This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

Quatuor Trial has started

By Charles Edouard!

Shortages: here is a testimony from Greece:


Today in Greece, Venezuela (rich country), Russia, Ukraine, soon in Spain, they have ARV shortages. Here is for Greece, and Venezuela.

Soon will come sanitary migration? Shortages where you live or in France ??? Which does not produce ARVs? Biggest producer of butter and we have shortages at the supermarkets (I did not believe it, but I saw, and made my stock). In the USA, where IRMA has devastated the ARV producers in Puerto Rico, Florida is in trouble... You have seen the circus with Levothyrox. We must anticipate!

ANRS-Quatuor officially announced

I have already posted Quatuor and Strategy # 1, followed by
Quatuor and Strategy # 2, and
French Guidelines just killed Quatuor

See the dedicated page (see comments and discussions)

It officially appears, for the first time, in August 2017, and is registered under number NCT03256422. Last week, (2017-10-04), ANRS published, on its site, the technical sheet, so, this time, it is a go!

You will hardly find any news in your usual medias: does that surprises you ?

ANRS-Quatuor and veterans

A totally false idea is circulating: aleviation should exclude veterans. A priori, we can think this way, but science shows the opposite. Science and trials serve to defeat misconceptions that are harmful to patients: the earth is not flat! Veterans are eligible. You have to pass genotype selection, maybe a bit problematic. In any case, it is enough to refer to the datasheet: there is no restriction on age, NADIR CD4, Zenith RNA, CD4/CD8 ratio, or reservoir. Nada.

ANRS-Quartet: better late than never?

The saying goes ... The reality is much more distressing: 15-20 years late! A very first article appears here, in 2000, by Act-up. So no! One can not let the thing pass, forgive, as if nothing had happened. Patients, thus blundered, will be entitled to claim accountability to retardants: Prs Delfraissy, then director ANRS, Molina and Katlama, as animators of the AC5 committee (AC = Coordinated Action, coordinated with ... with ... Follow my eyes...)

The demonstrated ability to do ICCARRE (with frequent VL) by oneself (without a doctor) has probably played a positive role in confronting ANRS, a mere retardant. Waiting for ANRS is a mistake!

Do not forget, do not forgive, the fault is too serious! Of the same order of magnitude as the contaminated blood scandal. People have died of bad medication: never forget it!

ANRS: nothing in the pipelines... So what ???

The new ANRS director, Pr François Dabis, says, refering to aleviation, that there are no new ideas in the pipeline. What a great simpleton! Does he not realize that when one has ZERO intrinsic failures in a trial (ANRS-4D), this means that there is no valid argument for patients, still very demanding, to stick to 4/7. Which argument against whoever would like to go 3/7. If well performed, the risk, at 4/7, is Zero (or epsilon, we will see): no risk, we can go further: this is a normal reasoning, which will emerge among patients: do not initiate an exploratory trial is guilty or imbecile, or both... ICCARRE 1/7 already gives us some clues...

A research organization, that does only does validation trials (for the great benefit of Big Pharma) of techniques already explored, and even already authorized, is ridicule!

Quartet, Stribild® / Genvoya® and Viramune®

I only know one attempt, ill-planned, of 5/7 under Stribild®: failure! Conversely, Nevirapine (NVP) works: why exclude it? Virology doesn't lack morons ...

ANRS-Quartet: I do not participate, what to do?

There is no moral, ethical or legal limitation to do for oneself. Even more, the French Guidelines do authorize 4/7. So, with or without a doctor, especially with frequent CV control, you can move forward (see the Practical Guide). Refer to the Quatuor Inclusion Conditions, or ANRS-4D. The ANRS-4D data sheet has disappeared from ANRS website (sic!) ... We have a copy in the complete file.

It should be remembered that nobody has the exclusivity or the privilege on personal experimentation. Nobody ... The advantage of ICCARRE is that the patient has all the tools available (try self-experimenting with injectables,if you can: you do not have access).

Let's compare the advance Autonomous mode, with the trial mode:

Importants points	If included in the trial	Autonomous mode
Inclusions criteria	Enforced (scrupulously?)	To follow scrupulously
Genotype reading	mandatory	preferred
Eligibles TRI	Almost all (exept NVP)	Almost all (NVP: OK, EVG : No)
Is is known beforehand	No but small (ANRS-4D)	No but small (ANRS-4D)
Accounted for	Yes	No
immidiate start	No	Yes
autorized by...	ANRS	french Guidelines (CNS/ANRS)
allows for stock	No	Yes
Donations (PreP...)	No	Yes, this is generous
Avandtages	Includes Stribild®/Genvoya®	Includes NVP, immediate start
Disadvantages	delayed start / no slots	frequent VL cost

In the news

flu vaccine: a warning from Dr Dupagne: The dangers of the flu vaccine are not those that you think. I will not get that shot!

Legal opioids: In the USA, the explosion of lethal overdoses with (illicit) opioids logically follows the over-prescription of (licit!) opioid drugs, largely encouraged by the medico-pharmaceutical mob. When in France?

Levothyrox: they suddenly switched 3 million patients (probably 1-2 million suckers): 15,000 report side effects; The ANSM blaims doctors for not adjusting dosage (cf Le Monde): yes, many are morons: one only realizes now?

Short Cycle Meeting: by amis d'ICCARRE (Oct. 12). Good idea, to be renewed...



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Have a good Week, good fuck and do not abuse of meds/drugs

This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

Raltegravir 1200 mg

Summer 2016: we offered a serial: ANRS-4D and the cheaters Summer 2017: we will debunk DOMONO: It starts here

This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

Towards Raltegravir 1200 mg: One thousand two hundred !!!

By Charles Edouard!

People eventually understand, which gives this:

There we go! One more who understood! Overmedication creates damage (sometimes fatal), and de-escalation is on the way. It has its enemies: the medico-pharmaceutical mob! Well, what is happening on Raltegravir will allow us to expose ambitions, mechanisms, tricks, actors and the lack of patient protection. Let's start by drawing the landscape...

Reminder: in our hit-parade towards 1/7, Isentress® is one of those to avoid

Isentress®: a problematic pill

Isentress® contains Raltegravir, the first (non-exclusive) Integrase Inhibitor, marketed in 2007. A revolution. Merck has tens of thousands of molecules. They played the mule (method now obsolete), have prepared as many test tubes as molecules and tested for a possible effectiveness against HIV. They find a candidate (diketo acid), ask the chemists to improve a little. One ends up synthesizing a molecule. And there we go ...

There is a catch: the molecule passes the stomach wall but not the intestinal wall. It is annoying: if the drug has not been well disintegrated in the stomach, the small remaining stone goes to the intestine, where it no longer has any chance to enter the bloodstream. Unlike NVP or Videx, among others.

If you miss your absorption in the stomach, there is no catch-up (the intestine): you succeed and you have your plasmatic dose, you miss and you have only half (at best). To do 365 times / year! In the same patient, there will be days with and days without ... Big problem!

We will increase the success rate by doubling the number of attempts: and Hop! There we go to Twice a daily (700 dosing per year!), It is a Royal Pain in the ass, but in 2007, we accommodate ourselves.

Obviously the dose is also maxed: 800 mg / day: the highest dose among usual ARVs!

But as one puts a lot into a tablet (400 mg), the tablet is very compressed. It is hard as a pebble, which will make things worse ... The pebble diffuses in the stomach in a very variable way, which is the only opportunity. Shit!

But hey, the manufacturer does not care, patients just have to swallow the shit: we take our money and you get lost. And above all, out of question to admit any error.

In maintenance, the 3 modes of dosing

Merck method: Twice a day, 12 hours apart (400 mg then 400 mg). A small study shows a very slight benefit to this method, and as the dosage is not the responsibility of the pharmacist, but of the physician, Merck plays conservatively. The Merck-boys will be deployed to spread the voice of their master. Merck, knowing the cause of the problem, has already planned to reformulate the drug ...

German method: very popular in Germany. Practitioners allow their 'observant' patients (since Germans...) to take the 2 tablets at 1 time. Overall satisfaction ... The practitioner is happy, the patient also, having the impression of having / being personalized (thus loyalty).

'Italian' Method (abusively known as Charles-Edouard's, I have only published the relevant info here, also see here): It consists in chewing before swallowing, which allows to take all in one go!

I have buddies who tell me 2x400 mg, in 1 time, My doctor tells me in 2 times (in 7/7). This team of Italian clinicians say 2x400 mg, chewing, in 1 time, in 7/7, and Leibowitch, it says 1 x 400 mg in 4/7! What a diversity! (with no significant difference in effectiveness).

Mandatory or influenza vaccines, Levothyrox®, RAL 1200 mg: a hysteria

With the Levothyrox® scandal, one could observe the morgue by the manufacturer (Merck, again), the State authorities, who deny, in block, any side effect. Three million French patients take Levothyrox®, and are despicable imbeciles proportionately! Obviously, there is over-prescription! The medico-pharmaceutical mob has no limits!

Same for vaccines, we will vaccinate our small frogs against Hepatitis B (multiple sclerosis will become an infantile disease). A child (made) deficient, it's for life! Influenza is a benign disease, and your cellular immunity (CD4) has nothing to do (or so little) with your humoral immunity (which protects those who have had it, or its vaccine, 2 or 3 times): no influenza vaccine for Charles-Edouard! (replay this interview)

Then Merck works towards a RALTEGRAVIR at 1200 mg. What made Merck move? The arrival of EVG (Stribild®) or Tivicay®, which are in a single dose per day? Well no, they are announced since 2010 ... The loss of market share is real. And especially the loss margin is even harder, with the arrival of generics: we must keep positions by giving a boost to patents; And since they did not invent anything, well they will propose the once-daily by imposing 1200 mg!

Those who practiced the German or Italian way will find themselves at the wall.

Reminder: anyone interested in remission (relative, of course) should proscribe RAL.

So they will double the dose! Doubling ?? Wait, Charles Edward! From 800 mg / d to 1200mg is quite already violent, but not quite double ... Yes, yes, double ... You will understand ... It will be for a next time ... we will follow this as it will be droll and ridiculous!

Well, the case is advertised in the Lancet: Raltegravir 1200 mg once a day versus raltegravir 400 mg twice daily. Good reading!

Have a good Week, good fuck and do not abuse of meds/drugs

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Comments

Steve 22 Oct. 2017


Charles-Edouard! 30 Oct 2017