141

This was originally published here, in French (link).
We provide this translation for your convenience. Practical aspects may differ where you live.



Coronavirus, HIV, ARVs, intermittence...(3)

By Charles-Edouard!

Coronavirus, HIV: the Live Continue below...

Graphic update by worldometers (based on Chinese 'war' propaganda).

Le 01/03/20: The virus soon in cruising speed?

The virus is gaining momentum Outside of China, but really Outside of Hubei, so the rest of China (outside of Hubei) is vulnerable. Japan is scrambling to save its Olympics, but if the rest of the world is under a rock, one wonders who will want to make the trip. Scenes of panic in supermarkets are making the rounds

On 02/28/20: Chloroquinine and focus

Here is a video of Pr Didier Raoult, Director of the IHU Méditerranée Infection and another one here just as interesting

The 27/02/20: Korea, Iran and the West take over

The Chinese method is hard, unbearable and ... effective(anyway!). The containment has an enormous economic cost: the factories are closed (China) and the customers are absent (West)

Where are the merchants of illusions? What about homeopathy? We stay in bed??? And if you believe that 5 prayers a day will bring you relief, then good luck! To believe is the droppings of the mind
The Shincheonji sect will have played a role, in spite of itself hopefully, in the resumption of the epidemic.

The 27/02/20: Sharp drop in deaths in China

While we were close to 150 deaths per day, we are now down to 30 deaths per day. If the figures are true, then hope seems to be able to change sides. The ball is now in Italy and Korea. In the last century, such a virus would have caused carnage. Let's bet that the funding will be sustained. A team from Nankai University, which writes that COV-19 has an 'HIV-like mutation' that allows it to enter the human body quickly by binding with a receptor called ACE2 on a cell membrane. Careful semantic slippage. It is one thing to say that COVID19 has attachment mechanisms like other viruses and to say that it uses the same receptor, which would give it a hint of relatedness. Alternatively, if we are talking about different receptors, this would give credence to the fact that there is no kinship. The conspiracy theorists are quick to make the amalgam, which is inappropriate.

Chinese factories will eventually reopen, but when? In a 'communist' country, this would be a good time to ask for wage increases!
For Chinese patients, facing the impossibility to get supplies (quarantine, shortages, etc.) the intermittence is to be studied closely! But well... I don't speak Chinese...

The Iranian Minister of Health, by his own admission infected with COVID-19, appeared in a governmental meeting, televised, sneezing 6 times. Nice example! Well, if he infected all these clowns...

On 02/26/20: Are you ready?

WHO etc. capitulate, today: WHO says the rest of the world is not yet ready for the spread of virus, cdc says coronavirus is probably pandemic, US may have up to 300 million masks for health workers. And since China doesn't export anymore, that means the market is dried up and you can't get any more!

Mortality will depend on the environment... Those who are going to die tomorrow are today counted as worrying cases (about 9.000 out of the 80.000 estimated cases). Let's say that a third will not survive. Let's say 3000... On top of the 3000 registered cases, that makes a rate of 7%. Not sure if we stay on a 2% rate as it is currently assumed. In any case, where the health care system is precarious, mortality will be higher. Among S+? We will see... For those who are not yet on treatment, there is still time to start, and then you can always go on intermittent treatment...

Be careful with the stock!!! If ARVs (in principle PIs and DTGs) are validated as useful for treatment, and therefore for prophylaxis, health workers in contact with patients will demand treatment, which is understandable... And then, the market will become very, very tight. And you will be happy to have a stock for family use, because, in case of rupture, a prescription is only a vulgar piece of paper... These are the same doctors, who yesterday refused you the intermittence, who tomorrow, will come whining to our door. We will respond as best we can, but not without compensation!

Key, lock and P4 laboratory: now that we can see that the release of the virus will have been successful, it remains to develop the antidote: vaccine or medication. With a bit of luck, an existing anti-viral will be a little bit efficient: for that we have to test. To develop a new drug, either we go forward at the shortest possible time (cf Islatravir), or we take the highway (cf dolutegravir). An inhibitor is a molecule that is placed in an enzyme to block its activity: the better the key fits in the lock, the better it is. And what could be more obvious than to have plans of the lock? To have a mapping, a kind of imaging of the enzyme, one has to produce the enzyme, crystallize it, pass it to the synchrotron, analyze it and give the plans to the chemists. This is not trivial, but the path to follow is known. Step number 1 is to produce the enzyme and for that you need virus (in numbers): a virus farm, that is, a P4 laboratory. At the moment, people who are well equipped and have access to the virus, are trying to put it into culture (for a good cause, one might say). The irony is that the 'solution' requires the same technical means that may have caused the outbreak. On the one hand, we can look with suspicion at those states that build P4s, such as France, since it is not to make caramel, but on the other hand, without P4s, you can't do anything in a hurry: you have to cultivate the Virus. Siliciano and Co, must be in a hurry...

The 25/02/20: Pandemic... or not ?

Of course, it looks bad for Korea, Italy (which is already struggling economically) or Iran, but the figures, based on Chinese propaganda, take an interesting turn: new cases, outside Hubei province, are down sharply, which puts China-hors-Hubei, on par with the rest of the World: containment measures are useful; they will remain necessary for a long time. Spring-like temperatures are coming. It's getting better because the plants are shut down... And they have to stay that way until the end of the epidemic.

A direct and unconditional bonus to households is the only way to get the economy moving again quickly. Because of the coronavirus, Le Maire announces '30 to 40%' less tourists: mass tourism ends up spoiling, so maybe it's not so bad...

Still nothing new on the ARVs front... It was a blank slate?

Le 24/02/20: Coronavirus, Pangolins and Scapegoats

South Korea at maximum alert level, Italy takes over, increasing mortality in Iran...

23.000 people are declared cured. That's as many candidates for the position of health assistant. However, we don't hear about it... The theory of natural emergence of the virus at the Wuhan fish market is now controversial in China itself... The publication is here.

Now that the story has been officially challenged, it is likely that the theory of the Huanan market (in Wuhan, epicenter of the virus release) as the origin of the pandemic is dead.

The published study reveals that the new coronavirus was introduced in the seafood market from another placeand then rapidly spread to the market.