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Thursday, June 29, 2017

French Guidelines just killed Quatuor



Summer 2016: we offered a serial: ANRS-4D and the cheaters
Summer 2017: we will debunk DOMONO;Fascinating! Stay tuned!!!


This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

French Guidelines just killed Quatuor

By Charles-Edouard!

[Note: The Morlat report refers to the French Guidelines; Quatuor is a large, 640 patients, trial for 4/7 validation] The Morlat report (= French Guidelines) endorses ICCARRE (in 4/7, on top of that). Its update (May 2017) is here! You are informed (no one had told you ...). The text is chiseled. The term recommanded strategy has been avoided.

StrategyFrench Guidelines (aka Morlat)
Darunavir 600/100 mg/j as of today, [...] can not be recommanded.
bitherapy (IP/r + 1 INTI)This strategy can be offered, [with] darunavir
bitherapy DTG/3TC[pending] can not be recommanded at this time.
bitherapy RAL + MRVcannot be recommanded.
bitherapy IP/r + raltegravir cannot be recommanded.
bitherapy INI + INNTIDolutégravir + Rilpivirine can be considered.
Monotherapy IP/rmonotherapy DRV/r can be considered.
Monotherapy Dolutegraviris not be recommanded     [NdCh-E: we will get back to this!]
ICCARRE (4/7)Case by case[...] 4 or 5 days a week can be considered


France authorizes 4/7: period!



This as arm wrestling: prepare for blows under the belt!


To Describe ICCARRE, without citing it is dishonest. It is a shame and an insult to doctors, volunteers, Science. Trump would twitt: it's a disgrace: it's shamefull rudeness!

It is not an expert report, but the result of a balance of power ... Between BigPharma, their 'experts', and the Savages. The Legitimists are merely the middle man.

ICCARRE de Truchis Garches youtube action traitement treatment group Quatuor failures
Legitimists serve us the soup: check them up on YouTube. I threw up. I have vomited ... On the pretence of presenting Quatuor, it is a hymn to the status-quo, the over-medication. Truchis, his eyes fixed on the sidereal vacuum of a distant Quartuor trial, every day more distant. Look at his eyes ... One feels the evasion (full of inaccuracies). As for his explanation for the 'failures' in ANRS-4D, it has been cleverly, but awkwardly, cut off, at a time when he could only point out that the number of intrinsic failures is ZERO, to which he has already testified, and to which he can not escape.

And what about his publication in a scientific journal: we are still in the waiting !!! And around the corner: the letter to the publisher, in case the truth is concealed, is ready: just a postage stamp away. Nothing is published and we wonder why ...

Whatever: we, patients, retain the basics: Morlat authorizes ICCARRE (4/7), period!

Quatuor a pretext trial


ANRS-4D is missing a comparator arm. No comparator arm, no 'recommendation', no non-inferiority ... compared to an arm that would follow the default strategy (7/7). The intellectual and moral inferiority is to ignore the comparator arm available: the huge cohort of patients under standard treatment. Or, equally, the patient's history. ANRS-4D has ZERO intrinsic failure, ie better than cohort results! And, even accounting for the 'pseudo-failures' (4%), an allowable margin of 12% (see the DOMONO calculation), and assuming that the controls are 100% successful, the non-inferiority threshold is at 88%. As there are also failures in the controls, the allowed threshold is well below 88%.

ICCARRE French Guidelines Morlat non-inferiority Breather HIV Genvoya cure
Any strategy with a success better than 100% less the margin of error (eg 12% therefore 88%) is non-inferior to the absolute: what else ???

The most stupid 'expert' will understand. The 'experts' are not stupid, far from it: they go to the manger. What forces Quatuor, it is the lack of connected neurons and of force in the arm wrestling ...

Quatuor: an unethical trial


Quartet is late, badly designed, hybrid (presence of Stribild® / Genvoya® !!!), and with a delayed arm, to the obvious harm of the poor volunteer!

Should only one of my readers participate and I would be in despair. I do not even imagine stealing the spot of a poor unfortunate for whom Quatuor is the only opportunity to benefit, at long last, from a strategy ... already authorized! And worse, for those who can not enroll! There are only 10 spots per participating French hospital!

What about informed consent! Are they going to tell candidates that they will, exceptionally, benefit from a new strategy, that is already authorized !!! When the candidates, already put on interminable waiting (it is already 1 year late), will be assigned to the delayed group, they will do as they please, either ICCARRE on-their-own or show them a well-deserved middle-finger.

And by doing ICCARRE on-your-own, or, at most, with a doctor (I added 2 to the list) of which no one can argue / prove that there is a risk, they will actively participate in building this a balance of power which is the only one that has proved effective in making Morlat (French Guidelines) surrender.

Your activist ICCARRISM and testimonials are welcome!

French Guidelines just killed Quartuor. Did they kill this blog?


I asked myself the question ... Since our subject is the weekly schedule, the authorization of 4/7 increases our potential readership, while it reduces that of the conventional ICCARRIENS. So the tailwinds are for us.

Good ... Gay Pride this Saturday and breaking the fast (end of Ramadan), this Sunday: Weekend of festivities and enjoyment: good Weekend, good fuck and not too many drugs!



Summer 2016: we offered a serial: ANRS-4D and the cheaters
Summer 2017: we will debunk DOMONO;Fascinating! Stay tuned!!!


This was originally published here, in French. We provide this translation for your convenience, practical aspects may differ where you live.

2 comments:

  1. AnonymousJuly 01, 2017

    I had an appointment with my doctor at 'Le 190' [a Parisian Men's Health Center]. And about Short Cycle, he and his colleagues, are, for "philosophical" reasons, against it. He said to me:

    - "there are not enough studies", whereas ICCARRE, at, Garches, and ANRS-4D have 500 cumulative intermittent treatments years at 4/7 days;

    - "it is dangerous, it is not only a personal matter, it is all the TasP that is at stake", whereas the promise of the 40% less medication should encourage patients with their treatment...;

    - "For TasP it is assumed that the viral load is the same in the blood and in the sperm, but at 4 days per week, there are no studies that check the load in the sperm." Inconsistency in glory! An undetectable virus in sperm has not been a predictor of non-transmission in more than 2,000 African couples. On the other hand, no contamination by PLHIV whose plasma HIV was less than 200 copies has ever been recorded or published. Finally, under ICCARRE, Dr. Leibowitch, with 4 days or less per week, allowed 9 serodiscordant couples to have 15 HIV-negative children, and negative partners are still negative;

    - "It's dangerous for your boyfriend and your other partners", So, what about the placebo arm in IPERGAY?

    - "We do not know for the proviral DNA, we have to study." However, the HIV DNA of patients under ICCARRE was measured, times and times over, and re-assessed (FASEB 2015 and ANRS 4D): not difference with the HIV DNA levels of patients under 7 days of treatment ...

    It is more for epistemological than philosophical reasons that they can not follow me, they are lost and / or blind.
    So he told me that if I really wanted to do it, I should look for another doctor who would accept me, but at 'Le 190' they would not prescribe more than two blood draw per year (but would't that be a risk for my partners ...)

    ReplyDelete
    Replies
    1. Biological monitoring is important at the beginning ... Your testimony is interesting.

      Biological monitoring is important, especially during start-up; This alone is of interest. One can also find an interest in the prognosis on Genotype.
      If the pre-ICCARRIEN prognostic is favorable, and you are really undetectable and respectful of your planning and in the framework of ANRS-4D, are these repetitive CVs useful? Indeed, there is no documented case of failure, under these conditions called 'Premium'.
      In ANRS-4D and ICCARRE, more than 5000 CVs were made, but nothing was found in strictly eligible patients. Nothing, nada, nichts ...

      Your doctor at 'Le 190' is mistaken, even lying, and he told you that his colleagues were not aleviating. How to know if it's true ... Besides, you have all freedom to name this doctor (who does not seem attached to you ...).
      'Le 190' was created as the Men's Health Clinic. Before PreP, it made sense, and it was unique. These people are obsessed by lowering the 'community' viral load; It turns hysteric.

      It was very interesting, but since the PreP, it is no longer relevant. No wonder they went bankrupt.

      Bankruptcy made, they restructured as a GEGID (therefore the PreP). Farewell 'Le 190' of the past. Too bad, go somewhere else!

      But is it not, in fact, to your advantage? They refuse you VLs, but also the PreP to your buddy ... Now, your prescription 7/7 allows you to offer the PreP to your / a buddy!
      1 ICCARRE = 1 PreP!
      You still have to do, if you insist, your VLs. It is 70 Eu in the lab (4 CV = 280 Euros), or ask other doctors.

      'Le 190' seems to participate in collective hysteria. We do not care: the pre-ICCARRIEN prognostic is done in Leibowitch or Truchis, ...; VLs at the lab. 'Le 190' is no more competent for HIVers.Fine...
      By claiming 'ICCARRE will be medicalized or will not be', we have obviously put patients in the impasse, while they have all the tools available. The soup is served to the opponent, and becomes a small coterie ... Of well-off people ...
      While the number of people with no other choice but a life-saving ICCARRE explodes: Ukrainians, Venezuelans, Greeks, soon Italy, Spain, Portugal ...

      Delete

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