DOMONO trial

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

DOMONO trial

DOMONO test: Tivicay ® monotherapy

Before Hypo-Dolu ... go through Mono-Dolu: a revolutionary single agent, I have undertaken to detail here ...

The way to get to 1/7 (weekly jack) involves passing by boxes, and breaks (like the board game): Case undetectable, pause 1 year to start.

In Hypo-Dolu proposal, the path is simple and continues:
MONO-DOLU box, pause 1 year. etc.
It may be possible to consider SINGLE DOLU as attack treatment without going through the tri-therapy box.
The latter, in maintenance therapy, is now available in experimental clinical trial registered under number: NCT02401828, detailed here: www.tinyurl.com/CHE-HYPO-DOLU

Iccarre DOMONO HIV HIV treatment dolutegravir NCT02401828 thebody Hypodolu

Test 48 weeks, unmasked, randomized phase IV. The aim of this study is to evaluate if the removal can be maintained by DTG monotherapy.

104 adults infected with HIV-1 will be randomized into 2 experimental arm. The first arm will undertake the direct passage. This population will pass directly from the stable triple therapy to monotherapy DTG.

The second arms undertake, but later, after 24 weeks. This group will remain on HAART, waiting for 24 weeks and then go after those 24 weeks IGT monotherapy.

The main objective is to verify that dolutegravir mono-therapy, maintenance is non-inferior to conventional maintenance triple therapy.

With a test on a patient hundred, proposal, transcribed into French, Dr. Mark Wainberg, arrives in the clinic.

That alone would be a major improvement, and accessible to all, not just a small clique of well-connected people.
Go Jan. In 2017 ... Things are moving ...
Note that the ANRS LAMIDOL is announced ... Bi-therapy Tivicay ® and Lamivudine (Epivir ® or generic). It's less glamorous, but with the support of ANRS, visibility is better. We also move there ...
The maintenance of undetectable monotherapy DTG is interesting, but not an insurmountable horizon: it is necessary to consider continuing with the reduction 5/7, 4/7 up to 1/7 ...

Among the things that do not move under weekly single dose in HYPO-DOLU, on Monday ... is the immunological response, still good.
That reassures me a little ... Everything was already very well in quadruple 1/7 (ICCARRE)
ICCARRE immunology tank ratio CD4 CD8 immune system cells lymphogramme

Note added 10.22.2015: the first results start to come out at EACS 2015

Good weekend and good fuck!

Welcome to the club

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

Welcome to the club

welcome to the club!

Hello hardly unknown in my country.

A friend wrote me:
I start the discussion with my doctor next week.

The new version of the Guide explicitly includes a prompt to download and give it to the doctor.
www.tinyurl.com/HPC-CHE-2014
And leave the ... Thanks in advance ... The returns have on hand will always be useful.
The protocol is well oiled. New, older want the 'welcome to the club.'
And rehash the acquired truths: it is not like before ... The toxicities are observed in far fewer patients. That is true

Once undetectable, you can forget the hood (in ad hoc circumstances), it is no longer contaminant can have children by natural means, everything is covered 100% And all this is true ... Take your pill once a day and basta ...

Salaams joyless

Then the new leaf a little, and falls inexorably on the forums: emaciated, weight gain, fatigue, dentist. It's manageable, but it's boring: pharmacy every month, taken daily without fail, insecurity about the future of the ALD

This is the judicial lifetime for a moment of distraction: you are at fault, you are punished: LIFE without remission. It really is that? It heals the incurable hepatitis C and for us .. nothing ... ?? In 2015 ???

The truth is the must for those in need:
On a file of 120 patients, in Garches, a hundred are already in the 4/7 relief (or better) including a dozen have already reached the 1/7. Other progress, confidence, towards that goal.
This is not a promise, but the invitation to enter early in treatment, to enter earlier in the long bevel relief and finally reach the 1/7 (weekly intake).

Modern treatments are effective: the patient 'modern' must be aware of and remove to itself (and not for the firm ...) the real benefit.
This is true for the young (8 years Breather), the most 'vintage' (84 years ICCARRE-2), which is jetset, Paris, Ugandans Siamese (see Breather ...) or provincial (including Belle Province ...)
It's true that truth attested: it is added modestly to salaams, the kind hospitality:
Iccarre HIV test HIV cure AIDS relief program Tivicay
There, it makes you want to say welcome to the club

The question some works: There will he a combo attack which facilitates the path to the 1/7 (weekly single dose)? In your opinion ?

The news is full of innovations: the work of Weinberg, Dr. Massimiliano Lanzafame, patent Leibowitch, monotherapy Tivicay ® ...

On Monday, for the first time, is my new weekly day single dose
Sunday is my day of relaxation, frolicking: Good Weekend and good fuck!

Hello hardly unknown in my country.

Once-Weekly for all

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

Once-Weekly for all

1/7 for all!

In my country ... There are no malignant shadow on the capsized boats.

Reportedly, the BREATHER success, publishing Leibowitch (94 Garches), 4 modes of reliefs (HYPO-DOLU, ICCARRE, BI-EBIT, Mono-IP) show that:
- There is no profile excluding patients relief. At most he will have to choose carefully.
- The single dose, weekly, is not an oddity reserved for those who have relations: it is 10% of ICCARRIENS.

There are not excluded ... All anyone can consider. The success is not guaranteed. Nor is guaranteed success in 7/7.

This demonstrates that Leibowitch, and Breather support, Foto and Faucy is that failure to cure a part (without doubt a minority or a minority) of patients, can cure half the entire population.

According ICCARRE and Breather, and the other, the pattern is funnel (in the most conservative estimate):
95% of patients can achieve the 5/7 (ICCARRE)
Of which 95% can pass the 4/7
Of which 95% can succeed 3/7
Of which 95% can pass the 2/7 (adding a NRTIs)
Of which 95% can succeed 1/7.

And if ICCARRE 1/7 does not suit you, there are still HYPO-DOLU.

Failing to fully heal some were partially healed all. It is less well, and yet ... It is perhaps even better: it has the advantage of being open to all:

Iccarre HIV cure HIV AIDS AIDS relief organization Leibowitch Efavirenz

Those who do not come under the scheme will ICCARRIEN, choice, change to HYPO-DOLU or more favorable combo or a less ambitious relief.

The article Leibowitch is definitive:
Iccarre HIV HIV Garches Leibowitch ANRS-4D exclusion criteria dosage

The same dispersion and the overall vulnerability of the non-selective sample of patients suggests a 4/7 rhythm applicability to many, if not all people, stable under cART; moreover excluding patients with resistance to multiple viruses prevent a combination of relief with 2 ARVs synergistic, in case their ICCARRE lacking.

For the vast majority, even for the bruised, the most capsized, there are solutions. And ICCARIEN relief is only one of them. The cleverest (or luckiest) of the 'new' patients outset position themselves on the most favorable combos.

There is therefore an optimization strategy of its entry in the treatment.

But even if one is not in the most ideal alignment of the stars, there is a way to reposition itself for successful therapeutic relief.

Who benefits from the relief?
Suppose the young, without other disease or medication, with no apparent side effect is hardly interested ... which act ...
But this profile is not a majority, contrary to what seem to forget those who stay warm in their cabin in Canada.
A wide choice of medicines, free, sophisticated techniques, redeemed, blood dosing: this is true in Canada. And this is true in Canada.
It's a shame ... The gray veil of indifference is the only shadow on the board.
The other, more exposed to on medication, the wrong-medication, to poly pharmacy, abused are much more numerous. Overdose is a plague of Egypt for the victims, those who make the ostrich.
For those who can benefit from it is a godsend.
That's because I'm overdose can I do the weekly outlet.
Overdosing is harmful to those who do not take advantage.
This Sunday is the day of HYPO-DOLU outlet.

There are no malignant shadow on the capsized boats.

Hypo-Dolu: I have started

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

Hypo-Dolu: I have started
HYPO-DOLU: go!

The quadruple of Leibowitch is published (ICCARRE 1/7); Meanwhile Dr Lafeuillade launched Hypo-Dolu.

Hypo-Dolu, supported by the observations made by Dr. Weinberg Laboratory, was a bit more favorable than ICCARRE 1/7.

ICCARRE in general, and 1/7 in particular, requires a perfect adherence, at inception and for about 2 years.

For some patients, goodwill, this perfect observance may be hampered by side effects.

They have side effects (eg. Shrink with Atripla), so they are not observing, therefore excluded from ICCARRE, then that would be a solution for them! inextricable situation. The fewer side effects, most patients will be watching and will therefore enter the reduction.

Since I knew ICCARRE 1/7 works for me, I decided to try Hypo-Dolu.

To do this I convinced my doctor to pass me in Tivicay ®.

To convince him I asked him if we could consider a ICCARRE 6/7 (with my old combo) (LOL). It took less than 30 seconds to offer me Tivicay ® ( 'offer' is a term a bit soft, it has imposed on me, but, as it was what I wanted ...).

So I ironed at 7/7 with substitution Tivicay ®.

Galley ... The transition to 7/7 reminded me how much it was painful to me, but I knew it would not last ...

I have done all validations (CV frequent always <20) much more quickly than I would not advise it. But I come from the 1/7 and, therefore, if ever, 1/7 Hypo-Dolu 'breaks', then I will return to ICCARRE.

I went (pretty quickly) to Tivicay ® monotherapy. I validated

I started ICCARRIENNE descent gradual, but faster than usual, and I am now 1/7 (already validated: CV <20 ...)

So for me it bathes! I close my CV. (Since it's a non-standard therapy)

My experience with Tivicay ® in 7/7 was very brief ... For me it was ... But the 7/7 reminded me last galley ... 7/7 = Headlock

undetectable viral load ICCARRE HYPO-DOLU Lafeuillade Leibowitch dolutegravir

Tivicay ® monotherapy, and now 1/7 is that happiness! ... Fingers crossed for the coming months (and close my CV) without being too worried.

Tivicay ® is 4 mm in diameter to 1 or 2 in height, it is very small, small ...

I will continue to share my experience ... ICCARRIENNE
But ... 'testimonies ICCARRIENS are many, Leibo released its latest results ... The case is heard (unless you are deaf ...).

So I continue my practice ICCARRE Guide, which now includes a FAQ: she already has 50 items.
Then I would do the ICCARRE Practical Guide 1/7 and practice GUIDE HYPO-DOLU.

The Net is full of testimonies of victims on medication!
People dare not testify because they read the TRI are supported: it is not true ... Fortunately, today there are alternatives or methods known to reduce the effect. For me, this reinforces my certain choices I made (with or without my doctor).

When it begins, as patient, is distraught and the choices we make are the result of chance and good intuition of the doctor.
I must admit that mine had intuitions 'awesome'. He made mistakes also ...
This is normal interactions of ARVs with other meds are not documented!
I had my own problems; this is behind me ... bitterness ... yes ... no ... sequelae

As for the patient, it is not to blame either ...
Information would be useful to him that (in my opinion, and I have only to gather on this blog) are completely drowned in a flood of continuous information (and often unnecessary):

There is 1/4 of a million published scientific 'HIV: 250,000!

I struggled to identify what is relevant to me.

Beyond HYPO-DOLU, ie an unfortunate catechu Sunday, I do not see what I could aspire to better.
Even the monthly injection does not interest me.

Fight against corruption poisoning the obvious associations and the medical community, this is not my thing either:
We must realize and draw practical consequences for oneself (within turn into anti-corruption activist).

My life continues where the right medication, certainly in the initial period (TRI to dad), which has become, over time, on a medication, was put on hold.

To repeat: 95% of patients, stable and undetectable are unnecessary and harmful on-medication!

A weekly single dose, HIV is far from me ...

HYPO-DOLU: go! YOUPI!

ICCARRE-2 has been published

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

ICCARRE-2 has been published
ICCARRE-2 est publié !

Jacques Leibowitch l'avait annoncé dans son article du 1 décembre 2014 dans Le Monde:
http://tinyurl.com/ngacdhb
L’étude concernant les 94 patients sous traitement Iccarre vient d’être validée pour publication dans une revue hebdomadaire scientifique dans laquelle il est clairement fait état de zéro échec avec 4 jours de traitement pour les 94 patients sous Iccarre pendant 87 semaines. Ces 4 jours de traitement pouvant s’étendre immédiatement à 90 % des patients actuels pour des combinaisons antirétrovirales efficaces. Comme nous l’avons résumé sous forme de slogan : « Si moins c’est bien, c’est mieux. »

Il est publié par le FASEB:
http://www.ncbi.nlm.nih.gov/pubmed/25833895

Soumis à publication en Oct 2014, les vérificateurs (indépendants, désignés par ce journal Américain) l'ont validé en Février 2015. Publié officiellement en Juillet.

ICCARRE FASEB Jacques Leibowitch publication article ANRS Christian Perronne Pierre de Truchis

J'ai fait une traduction en Français; Ceci en est la première page:

ICCARRE FASEB Leibowitch traduction article ANRS Perronne de Truchis Dominique Mathez Garches
La vérification, indépendante, et peu complaisante, apporte (compte tenu des dates) une confirmation convaincante de l'affirmation de Leibowitch (déc 2014), au 20h00 de TF1 et transcrite ici:
www.tinyurl.com/HPC-CHE-2014

Peu à peu il y a eu une centaine de patients, sur onze ans, maintenant, qui sont descendus à 6 jours 5 jours 4 jours, puis même à 3 , 2 et 1 jour , j'ai une quinzaine de patients à 1 jour par semaine. Le code d'éthique médical est de donner aux patients ce qu'il faut aux gens, pas plus...

L'importance de la vérification minutieuse faite par l'éditeur ne doit pas échapper au lecteur:

C'est de l'info ... Pas de l'intox (du genre je connais l'homme qui a vu l'homme qui a vu l'homme qui...) comme on peut en lire ici ou là.
Le succès à 100% pour la centaine de patient à 4/7 y est confirmée.
La véracité du 1/7 4-T est confirmée par une revue de haute tenue scientifique.
La nécessité d'une méthode rigoureuse y est confirmée.
Une info chasse l'autre...Nous reviendrons sur Breather, les témoignages des allègeurs, les articles de Weinberg (Hypo-Dolu) , l’attribution du brevet, etc. Pensez à suivre l'info sur les grands médias HIV, nationaux ou internationaux, listez méticuleusement ceux qui reprendront l'info et ceux qui l'occulteront; c'est très instructif ! Vous verrez... c'est simple et ça montre l'inmontrable

Rapellons-le: 95% des patients, stables et indétectables sont en sur-médication inutile et délétère !

Avec les Iccariens, les vrais, partageons !, les larmes aux yeux, ce moment de jubilation !!

Pour cette rentrée, on ne pouvait espérer mieux ...

BREATHER: Fiat Lux !

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

BREATHER: Fiat Lux !

Breather: Fiat Lux ...!

The truth awaits the dawn next to a candle. The window glass is neglected.

The tests, the results are convincing. They were already there. Others come ... Facts are stubborn ... The information is sparse. Each in a different newspaper, to years of differences, in English ... Whatever ... just gather the facts.

It's pretty exciting in itself. Better than a whodunit ... One draws the ball and through the frosted glass is observed.

Breather: Fiat Lux ...!

All major media covered that concern us CROI 2015, the USA. All were there ... Postponed Breather: aidsmap (UK), i-based (UK), vih.org (FR). etc., etc ? Really ?? No...

On the other major support (US, CA, DE ...): it's radio silence ... A silence that speaks.

The webcast is yet in the politically correct ... So there will be material to search ...
http://tinyurl.com/HPC-BREATHER-WC
Breather changes the game ... The cumulative number of patients in 5/7, published, was 20 + 50 + 50 (Photo Faucy, Iccarre-1).
Add Breather: ca 220 double! When we have ANRS 162-4D, there will be 320, and fifty more Garches: we approach the 400 ... As long as Canada and make a difference ...

400 is the target of a marketing authorization or FDA test ... Well enough for RTU ...

We give (sit ...) Efavirenz + AZT to young people, including kids 8 years!

Those who were lucky enough (sic) had Atripla ® instead ... we understand the motivation of doctors!

BREATHER HIV kids children child HIV AIDS MSF Efavirenz
4 million infected children, 2 million children waiting for treatment, 1 to 2 million under EFV + ZDV (XTC +), 250,000 newly infected each year!

So yes ... Breather is a major information

Yet young people, they do not care ... What they kiffent: the weekend of freedom with friends, thinking ... mmm ... something else ...

They were as much to remain undetectable ... Youth of Breather ... and me too for that matter!

Breather HIV viral load HIV viral load undetectable limit of detection Atripla ICCARRE

Good Night and Good wad young! You is foooooormidables !!!

Here ... indignant and rebellious! In ICCARRE 1/7 after my breakfast. Sunday, rose Four color is NADA all week! And Hypo-Dolu is kif: that happiness ...

The truth awaits the dawn next to a candle. The window glass is neglected.

Good Job Kids! (BREATHER)

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

Good Job Kids! (BREATHER)
Congratulations kids! (BREATHER)
In my country, tender evidence of spring and the badly dressed birds are preferred to distant goals.

The test Breather (penta 16) is here:
http://tinyurl.com/HPC-BREATHER1
The Webcast is super interesting:
http://tinyurl.com/HPC-BREATHER-WC
Transcription and translation here:
BREATHER 5/7 Clinical Trial
The bibliographic notes follow:
www.tinyurl.com/CHE-BREATHER

Here is a summary:

Breather HIV HIV Efavirenz Leibowitch ICCARRE

Test results BREATHER (Small pause) with the combo used, it is safe for HIV + youth to have a short break at the weekend.

BREATHER (Petite Pause) was set up to check if young people could have a break Weekend safely compared to efavirenz daily.

199 HIV + youth 8 to 24 years, all in the treatment of HIV, and undetectable, all on a combination containing efavirenz. By lot, half continued in 7/7, 5/7 in the other half.

After a year, young people in 5/7 were just as likely to have their virus under control than those in 7/7. Very few viral rebound (6 5/7 and 7 7/7 for the group). 6 5/7 in check were handed over 7/7, and again became undetectable. No excess risk of resistance was observed.

Some young people were asked about their views and experiences in 5/7. For starters, some of them go from 7/7 to 5/7 was confusing and disturbing. However, once they had adapted to weekends without meds, young people have enjoyed this freedom, and preferred to 7/7.

iccarre Breather HIV HIV Atripla Efavirenz Leibowitch Butler AIDS AIDS
Me, taken weekly, tomorrow, Sunday. Monday I take the plane ... without my meds! Phew ...

In my country, tender evidence of spring and the badly dressed birds are preferred to distant goals.

The first step

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

The first step

The first step

It is sometimes difficult to make the first move: jump Sunday socket ... Many do, incidentally ...

Discussion with another doctor:
What surprised me greatly is that he is afraid, as part of the therapeutic relief, non patient compliance. To know that many do not have the necessary rigor to a specific outlet and a non taken precise treatment. "Are you sure that if you do not take your tablet on Sunday and Friday and take Saturday and other days you will follow them? Do not go you invert days? In forget others? Do not think not the daily routine and taken at the same time is less risky? " me he asked.

Doctor LIOTIER Iccarre HIV cure HIV doctor first step Eviplera relief
So I reassured. I told him that I was determined relative to the relief. I just told him that my relief works "psychologically" I needed a yes from him, even riquiqui.

But this ... No need to count on it!

A compatible version with the planning of Safe Practice Guide 4-of-7 consists in 1/2 steps; can be 5.5 to 7 for example. 2 methods:
A- take half a tablet to the 0.5
B- the last day of 5, take, not one dose, but 2 doses, ideally several hours apart.

I used both method A as B.

They allowed me to 'pass' psychological caps. And initiate the first move.
However, I have never departed from my rule closer CV, nor of consecutive days (not sprinkling).
The weekly break, extended to Weekend, then the extended weekend has an advantage over other possible planning:
Whatever the generation, the kid at the senior, Weekend, it is easy to identify, we expect it, one feels, and knows only too well that an end ...

I've been there, I know that the fear is real ... But that too, it has a purpose ...

A practical guide to 4/7

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

A practical guide to 4/7 The Practical Guide 4/7
Just after the blood test, I take my meds (for the week at once).
Presto, after taking blood, on Monday morning, and presto! It's finish !
Iccarre HIV cure HIV AIDS testing protocol guide relief memento Jacques Leibowitch

We know explain how Tivicay ® (dolutegravir) is different (higher ...) to other molecules and therefore allows to reinvent treatment.
Where Leibowitch had believed succeed (Stalingrad test) definitively, it has, in fact, that the enemy content and, through trial and error, developed a method which is not bad at all .. .
But aside from that, it's dolutegravir the atomic bomb: nothing grows back.

Mark Wainberg (McGill, Montreal) published an overview and explains why ... It discusses resistance INI and their impact on reservoirs and possible eradication of HIV.

The article, in English, is here:
Integrase Strand Transfer record Resistance against Inhibitors and Relevance to HIV Persistence
Worth for dolutegravir, but not other INI (Isentress ® RAL or Stribild ® EVG). I will put a French translation soon ...

With Hypo-Dolu on newcomer, we have to move ... Hypo-Dolu he makes ICCARRE obsolete? In any case, he puts the spotlight on ICCARRE ... Those who, like me, have followed a method ICCARRIENNE, will know that they are good candidates for HYPO-DOLU

So my Field Guide remains valid ...
For a given patient, if ICCARRE 4/7 with TRIUMEQ ® does not work, then there is no chance that HYPO-DOLU walking
So ICCARRE remains in the race!

Tomorrow, Sunday, sleep and weekly intake, I did not need breakfast ...

This paper was originally published here, in French. We are providing the google translation for your convenience

My doctor sucks!

My doctor sucks!
Hypo-Dolu it's great ... And with ICCARRE, tested, validated 1/7 in reserve, Plan B is nickel! Hypo-Dolu thank you and thank you to Alain Lafeuillade

4 eminent clinicians in four different hospitals (Leibowitch, Katlama, Raffi and Lafeuillade, among others ...) explain to their patients that the treatment result has no reason to be the same as the initial treatment.

One 'sorts' not patients ... especially not in Toulon (Hypodolu) where they are not millions. At Toulon, Dr. Lafeuillade done with those volunteers ...

Patients who understand that the treatment of attack is one thing, and maintenance treatment another, are not privileged members of a caste or association ...
By chance, they fell to a doctor who, he understood. By chance ... or cronyism ... We keep it between themselves ...

I did not understand right away ... I put the time ... I'm not 'handpicked', and I do not have a cutter.

By against my doctor is zero. Not 100% no ... Sometimes he has good intuitions. But OK...
- TASP: treatment makes no contaminant, the virus stops where the treatment is effective: that he did not understand
- PreP: prophylactic treatment protects the virus stops where he is face to ARVs: that he did not understand
- Drug interactions, many of which are unknown, unsuspected, not considered: that he did not understand
- ICCARRE the cycle by reducing short remission =: that he did not understand. Or rather, he understood the interest ... But Môssieur can not do ... and deprives patients
- Hypo-Dolu ... Do not even think ...

Môssieur HIV Specialist is ... "It's interesting, but I do not know how" that's no good!
ICCARRE can be learned ... The Chinese, I do not say. But ICCARRE is simple!

I read (here ...) I cogitated, I tilted ... There is nothing magical. I read the 4 clinical studies, 4 studies and consistent walk. I got it. Tilt!

And I made the cut and I brought them closer CV: I'm not completely stupid: I'm in much better shape and the virus is still and always undetectable.

I understood and explained how to close the CV. It can be Learnt. I even made a handy little guide

Iccarre HIV cure HIV AIDS viral load test protocol relief program

http://i62.tinypic.com/2hofaty.jpg Under ICCARRE 1/7, Sunday is the weekly dose ... Cool ... Patient banal, trite profile banal combo, and ... almost-healed ...

Under HYPO-DOLU, being confirmed, it is similar. And Tivicay stamp, it is small, small. A relief ...

Good Weekend and good fuck