !... We almost fell for it!

6 years to rehabilitate a body made stupid by the disease and its treatment, one understands well that it was not the moment to spread, in this sad state, on the TV sets.

If the gold medal is at this price, then we think twice. Especially since it is the result of a brilliant opportunism, where we have a strategy, duplicable, economical and painless!

The Visconti: is it a strategy?

The Visconti cohort is made up of a few patients who control their virus after an interruption of a treatment initiated very early. The proportion of those who succeed is very low, and the majority of those who do not succeed. One can even say that the attempt to reproduce this French cohort, within the SPARTAC trial, is a failure.

Frankly, being rescued for falling into the water at the feet of the lifeguard and his stock of buoys does not deserve the name of strategy or something to be proud of.

The inability of the French virology, lined up against the interest of the patients, in favor of Gilead's interests, to provide even a few Neo-Viscontis is flagrant. In the last few years, only one patient, to be confirmed, at most. No one dares to ask the question: why we were able to make Viscontis at the beginning of this century and we can't do it anymore 10 years later, despite the doctrine of treating (too?) early. If the Visconti approach could be considered as a strategy, it is no longer so, since we do not know how to make it live. Let's get new Viscontis, in numbers, and we will put Visconti back on the podium.

To die cured or to be cured reasonably

One can speculate for a long time who was the chicken or the egg, who was the virus or its aggressive treatment that contributed to this leukemia, whose fatal outcome could have been delayed for a while. Living with a sword of Damocles over your head... Given the success rate, being a Visconti must not be much fun. We, at 1/7 (or even 1/15), are doing well. I am going to finish and publish the table which allows to visualize the evolution of the Eclipse after the interruption of the treatment. In about fifteen years, it has gone from a few days to a few weeks... That's what occupies my confined time ...

The risk of observing a rebound of the virus has shifted: the monster has withdrawn into its reserve. But isn't there a risk of increasing the reservoir to be interrupted intermittently? If this were the case, we would observe an enrichment of the reservoir during ATIs(Analytical Treatment Interruption). We have looked at it from every angle and we have never seen it... But if we have a rise of the virus, don't we risk, theoretically, the appearance of resistances? Well, theoretically, no! And even less as the cycle is ultimate. It is paradoxicalI know, but the very Gileadist Dr Joel Gallant gives us the keys and reassuring observations. We will come back to this, because it is ineresting...

Quasi-healing... What responsibility?

Being cured doesn't make you an obligatory activist! Who benefited from the Timothy Brown affair? If not those who are funding the whole thing? The important thing is to get the truth out, to exploit the opportunities, to live with as little toxicity as possible. In short, LIVE!

Afterwards... There is progress to follow:

- We wonder if it makes sense to consider the PreP in 4/7
- We wonder if it makes sense to consider a switch to Doravirine in 4/7

Little Wolf does the occasional PreP, he tells me... Not continuously, because his I'm-out-and-I'm-out period is put on hold. So the question doesn't arise directly, but well... I'll come back to that.
The same goes for Doravirine, which may have a small advantage for those who practice 2/7 (or even less) in Quadri, and do not know how to use NVP. So the question does not arise directly, but well... I'll come back to it.

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Turn off the TV and don't be fooled by Pharisaical veracity

165

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



I test IHU and IHU tests me

By Charles-Edouard!

Travel Medicine: Prophylaxis and/or vaccines are essential for travelers... Well... I testify...

And the young girl nervously called her mother.

COVID test in 10 hours!

You can find almost nothing on the Internet, except this excellent post: I tested for you... the PCR-72h at the IHU of Timone in Marseille: 3h30 watch in hand to get the sesame within 24 hours.

I can confirm: 40 minutes in line, about 20 people in front of me. The results, in routine mode, asymptomatic, were published in 10 hours.

Raoult, the media-savvy professor from Marseilles, has set up a formidable screening war machine that is reactive and runs smoothly, despite his detractors.

Raoult organizes and advertises

The stewardship follows... The video was published after my blind test. It says it all, explains it all. You can find it here. The national municipal sport of Marseille is the attempt of free-riding. There are PROs. There is also a service of order... We are not in a model city, either!...

Why IHU rather than elsewhere? 24 hours and Ct = 35

I chose IHU because of 2 technical parameters, guaranteed, availability within 24 hours and a 35 Ct. Ct's of 40, or even 42, have a 1 in 2 chance of unnecessarily cancelling the trip! They are misleading! At check-in/disembarkation no one checks your Ct. I am putting all the chances of success on my side...

I am also testing the Raoult triple therapy

It's negative, of course, and I have no desire to catch it on the plane. Once I passed the test, at the very minute, in the corridor of the IHU, I swallow my first dose of HCQ + Doxycycline + Zn. I use Doxycyline because it is prescribed as an anti-STI prophylaxis, thanks to Molina, useful for this time... Here is the Molina publication: Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections. Here is the Molina dosage: doxycycline 200 mg within 24-72 hours of condomless sexual encounters. Not the same as the Marseilles potion. The box is the same.

If I am positive, I will become negative again faster!

HCQ is harder to find since the infamous Buzyn decree. But hey... There is not only France in the world!!! There is also the Northern Districts!!! Marseille, you can find everything!

I am used to Nivaquine. This product has been sold over the counter since the dawn of time: it has no business being on list 2... I never had any problem, and now, I don't feel anything at all. No interaction, that's one of the advantages of the 1/15, you go between the drops. Note that Raoult had excluded some patients because of their continuous ARV treatment. This does not concern me...

It appears that HCQ is to be reserved for outpatients or first line (emergencies). Its administration in intensive care, or even in hospital, late, beyond 2 days from the onset of symptoms and/or in severe forms, is still under debate. Hydroxychloroquine + Azithromycin as early as possible (first day of onset of symptoms), Zinc, Vitamins C and D have their place in the management of COVID-19 viral infection.

In short, treat as soon as possible. Waiting for PCR results for several days is a deleterious loss of chance. The Moroccan strategy takes the Raoulian motto the wrong way. Instead of test, isolate, treat, it is treat, isolate, test. This makes sense because the treatment is, in a civilized country like Morocco, immediately available, very inexpensive, and safe.

Can you get a result within 24 hours ? If yes, Raoult procedure, if not, Moroccan procedure, if yes, that works too! Can you get HCQ+... within 24 hours ? If yes, prescription/pharmacy. If not, anticipate and manage! This can save you a lot of worry and anxiety. My pharmacist tells me it's on back order...

Raoult procedure or better yet... the Moroccan alternative

The leaflet distributed at IHU ...

The official Moroccan protocol is here : Hydroxychloroquine is not a cure, but it slows down the contagion (Ait Taleb) .

Here is what he says:
Here is what this speech hides: an over-the-counter medication (as it has always been) is a matter of patient freedom! Chloroquine is Quinine syrupIt is found in the syrup of my ancestors and in Campari! This molecule has nothing to do in list 2: it is even a crime to have put it therewithout any justification!

Here again, the zotorities have seriously harmed the interest of the patient...

I act accordingly... If I need the test, I know where to go... To go from Paris to Marseille cost me 89 Eu. and a tiring day. If I had been sick, it would have been impossible! So the test, from the point of view of the interest of the non-marseillaise patient, is a waste of time, of chance. What does going through the toubid box bring?

Better to avoid doctors: there are too many who are very bad

163

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



I baptize you "Eclipsotherapy "

By Charles-Edouard!

Ameli publishes every year a detail of the health expenses. 1.27 Billion (billion!!!) Eu. are spent on HIV/AIDS drugs. That is about 12.000 Euros per patient... For standard treatments, it is more like 8.000 Eu/year. This is still enormous and hardly bearable by a faltering economy.

We change the terminology

There are 2 types of lightening: the cycle or the reduction of molecules. The cycle works (Faucy, FOTO, etc.), the reduction did not work (Katlama, Delfraissy, Pialloux, Rouzioux: Trilège...) quite well. Historically, the only reduction that worked was the Cycle. The rest was left out. Lightening or cycle was synonymous, and lightening spoke to patients. With DTG, which counts as 2... the reduction from 3 to 2 (or even 1) makes sense again, and, lightening by molecule reduction has surfed on the nascent success of the Cycle, phagocytizing its success and its appeal to patients. To clarify, I no longer use the word alleviation to refer to short-cycle alleviation. I prefer Intermittence, a term that can unfortunately be confused with CD4 guided intermittence, which will have been a failure, when done poorly... I like Dynamic Remission better. Again, this can lead to confusion...

The name ICCARRE was based on an interesting idea: to create a brand. The word play is not convincing, and, except for advertising the 'brand', the attention is quickly diverted.

Eclipsotherapy

This term is inspired by serotherapy (therapeutic use of blood serum). Since we use the properties of Eclipse, we circumscribe to this property only. It is easily anglicized...

What I like is that there is then no no confusion with the products and techniques put forward by the Labs and their henchmen. They won't be able to lump us in with SMART, TRILEGE, MONO-IP or other strategies that don't interest us here.

Eclipsotherapy and medical corporatism

One topic that tickles my readers is the following:
The Eclipse is, on average, about, say, 2 to 3 weeks. On average... So there are people who are at less, others who are at more. On one side of the space defined by this bell curve, there are patients at 7d. (there are almost none below) and patients at 45 days. For some it is detrimental to do the 1/15, for others it is detrimental not to do. And since the median is around 15-21, to put it simply, let's say that 50% of patients would be wrong to aim for 1/15, while 50% would be wrong not to.

Having written the 4/7 Practical Guide, back in 2014, which has not been denied since, I note this: in 4/7, there is no question about medication choice. The only question to eventually ask a doc is: am I eligible? To which 99.95% of the doctors answered no, when the correct answer was yes! So 99,5% were bad advice: we must not forget it. In fact, everyone is eligible, a priori. Young people (Breather), veterans, pregnant women (FASEB-2). You just have to follow the right rhythm, leave yourself some time before starting, take according to the planning, make your CVs well(at the beginning...), and progress gradually. If someone wants to demonstrate that the doctor is useful, go ahead and argue. On this subject, there is no real debate, in the absence of arguments and... doctors. My doctor declared himself incompetent. Duly noted. It's honest, at least.

Some people fear that if they start a race to the bottom, they will fail, others don't care. Those who lived through the difficult years are on one side, those who dealt early, with a zenith of 5000 copies, are on the other. And what is desirable is to manage the risk well, something to which, if you know someone competent, or allegedly, you tell us: we will send him the readers. For the moment, there is no one, Leibo has left us, and, the entourage has lost the focus.

Eclipsotherapy and pharmaceutical choice

The opportunity exists, for about 50% of patients, and the risk exists, for about 50%. But if you're interested in 1/15, you have to be able to assess your risk and manage it, without a doctor, of course. But it's possible, and it's not that complicated. It requires a little expertise, expertise that is not the exclusive domain of doctors. Expertise is not the exclusive domain of anyone, it's like Chinese... You have to study your case carefullyAnd having a diploma for having learned a medicine that is now outdated, does not help. Writing the algorithm for calculating the risk: it's possible, it's done, I did it. To write a method of risk minimization, it is possible, it is done, I have done it, I have put it on paper. And I keep it to myself, because in practice, people do as they please. I did the Practical Guide for 4/7, 3/7, 2/7 and... the 1/15, where the questions are addressed: Am I eligible, am I on the right medication, how to manage my schedule and how to deal with a possible failure?.

In Eclipsotherapy, if you ask the question about meds, there will be no one to answer you. The only two known 1/15s are, one on DTG/3TC, the other on Dodeca, and the vast majority of patients are on 1/7, possibly to be extended to 1/15, with a triple therapy that is neither DTG/3TC nor Dodeca. I do Dodeca specifically to avoid the question of choice of medication. If you try 1/15 in DTG/3TC and it goes off, you don't know if it's because of the 1/15 or the drug. No one is going to want to do Dodeca and no one is going to go with DTG/3TC. Me first... I'm not going to do 1/15 DTG/3TC when I jumped, and admirably caught up, on 1/7 DTG (150 mg).

Eclipsotherapy: To each his own

It's simple isn't it???

In fact, we don't really have any alternatives to leaving ICCARRE or the one-fit-all cycles. Why not? Because the time to rebound has become longer, on average, and so has the standard deviation. So a protocolized rhythm, limited by the shortest Eclipses, does not make sense anymore. There are too many people with long eclipses to be neglected. And it will be even worse with Islatravir, which is coming...

Well... By chance, an interesting topic has appeared in our discussions... Go ahead! We will take time to think about it, as this blog is not a medical advice

We'll see the rest next time ...

In the news

- of Peronne an interview in 3 parts, very instructive, #1- medicine is going seriously off the rails. followed by : #2- screwed up study for toxic medication. And finally: #3- It seems that some people don't want the epidemic to stop.

- the google searches that got us the most clicks were: nathan peiffer-smadja gilead and nathan peiffer-smadja conflict of interest. Google says so, so it's true... It's funny, since it's off topic. Bichat is BigPharma's honeypot, and that's in all specialties. It is obvious that we are not going...

- Again, a very interesting topic. It's in a famous show, at 2:33 Pr PERRONNE throws everything and... It is very interesting because it puts the molecule at the disposal of the poorest... You will note, while Quatuor is published and we are nearing the end of the long term follow-up, Perronne, under whose aegis ICCARRE-1 and & 2 was published, not once has he mentioned HIV. That is to say that another battle is looming and that he avoids polution. Will it last???

The French genius

The fun never ends... After the distressing phase, here is the entertaining phase, where we see the rotten virology sinking further. A very instructive portrait of Raoult is published here: Didier Raoult, rebel professor, against all odds. This chapter of scientific history is not closed and it is very instructive: it allows us to identify new potential allies, and that, obviously, is important...

A person with a little bit of gumption would start asking the question: why Sanofi, producer, asked Mrs Buzyn, in October 2019, to classify HCQ as a dangerous product after having allowed us to swallow it for 50 years without a prescription...

Feel free to comment, like, share and use

good weekend, good stuffing and not too many meds ... Huh?

162

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



4/7 in Italy! It's coming, it's coming...

By Charles-Edouard!

Very pertinent question, asked here:
What could be more natural than to think about it! When you see success rates of almost 100% in 4/7 for others, and a prolonged efficiency for yourself, you would like to think that limiting yourself to 5/7 would have been a missed opportunity. As it is iterative and Darwinian, the next increment is 3/7, it is obvious. This is not validated by a large clinical trial... So what??? it has not been invalidated either. If you don't even look for it, you can't find it!

The experimental method is described in FASEB-1: make sure of the good susceptibility of HIS virus (something that must have been done before initiating 4/7, so normally it's good), make sure of the efficacy at 4/7, don't try it under Isentress, Genvoya, Kaletra (but who still takes that?) monitor at the beginning by CV 1 month, 2 months, 4 months, 6 months (at the beginning only), and that's all! BIOLOGICAL follow-up necessary. The medical follow-up? Well... For the comfort of the mind? Maybe ? And still ... In any case, the medical follow-up in 3/7, did exist (100% success rate, subtracting the risk combos), and, in practice, it disappeared with Leibowitch...

What does the ANRS tell you? It could not be clearer: ' Get on with it'...

A new publication in 4/7

This publication comes from Italy. We had distributed our biblio to various clinicians. Including them... Did it help? I don't know. We can see that French works are abundantly cited (ICCARE, Leibowitch, Calin, ANRS-4D, Quatuor). Normal, there are not many others (Breather, in 5/7, at most...). The results are the same: 100% success, a few dropouts... It's like usual... Nothing new... And the nothing new is reassuring!

The very interesting discussion is in the body of the text. That's why I made a translation in french, in extenso. You have to read it. There is a vibrant tribute to ICCARRE, despite a small inaccuracy: Leibowitch et al. published in 2010 (FASEB-1 and 2015 FASEB-2), BREATHER was published in 2016, so Leibowitch is earlier, not the other way around...

The dosages... They are instructive!

They made 4 dosages per patient... It is instructive, because as in ANRS 4-D, there are cheaters, and it shows! There seems to be 1 or 2 who take more, but mostly a dozen, or a third, who take less. And it works just as well! It shows us the way: 4/7 is good to start... It's a start... And, after a while, you have to grow up

The threshold dose is a joke!

The threshold dose is determined by the failures when introducing the molecule in a new therapeutic scheme. Never in the long term, never... I challenge you to find a threshold dose at T plus 1 year that is equal to that seen in the short term. The good example is Nevirapine, with its dose-dependent failures at less than 6 months(thanks to poor tolerability in some), but no failure beyond 8 months. No failures: no threshold.

The authors discuss here the doses observed after 3 days of interruption (but perhaps more, the patients were just doing their own thing), and we are successful even at values well below the IC90. Note that the 'official' therapeutic dose is 3 times IC90 for Rilpivirine, while it is 15 times IC90 for the more effective Dolutegravir. Look for the mistake...

The Eclipse exists: we see it, so what does the threshold dose mean? Moreover, in the long term, we don't know how to determine it. In the stable phase, it's just a flan!

Can do better...

I like this kind of publication: it is an obvious progress in the percolation of ICCARRE at the international level. This publication is in addition to the others. This poses 2 problems:

- as long as one perceives that the Eclipse is only a few days long, for everyone(vision of the 2000s), it is quite logical to consider the results of others for a reflection on oneself. Now that we have Eclipses that are both longer and more dispersed, these tests on others, on non-identical viruses, no longer make any sense!

- The tests accumulate ad nauseam. Medical Darwinism obliges, it is only a question of time that we pass to 3/7... And what a waste of time! Obviously, if 4/7 is as 'good' as 7/7, it is no less 'bad'.

The 'enemy' of yesteryear was 7/7(will there still be people to practice it in a few years?). It has fallen. The new 'enemy' is the 4/7: it will necessarily fall one day...

In the news

- Satoshi Omura, Japanese Nobel Prize winner, presents I*T as a treatment against C*D: no doubt, a Nobel Prize is no match for 'fax checkers' without the slightest scientific background. It should be noted thatin vitro I*T is as effective on Omega as on the others...

- Before/After critical analysis of the pasteurian 'predictions', it's here, and it's scouring! (it's good too...)

- Very well documented article by Helene Bannoun: The origin of the Covid-19 virus

- Very interesting Evaluation of the methodological methodological practices implemented in Pfizer trials, by Christine COTTON

- Genetic Forcing, Self-Disseminating Vaccines, Chimeric Viruses... The sorcerers' apprentices of the genome by our excellent Bruno Canard, Étienne Decroly Jacques Van Helden (it's not free, but if you ask nicely...)

Pieces of Anthology

- The virus has not mutated,' says Professor Karine Lacombe on RTL (at 4 min 50 sec): To be enjoyed in moderation!

- Typhus, a little history on Science.org:

The French genius

Today is Saint Darwin's day! It was Lamarck who discovered Evolution. Darwin, the Evolution under pressure from Selection. This is still relevant, even if many advances have been made since then. Our French genius is Montagnier, who died on February 8.
If he had not set up the Pasteurian Laboratory on Oncoviruses, there would not have been the very lucrative patent, there would probably not have been Barré Sinoussi or Schermann at the head of this world competition. There would have been a genius, but not French...

We don't care about the rest, the squabbles, the greatness and the smallness. Read again Darwin, Descartes or Newton, it's not all rosy either; they also said some bullshit with no equal; history will sort it out.

The fact remains that for us, Montagnier was the beacon of a whole generation! In fact, I am interested in 2 concepts that he exposed:

- DNA does not integrate randomly anywhere (so depending on where it is integrated, it will be more or less active)

- silencing(passive reservoir) is a reasonable therapeutic goal(as for tuberculosis)

We will come back to this, it is inevitable, since it is our salvation...

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Turn off the TV and don't be fooled by Pharisee venality

161

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Leibowitch on television

In an ancient post JCM declares (whom I thank, by the way):

The video 'Leibowitch chez Drucker (Vivement Dimanche)' has disappeared from YouTube (like almost everything that remains of Leibowitch as a testimony Video). I am working on archiving copies. I have the video, but I don't know where I found it. There is an audio track (which is more than enough), which you can listen to from the Valas website, here. I keep a copy, so let me know if the link disappears.

Michel Drucker:
We are going to welcome a great researcher who teaches at the Raymond-Poincaré hospital in Garches, an AIDS specialist... He was one of the pioneers of the discovery of the virus, I ask you to welcome Doctor Jacques Leibowitch...
You wanted him to be there because the way to treat yourself has changed...

Josiane Balasko: I have a friend who simply told me that Jacques was doing a test protocol on a hundred patients:
Instead of taking a lot of medication every day, people with HIV are taking much less, making their lives easier and more comfortable.

Michel Drucker: You invented triple therapy in the mid-1990s, and for the past 10 years you have been leading a project called Icare. Intermittent, short-cycle antiretrovirals remain effective, which means that you are in the process of demonstrating that it is possible to lighten the treatment while maintaining its effectiveness...

J. Leibowitch: It is possible to go a certain number of days without medication without the virus returning, i.e. after an effective attack treatment, conditions are such in the patient's body that the virus has difficulty in rebounding, a viral eclipse aka viral latency time that allows us to space out the antiretroviral bombardments.

Michel Drucker: So far, triple therapy is a lot of pills 7 days a week...

J. Leibowitch: The established rule, which I have a hard time getting the invention to work against, is that it's 7 days a week, otherwise you're going to hell.

Michel Drucker: Now it's between 4 times and 1 time a week...

J. Leibowitch: Some treatments can be stopped for up to 6 days a week without the virus having had time to rebound.

Josiane Balasko: What needs to be done to make this a widespread thing?

J. Leibowitch: The rule has to be changed. It's a question of psychology, of physiology, that's a lot less chemical medication...

Michel Drucker: However, we should not think that we can do this in a wild way...

J. Leibowitch: Self-prescribing is forbidden, it has to be driven by a doctor, and until now, doctors don't do it because the rule has not been changed, that's why I'm happy to be here to present the Iccarre project and the good news, which is the reduction from 40% to 85% of the drugs for those who have to take them for life.

Josiane Balasko: I will read an excerpt from a letter from one of his patients: I am 49 years old, I am HIV positive, today I testify to be heard. There are a few hundred of us patients who take triple therapy between 1 and 3 times a week instead of the 7 days a week recommended by the medical profession: for my part, I am at 3 days a week and everything is fine.
In addition, it is time to say that HIV-positive people on treatment do not infect their partners, i.e. they can have unprotected sex without transmitting the virus.
AIDS DOES NOT PASS THROUGH YOU BECAUSE I AM TREATED ...

Michel Drucker: This means that with these simplified procedures, HIV-positive patients under care are no longer transmitting the virus... Do you have trouble convincing your colleagues?

J. Leibowitch: Yes, because it was established the hard way, over the last 15 years where the marks were taken under difficult conditions - it was more the virus that was winning; so a rule was set up defensively, and to change it, the HIV-positive people have to demand it.
The rights of the HIV positive patient to be properly treated, the right to the right dosage, it will not just come to you, you have to ask for it, and I had a lot of trouble to get to you, and I thank the host and this patient.

Michel Drucker: So, it is a question of adjusting the antiviral doses to the strict minimum necessary and sufficient...

J. Leibowitch: Yes, this is the deontological medical rule, it is to adjust the treatments to what is necessary.

Josiane Balasko: You think that consuming less medication will piss off the laboratories?

J. Leibowitch: Let's not attack the laboratories, for the moment, it is the barons of the pulpit who manage the situation and they have a lot of trouble accepting that this pacifying and liberating revolution comes from them.
The good news is that we will be able to reduce from 40 to 85% when we change the rule, the bad news is that I am the only one doing it, it would be nice if others did it.

Michel Drucker: That's why you're here today. Thank you, Doctor. Goodbye, thank you.

160

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



The Eclipse is getting longer with the (new) INIs
and LIVE COVID...

By Charles-Edouard!

DTG changes everything... and nothing at the same time

Let's make the hypothesis A that the 'modern' administration, i.e. earlier and with DTG (or BIC), which are at the top of the first-line recommendation, gives a significant possibility to control the virus. Indeed, Hocqueloux has stated, somewhat naively, that to hope to cure one would have to treat earlier, stronger. You and I, we are already in the treatment and, for us, the project of treating earlier does not concern us. It doesn't matter... To test hypothesis A, we take 'modern' patients, in the sense of A, treated early with a second generation INI. We stop the treatment and see if one of the patients controls the virus. And we compare... Compare to what? To the history... That is to say, the period when the treatment was deferred somewhat, and when the first generation INIs did not exist. Nothing better, therefore, as a comparator than Davey's series, which dates from 1999, that is to say 2-3 years after the arrival of triple therapy... My table with the published eclipses is here: Time on the rebound: I finally see you!

&nbspPt.	T50
1	5,4
2	3,8
3	8,9
4	11
5	47
6	8,4
7	9
8	9,8
9	5,6
10	12
11	9,8
12	11
13	8
14	15
15	13
16	12
17	7
18	7

Historical values (Davey 1999)

source: jstor.org/stable/121215.
In Davey's series, the presence of an Eclipse at 47 days distorts the mean (11) and standard deviation (9) to the point of suggesting that there are statistically negative values. Removing this exceptionally long Eclipse patient gives a mean of 9.2, a median of 9 and a standard deviation of 3, which is already more reasonable.

With these corrected values, the number of patients with an eclipse of less than 7 d. (6 or less) is 16%. With Davey's calculation, we would find 29%. In clinical intermittence, ICCARRE and Faucy find only 2-3%. For the calculation we use onlinestatbook.

The 'classic' risk is lower than it seems

The first error consists in taking an exceptionally high value (47 days), which is a value to be excluded(outlier). The second is to take a statistical model, of Gauss, which is symmetrical, whereas the Eclipse is not symmetrical: there is no negative Eclipse. When the series is temporal, stochastic, it is appropriate to use a Poisson model. But well... Let's pretend, since what we are interested in is an order of magnitude. It is obvious that a patient with an Eclipse of 3.8 days cannot hope to achieve 1/21... In the classical view, in Davey's time, one can have an appreciation of risk such that even the modest 4/7 shows a statistical risk.

Here is the risk calculated in a very primitive way, without incorporating any risk factors. In 4/7, with Davey's figures, we find 19% of patients at risk of failure. With the corrected figures, we find 2%, and, in the clinic, we find very few (e.g. zero intrinsic failures in ANRS-4D). So the risk is overestimated. Let's say that this error of evaluation, made by many 'specialists', and which ICCARRE denies, is, let's say, forgivable a priori. A Gileaolatre could have used this putative risk to try to block ANRS-4D, a priori. If we look closely, it does not hold, but well... That's the past.

What Davey claims, Leibowitch denies

According to Davey, in whom the shortest Eclipse is 4 days, doing the 5/7 (FOTO - Dr. Cal Cohen) is possible, but in Davey 'Classic', the expected failure rate to do 2/7 'direct' is 25%. Besides, there has not been a Truchis, a Leibo or anyone else to attempt the 2/7'direct'. In light of Davey's dônnées on the Eclipse, the 2/7 (or even 1/7) would be unreasonable. Except that the 2/7 have gone through 3/7, validated: they no longer carry the risk of 3/7... The risk to fail, in progressive method is R(2/7)-R/3/7), that is 25% -21% = 4%; in recalculated Davey risk, it is 5%.

As Leibowitch has shown that it is possible to compensate for a negative event (virological failure) by returning to 7/7 immediately, the risk is doubly minimal; it is less than 5% and the negative consequence of the risk (virological failure) is without prejudice, since we know how to compensate. On a personal level, one could find it bad to fail at 2/7, but then, one would have to make up one's mind...

In practice, Leibo has a much lower failure rate, because it also plays a little on the pharmacokinetic window, by using preferentially and almost exclusively NVP(or at least EFV). In this perspective, the 1/15 is unthinkableThe use of NVP, with the possible exception of a few exceptional cases.

With the New Eclipse everything will change!

With the new Eclipse, this will change, and even more so with the arrival of Islatravir.

Live COVID

Multi-therapy: For the moment the concept remains a bit vague, but this article from Le Collectif Citoyen for FranceSoir (which no one doubts is brilliantly inspired) Covid-19: What is the standard treatment? Does it include hydroxychloroquine? opens a new era: that of a cocktail/care pathway where HCQ would only be an option. The hysteria around HCQ (and the prohibition for pharmacists to dispense it, but not for doctors to prescribe it, yes, yes, this is the French ridiculousness: Liberation: Covid-19: is the dispensing of hydroxychloroquine authorized again?) is such that an alternative must be considered. For myself and my relatives, I will not remain without considering anything.

And to make this strategy my own: 'treat the patients who present themselves as well as possible. That means testing them, assessing the status of those who are positive, and treating them with available therapies. ' ( source Covid-19 - Interview with the man at the heart of the controversy: Didier Raoult)

My available tools: Atazanavir, Doxycycline, Zinc. No PCR, but we can access it if needed, and thus initiate a treatment and interrupt it if the PCR comes back negative. The very vaccine-oriented B. Gates declared that the PCR, if the results are not quick, is useless... Yes, it does to interrupt a treatment taken blindly. I don't really care whether it works or not to the point of recommending it or not, which is not my purpose. I treat, and not with Doliprane!

In the news... As the water flows

La pitie salpetriere publishes its results in 5/7 and 4/7, under INIs, Efficacy of intermittent short cycles of integrase inhibitor-based maintenance in virologically suppressed HIV patients. It works! What did you expect?

The genius of French

I find this video, anachronistic, in the air of time...

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good weekend, good stuffing and not too many meds ... Huh?

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This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



A New Eclipse has appeared
Followed by LIVE COVID

By Charles-Edouard!

Lescure is the anti-medicine, the anti-science, the anti us: he is our enemy(source), and his delay in publishing the deleterious effects of Remdesivir makes us even more suspicious.

We let JCM comment:

The doctor's concealment of the real causes of the changes in recommendation is amazing.
The problem with Lescure is that he is like Gamelin, he only acts when he is sure, and only attacks when he is in the last line. [...] So, Mr. Lescure, Iccarre or not Iccarre? The problem is that even if Iccarre doesn't work well, when we rather suspect that it does, no one really wants to wait and even less to follow the prudent (and especially prudent for himself) advice of Dr. Lescure.

A New Eclipse has appeared: you had not observed it!

Here is how the case is presented. A new drug appears, more 'powerful' than the others, with opportunities in terms of eradication. So we try... It doesn't eat bread and it keeps you busy. We put a good handful of patients on a promising combo (usually quite strong) and we see if this super-regimen favors PTC: Post-treatment Controllers. With a bit of luck, we may succeed, occasionally, since by treating everyone, without distinction, we also treat the 1% who naturally control. We would not be surprised to find 1 or 2 of them, by chance. There may be such a case here (an experimental treatment may have eliminated HIV in humans, according to doctors), but that is not our topic today. In the study we are interested in, we are not going to find any... Lack of luck, small number of patients... It doesn't matter. The patients take something, we stop, we do the biological follow-up (the PCR... Biological follow-up, there is nothing medical about itwe can do the same thing with mice, bats or pangolins.... No luck (well, yes... it suits the Gileadolatres), it does not work! So the merchants of variety articles and trinkets, at 1000 eu./month, still, are ecstatic: we can't stop the treatment. Unlike the profiteers of the situation, I would like it to work... Don't you? And what I tried, with the infinitesimal hope that it might work, didn't work. Close the bench, the Charles-Edouard's is a lot of bullshit, Fake-News, Public Danger... Quick, let's call Miss Avia and her sulphate machine.

The rebound takes place, relentlessly, but not immediately

Leibowitch never said that the treatment could be stopped. Never... The argument is that the rebound takes place, relentlessly, but not immediately. In a country that has eradicated the virus, one can lift the containment and live in fear of a second wave. Not a great method. We can, alternatively, lift the confinement of the active during the week, to confine the weekends only (Castaner would have loved that against the GJ). There are alternatives to stupid diktats... Second wave or not, everyone sees that the delay to the second wave, gives respite, and that we must take advantage of it!!!. Otherwise, it becomes wearing...

Faucy and Chun back on the rebound and ... The Eclipse

Michael C Sneller, under the supervision of Anthony S Fauci and Tae-Wook Chun publishes Kinetics of plasma HIV rebound in the era of modern antiretroviral therapy.

The conclusion is unwarranted, but the raw data published

The conclusion does not match the body of the article, which is not surprising with Faucy-la-couleuvre, but the data is there, is recent and usable. It has taken years and years to document for 'ethics' committees that analytical interruption is safe and can be used to view/verify/validate any intervention. There has never been any danger, but here it is the American Lacombe/Pialloux/Hydroxychloroquine who are blocking any attempt at a clinical trial. In France, they succeed perfectly since there has never been a single clinical trial in reservoir/remission research. Never.... But in the USA, there are some... And they are legitimate because the US does research on the reservoir and ATIs (Analytical Treatment Interruptions) are considered acceptable there.(In France, the question doesn't even arise, since there is no idea to test). The objective enemies of research, the American Gileadolatres, argue that what was tolerable yesterday, might not be tolerable anymore with the new caviar drugs. It's stupid, but wasting time is a classic tactic.

So Faucy & Co want to show that no, it's the same as always! That's the conclusion they wanted to reach. In order to do this, we need data and we need to publish them, and here, these data enlighten us, once again, about the Eclipse. Now, comparing the Eclipses of the past and the modern ones we see a very important change... To see this, we must take the old and newly published eclipse data...

Well... We'll see it next time...

13/07: The Live COVID resumes

We resume the COVID live, because, there are many things that concern us... In the meantime, Politico has published an interesting opinion: Hydroxychloroquine and remdésivir: small reference points to try to see more clearly in the 'match' of treatments against the coronavirus

07/15: Double co-incidence is evidence

France Soir: Covid-19: hydroxychloroquine works, an irrefutable proof. The argument is simple: Switzerland normally authorizes HCQ (as a reminder, the American FDA acts as an agency for Switzerland, which pays it a share). It's going pretty well. Following @LancetGate (we are still waiting for the trial of the forgers...), Switzerland is infected by the Virus of Prohibition: it bans. 13 days later, the mortality rate (based on solved cases) climbs, climbs. In the meantime, Switzerland reauthorizes, and 13 days later the mortality rate returns to normal.

If you want to avoid dying, you have to take HCQ 13 days before ... (NOT) die... Macron, him, tells us that he would not take it (we don't care... He is the boss at Véran, so discredited...) ... Wait until Brigitte catches it (the virus, not the Macron), you'll see that he'll change his mind quickly... If not, too bad for him...

The genius of French

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overmedication is an opportunity if you know how to use it!