hypo-dolu: an attractive once-weekly

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon

hypo-dolu: an attractive once-weekly

Hypo-Dolu: 1/7 truly a very attractive

In ICCARRE 1/7, Dr. Jacques Leibowitch offers a complete lock reverse transcriptase. Beginning in 2015, Dr. Alain Lafeuillade offers maintenance treatment, single dose, weekly, lock integrase.

Alain Lafeuillade offers the following diagram: triple therapy based Tivicay ™ (eg Triumeq ™ or Tivicay ™ + Kivexa ™ or Tivicay ™ + Truvada ™) monitoring Tivicay ™ mono-therapy, then gradual reduction to 1 decision weekly. It seems that the official test to be considered as a first step in Toulon. It also appears that there have been some patients in this process.

The key idea is that dolutegravir (DTG) has little mutation sites that confer resistance, and that, if selected, these mutants have a viability ( 'fitness') so small that it is as if they were gone.

For Hypo-Dolu test, you can inform you here:
Press Release of 20/01/2015 (English)
HYPO-DOLU Lafeuillade HIV HIV treatment dolutegravir Tivicay Hypodolu once-weekly
Personally, I have enough validated my ICCARRE 1/7, and I admit that the proposal of Alain Lafeuillade easier to generalize, easier to swallow, 'and even more economical (at least in France. ..). So I decided to do HYPODOLU way ... This is ongoing, and I am very happy!

Obviously this method will change the perception of therapies weekly catch ... It's going to open the field ... A bit emulation will do good.

Here is the French translation of the press release Hypo-Dolu
January 20, 2015 (MMD Newswire) - Dr. Alain Lafeuillade, MD, PhD, said: The new inhibitor of HIV integrase dolutegravir is a very potent drug not only able to maintain HIV RNA <20 copies / ml in patients naive to treatment or switch patients in monotherapy, but also to maintain control of viral load with 50 mg three times a week, and sometimes twice a week.
Alain Lafeuillade, a clinical researcher for 20 years on HIV, observed that dolutegravir alone is very effective in patients without resistance to integrase. "The viral load remained undetectable in my patients, and proviral HIV DNA into the cells remained stable with only 50 mg 2-3 times a week with an average follow-up of 6 months, adds Dr. Lafeuillade. Therefore he proposed a protocol called "Hypo-Dolu" in HIV patients to determine, in the absence of resistance to integrase inhibitors, the minimum weekly dose of dolutegravir necessary. patients on two reverse transcriptase inhibitors, more dolutegravir 50 mg / day would be spent in dolutegravir mono-therapy for 3 months and then, if the viral load remained <50 copies / mL, will be passed to dolutegravir 50 mg every 2 days, and if the plasma viremia is still contained 50 mg twice a week, then once a week.
"There is hardly any risk of resistance selection, Doctor Lafeuillade added that the single mutation Selectee rarely dolutegravir by the codon 263 of the integrase gene significantly affects the viability of HIV, and that's why dolutegravir healing is tested in trials. Unfortunately, ViiV Healthcare n 'was not interested in the process, preferring to sell its drug at the highest dose, as tested in clinical trials, even if it was too high.

Dr Lafeuillade launch this test as a trial in his institution; he stressed that "in a difficult economic situation, it may be helpful to save medication if a single anti-retroviral triple therapy compared to -By-can do the job at lower doses, and it will also help to save the long-term side effects ".

Contact: Alain Lafeuillade
Head of the Department of Infectious Diseases
General Hospital, 54 rue Henri Sainte-Claire Deville
83100 Toulon, France
Ph: +33 (4) 94 14 50 84
Email: alain.lafeuillade ... then put the at sign, then ... ch-toulon.fr
Complete information is gathered here:
tinyurl.com/CHE-HYPO-DOLU

Several features of dolutegravir and its pharmaceutical form Tivicay ™ justify this approach: we will discuss on this blog. See: Monotherapy Tivicay ® (DTG)




This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon

Once weekly on prime time TV

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon

Once weekly on prime time TV

1/7 submitted to 20 hours of TF1

Fast Forward >> In 2014, there was this story on TF1:
Iccarre HIV cure HIV AIDS AIDS relief organization Leibowitch Efavirenz
http://i59.tinypic.com/2qd1q8o.jpg When I read the first accounts (Alexandre Bergamini), with Leibowitch in Garches (ICCARRE), I thought the guys were either fantasists whether they had found something unique, that was out of my reach .

The method is explained right, left, is a bit scattered. By bringing together the snippets we can reconstruct the strategy, and the problem is solved. Except that conveys a lot of imprecise or inaccurate information that put the patient faces a risk of failure, and by the same strategy.

The 1/7 is maintained in a fog, mist fed ... Outside our Church 'no salvation: ICCARRE hospital will or will not: hogwash!

Just know the recipe and method ...

In light of recent publications relief in 5/7 or 1/7 are no longer hypothetical but fantasies a reality available to all.

I propose a practical guide for the beginner ICCARRIEN. We found it to:

Now that Leibowitch published, it is no longer needed to do in the politically correct. Besides ... Political correctness it intoxicates me ...

For my part, I take long to realize that this is great! But I finally understand ...




This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon

4 different proposals for relief

This paper was originally published here, in French. We provide the google translation for your convenience. Proper translation will come soon. Some practical aspects may differ where you live.

4 different proposals for relief

You are cured!

This paper was originally published here, in French. We are providing the google translation for your convenience

You are cured! ICCARRE: Sir, you ARE Healed!

Sir, you ARE Healed!

Oh ... The title surprises ...

YET That is Fauci, Dybul, Leibowitch and other doctors, very advanced, the early days of triple therapy DIT Ë Have Their patients. With the disappointment Whether on SAIT

I said, sir, you ARE Healed. ARRÊTONS the treatment

At the bottom of p. 4, here:
www.tinyurl.com/CHE-REPI
ou here: CR_Recherche.pdf
and when I left Washington to pay Announce Results of triple therapy, it already Had Recurrence
Indeed, the sauce commit.
As I edited, pour facilitate dissemination, the micro-story of TF1, he turned loop and yes ... Turned in a loop, it's hard to Aunt Imagineur, We Are important pre-conditioning and traumatized by The Who fOREGOING.



However ... at 1/7, I'd say What can Leibo

Charles Edward, you ARE Almost Healed. ARRÊTONS gradually the treatment, and maintain weekly prophylaxis June. And when I went to Washington, and elsewhere, pour continuer my life, he had not Always Had Recurrence

So I OJEU 2015 ... and my i-Phone:

Yes, Jacques, I'm Almost Healed. So thank you Doctor ... Yes ... ICCARRE e Hypo-June Dolu gives response (partial) and YES ... on May cure HIV (and AIDS).

Healing almost certainly cure But anyway! ...


This paper was originally published here, in French. We are providing the google translation for your convenience